CHEMICAL ENGINEERING JOURNAL
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2026
·
IF 13.2
Menghuan Wu,Yifang Zhang,Zhiping Xu,Yuqi He,Jialei Wang,Tian Xie,Shuduan Deng,Lidan Zhang,Gang Zhu
Metal–organic frameworks often lose CO 2 capacity in hot, humid flue gas because H 2 O competes for open metal sites (OMSs). Here we report a dual-stabilized, wood-based adsorbent in which Mg-MOF-74 is grown on an aminated wood sponge and overcoated with an ultrathin polydimethylsiloxane (PDMS) layer, coupling support immobilization with interfacial hydrophobization while preserving access to OMSs. Under flue-gas-relevant conditions (323 K, 50% RH), the material delivers a CO 2 uptake of 1.68 mmol·g −1 (≈89% of its dry-state capacity) and an IAST CO 2 /N 2 selectivity of 144 for a 50/50 mixture at 323 K. Humid-gas breakthrough tests confirm robust separation performance. Density functional theory (DFT) calculations attribute the humidity tolerance and selectivity to the synergy between accessible OMSs and PDMS-mediated interfacial polarity, without increasing the isosteric heat of adsorption, thereby enabling energy-efficient regeneration. The framework retains its crystallinity after 30 days of water immersion, and a techno-economic estimate projects a material cost of approximately US$10.36 kg −1 at a 1000 t·yr −1 scale. This scalable architecture reconciles capacity, selectivity, humidity resistance, and cost for post-combustion CO 2 capture.
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MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 2
·75
·
IF 5.3
Chen Jia,Ma Yuan,Xiang Juan
Phosphorylation plays a pivotal role in neurodegenerative diseases, and the ratio of phosphorylated neurofilament light chains (pNfL) to total neurofilament light chains (tNfL) (pNfL/tNfL) has emerged as a promising biomarker. Detecting serum pNfL/tNfL remains challenging due to the extremely low abundance of pNfL. Effective detection requires spatial differentiation between protein capture sites, recognition sites, and post‑translational modification sites, together with precise spatial compatibility among multiple signal amplification sources to simultaneously identify proteins and their phosphorylation states. In this study, we systematically analyzed the structure of pNfL to identify optimal capture and recognition sites with distinct spatial localization. Systematic evaluation demonstrated that matching the size of signal amplification particles to the target protein significantly enhances sensor performance. By optimizing particle size, signals of pNfL and tNfL were amplified using 2 nm carbon dots loaded with Cu 2+ /Ti 4+ and an antibody–horseradish peroxidase complex, respectively. Coupled with an interface–solution dual‑pathway amplification strategy, this approach enabled convenient one‑step dual-signal electrochemical quantification of pNfL/tNfL. The developed sensor exhibited excellent sensitivity, selectivity, and reproducibility, with dynamic ranges of 0.2–20 pg·mL − 1 for both tNfL and pNfL. Preliminary serum analysis suggested that the pNfL/tNfL ratio provide improved discriminatory capability between neurodegenerative conditions, non-neurodegenerative brain injury, and healthy controls. Notably, the pNfL/tNfL ratio showed improved specificity compared to individual tNfL or pNfL measurements in this exploratory cohort. This work introduces a novel spatial design strategy that integrates particle size optimization with dual-pathway amplification, representing the first one-step dual-signal electrochemical platform capable of simultaneously quantifying total and phosphorylated neurofilament light chains in serum.
Section
Graphical
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Materials Today Bio
·
2026
·
IF 10.2
Huanyu Li,Chuanyu Zhang,Ziwei Yang,Yifan Li,Dan Liu,Yanan Zhang,Lingmin Zhang,Ning Wang,Mingxin Zhang,Mingzhen Zhang,Zhaoxiang Yu,Xueyong Wei,Yujie Zhang
Background Ulcerative colitis (UC) is a common type of inflammatory bowel disease, where the vicious cycle of inflammation and oxidative stress poses a major challenge in its treatment, and existing therapies have limitations. Berberine (BBR) and curcumin (CUR) have the potential for synergistic treatment of UC, but this potential has not been verified in UC. Additionally, both BBR and CUR suffer from poor water solubility and low bioavailability. This study aims to construct prebiotic microcapsules (BBR/CUR@MC) for the co-delivery of BBR and CUR and explore their therapeutic mechanism in UC. Methods Network pharmacology was used to predict the targets and pathways of BBR and CUR in UC. BBR/CUR@MC was prepared using microfluidic electrospray technology, and its colon targeting and biocompatibility were evaluated through in vivo experiments. In a Dextran sulfate sodium (DSS)-induced UC mouse model, the therapeutic effect was assessed using multiple indicators, and the mechanism of action was explored by transcriptome analysis. Results Network pharmacology showed that BBR and CUR can exert therapeutic effects on UC through synergistic regulation of TNF and AGE-RAGE signaling pathways. The successfully constructed BBR/CUR@MC had good colon targeting and biocompatibility. In the mouse colitis model, oral administration of BBR/CUR@MC inhibited ADAM17 in the TNF signaling pathway and MAPK11/13, COL4A1, and COL1A1 in the AGE-RAGE signaling pathway, thereby downregulating pro-inflammatory cytokines such as TNF-α and IL-1α, upregulating IL-10, scavenging ROS, significantly alleviating colonic inflammation and repairing the intestinal barrier in mice, with a therapeutic effect superior to that of single-drug microcapsules and 5-ASA. Conclusion BBR/CUR@MC can exert synergistic anti-inflammatory and antioxidant effects in UC treatment by regulating TNF and AGE-RAGE signaling pathways, providing a new multi-mechanism therapeutic strategy for UC.
