BIOMASS & BIOENERGY
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2026
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IF 7
Die Gao,Zhengyu Guo,Hui Ma,Huimin Cao,Leiyu Liu,Jingliang Xu,Shen Zhang
Xylose, a primary sugar component of lignocellulosic biomass, is isomers or epimers of many high-value or rare added pentose. Traditional utilization of xylose predominantly involves dehydration to furfural or hydrogenation to xylitol. In this work, we prepared a carbon-supported molybdenum disulfide catalyst (MoS 2 @C) via a hydrothermal pretreatment, which facilities multi-step isomerization of xylose toward three high-value monosaccharides: lyxose, arabinose, and ribose. NH 3 -TPD and EPR characterizations proved that abundant MoS 2 and S vacancy sites are generated on carbon surface. S 2− species function as Lewis basic sites to stabilize key intermediates and facilitates hydrogen transfer. These dual-functional sites jointly promote a sequential isomerization and epimerization of xylose pathways. Multi-isomerization process of xylose was occurred by MoS 2 @C at 120°C. The isomers and epimers including lyxose (20.06%), arabinose (15.87%), and ribose (10.84%) were obtained in water. A multi-step reaction sequence includes sequential 1,2-hydrogen migration and carbon skeleton rearrangement, leading to synthesis of arabinose and ribose. Furthermore, a mechanistic hypothesis for multi-isomerization process of xylose by MoS 2 @Carbon catalyst was proposed, sulfur species promote hydrogen transfer and carbon rearrangement through nucleophilic attack and vacancy-assisted mechanisms. This study provides an effective catalyst design strategy and mechanistic basis for the conversion of xylose into high-value products using molybdenum disulfide.
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JOURNAL OF HAZARDOUS MATERIALS
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2026
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IF 10.6
Xiaoran Ma,Yabing Xiong,Yimu Wei,Shengchen Lv,Yaofeng Fang,Xueke Liu,Donghui Liu,Peng Wang
Human exposure to concurrent multiple pesticide residues is inevitable given the application of pesticides in modern agricultural, yet the associated health risks remain insufficiently characterized. A mixture of ten frequently detected pesticides was incorporated into the diet of male ICR mice at three dose levels (ADI, 100 ×ADI, and 10 ×NOAEL) for 17 weeks to evaluate intestinal risks. ADI exposure caused no significant colonic inflammation or injury, whereas 100 ×ADI and 10 ×NOAEL caused IBD, characterized by shortened colon length, epithelial injury, upregulated pro-inflammatory cytokines ( IL-1β , IL-6 , IL-22 ), and downregulated tight junIction proteins ( ZO-1 , occludin ). In DSS-induced model, even ADI group developed evident IBD, and those at 100 ×ADI and 10 ×NOAEL group exhibited more exacerbated intestinal inflammatory responses and tissue injury, indicating that chronic ADI dose pesticide cocktail exposure markedly increased susceptibility to IBD. At 10 ×NOAEL dose, the relative abundances of Lactobacillus , Streptococcus , and Candidatus_Saccharimonas were significantly reduced, whereas Faecalibaculum and Akkermansia were significantly enriched, which was closely associated with increased pro-inflammatory cytokines ( IL-6 , IL-22 ) and upregulation of RORγt and IL-17a alongside reduced Foxp3 and IL-10 , indicating a disrupted Th17/Treg balance linked to colonic inflammation and barrier dysfunction. FMT confirmed the critical role of the gut microbiota in mediating both pesticide-induced colonic inflammation and aggravation of DSS-induced colitis. Collectively, these findings demonstrate that chronic low-dose pesticide cocktail exposure disrupts gut microbial homeostasis, alters the Th17/Treg balance, upregulates pro-inflammatory cytokines, and compromises intestinal barrier integrity, thereby triggering colonic inflammation and exacerbating DSS-induced IBD. This work highlights the necessity of the evaluation of mixed pesticide residue.
