MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Biaobiao Ge,Jie Huang,Qianmin Dong,Fen Yang,Mengmeng Wang,Pei Liang
This work reveals a novel SERS enhancement mechanism of “satellite” structure. • Stable and uniform L-Au@ZIF-67@S-Au NPs were synthesized by self-assembly method. • L-Au@ZIF-67@S-Au NPs substrates was prepared with an enhancement factor of 3.4 × 10 6 . • Determination of fenpropathrin in citrus peel, and its LOD reached 0.995 μg/L. A new hybrid substrate of core-satellite plasma MOF, namely L-au @ ZIF-67 @ S au NPs, was developed in this study. The substrate aims to improve SERS performance by combining the molecular trapping layer of ZIF-67 with double electromagnetic hot spots distributed on the inner surface and the outer surface. The interface self-assembly strategy was adopted to combine MOF with plasma nanostructures, thus combining excellent molecular adsorption ability with strong local field enhancement effect. The results showed that the substrate had a low detection limit of 1.43 × 10 −10 M for rhodamine 6G, achieved rapid adsorption equilibrium within 10 min, and showed high signal reproducibility (relative standard deviation, RSD = 1.66%, n = 20). The substrate was applied to the detection of fenpropathrin residues in citrus peels, showing good sensitivity, and the detection limit was 0.995 μg·L −1 , with an enhancement factor of 3.4 × 10 6 and excellent reproducibility. This work builds a multifunctional and environment-friendly SERS platform, which effectively combines advanced nano-material design with practical applications of food safety monitoring Download: Download high-res image (146KB) Download: Download full-size image
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Ying Chen,Kun Ge,Xing Liang Cheng,Yuling Hu
Cu@CuO@TCPP-Cu heterojunction with electronic bridge was fabricated. • Cu 2+ bridge boosts charge transfer and strengthens interfacial coupling in Cu@CuO@TCPP-Cu. • The heterojunction shows enhanced SERS performance and POD-like catalytic activity. • Dual-target strategies enable sensitive PAT and H 2 O 2 detection for food safety monitoring. Engineering heterojunctions with efficient carrier separation and interfacial charge transfer is crucial for high performance surface-enhanced Raman spectroscopy (SERS) and enzymatic catalytic activity. However, conventional asynchronous synthesized heterostructures suffer from insufficient interfacial contact, which severely restricts charge transfer kinetics and SERS/catalytic response. Here, we rationally engineer a novel flower-layered Cu@CuO@TCPP-Cu heterojunction mediated by an in situ formed “electron bridge” for high sensitivity sensing applications. A facile surface oxidation technique was employed to grow flower-like CuO in situ on a Cu foil, followed by surface-initiated encapsulation of two-dimensional MOF of TCPP-Cu through coordination between TCPP and Cu 2+ ions released from CuO. The dissociated Cu 2+ ions at the interface serve as an “electronic bridge” between CuO and TCPP-Cu, which drastically shortens the charge transfer distance and enhances interfacial coupling. This unique heterojunciton exhibits remarkable synergy in SERS signal enhancement and peroxidase (POD)-like catalytic activity, as confirmed by density functional theory (DFT) calculations. A robust solid-state SERS sensing chip was thereby constructed. Two distinct analytical strategies were subsequently established, including aptamer-mediated specific detection of patulin (PAT) and enzyme mimicking - amplified turn-on SERS assay for quantitative analysis of H 2 O 2 . The as-constructed sensing chip exhibits excellent analytical sensitivity and selectivity, achieving low limits of detection of 0.640 μg/L for PAT and 13.8 μg/L for H 2 O 2 , respectively. Furthermore, the chip successfully identified both analytes in complex food samples with high accuracy. This work provides a versatile engineering strategy for constructing high