CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
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2017
·
IF 0.795
Ying-Hui DENG,Li-Na SU,Yan-Hua PANG,Ya-Fei GUO,Fen WANG,Xia-Li LIAO,Bo YANG
To improve the water solubility of daidzein, solid inclusion complexes of daidzein with two amino-modified β -cyclodextrins (ACDs), i.e., mono-6-amino-6-deoxy- β -cyclodextrin (NCD) and mono-6-ethylenediamino-6-deoxy- β -cyclodextrin (ENCD), were prepared by the saturated solution method in water with yields of 83% and 67%, respectively, under the optimized conditions including the ratio of daidzein/ACD of 3:1 and the stirring time of 72 h. The formation of the two inclusion complexes was confirmed by X-ray diffractometry (XRD) and thermo gravimetric (TG) analysis. The inclusion stoichiometry of the inclusion complexes was 1:1 from the Job plot and their complexation stability constants ( K S ) were 899.2 and 203.8 M −1 from fluorescence titration, respectively. After formation of inclusion complexes with NCD and ENCD, the water solubility of daidzein was dramatically raised to 15.2 and 13.2 mg mL −1 at 25 °C, increasing by 1800 and 1500-fold compared to native daidzein (8.31 μg mL −1 ).
研究领域:
药物化学
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材料科学
·
生物化学
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产品关联
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2022
·
IF 10.723
Huli Yu,Liangjie Wang,Sheng Liu,Biao Zhao,Ke Xiao,Bo Yang,Huabo Duan,Huazhang Zhao,Jianping Deng
Poly/oligosaccharides are renewable natural resources with abundant chirality . Herein, we develop a general route to prepare optically active particles by using poly/oligosaccharides as both chiral inducers and growth templates. By complexing with Cu(NH 3 ) 4 2+ ions, OH groups on C2 and C3 in poly/oligosaccharides can transfer the chirality to Cu(II) and retain it in CuO . At the same time, poly/oligosaccharides direct growth of CuO by in situ transformation of Cu(NH 3 ) 4 2+ ions. Cellulose nanocrystal (CNC) and starch (ST) are used as representative polysaccharides , and β-cyclodextrin (β-CD) as a representative oligosaccharide, thus dandelion , duchesnea, and chrysanthemum-like composite particles with chiroptical activity are obtained. Besides, chiral CuO/poly(oligo)saccharide particles (CSP) demonstrate enantioselective ability by differentiating coordination with tryptophan (Trp) enantiomers and form Cu-Trp metal organic framework architectures with different morphologies. The study provides an easily accessible approach to prepare novel functional materials by poly/oligosaccharide-based chiral induction and hold great promise in chiral applications.
研究领域:
材料科学
·
化学
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产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2020
·
IF 8.758
Jie Chen,Qiang Sun,Deyu Bao,Taoyi Liu,Wei-Di Liu,Can Liu,Jun Tang,Dali Zhou,Lei Yang,Zhi-Gang Chen
Owing to the intrinsically good near-room-temperature thermoelectric performance, β-Ag2Se has been considered as a promising alternative to n-type Bi2Te3 thermoelectric materials. Herein, we develop an energy- and time-efficient wet mechanical alloying and spark plasma sintering method to prepare porous β-Ag2Se with hierarchical structures including high-density pores, a metastable phase, nanosized grains, semi-coherent grain boundaries, high-density dislocations, and localized strains, leading to an ultralow lattice thermal conductivity of ∼0.35 W m–1 K–1 at 300 K. A relatively high carrier mobility is obtained by adjusting the sintering temperature to obtain pores with an average size of ∼260 nm, therefore resulting in a figure of merit, zT, of ∼0.7 at 300 K and ∼0.9 at 390 K. The single parabolic band model predicts that zT of such porous β-Ag2Se can reach ∼1.1 at 300 K if the carrier concentration can be tuned to ∼1 × 1018 cm–3, suggesting that β-Ag2Se can be a competitive candidate for room-temperature thermoelectric applications.