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JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
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2026
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IF 5.4
Xiaoliang Wang,Mengting Lou,Yuting Wang,Miao-Miao Niu,Dongli Zhang
Lung cancer, a globally prevalent fatal malignancy, remains a major therapeutic challenge. X-linked inhibitor of apoptosis protein (XIAP) is overexpressed in various cancers, driving uncontrolled proliferation, while its specific inhibition suppresses tumour growth. Through virtual screening, we identified five novel candidate peptides (Peptides 1–5) with picomolar-level inhibitory activity. Peptide-5 showed the highest binding affinity (Kd = 10.2 ± 0.5 pM), and FP assay indicated that Peptide-5 competitively binds the BIR3 domain of XIAP against caspase-9. Molecular dynamics simulations confirmed the structural stability of its complex with XIAP. Meanwhile, Peptide-5 showed good serum and metabolic stability, as well as favourable cellular permeability. Notably, Peptide-5 exhibited potent antiproliferative activity against various tumour cells with no obvious toxicity to normal cells. Peptide-5 potentially activates apoptotic signalling through modulating the Bcl-2/Bax mRNA expression. In summary, our study confirms that Peptide-5 is a highly potent and promising XIAP-targeted inhibitor for the treatment of cancer.
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International Journal of Nanomedicine
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2026
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IF 8.7
Ping Sheng,Liang Zhang,Wenwei Xie,Yu He,Yanjiao Wu,Jinyu Huang,Dan Li,Jiafu Leng,Debing Xiang
Introduction Pancreatic ductal adenocarcinoma (PDAC) poses a major challenge due to the lack of effective treatment options and its extremely poor prognosis. Nanodrug delivery systems can improve drug solubility and enable efficient targeted delivery, offering new possibilities for PDAC therapy.Methods The oncogenic role of KCa3.1 in PDAC was validated through analyses of The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) databases combined with functional assays. To overcome the limitations of conventional therapies, we developed a targeted nanodrug delivery system, TRAM@PPF, based on PLGA nanoparticles modified with polyethylene glycol-folate (PEG2000-FA). This system was prepared by the emulsion-solvent evaporation method to specifically deliver the KCa3.1 channel inhibitor TRAM-34 to PDAC cells. We characterized the nanosystem’s physical properties and release profile and evaluated its antitumor efficacy in vitro and in vivo.Results The synthesized TRAM@PPF nanoparticles demonstrated uniform size (~142 nm) and excellent stability, with superior cellular uptake compared to non-folate-modified nanoparticles. In vitro, TRAM@PPF showed potent antitumor activity by markedly inhibiting cell proliferation and enhancing apoptosis. Following intravenous administration in pancreatic cancer mouse models, TRAM@PPF significantly inhibited tumor growth, reduced tumor weight, and prolonged survival. Moreover, TRAM@PPF showed excellent biosafety in animal models, suggesting strong potential for further clinical translation in PDAC therapy.Conclusion TRAM@PPF preserves folate-mediated tumor-targeting capability while significantly enhancing antitumor activity, offering a promising strategy for targeted therapy of pancreatic cancer.
