ACS Sustainable Chemistry & Engineering
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2020
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IF 7.632
Ying Sun,Shuhang Ren,Yucui Hou,Kai Zhang,Qi Zhang,Weize Wu
A series of environmentally benign functional ionic liquids (ILs) based on l-proline as the anion to efficiently absorb low-concentration NO have been investigated in this work. The results indicate that the ILs with an l-proline anion have high absorption capacities for 0.16 vol % NO, reaching a maximum absorption capacity of 0.51 mol of NO per mol of IL at 30 °C and ambient pressure for l-proline choline IL ([Ch][l-Pro]). The absorbed NO could be recovered from [Ch][l-Pro], and the regenerated IL had no significant loss of NO absorption capacity for at least 7 recycles. We verified the mechanism through both experimental and theoretical methods. The results indicate that the absorption of NO in [Ch][l-Pro] mainly resulted from a chemical process—NO and the secondary amine group in the anion form a NONOate with a chemical formula [l-Pro]−–(NO)–NO. We believe that this efficient and reversible absorption of low-concentration NO by the ILs has potential as a new NO capture technique.
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JOURNAL OF MEDICINAL CHEMISTRY
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2012
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IF 5.248
Yao Chen,Jianfei Sun,Lei Fang,Mei Liu,Sixun Peng,Hong Liao,Jochen Lehmann,Yihua Zhang
In search of multifunctional cholinesterase inhibitors as potential anti-Alzheimer drug candidates, tacrine–ferulic acid–NO donor trihybrids were synthesized and tested for their cholinesterase inhibitory activities, release of nitric oxide, vasodilator properties, cognition improving potency, and hepatotoxicity. All of the novel target compounds show higher in vitro cholinesterase inhibitory activity than tacrine. Three selected compounds (3a, 3f, and 3k) produce moderate vasorelaxation in vitro, which correlates with the release of nitric oxide. Compared to its non-nitrate dihybrid analogue (3u), the trihybrid 3f exhibits better performance in improving the scopolamine-induced cognition impairment (mice) and, furthermore, less hepatotoxicity than tacrine.
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CHEMICAL ENGINEERING JOURNAL
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2023
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IF 15.1
Jiancheng Zhang,Congcong Zhang,Yuyang Li,Jingjing Xiao,Yilun Zhang,Min Jia,Lixia Lu,Hongyan Zhang,Jun Zhou,Zhenguo Zhang,Xin Du
Plastic particles are common pollutants in our daily lives and cause a range of potential toxicities when ingested by living organisms. However, the complex morphology of plastic particles in the natural environment makes it difficult to assess their potential toxicity using conventional ecological monitoring techniques. Therefore, we constructed an electrochemical sensor based on gold/multi-wall carbon nanotube-Fe(III) meso -tetra (4-carboxyphenyl) porphyrin/Nafion (Au/MWCNT-FeTCP/Nafion) composite material to evaluate the potential toxicity of plastic particles through the detection of nitric oxide (NO). The sensor exhibited good catalytic performance for NO with a linear relationship within 0.1–––0.7 μmol/L and 0.8–––5 μmol/L and a detection limit of 0.08 μM. We used this sensor to evaluate the changes in NO released by cells and tissues exposed to polystyrene (PS) plastic particles which showed that as the concentration of PS incubated with cells increased and the incubation time prolonged, the level of NO released by cells also increased. Notably, we combined immunofluorescence, immunoblotting, and electrochemical analysis methods simultaneously to reveal the cellular signaling pathway of NO production and apoptosis induced by PS. Furthermore, the effectiveness of the sensor in biomonitoring the oxidative damage of PS plastic particles on NO was further verified at the tissue level by constructing a mouse model treated with PS plastic particles. The sensor presented here offers a promising approach to study the biotoxicity of plastic particles and may contribute to the development of novel solutions for mitigating their hazardous effects on the human health.