performance heterojunction toward advanced analytical and food safety applications. Herein, a novel flower-layered Cu@CuO@Cu-TCPP heterojunction is constructed via an electronic bridge strategy. The bridge-mediated interfacial electron transfer synergistically boots peroxidase-like catalytic activity and SERS performance. Integrating aptamer recognition with nanozyme amplified turn-on SERS sensing enables highly sensitive detection of PAT and H 2 O 2 , offering a universal heterojunction design paradigm and broadening applications in food safety monitoring. Download: Download high-res image (166KB) Download: Download full-size image
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高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2026
·
IF 8.3
Wanyi Xiong,Shunbi Xie,Youlin Tang,Runzi Zhang,Xiaoyu Yang,Yi He
Lomefloxacin (LOM) residues in food can induce bacterial resistance and pose serious health risks. Therefore, sensitive detection of trace LOM is of great significance. A recyclable and degradable surface-enhanced Raman scattering (SERS) biosensor, which is based on stimuli-responsive DNA/covalent organic frameworks (COF) and cellulose hydrogel (CA-β-CD), was developed for the ultrasensitive detection of LOM. Specifically, by utilizing the high adsorption capacity of COF, a large number of Raman-active signal molecules (methylene blue, MB) were incorporated to form a stimuli-responsive DNA/COF complex that responds to the LOM. Subsequently, a recyclable SERS substrate was fabricated through the integration of cyclodextrin-functionalized cellulose gel (CA-β-CD) with green leaf@Ag NPs. Upon exposure to the target, LOM competitively bound to the aptamer, triggering the release of MB, which was then captured through host-guest interactions by the CA-β-CD, thereby generating a strong SERS signal. The immobilized MB can be desorbed by modulating the pH, which enables the efficient regeneration and reuse of the SERS substrate. Furthermore, the cellulose gel can be degraded in the presence of cellulase, ensuring an environmentally sustainable detection approach. The proposed method achieved ultrasensitive detection of LOM over a linear range of 1.0 × 10 −11 to 1.0 × 10 −5 mol/L, with a detection limit as low as 3.56 × 10 −12 mol/L. Moreover, the biosensor demonstrated outstanding specificity and robustness in the face of potential interferents and has been successfully applied to the analysis of real-world samples. This work offers a novel and reliable strategy for the sensitive detection of antibiotics in food matrices.
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高影响因子
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
·
2025
·
IF 4.6
Xinran Yang,Zonglin Li,Junhui Du,Xueli Zhang,Haibin Liu,Xuechao Zhang,Lijun Li,Chuanjin Cui,Hongshuo Chen
In this paper, a SERS/electrochemical dual-channel aptamer biosensor was established for ultrasensitive detection of Pb 2+ . Firstly, the capture probe Fe 3 O 4 @Au@PAMAM@Aptamer and the signal probe AuNs@4-MBA@Au@ssDNA were chemically synthesized step by step. Secondly, the carboxyl graphene oxide (GO) was electrodeposited onto the electrode surface to gain the GO/SPCE. Meanwhile, PAMAM@Au nanomaterials were successfully synthesized and thus prepared the Aptamer/PAMAM@Au/GO/SPCE. During the process, SEM, TEM, FTIR and XPS were applied to characterize the synthesized nanomaterials which confirmed the successful synthesis of the nanomaterials. Finaly, the performance of this biosensor was evaluated in a series of Pb 2+ aqueous solutions by surface enhanced Raman (SERS) and differential pulse voltammetry (DPV). The results showed that the lowest limit of detection (LOD) was 3.16 × 10 −5 nM, and the sample recovery was 99.50–103.67 %. Furthermore, the biosensor demonstrated good specificity, repeatability, and stability. Reliable results were also obtained in actual sample testing. Therefore, it can provide a viable method for trace detection of heavy metal ions.