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Journal of Future Foods
·
2026
·
IF 7.2
Bingkun Bao,Ying He,Jufang Li,Xiangyu Li,Hao Shi,Jinkuan Chen,Jinhan Zhao,Koukou Duan,Hongyu Zhang,Qinggang Xie,Jane Shearer,Zhigang Liu,Yongbo She
Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder primarily characterized by social deficits and repetitive behaviors. 2’-Fucosyllactose (2’-FL) and Lacto-N-neotetraose (LNnT), the two human milk oligosaccharides (HMOs) approved for infant formulas in China, have exerted potentials to modulate gut microbiota, immune system, and cognitive function. Yet the exact mechanism underpinning the etiology of HMOs on improving neurodevelopment and particularly the ASD-related cognitive impairments remain unclear. In this study, mouse model of ASD was established via maternal immune activation (MIA), specifically by introducing polyinosinic:polycytidylic acid (poly(I:C)) to pregnant mice. Male offspring were selected and received either an individual (2’-FL or LNnT) or a combination (2’-FL+LNnT) interventions for 6 weeks. As expected, ASD mice exhibited significant social deficits and repetitive stereotyped behaviors, accompanied by neuroinflammation and decreased expression of BDNF, and morphological changes in cortex as well as hippocampal area. Regardless of the type of sources, HMOs ameliorated ASD-like behaviors in ASD mice, attenuated neuroinflammatory responses, and elevated BDNF expression. Additionally, the HMOs alleviated intestinal inflammation, enhanced gut barrier, and modulated the gut microbiota structure by upregulating the abundance of beneficial bacteria ( Akkermansia, Lactobacillus , and Butyricicoccus ). Notably, the combination of two HMOs also promoted the production of short-chain fatty acids (SCFAs). In addition, flow cytometry analysis showed a significant increase in the regulatory T cell (Treg) ratio and an decrease in T helper 17 cell (Th17) ratio in the mesenteric lymph nodes of ASD mice following the combination intervention. These findings suggest that the promising efficacy of HMOs, particularly the combination of 2’-FL and LNnT, on counteracting ASD-related pathophysiological changes may be mediated by the gut-immune-brain axis.
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 13.2
Yilin Wu,Jichao Zhang,Jing Su,Yutong Wu,Shaohai Fu
Existing separation technologies struggle to separate nanosized oil droplets from highly stabilized emulsions to address the water supply shortage, exhibiting an inherent shortcoming of poor permeability and severe oil fouling. Herein, we presented a microscale channel of ceramic membranes with a piezoelectric semiconductor microsphere skin constructed of hydrophobic nanodomains and rich oxygen vacancies. The sprinkled hydrophobic nanodomains acted as “oil capturing tentacles”, facilitating the efficient coalescence of oil droplets and preventing the formation of oil cake layer. The obtained membranes with microchannels could efficiently separate 16 types of oil-in-water nano/submicrometer-emulsions, achieving an ultrahigh permeation flux of up to 6550 L·m −2 ·h −1 with the separation efficiency exceeding 99.85%. Additionally, oily foulants on the membrane undergo degradation by piezotronic effect-enhanced photocatalysts, where piezoelectric-induced band bending drives highly efficient separation of photogenerated carriers, markedly boosting oil degradation with a nearly 99.5% flux recovery of the membrane. This research pioneers new pathways to advance membrane separation and environmental remediation for real-world applications.
