Oncology Letters
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2018
·Vol. 17
·期 2
·2498-2506
·
IF 1.664
Xuefeng Yang,Handong Huang,Maijian Wang,Xingbin Zheng,Ming Xie,Jie Xu
Previous studies have indicated the potential role of estrogen in the development and prognosis of colorectal cancer (CRC). Nonylpheno (NP) is an endocrine‑disrupting chemical, which may influence the development of estrogen‑dependent types of cancer. However, the molecular mechanism of NP in the development of CRCs remains unclear. In the present study, various concentrations of NP were used to treat COLO205 CRC cells, and the expression of protein kinase C ζ (PKCζ) was knocked down using PKCζ small interfering RNA. The effects of NP in various concentrations on the cell cycle and apoptosis of COLO205 cells were examined, and the change in the expression level of PKCζ was analyzed. The results indicated that NP may significantly induce proliferation of COLO205 CRC cells, and significantly reduce cell apoptosis. However, suppression of PKCζ expression may inhibit proliferation, while NP could reduce this inhibition. The results of a western blot analysis indicated that the expression level of cyclin D1 and E were significantly increased following NP treatment, and the expression of p27 was significantly decreased. The phosphorylation of PKCζ and extracellular‑signal‑regulated kinase (ERK)1/2 was significantly increased following NP treatment in a dose‑dependent manner. Overall, NP induced human CRC COLO205 cell proliferation and inhibited the apoptotic rate of COLO205 cells by increasing the activity of PKCζ and ERK1/2.
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LANGMUIR
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2018
·
IF 3.789
Jiayin Song,Yingnan Zhu,Jiamin Zhang,Jing Yang,Yan Du,Weiwei Zheng,Chiyu Wen,Yumiao Zhang,Lei Zhang
Silver nanoparticles (AgNPs) have been widely used as catalysts in a variety of chemical reactions owing to their unique surface and electronic properties, but their practical applications have been hindered by severe aggregation. The immobilization of AgNPs is crucial to preventing their aggregation or precipitation as well as to improving their reusability. Herein, we developed a facile route for the reductant-free in situ synthesis of AgNPs in zwitterionic hydrogels. Via this method, the embedded AgNPs had a uniform distribution, high activity, and antibiofouling capability. The catalytic reduction of 4-nitrophenol (4-NP) to 4-aminophenol (4-AP) using polycarboxybetaine-AgNPs (PCB-AgNPs) could achieve >95% conversion efficiency within 5 min. Meanwhile, the normalized rate constant knor (10.617 s–1mmol–1) was higher than that of most of the reported immobilized nanocatalysts. More importantly, in a biofouling environment, PCB-AgNPs could still exhibit >97% initial catalytic activity while AgNPs in the PSB or PHEMA hydrogel lost ∼60% activity. This strategy holds great potential for the immobilization of nanoparticle catalysts, especially for applications in biological environments.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2018
·
IF 5.091
Feiya Fu,Jiayuan Gu,Ruihong Zhang,Xinyi Xu,Xiaodong Yu,Lin Liu,Xiangdong Liu,Jinping Zhou,Juming Yao
Cellulose based Ag-functionalized ZnO nanocomposite (AZC) films were prepared using a green and easy scale-up strategy. Firstly, ZnO embedded cellulose (ZC) nanocomposite was synthesized from a cellulose-NaOH/zincate/urea solution through a biomimetic approach. Secondly, Ag nanoparticles (NPs) with a mean diameter of 53.2 nm were efficiently deposited onto the surface of embedded ZnO in cellulose matrix under UV irradiation (16 w), yielding the multi-hybrid AZC film. Owing to the porous structure of cellulose substrate and its rich hydroxyl group , the NPs in the ACZ films displayed good stability. Because of the formation of Schottky barriers in the Ag-ZnO regions, the catalytic activity of ACZ films increased by 20 times when compared to that of ZC sample. Furthermore, the AZC films could completely inhibit both S. aureus and E. coli growth. This facile and eco-friendly approach is expected to pave the way for constructing multifunctional cellulose material for various niche applications.
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Advanced Materials Technologies
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2018
·Vol. 4
·期 2
·1800515
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IF 4.622
Juanjuan Wu,Ying Yan,Lijing Zhang,Zizhen Qin,Shengyang Tao
Mass transfer and catalyst recovery are both influential factors in heterogeneous catalytic processes, which significantly affect the reaction efficiency. Therefore, design and fabrication of reactors and catalysts with reasonable structure and property are central issues in heterogeneous reactions. Herein, agitating impeller (AI) with prismatic structure and catalytic property is conveniently constructed via the combination of 3D printing technology and polymeric ionic liquids (PILs). The further modification of the PILs on impellers endowed them with the ability of ion exchange, which helped to load Pd nanoparticles on the surface as catalysts for reduction, Suzuki coupling, and dye decolorization reactions. Prisms on the impellers significantly enhance the catalytic efficiency of these reactions through improving the mass transfer. The yield reaches nearly 100%. Catalytic impellers could be easily separated from the reactor and without a visible leak of Pd catalysts so that they could repeatedly be used more than ten times with high performance. The numerical simulation and experimental characterizations are both used to explore the mechanism of the mass transfer and the activity of the catalytic surface, which give a full understanding of the benefits of 3D printing and PILs in heterogeneous reactions.