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Small
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2026
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IF 12.1
Yueguang Fang,Chenxi Li,Xinqi Li,Lanling Xiu,Dingwen Xiao,Miao Wang,Lin Sun,Junwei Ye
Titanium-based materials hold great biomedical potential owing to excellent biocompatibility. But titanium diboride (TiB 2 ), an emerging metal boride, is rarely explored for antitumor use, and developing multifunctional TiB 2 -based nanoplatforms with enhanced catalytic activity is urgently needed. Herein, we constructed a nanoplatform (TiB 2 -PEG-DOX) by modifying TiB 2 nanosheets (TiB 2 NSs) with amino polyethylene glycol (NH 2 -PEG-NH 2 ) and loading doxorubicin (DOX) via electrostatic interaction. We first clarified the boron (B)-mediated Ti valence cycle: B regulates Ti electron transfer, promotes Ti 4+ reduction to Ti 2+ , enhancing H 2 O 2 -rich tumor microenvironment Fenton-like reaction to generate cytotoxic •OH for chemodynamic therapy (CDT). Meanwhile, TiB 2 -PEG-DOX shows 53.53% photothermal conversion efficiency under 808 nm near-infrared (NIR) irradiation for efficient photothermal therapy (PTT), and NIR further triggers on-demand DOX release. DOX accumulates at tumor sites via the enhanced permeability and retention (EPR) effect to exert chemotherapy (CT). In vitro, it eliminates 86.32% of HCT-116 colorectal cancer cells via CDT/PTT/CT synergy; in vivo, it achieves nearly complete tumor ablation in mice with excellent biocompatibility. This work provides a high-performance synergistic antitumor platform and establishes a B-modulated metal valence cycling paradigm, paving the way for titanium-based nanomedicines.
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Advanced Healthcare Materials
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2026
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IF 11
Douhui Guo,Jing Ye,Changxiong Cai,Ting Xiong,Xueqiang Deng,Yaqi Hua,Wenqi Duan,Chen Li,Liang Hao
Rotator cuff tears (RCT) are one of the most common causes of shoulder joint pain and mobility disorders affecting the health of middle-aged and elderly patients. Although the arthroscopic repair can effectively suture the torn rotator cuff, the retear rate is still high, especially for patients with osteoporosis. Excessive oxidative stress, uncontrolled inflammatory infiltration Bone mass reduction, muscle atrophy, and fatty infiltration would gradually aggravate during the development of RCT, which would seriously hinder the effective repair of the repaired rotator cuff after arthroscopic surgery. Herein, a novel nanozyme-based drug delivery system Nb 2 C@Mg-MOF/Pluronic F127 (NMP) consisting of niobium carbide (Nb 2 C), magnesium metal–organic framework (Mg-MOF), and a temperature-sensitive hydrogel (Pluronic F127) was developed for effective regulation of inflammation and orderly regeneration of various tissues from bone to muscle. The in vitro and in vivo studies have shown that NM (Nb 2 C@Mg-MOF) has excellent anti-inflammatory properties. It could actively promote various tissue regeneration, including osteogenesis, inhibition of osteoclastogenesis, myogenesis, inhibit fatty infiltration and angiogenesis. This nanozyme-based drug delivery system plays an effective role in promoting healing in the complex repair process of rotator cuff tears with osteoporosis, which would provide new insights and a promising strategy for treating of osteoporotic rotator cuff tears.
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Advanced Healthcare Materials
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2026
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IF 9.6
Jian Gao,Miao Yu,Youdi Hu,Wenjiao Chang,Jiale Yong,Jinpeng Fang,Nianwei Dai,Dong Wu
Polypropylene (PP) mesh implanting has emerged as a breast reconstruction approach to restore normal anatomical contours. However, developing biomedical PP mesh with enhanced anti-inflammatory properties, superior mechanical strength, and efficient manufacturing remains a significant challenge. In this study, we report a drug-loading PP mesh by incorporating triclosan into femtosecond (fs) laser-treated PP mesh scaffolds. The fs laser induced micro/nano structures significantly enhanced the drug-loading capacity and antibacterial efficacy of triclosan-modified PP mesh, as indicated by the area of inhibition rings (2.5-fold relative to the blank groups). In vivo breast reconstruction experiments using female Sprague-Dawley (SD) rats demonstrate accelerated scab formation and wound healing. Additionally, the Enzyme-linked immunosorbent assay (ELISA) test reveals high vascular density (11.43 µg/mL of CD31 and 0.32 µg/mL of CD163) and reduced proinflammatory cytokine levels (145 pg/mL of IL-6 and 33 pg/mL of TNF-a), further confirming the anti-inflammatory properties of the fs laser-treated triclosan-modified PP mesh. This study presents a novel approach to improving the clinical performance of PP meshes for biomedical applications.