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GREEN CHEMISTRY
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2023
·Vol. 25
·期 15
·5999-6008
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IF 9.8
Yuanyuan Zhang,Wanxiang Zhang,Yan Wang,Shuhang Ren,Yucui Hou,Weize Wu
To reduce the emission of NO from fossil fuel combustion and the energy consumption associated with NH3 production, the development of simple and efficient methods to transform NO into high-value-added NH3 is essential. Here, we report the efficient catalytic hydrogenation of NO to NH3 under mild reaction conditions by the synergistic catalysis of functionalized ionic liquids (FILs) and Pd catalysts. In this system, an FIL [TEPA][Im] acted as both an absorbent and a catalyst. The presence of [TEPA][Im] enhanced the catalytic performance by changing the coordination and electronic environment of Pd on the Pd/C catalyst. First, NO was absorbed by [TEPA][Im]; then, the hydrogenation of absorbed NO to NH3 was performed at a low temperature via the synergistic catalyzation of [TEPA][Im] and Pd/C. The effects of various factors on NO hydrogenation to NH3 were also investigated. Remarkably, Pd/C exhibited outstanding properties in the formation of NH3 with a high yield of 67% in the FIL [TEPA][Im] under the conditions of 100 °C and an H2 pressure of 0.5 MPa. [TEPA][Im] could be reused multiple times and the product NH3 could be recovered by flashing.
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Nano Energy
·
2023
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IF 17.6
Chaoliang Zhang,Yangkun Xu,Hongjie Bai,Dengfeng Li,Lai Wei,Chuanliang Feng,Yanhao Huang,Zhengshang Wang,Xiaoyan Li,Xudong Cui,Chenguo Hu,Feng Wang
Modifying photocatalysts for effective NO removal has profound implications for environmental protection. In this work, a novel g-C 3 N 4 containing non-intrinsic oxygen vacancies (V O -CN) is synthesized via a facile oxygen pre-doping followed by elimination. Compared to pristine g-C 3 N 4 , V O -CN exhibits remarkably enhanced visible-light photocatalytic activity , increasing NO removal by 54.3%, with high NO 3 - selectivity. This photocatalytic enhancement is attributed to the non-intrinsic oxygen vacancies introduced in Vo-CN. As comprehensively revealed by experimental characterizations coupled with density functional theory (DFT) calculations. The results show that the midgap state generated in the V O -CN electronic band structure accelerates photogenerated electron-hole separation. Additionally, the unique surface structure of V O -CN provides favorable channels for carrier migration while enhancing O 2 and NO adsorption. Consequently, the markedly improved generation of reactive oxygen species by Vo-CN promotes highly efficient NO removal. This work provides novel insights into designing high-performance g-C 3 N 4 -based photocatalysts for eliminating hazardous NO pollutants.
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CHEMICAL ENGINEERING & TECHNOLOGY
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2023
·Vol. 46
·期 10
·2217-2225
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IF 2.1
Shuangshuang Lv,Xianlong Zhang,Haoyang Dong,Shi Jin,Xinyu Wang
Manganese-antimony composite oxide catalysts were prepared for use in low-temperature selective catalytic reduction of flue gas, by adopting the strategy of passivation to regulate the valence state of the active component and control catalytic activity. Activity evaluation results found that MnSb 0.36 O y delivered 80 % NO conversion in the presence of SO 2 at 200 °C, and nearly 90 % conversion at 250 °C. Doping with Sb changed the surface micromorphology, resulting in a perforated porousness layered foam with a porous structure of tens of nanometers, which was conducive to molecular mass transfer of the reaction gas. Doping with Sb regulated the valence state of the active MnO x component, which diminished catalytic oxidation of SO 2 , thus promoting catalyst stability and limiting the toxic effect of SO 2 .
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Nature Communications
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2023
·Vol. 14
·期 1
·1-14
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IF 16.6
Tang Xiaoduo,Ren Jingyan,Wei Xin,Wang Tao,Li Haiqiu,Sun Yihan,Liu Yang,Chi Mingli,Zhu Shoujun,Lu Laijin,Zhang Junhu,Yang Bai
Autologous skin flap transplantation is a common method for repairing complex soft tissue defects caused by cancer, trauma, and congenital malformations. Limited blood supply range and post-transplantation ischemia-reperfusion injury can lead to distal necrosis of the flap and long-term functional loss, which severely restricts the decision-making regarding the optimal surgical plan. To address this issue, we develop a hydrogel patch that releases carbon monoxide and nitric oxide gases on demand, to afford a timely blood supply for skin flap transplantation during surgery. Using an ischemia-reperfusion dorsal skin flap model in rats, we show that the hydrogel patch maintains the immediate opening of blood flow channels in transplanted tissue and effective blood perfusion throughout the perioperative period, activating perfusion of the hemodynamic donor site. We demonstrate that the hydrogel patch promotes distal vascularization and long-term functional reconstruction of transplanted tissues by inhibiting inflammatory damage and accelerating blood vessel formation.