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高影响因子
Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment
·
2019
·
IF 2.17
Tehseen Yaseen,Hongbin Pu,Da-Wen Sun
In this study, a surface-enhanced Raman scattering (SERS) approach based on silver-coated gold nanoparticles (Au@Ag NPs) was established for rapid detection of multiple organophosphorus pesticides (triazophos and methyl-parathion) in peach fruit. The Raman enhancement of Au@Ag NPs for detecting organophosphorus pesticides was stronger than those of single Ag and Au NPs. It was revealed that core size of Au NPs was a critical parameter affecting the enhancement of Raman signals by joining two plasma resonance absorptions. The Au@Ag NPs with 26 nm Au core size and 6 nm Ag shell thickness showed significant Raman enhancement, especially by the creation of hot spots through NPs aggregation induced by connection between Au@Ag NPs and target molecules. The detection limits of triazophos and methyl-parathion in peach were 0.001 mg/kg. Good recovery (93.36 to 123.6 %) and high selectivity of the SERS activity allowed excellent precision for the detection of the triazophos and methyl-parathion in peach. Compared to earlier studies, the current approach was rapid, inexpensive and simple without lengthy sample pre-treatment. This study revealed that the proposed method could be employed for the analysis of trace contaminants such as triazophos and methyl-parathion in many food matrices.
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高影响因子
MICROCHEMICAL JOURNAL
·
2022
·
IF 5.304
Yaqing Yu,Xiaoyi Jin,Ling Shen,Jin Wang,Jing Lei,Hui Zhang,Juan Zhang
Surface-enhanced Raman scattering (SERS) has proven to be a powerful diagnostic technique for conservation science. In this work, a novel swab-based detection strategy is proposed for minimally invasive SERS analysis of synthetic organic dyes in the cultural heritage field, employing flexible paper-based SERS probes prepared with a facile, cost-efficient and reproducible recipe. It was demonstrated that Ag nanostructures/paper probes composed of interconnected Ag nanostructures immobilized on unmodified cellulose paper showed excellent SERS enhancement for the investigated synthetic organic dyes. The high flexibility and conformability of paper-based substrate allows to extract minimal amounts of dyes from the work of art by gently swabbing in a dry-state condition, thereby avoiding potential damage to colorants from close contact with solvents such as water. Dyes could be transferred via swab-based extraction method without removing any visible fragments of the paint layer, which facilitates preserving the physical integrity of the artwork. SERS detection was subsequently performed directly on flexible substrate surfaces after micro-extraction of dyes. The minimally invasive nature of this strategy has further been confirmed by the spectrophotometric color measurements and successfully applied to the identification of synthetic organic dyes on real paper artworks---Chinese woodblock New Year paintings from the late Qing Dynasty. These results highlight the great potential of flexible paper-based Ag substrates based on swab-detection method for minimally invasive analysis of organic dyes in cultural heritage.
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高影响因子
TALANTA
·
2022
·
IF 6.556
Yan Yang,Guoliang Li,Panxue Wang,Lihua Fan,Yiheng Shi
Rapid and reliable multiplex detection of foodborne pathogens is in great demand for ensuring food safety and preventing foodborne diseases. In this study, we developed a highly sensitive SERS immunosensor for the simultaneous detection of multiple foodborne pathogens. Novel biologic interference-free Raman tags synthesized by using the covalent organic frameworks (COF) TBDP as nanocontainer to load biologic interference-free Raman reporters and specific antibodies for interested targets were used to convert and amplify signals of foodborne pathogens. In addition, lectin functionalized magnetic nanoparticles (MNPs@Con A) which could efficiently bind to the carbohydrate constituents on the surface of pathogens were prepared to capture and isolate multiple pathogens simultaneously. The recognition of the target foodborne pathogen impels the generation of sandwich-like composites of MNPs@Con A/pathogen/TBDP@Raman tags, and these composites could be quickly separated from the sample matrix with the assistance of an external magnet. Besides, a mass of Raman reporters was released by eluting the collected MNPs@Con A/pathogen/TBDP@Raman tags composites. Combined with a portable Raman system, characteristic Raman signals (2271 and 2113 cm −1 ) of the occupied reporters located at the biologic interference-free region were observed and used for the simultaneous detection of two different foodborne pathogenic strains. And an equal limit of detection of 10 1 CFU/mL was achieved for each strain. This strategy provides new insight into the application of SERS in the detection of pathogenic bacteria.