研究领域:
材料科学
·
热电材料研究
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DOI
PubMed
高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
·
2024
·
IF 6
Shuxian Zhang,Xiaofei Wang,Xiaoxuan Fan,Keshuai Liu,Gidion Wilson,Xueqin Ma,Guoning Chen
Lactose can cause health problems in patients with lactose intolerance. β-Galactosidase is commonly used to catalyze the hydrolysis of lactose, thereby producing low-lactose or lactose-free products. However, most existing methods employ free enzymes, which significantly increases the economic cost. In this study, the polyurethane sponge (PUS) was selected as the carrier, and the cross-linked enzyme aggregates (CLEAs) were loaded onto the carrier after the sponge was modified. The reaction products were characterized by scanning electron microscopy, X-ray photoelectron spectroscopy, Fourier infrared transform spectroscopy, and simultaneous thermal analysis, respectively. The loading amount of β-galactosidase under the optimal conditions was 63 U/g support . The prepared PUS@β-galactosidase-CLEAs was successfully used for the hydrolysis of lactose in milk and could hydrolyze 228–304 μg of lactose in 30 min with good stability (RSD = 4.4%) and reusability. The method proposed in this study effectively combined the advantages of sponge and cross-linking enzyme aggregates, successfully achieving the decomposition of lactose in milk and rapid separation of the product. It is worth mentioning that this study provided a more effective and convenient industrial option for the production of lactose-free milk.
研究领域:
食品科学
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生物工程
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产品关联
DOI
高影响因子
ANALYTICA CHIMICA ACTA
·
2024
·
IF 5.7
Hui Zhang,Ma Yan,Lina Ma
Background Scintillation cocktails cannot directly measure samples with extreme acidity or alkalinity in β-nuclide liquid scintillation analysis. Plastic scintillation microspheres (PSm), as a novel scintillation material, offer the potential to overcome these limitations by allowing direct mixing with a variety of solutions for measurement, particularly in challenging chemical environments. Results This study evaluated the performance of PSm in various chemical environments, including four acids (nitric, hydrochloric, sulfuric, and phosphoric acids), an alkaline solution (NaOH), a high-salinity solution, and methanol. PSm formed stable mixtures with most solutions and exhibited excellent chemical stability in high-concentration NaOH, with minimal chemiluminescence interference. However, concentrated nitric and sulfuric acids caused chemical reactions with PSm, leading to discoloration and potential color quenching. Efficiency calibration was performed using ultrapure water, allowing for accurate measurement of 14 C activity across different solutions with simple efficiency corrections. Significance The findings of this study highlight the advantages of PSm for β-nuclide measurement in a variety of complex chemical environments. PSm's stability in highly acidic, alkaline, and saline conditions makes it a promising tool for applications such as radioactive waste monitoring and pharmacokinetic research, providing a reliable and efficient alternative to conventional scintillation cocktails.
研究领域:
核医学
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分析化学
✓ 已验证
DOI
PubMed
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
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2016
·
IF 3.42
Jingting Tan,Na Meng,Yunting Fan,Yutian Su,Ming Zhang,Yinghong Xiao,Ninglin Zhou
A novel drug carrier based on hydroxypropyl-β-cyclodextrin (HP-β-CD) modified carboxylated graphene oxide (GO-COOH) was designed to incorporate anti-cancer drug paclitaxel (PTX). The formulated nanomedicines were characterized by Fourier transform infrared spectroscopy (FTIR) and atomic force microscopy (AFM). Results showed that PTX can be incorporated into GO-COO-HP-β-CD nanospheres successfully, with an average diameter of about 100 nm. The solubility and stability of PTX-loaded GO-COO-HP-β-CD nanospheres in aqueous media were greatly enhanced compared with the untreated PTX. The results of hemolysis test demonstrated that the drug-loaded nanospheres were qualified with good blood compatibility for intravenous use. In vitro anti-tumor activity was measured and results demonstrated that the incorporation of PTX into the newly developed GO-COO-HP-β-CD carrier could confer significantly improved cytotoxicity to the nanosystem against tumor cells than single application of PTX. GO-COO-HP-β-CD nanospheres may represent a promising formulation platform for a broad range of therapeutic agent, especially those with poor solubility.