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COMBUSTION AND FLAME
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2023
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IF 4.4
Yitong Zhai,Qiang Xu,Beibei Feng,Can Shao,Zhandong Wang,S. Mani Sarathy
Low-temperature (low-T) oxidation experiments of n -heptane –with and without NO addition– were experimentally and numerically investigated at stoichiometric conditions in a jet-stirred reactor. Experiments were performed at atmospheric pressure over a temperature range of 500–800 K. Reactants, intermediates, and products, were measured using synchrotron vacuum ultraviolet photoionization mass spectrometry . A detailed kinetic model was developed to gain insight into the chemical effect of NO on low-T oxidation chemistry of n -heptane. Taking 650 K as the transition temperature, the results revealed that NO addition exhibited an inhibiting effect on fuel reactivity below 650 K and a promoting effect above 650 K. The reactions of ROO + NO = RO + NO 2 and HO 2 + NO = OH + NO 2 at different temperature regions were responsible for the inhibition and promotion effects, respectively. Evidence gathered from both experimental measurements and kinetic model predictions indicated that NO addition had a significant inhibitory effect on the formation of cool flame species during the low-T oxidation process. NO suppressed low-T oxidation via the reaction of ROO + NO = RO + NO 2 , which impeded the subsequent isomerization, O 2 addition, OH-, and HO 2 -elimination reaction, and influenced product distribution of the cool flame species. The experimental observations provided detailed information about these reactive intermediates, which offered new insights into low-T oxidation phenomena and clarified the importance of NO reactions which prevent the formation of cool flame products during low-T oxidation.
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Acta Biomaterialia
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2023
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IF 9.7
Chenyi Huang,Jia Tang,Yuanqi Liu,Ting Chen,Junyang Qi,Shengjie Sun,Huisong Hao,Weiwei Zeng,Jing Zhao,Meiying Wu
Nitric oxide (NO) is a crucial gaseous medium for tumor growth and progression, but it may also cause mitochondrial disorder and DNA damage by drastically increasing its concentration in tumor. Due to its challenging administration and unpredictable release, NO based gas therapy is difficult to eliminate malignant tumor at low safe doses. To address these issues, herein, we develop a multifunctional nanocatalyst called Cu-doped polypyrrole (CuP) as an intelligent nanoplatform ( [email protected] ) to deliver the NO precursor BNN6 and specifically release NO in tumors. Under the aberrant metabolic environment of tumors, [email protected] catalyzes the conversion of antioxidant GSH into GSSG and excess H 2 O 2 into ·OH through Cu + /Cu 2+ cycle, which results in oxidative damage to tumor cells and the concomitant release of cargo BNN6. More importantly, after laser exposure, nanocatalyst CuP can absorb and convert photons into hyperthermia, which in turn, accelerates the aforesaid catalytic efficiency and pyrolyzes BNN6 into NO. Under the synergistic effect of hyperthermia, oxidative damage, and NO burst, almost complete tumor elimination is achieved in vivo with negligible toxicity to body. Such an ingenious combination of NO prodrug and nanocatalytic medicine provides a new insight into the development of NO based therapeutic strategies. Statement of significance A hyperthermia-responsive NO delivery nanoplatform ( [email protected] ) based on Cu-doped polypyrrole was designed and fabricated, in which CuP catalyzed the conversion of H 2 O 2 and GSH into ·OH and GSSG to induce intratumoral oxidative damage. After laser irradiation, hyperthermia ablation and responsive release of NO further coupled with oxidative damage to eliminate malignant tumors. This versatile nanoplatform provides new insights into the combined application of catalytic medicine and gas therapy.