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PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2022
·
IF 9.221
Dan Wang,Guanchen Xu,Xingshuang Zhang,Hongyu Gong,Li Jiang,Guanliang Sun,Yu Li,Guoran Liu,Yong Li,Shikuan Yang,Xiu Liang
A novel approach is developed to fabricate an ultra-thin layered flexible wearable Surface-Enhanced Raman Scattering (SERS) substrate named silk fibroin-anodic aluminum oxide-Au nanoparticles (SF-AAO-Au), which consists of biocompatible SF film as flexible support, ultrathin cavity AAO as template, and plasmonic Au NPs. The SF-AAO-Au sensor exhibits excellent SERS mechanical flexibility, homogeneity and sensitivity for its effective enhancement ability and highly ordered 3D periodic porous particle-in-cavity (PIC) arrays structure. The humidity-driven interface structure of biocompatible SF film provides good skin adhesion under various fitness tests and excellent mechanical flexibility as a wearable SERS sensor on natural skin (deformation within 5%). The flexible SF-AAO-Au can be developed as quantitative sweat glucose sensor in the concentration range of 10 − 7 to 10 − 3 M with a limit of detection (LOD) of 1.68 × 10 − 7 M and qualitative human sweat glucose detection ability. This SF-AAO-Au substrate can be further designed as lab-on-glove SERS sensing platform for ultrasensitive (LOD ~5.7 ppt) quantitative on-site detection of agricultural residues in a wide range. The effective dual-functional SERS wearable sensor realized for the first time paves a new way to develop smart wearable and non-destructive devices in environmental safety, forensic identification and point-of-care testing (POCT) diagnosis of physiological disease.
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高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2022
·
IF 9.965
Jingxuan Pei,Yibo Sun,Xiang Yu,Zhenfei Tian,Shuting Zhang,Songbo Wei,Yanfang Zhao,Rabah Boukherroub
Development of reliable sensing strategy combining surface-enhanced Raman scattering (SERS) and surface-assisted laser desorption/ionization-mass spectrometry (SALDI-MS) is of significant interest to distinguish cysteine enantiomers in body fluid for understanding their physiological roles and toxicity hazards. In this work, a SERS/SALDI-MS dual-mode sensing platform of gold nanoparticles (Au NPs) decorated holey carbon nitride (hg-C 3 N 4 ) was fabricated for sensitive detecting cysteine. The designed Au@hg-C 3 N 4 matrix featured a uniform distribution of Au NPs with the help of anchoring effect of hg-C 3 N 4 holey structure, which was conducive to produce highly repeatable signals. Moreover, the combination of Au NPs and holey g-C 3 N 4 endowed this matrix with superior enrichment capacity, enhanced charge transfer and strong UV absorption. These merits allowed the matrix to acquire high sensitivity and enhanced reproducibility for l -cysteine by means of SERS/SALDI-MS. Likewise, reliable detection of l -cysteine and efficient recognition of d -cysteine in human serum jointly revealed its prospect for detecting cysteine enantiomers in body fluids. This work offers a reliable SERS/SALDI-MS strategy for determining L/D-cysteine enantiomers, and the designed Au@hg-C 3 N 4 matrix becomes a potential application candidate for selective detection of bio-enantiomers.