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Advanced Healthcare Materials
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2026
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IF 11
Jingfei Wang,Shuting Li,Liwu Liu,Fukai Liu,Cheng Lin,Yanju Liu,Jinsong Leng
Nowadays, the implantation of occluder is an effective approach for treating patent foramen ovale (PFO); however, the slow endothelialization poses significant complications associated with occlusion devices. Herein, a 4D-printed intelligent reconfigurable PFO occluder with pro-endothelialization, anti-thrombosis, and absorbability is designed. The combination of the occluder implantation and topical drug delivery of anti-thrombosis drugs offers a solution to stroke. The occluder is designed based on the biomimetic structure, facilitating the integration of mechanical response behavior compatible with cardiac tissue. In vitro degradation and in vivo histological examination demonstrate the bioabsorbability of the occluder, and the anti-thrombosis efficacy is preliminarily demonstrated through anti-thrombosis experiments. The effective expression of VWF and CD31 markers validates the superior pro-endothelial efficacy of the occluder. To summarize, the 4D-printed occluder in this work represents an accessible strategy to combat PFO through integrated occlusion and topical drug delivery.
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ADVANCED FUNCTIONAL MATERIALS
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2026
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IF 19.9
Xinqiuyue Wang,Lei Zhang,Jiajia Su,Haokun Xue,Han Zhou,Fanglei Xue,Yajie Wang,Danyi Quan,Jianping Liu,Wenli Zhang
Conventional therapy for Helicobacter pylori ( H. pylori ) is often compromised by host autophagy dysfunction. Host-directed therapy (HDT) presents a viable solution; however, its efficacy is hindered by biological barriers and the difficulty in targeting infected cells. Herein, we developed BPI-CD-L CR , a self-propelled “Trojan Horse” nanoplatform functionalized with bacterial-targeting peptide (B-mBPI) and urease-powered motor (TPGS-β-CD@Urease), in which TPGS-β-cyclodextrin (TPGS-β-CD) plays multiple critical roles from drug delivery to autophagy modulation. Initially, TPGS-β-CD maximizes urease motor activity against the gastric environment by forming a dynamic complex with urease, thereby powering active propulsion for deep mucus penetration. Upon reaching the infection site, BPI-CD-L CR employs a Trojan horse mechanism by tracking bacteria and mediates opsonophagocytosis by macrophages. Meantime, TPGS-β-CD outside facilitates BPI-CD-L CR phagocytosis by increasing the membrane fluidity of infected macrophage via cholesterol extraction. Intracellularly, BPI-CD-L CR modulates the autophagy pathway by promoting autophagosome-lysosome fusion with the aid of TPGS-β-CD and restoring lysosomal function through resveratrol (Res), thereby reactivating the clearance of intracellular bacteria. In the murine infection model, BPI-CD-L CR achieved a remarkable 33-fold reduction in gastric bacterial load compared to antibiotic-based triple therapy. Overall, this platform represents a nanoengineered delivery strategy for intractable infections, providing a promising solution for guiding HDT to achieve on-demand antimicrobial activation within infected cells.
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Advanced Science
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2026
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IF 14.1
Binbin Cui,Shilei Dai,Ivo Pang,Dingyao Liu,Xinran Zhang,Jing Bai,Xinyu Tian,Shiming Zhang
Synthetic bioelectronics is rapidly advancing, propelled by breakthroughs in synthetic biology and bioelectronics. This convergence is key to next-generation wearable and implantable devices, enabling seamless integration with living systems. Here, we introduce an enzymatic hydrogel electrode (GelZymes) developed via a synthetic bioelectronic strategy to overcome the mechanical and interfacial limitations of conventional enzyme electrodes. GelZymes deliver two core advances: i) a monolithic and scalable 3D architecture that unifies the enzyme membrane and electrode, simplifying fabrication and eliminating interfacial instability; and ii) tissue-like viscoelasticity—combining stretchability and adhesiveness—rarely achievable with rigid enzyme membranes. GelZymes are synthesized through three steps: engineering a stretchable, mixed-conducting 3D hydrogel; implementing an enzyme-compatible, cascading crosslinking scheme to immobilize enzymes within the network; and balancing the trade-off between electronic/ionic conductivity and the density of redox-active enzyme sites to maximize bio-electrochemical performance. We further show that GelZymes enable a shift from invasive, tissue-interfaced biosensing to noninvasive, tissue-integrated biosensing, offering a practical pathway to bridge current biosensor technologies with living systems.