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Energies
·
2019
·Vol. 12
·期 15
·2966
·
IF 2.707
Pijian Gong,Xinxue Li
In this study, NaClO2was selected as a denitration oxidant. In order to clarify the mechanism of NaClO2as an oxidation agent for NO removal efficiency, the effects of H+and other factors (NaClO2concentration, temperature, and the other gas) on the NO removal efficiency were investigated. NaClO2showed a promotional ability on NO removal, whose efficiency increased with the increase of NaClO2concentration. One hundred percent removal efficiency of NO could be achieved when the NaClO2concentration was 0.014 mol/L. Furthermore, raising the reaction temperature benefited the removal of NO. The lower the pH, the better the NO removal efficiency. The promoting effect of H+on the NO removal was studied by the Nernst equation, ionic polarization, and the generation of ClO2. Under the optimal conditions, the best removal efficiency of NO was 100%. Based on the experimental results, the reaction mechanism was finally speculated.Keywords:sodium chlorite (NaClO2);wet scrubbing;removal efficiency;NO reaction mechanism
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2015
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IF 3.368
Xiaole Weng,Xiaoxia Dai,Qingshan Zeng,Yue Liu,Zhongbiao Wu
Heteropoly acids (HPAs) have been effectively utilized in selective catalytic reduction (SCR) of NO to improve the NH 3 absorption capacity and alkaline/alkali metal resistance for SCR catalysts. However, despite the promise on super-acidities, their other properties that would work on SCR process are still lack of exploration. In this study, a 12-tungstaphosphoric acid (H 3 PW 12 O 40 , HPW) was selected to modify a well-reported CeO 2 catalyst. The resulted CeO 2 /HPW catalyst was subsequently utilized for SCR of NO with excess NH 3 , which revealed a significantly promoted performance in SCR reaction. DRIFT analyses showed that the unique NO 2 absorption capacity of HPW could prevent the NO 2 being further oxidized into nitrate species and the abundant Brønsted acid sites could effectively retain the NH 3 , avoiding them being over-oxidized at evaluated temperatures. The presence of NO 2 was demonstrated able to induce a so called “fast SCR” reaction over the CeO 2 /HPW catalyst, which effectively facilitated the SCR reaction. Furthermore, we have also constructed a CeO 2 @HPW catalyst, which showed an enhanced SO 2 poisoning resistance in SCR reaction.
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Catalysis Science & Technology
·
2016
·Vol. 6
·期 14
·5543-5553
·
IF 5.287
Xin Zhao,Lei Huang,Supawadee Namuangruk,Hang Hu,Xiaonan Hu,Liyi Shi,Dengsong Zhang
A novel Zr–CeVO4/TiO2 catalyst was developed for the selective catalytic reduction (SCR) of NO with NH3. Both TiO2 nanosheets (TiO2-NS) and nanoparticles (TiO2-NP) with different crystal facets were used as supports for the catalyst. It was found that the TiO2-NS-supported catalyst showed much better activity, stability and H2O/SO2 durability than the TiO2-NP-supported catalyst. In particular, the catalyst loading amount was much lower than those of previously reported vanadate-based SCR catalysts. The crystal structures and morphologies were analysed by X-ray diffraction (XRD), Raman spectroscopy and (high-resolution) transmission electron microscopy ((HR)TEM). The redox properties, surface active species and acid sites of the catalysts were investigated through hydrogen temperature-programmed reduction (H2-TPR), X-ray photoelectron spectroscopy (XPS), ammonia and nitrogen oxide temperature-programmed desorption (NH3-TPD and NOx-TPD) and in situ diffuse reflectance infrared Fourier transform spectroscopy (in situ DRIFTs) experiments. The improved activity at lower temperature was due to the presence of more active oxygen species and Brønsted acid sites, as well as the formation of NO2 on the surface of the TiO2 nanosheets which have exposed (001) facets. The enhanced stability and H2O/SO2 durability of Zr–CeVO4/TiO2-NS was due to the limited formation of NH4NO3 and (NH4)2SO4/NH4HSO4. The excellent low operation temperature, low vanadium content and absence of WO3(MoO3) in this catalyst indicated that it has promising potential as a SCR catalyst for practical applications.
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