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DOI
PubMed
高影响因子
ACS Sustainable Chemistry & Engineering
·
2021
·
IF 8.198
Xiuting Li,Hongmei Liu,Ying Chen,Chenjie Gu,Guodong Wei,Jun Zhou,Tao Jiang
Pesticides and additives, extensively used in the raw agriculture samples and processed food, have attracted tremendous interests owing to their latent menace to the surroundings and human health. Herein, a rationally designed multifunctional polymethyl methacrylate-silver/graphite-like carbon nitride/silver (PMMA–Ag/g-C3N4/Ag) hybrid substrate with plasmonic-enhanced intrinsic Raman signals was exploited and served as a recyclable and quantitative surface-enhanced Raman scattering (SERS) sensor. Especially, the as-prepared flexible substrate with an electromagnetic enhancement factor of 1.64 × 106 could realize the sensitive monitoring and in-situ degradation of thiabendazole (TBZ) and carmine acid (CA) on apple or in applesauce with limits of detection as low as 2.29 × 10–6 and 6.76 × 10–5 mg/mL. Furthermore, heightened linear correlations with coefficients of 0.996 and 0.997 were accurately acquired using the film peak of PMMA as an internal standard. It was proved that the proposed sophisticated substrate may present attractive superior-in-practice multiplexed quantitative monitoring and facile decomposing of harmful molecules. The resulting recovery values distributed from 60.9 to 126% for the deeply processed foods that were decorated by 10–4 to 1 mg/mL CA together with TBZ.
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高影响因子
Advanced Materials Interfaces
·
2021
·Vol. 8
·期 12
·2100412
·
IF 6.147
Xinxin Li,Xiang Lin,Shuang Lin,Shijie Zhou,Guoqiang Fang,Haiyan Zhao,Li Wang,Shulin Cong
The nanoparticle density (PD) of the substrates is crucial for surface-enhanced Raman scattering (SERS) performance. Here, bottom-up SERS substrates based on rough gold nanorods (R-Au NRs) with different PD are fabricated and their SERS property are investigated. In particular, R-Au NRs are deposited on the Si wafer from sparse to dense through electrostatic interaction and from monolayer to multiple layers by interface self-assembly technique. It is found that the SERS intensity increases dramatically with increasing PD and remains almost unchanged when the PD increases to 241.22 counts µm −2 , and the limited penetration depth of laser is the reason for the intensity saturation. Additionally, similar results are observed in the smooth Au NRs substrates, re-confirming the PD-dependent SERS performance. Importantly, the SERS activity of R-Au NRs substrates is higher than smooth Au NRs substrates in each PD, indicating that R-Au NRs can produce stronger electromagnetic field enhancement, which is supported by the theoretical simulation results. Finally, it is demonstrated that the optimal SERS substrates can be effectively utilized for the quantitative measurement of thiram in soil. Briefly, the PD of substrates has a great impact on SERS activity, which offers an idea for the design of highly efficient SERS substrates.
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高影响因子
ACS Sustainable Chemistry & Engineering
·
2020
·
IF 7.632
Yiran Tian,Hongmei Liu,Ying Chen,Chenjie Gu,Guodong Wei,Tao Jiang
Sophisticated surface-enhanced Raman scattering (SERS)-active nanocomposites with both self-correction and cleaning capabilities provide new perspectives for the quantitative detection and degradation of hazardous molecules. In this work, a multifunctional GO-coated Fe3O4@TiO2@AuAg SERS substrate was developed. Attributed to the magnetic core, a relatively uniform substrate was induced by an external magnetic field and a sensitive SERS-based detection of trace mixed additives in foods was facilitated by electromagnetic enhancement from the well-modified Au/Ag binary nanoparticles in conjunction with the molecular enrichment ability of the GO. Particularly, the intrinsic Raman signal at 149 cm–1 of TiO2 was fully exploited to act as an intrinsic internal standard for the improvement of the quantitative level of such detection. Additionally, the efficient green elimination of these target molecules within 60 min was enabled by the multifunctional TiO2 layer. It is expected that this novel SERS substrate with both quantitative analytical and photocatalytic capability may extend to a broad application for detecting analytes in complex systems.
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高影响因子
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