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CHEMICAL ENGINEERING SCIENCE
·
2026
·
IF 4.3
Taipeng Jiang,Yingying Wang,Jian Wu,Jingjing He,Sheng Chen,Meng Li,Weijie Wei,Lingling Zeng,Jin Li,Zhuwei Gao
With the frequent occurrence of petroleum product spills, it caused serious economic losses and ecological problems. In this study, covalent organic framework (COF) was first grown by in situ polymerization on a polyurethane sponge (PU). Subsequently, the resulting product was modified with polydopamine (PDA) and polydimethylsiloxane (PDMS) to obtain PDMS/PDA/COF-modified polyurethane sponge (PPCPS). After testing, PPCPS was shown to have superhydrophobic properties with a contact angle of up to 154.42°. The material for oil–water mixture separation efficiency was very high, after 50 times of circulation still reached more than 99.6 %. It had excellent adsorption capacity for a variety of oils and organic solvents, such as carbon tetrachloride oil-absorbing capacity could be 48.7 times. Its structure was stable under complex chemical environments and mechanical external forces, with good flame retardancy. In addition, the material had excellent photothermal conversion capacity, with a temperature of up to 70.1 °C at 1 kW/m 2 light intensity, which could effectively reduce the viscosity of crude oil. COF and PDA synergistically enhanced photothermal heating and crude oil adsorption, enabling efficient crude oil separation and cyclic reuse.
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 13.2
Siru Su,Duoduo Li,Xue Tang,Junjie Ma,Lichao Zou,Qiuyun Chen,Lei Xiao,Zhifeng Zhao,Jiabin Chen,Zhigao Liu,Quanping Yuan
Natural cellulose aerogels with super-hygroscopicity and biocompatibility have attracted much attention in the development of moist-electric generators (MEGs) and are considered an important strategy to tackle the current energy crisis. However, conventional cellulose aerogels exhibit limited voltage output due to their intrinsic structural characteristics, which significantly restricts their practical applications. Herein, a hierarchically porous aerogel with conductive network is constructed by loading metal-organic framework 801 (MOF-801) onto a cellulose nanofiber substrate, followed by incorporation of poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS). The combination of MOF-801 micropores with the macropores/mesopores of the cellulose network increases the specific surface area from 146.2 to 610.1 m 2 /g and creates abundant ionizable sites for continuous hydronium (H₃O + ) generation under humid conditions. PEDOT:PSS forms a three-dimensional percolating conductive network and introduces additional sulfonate groups, which together reduce carrier-transport resistance and couple ion and electron transport. As a result, the 10-CPM-MEG achieves an open-circuit voltage (V OC ) of 7.00 V at 85 % relative humidity (RH) and maintains a V OC of 0.52 V even at 33 % RH. Series-connected 10-CPM-MEGs can power LEDs and produce a sustained current of 0.14 μA under high-temperature steam conditions (80 °C, 90 % RH). This moist-electric energy harvesting system demonstrates significant potential for high-voltage electronics applications while providing a viable pathway for recovering low-grade thermal energy from industrial waste steam.
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FOOD CHEMISTRY
·
2026
·
IF 9.8
Linpin Luo,Wengang Cai,Zihan Qiu,Wenqiao Su,Yiya Ping,Bingzhi Li,Qianjin Liu,Jianlong Wang
Herein, we propose a composite packaging film with pasteurization-like activity by doping the MnO x /MoO x into chitosan film (CMM). The prepared CMM films exhibited excellent photothermal activity, which was inherited from the material. Under near infrared (NIR) irradiation, CMM films showed pasteurization-like activity due to the photothermal performance, in which CMM 0.1 was able to kill 99.15 % of E. coli and 99.39 % of S. aureus . CMM 0.1 film also showed good light transmittance (T 660 = 69.2 %), tensile strength (TS = 41.4 MPa) and UV-light/water vapor/ oxygen barrier ability. Less than 4.28 % of hemolysis rate and more than 92.89 % of cell survival rate after being treated with MnO x /MoO x demonstrated the biosafety of the CMM films. The shelf life of tangerines treated with CMM 0.1 + NIR can be extended from 9 days to 21 days, in which the nutrients can be retained well during storage. Our work provides a new perspective on the combination of pasteurization and packaging technology.