研究领域:
药剂学
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肿瘤学
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材料科学
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产品关联
DOI
PubMed
高影响因子
CHINESE CHEMICAL LETTERS
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2016
·
IF 1.947
Hong-Lei Xie,Chun-Chi Liu,Yi-Qun Li,Chang-Lin Bai,Chen-Zhou Hao,Jing Guo,Chang-Qun Luo,Dong-Mei Zhao,Mao-Sheng Cheng
A novel series of β -propanamide derivatives as inhibitors of cholesteryl ester transfer protein (CETP) were synthesized. Previously, H3 (IC 50 2 μmol/L) was observed to inhibit CETP moderately (Xie et al ., 2016). Structural modifications based on H3 led to discovery of the successful CETP inhibitor, known as 1-methyl-4-arylpyrazole. Using a similar approach, compound Q08 was identified as a highly potent CETP inhibitor with an IC 50 of 490 nmol/L in vitro .
研究领域:
药物化学
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生物化学
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DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2020
·
IF 7.183
Jing Xue,Jianliang Shen,Runnan Zhang,Fei Wang,Shuwei Liang,Xinda You,Qianqian Yu,Yufeng Hao,Yanlei Su,Zhongyi Jiang
In this study, high flux β-CD/GQDs nanofiltration (NF) membranes were prepared by interfacial polymerization with β-cyclodextrin (β-CD) as the aqueous monomer , graphene quantum dots (GQDs) as the additive and trimesoyl chloride (TMC) as the organic monomer. The addition of GQDs not only modulated the membrane surface properties, but also led to the formation of a loose selective layer due to the nonspecific hydrogen bonding interactions between GQDs and β-CD. The pure water flux of the β-CD/GQDs NF membranes increased from 122.2 to 474.7 L/m 2 h (at the pressure of 0.1 MPa) when the concentration of GQDs increased from 0 to 0.5 wt%, almost 3.9 times higher than that of the pristine β-CD membrane. The dye rejection of Eriochrome Black T and Congo Red essentially remained above 93.0%. The β-CD/GQDs NF membranes with superior filtration performance and excellent chlorine resistance hold great promise in dye wastewater treatment .
研究领域:
材料科学
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环境工程
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DOI
高影响因子
Journal of Materials Chemistry A
·
2015
·Vol. 3
·期 30
·15755-15763
·
IF 7.443
Long Kong,Lili Yan,Zan Qu,Naiqiang Yan,Liang Li
In this study, magnetic β-cyclodextrin stabilized Fe3S4 nanoparticles (CD-Fe3S4) were fabricated via a facile one-step route. The as-prepared CD-Fe3S4 exhibited a high Pb(II) adsorption capacity of 256 mg g−1, and it also showed a surprisingly efficient adsorption toward Zn(II), Cd(II), and Cu(II). XRD, FTIR and XPS analyses suggested that the mechanisms governing Pb(II) removal by CD-Fe3S4 were precipitation (formation of galena) and surface adsorption. Additionally, the magnetic properties of the synthesized Fe3S4 nanoparticles allow fast separation of sorbents from water. The sorption kinetic data were well-described by a pseudo-second-order model, whereas the adsorption isotherms followed a Langmuir isotherm model. Our experimental results proved that the β-cyclodextrin stabilized Fe3S4 could be a promising candidate for the removal of Pb(II) from water via simultaneously taking advantage of its magnetic properties and high affinity for heavy metals.