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Advanced Science
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2026
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IF 14.1
Lixia Feng,Simei Zhao,Zheng Wei,Wenwen Wang,Feiquan Ying,Lin Huang,Mengna Zhu,Mengqing Chen,Qiang Yang,Si Sun,Dawei Jiang,Lingling Gao,Jing Cai
Therapy targeting cancer stem cells (CSCs) has been proposed as a promising strategy to reduce chemoresistance and relapse risks in ovarian cancer (OC) patients. However, the lack of targetable markers impedes research progress. Here, we demonstrate that CXC motif chemokine receptor 4 (CXCR4) may be a targetable functional marker of ovarian CSCs and propose a new translational model incorporating targeted imaging and CXCR4 blockade in CXCR4 + tumors. Expression profile analysis of chemoresistant CSC-like ovarian cancer cells highlighted that CXCR4 functions as a potential stemness marker. CXCR4 + ovarian cancer cells exhibited high self-renewal capacity in vitro and in vivo, and an association with chemoresistance. CXCR4 inhibitor AMD3100 significantly impaired the self-renewal ability of CSC-like ovarian cancer cells and enhanced their sensitivity to cisplatin. CXCR4-targeted [ 68 Ga]Ga-Pentixafor was highly specific in delineating CXCR4-high cell line-derived xenografts and patient-derived xenografts (PDXs) via positron emission tomography (PET) imaging, with precise tumor-targeting and persistent retention. A combination of AMD3100 and CDDP exerted an excellent antitumor effect in CXCR4-high PDXs, but not in CXCR4-low PDXs. These results suggest that CXCR4 may represent a functional CSC marker associated with chemoresistance. Moreover, [ 68 Ga]Ga-Pentixafor PET imaging can guide decision-making for AMD3100 therapy, paving the way for further clinical translation.
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ACS Applied Materials & Interfaces
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2026
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IF 7.8
Yu Chen,Xiaodi Hao,Boqi Gu,Zhentan Lu,Dong Wang
Bacterial infected wounds pose a serious threat to human health. Developing a novel strategy that integrates real-time infection monitoring with exceptional antibacterial performance is urgent for advancing wound management. Herein, a multifunctional hydrogel (CMCS-PA@Fe/MUG hydrogels) integrating real-time infection diagnosis and therapeutic intervention capabilities has been successfully developed through the formation of Schiff bases between CMCS and PA@Fe solutions with the addition of 4-methylumbelliferyl β-d-glucuronide (MUG). The detection of the bacterial presence is achieved by visually monitoring the blue fluorescence emitted from 4-methylumbelliferyl (4-MU), which is produced through the enzymatic hydrolysis of MUG by pathogen-specific enzymes. In addition, the tissue adhesion and self-healing properties of CMCS-PA@Fe/MUG hydrogels enable them to seamlessly adapt to the mechanical demands of skin movement and stretching. Moreover, the combined photothermal activity of PA@Fe and the intrinsic antibacterial capability of chitosan endow the hydrogel with a superior antibacterial performance. The in vivo experimental results demonstrate that the hydrogel could effectively diagnose the infection status of a wound in real time and promote wound healing. Therefore, this advanced hydrogel sensor provides an innovative solution for infected wound management through real-time infection monitoring and efficient antibacterial strategies.
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