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NATURE
·
2026
·Vol. 649
·期 8096
·366-374
·
IF 48.5
Lan Yuqun,Li Shuang,Guo Haitao,Liu Qinyuan,Wang Tairan,Zhou Lianqiao,Fang Jiahuiyu,Zhao Yang,Zhou Zanxin,Wang Qi,Li Jing,Zhu Yiping,Su Rongfang,Wen Xinyi,Xu Xinkai,Wu Yuhong,Wang Zixuan,Liu Bo,Li Jiaqi,Li Hui,Gao Hanfei,Wu Yuchen,Gu Qi,Feng Xi-Qiao,Yu Xinge,Su Yewang
Monitoring internal physiological signals is essential for effective medical care 1 , yet most current technologies rely on external measurements or imaging systems that cannot capture enough deep-tissue dynamics 2 , 3 , 4 , 5 , 6 . Implantable devices offer a solution, but conventional designs often require batteries or magnets 7 , 8 , 9 , 10 , 11 , which carry risks during removal, and existing biodegradable sensors based on passive inductor–capacitor circuits are limited by short readout distances and unstable communication issues 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 . Here we describe a soft, biodegradable, wireless sensing device that can monitor pressure, temperature and strain over long distances (up to 16 cm), maintaining accuracy across varying positions and angles. This is achieved through a ‘pole-moving sweeping’ readout system combined with a folded structure that integrates mechanical flexibility with electromagnetic function. In vivo tests in the abdominal cavity of horses reliably captured deep-tissue pressure and temperature, and ex vivo measurements demonstrated accurate strain monitoring without strict positional control. The long-distance and wide-angle readout of soft biodegradable implants holds translational promise for accessing deep-tissue physiological signals.
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 13.2
Kun Zhang,Shunxi Wang,Kai Qu,Yi Zhao,Qian Feng,Wei Wu,Xian Qin
Diabetic wounds remain difficult to treat due to persistent inflammation, oxidative stress, impaired angiogenesis, and bacterial infections. To address these challenges, a pH-responsive boronate crosslinked chitosan based hydrogel incorporating resveratrol loaded hydroxypropyl-β-cyclodextrin nanoparticles (PPCH Gel@RVT NPs) was developed, offering antioxidant, anti-inflammatory, and antibacterial properties. The pH-triggered design enables hierarchical release of resveratrol under acidic wound microenvironment, which is typical of chronic diabetic wounds, thereby enhancing local drug bioavailability and therapeutic precision. In vitro , PPCH Gel@RVT NPs effectively promoted macrophage repolarization from the pro-inflammatory M1 phenotype to the pro-healing M2 phenotype, thereby attenuating inflammatory signaling. In a full-thickness diabetic wound model, PPCH Gel@RVT NPs markedly accelerated wound closure, achieving a 98.9 % healing rate by day 14 and supporting robust tissue regeneration, including the formation of new epithelial layers, hair follicles, and blood vessels. Together, these findings indicate that PPCH Gel@RVT NPs integrate stimuli-responsive drug delivery with immunomodulation and microenvironment regulation to enhance diabetic wound healing, representing a promising strategy for the treatment of chronic diabetic wounds.
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 13.2
Shan Zhang,Mi Zhang,Xinye Zhou,Xuewen Li,Yangyang Ye,Zeyuan Chen,Kaining Yu,Qingyi Yang,Hui Sun,Min Li,Wenguang Liu,Xu Zhang
The composition and physical architecture of bone play vital roles in bone defect repair. Non-vascularized autografts are constrained by limited bone availability and unpredictable resorption. In this study, we synthesized artificial lamellar bone (ALB) by mimicking the physical structure of natural lamellar bone, integrating structure, properties, and function. Based on the principles of macromolecular crowding and charge shielding in regulating the hierarchical assembly of collagen, our strategy utilized the co -assembly of concentrated collagen with polyaspartic acid-Ca 2+ complexes (PAsp-Ca) to guide collagen ordered assembly and cross-linking, thereby fabricating a biomimetic organic scaffold. During assembly, abundant PAsp-Ca was embedded within the collagen, priming the dense collagen block for deep mineralization. The resulting mineralized ALB closely matched the structure, properties of natural bone and exhibited superior osteogenic performance to autograft in rat critical-sized mandibular defect models. The synergistic effect between new bone formation and material resorption persisted until ALB was completely replaced. This strategy establishes a new paradigm for enhancing the overall performance threshold of osteogenic materials.
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Nano-Micro Letters
·
2026
·Vol. 18
·期 1
·171
·
IF 36.3
Dai Xin-jian,Wang Xin,Hu Ji-hang,Jiang Pan,Wang Xiao-qing
Highly elastic, fatigue-resistant, and conductive lamellar wood sponges are developed via a cell wall reconfiguration strategy.
The strain-induced conductivity changes in lamellar wood sponge enable tunable electromagnetic interference shielding effectiveness and high-sensitivity pressure sensing (0.72 kPa −1 ).
The wood sponge exhibits a low through-plane thermal conductivity of 0.037 W m −1 K −1 , which is compression-tunable for smart thermal management.
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