研究领域:
环境科学
·
材料科学
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DOI
高影响因子
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY
·
2019
·Vol. 94
·期 1
·85-94
·
IF 1.429
Li Shuhan,Tang Yue,Zhang Xinru,Dou Yushun,Shen Xiangchun
This research is to study on preparation and characterization of diclofenac sodium β-cyclodextrin (DS-β-CD) inclusion complex eye drops in order to improve the solubility of diclofenac sodium (DS) and reduce the irritation of DS eye drops in the market. First, DS-β-CD inclusion complex was prepared by co-precipitation method and then mixed with excipients to prepare inclusion complex eye drops. Finally, instruments were used to determine the basic properties of eye drops and animal experiments were used to investigate the irritation of the DS-β-CD inclusion complex eye drops. The drug content, the encapsulation efficiency and the yield of DS-β-CD inclusion complex were respectively 17.11, 84.20 and 60.00%. And the DS-β-CD inclusion complex was identified by FTIR, DSC, XRD and 1 HNMR. The solubility of the inclusion complex was 20 times more than DS. The pH value, the osmotic pressure, the viscosity and the drug content of the eye drops were respectively 7.20, 298 mosmol/kg, 4.88 mPa s and 97.98%. In brief, DS-β-CD inclusion complex eye drops had stable properties, high solubility and the test items met the requirements. The eye drops were almost non-irritating, significantly reducing the irritation of the original prescription (P < 0.01).
研究领域:
药剂学
·
药物化学
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产品关联
DOI
高影响因子
ACS Applied Electronic Materials
·
2024
·
IF 4.3
Shengyang Zhou,Hongjian Zhang,Changzhou Du,Ming Liu,Liming Liu,Yong Zhang
Polymer-based piezoelectric composites have shown a large potential in various fields of wearable electronics, man–machine interaction, transducers, etc., due to their integrated advantages of high piezoelectric properties, benign flexibility, and pressure sensitivity. As the representative polymer matrix in piezoelectric composites, polyvinylidene fluoride (PVDF) is characterized by its intrinsic piezoelectric response induced via the existence of ferroelectric β and γ phases. However, the most stable phase at ambient temperature and pressure is the nonpolar and paraelectric α phase, which serves as a long-standing issue. Herein, chitosan was introduced into the PVDF matrix to promote the transition from α phase to β phase via the interaction between the –OH and –NH2 groups in chitosan and the H and F atoms in PVDF. As evidenced, the portion of the β phase increased from 47.9 to 63.7%. An electrospinning technique was adopted to prepare PVDF/chitosan composites with a chitosan content ranging from 1 to 4 wt %, and the correlation between structural characteristics and piezoelectric properties is illustrated in detail. Then, a flexible pressure sensor based on PVDF/chitosan composite was prepared, which presents a low detection limit of ∼220 Pa in a wide range of 220 Pa–81 kPa. The pressure sensor presents a good capability for detecting pulse signals and speech recognition accurately. As well demonstrated in this work, the treatment of PVDF with low-cost chitosan may boost its practical application in future flexible electronics.
研究领域:
材料科学
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电子工程
·
生物医学工程
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产品关联
DOI
高影响因子
FOOD RESEARCH INTERNATIONAL
·
2018
·
IF 3.52
He Ren,Yongbo Lyu,Xinying Li,Shuxiao Zhang,Yusong Ye,Defu Li,Changdao Mu
Consumers demand more alternatives of riskless antibacterial agents to prevent microbial contamination in food industry. Oxidized carbohydrate may be a potential option as new antibacterial agent. However, the relatively weak antibacterial property of oxidized carbohydrate is not satisfactory. In this paper, dialdehyde β-cyclodextrins with different oxidation degree were prepared by periodate oxidation and their antibacterial properties were systematically studied. The results showed that multi-aldehyde groups were successfully introduced into β-cyclodextrin molecules by periodate oxidation. The aqueous solubility and stability of dialdehyde β-cyclodextrins were improved as expected. It is interesting that dialdehyde β-cyclodextrins possessed outstanding antibacterial activity against both Gram-positive and Gram-negative bacteria. The minimal inhibitory concentrations against E. coli, S. aureus and B. subtilis reached 0.63, 1.25 and 0.63 mg/mL, respectively. Moreover, dialdehyde β-cyclodextrins effectively inhibited bacterial growth on the surface of apples. The results demonstrated that oxidized oligosaccharide with multi-aldehyde groups and good dispersibility in aqueous solution possessed satisfactory antibacterial activity, which can be used as new antibacterial agent in food industry.
研究领域:
食品科学
·
微生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）