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FOOD CHEMISTRY
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2018
·
IF 4.946
Shijuan Zhang,Ting Xu,Qian Liu,Jiammin Liu,Fengli Lu,Mingbo Yue,Yanxin Li,Zhiwei Sun,Jinmao You
A new cationic gemini surfactant-resorcinol/formaldehyde resin was designed and synthesized. Cationic gemini surfactant was introduced into the resorcinol/formaldehyde resin for the first time and led to the retention of negatively charged endocrine disrupting compounds (EDCs) through electrostatic interactions, hydrogen bonding and π-π interactions. The synthesized material showed good performance in the dispersive micro-solid phase extraction (D-μ-SPE) of EDCs such as alkylphenol and phenoxy acid herbicides from food packaging migrants. Extraction parameters such as pH, adsorbent dose, extraction time and salting out effect were optimized. The limits of detections were in the range of 0.5–0.8 ng/mL, and the recoveries were in the range of 90–100%. The developed method was applied to the analysis of EDCs from food contacting materials migrants with pentachlorophenol, 2,4-dichlorophenoxyacetic acid and bisphenol A detected in the concentration range of 0.2–1.2 mg/kg. It also showed great potential in the D-μ-SPE of other compounds with negative charge or high hydrophobicity.
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JOURNAL OF HAZARDOUS MATERIALS
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2018
·
IF 6.434
Chirag B. Godiya,Xiao Cheng,Dawei Li,Zhan Chen,Xiaolin Lu
A new bio-based bilateral hydrogel containing carboxymethyl cellulose (CMC) and polyacrylamide (PAM) was prepared for the wastewater remediation. The obtained CMC/PAM composite hydrogel reveals a strong single-ion affinity for copper (Cu II ), lead (Pb II ) and cadmium (Cd II ) ions, as well as multi-ion absorbability with its equilibrium data following the Langmuir adsorption model and its adsorption process abiding by a pseudo-second-order kinetics. To demonstrate its recycled use for the metal ions, the adsorbed Cu II ions in the hydrogel were reduced in situ to form homogeneously dispersed Cu nanoparticles (NPs), leading to the Cu NPs-loaded CMC/PAM hydrogel. Reduction of 4-nitrophenol to 4-aminophenol with high efficiency was successfully achieved by this Cu NPs-loaded CMC/PAM hydrogel, verifying the hydrogel’s dual functionalities towards the wastewater treatment and catalytic application.
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Materials Research Express
·
2018
·Vol. 6
·期 1
·015002
·
IF 1.151
Weidan Chang,Shili Liu,Aori Qileng,Weipeng Liu,Yingju Liu
A facile, green and in situ synthesis for the immobilization of monodispersed Au nanoparticles (Au NPs) on eggshell membrane (ESM) using the Lagerstroemia speciosa leaves extract (LSE) was reported. The stable fibrous-network structure of the ESM offered great surface area and abundant functional groups to provide an ideal support, while the leaves extract of Lagerstroemia speciosa can act as stabilizing and reducing reagents for Au NPs without capping reagents or heating. The morphology and surface chemical information were characterized via transmission electronic microscopy (TEM), field emission scanning electron microscopy (FESEM), Fourier transform infrared spectroscopy (FTIR), x-ray photoelectron spectroscopy (XPS), x-ray diffraction analysis (XRD) and thermogravimetric analysis (TGA). The catalyst exhibited excellent performance for the reduction of 4-nitrophenol (4-NP), showing that ESM@LSE@Au from a 0.6 mM Au precursor exhibited the best catalytic activity with the reaction rate constant of 29.70 s−1 · g−1 and a conversion of over 99.84% in 6 min. Moreover, the catalyst can be efficiently recycled by mild centrifugation with a remained conversion over 92.40% after 10 cycles, suggesting the potential for the reduction of nitroaromatic compounds.
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JOURNAL OF HAZARDOUS MATERIALS
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2018
·
IF 6.434
Lei Han,Shi Gang Liu,Jia Yu Liang,Yan Jun Ju,Nian Bing Li,Hong Qun Luo
Being a common hazardous waste, 4-nitrophenol (4-NP) has caused a serious threat to humans and environment. Therefore, rapid and selective detection of 4-NP, especially using a simple and portable instrument, is highly desired for human health and environmental monitoring. Herein, we develop a novel pH-mediated reversible fluorescence nanoswitch for selectively detecting 4-NP by using water-soluble fluorescent polymer carbon dots (PCDs) as a probe. The fluorescence of PCDs can be quenched by 4-NP via inner filter effect (IFE) because its excitation spectrum well overlaps with the absorption spectrum of 4-NP under alkaline condition. However, an obvious blue shift of the absorption peak of 4-NP occurs under acidic condition, causing the fluorescence recovery of PCDs due to the disappearance of IFE. On the basis of this principle, a pH-mediated reversible fluorescence nanoswitch was constructed and a broad linear range was obtained from 0.5 to 60 μM with a detection limit of 0.26 μM for 4-NP. Furthermore, this approach was successfully applied to detect 4-NP in real water samples and a portable polyamide film-based sensor was developed for visual detection of 4-NP, which offers a promising platform for the detection of 4-NP in on-site and resource-poor settings.
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Nanoscale
·
2018
·Vol. 10
·期 37
·17647-17655
·
IF 7.233
Ke Yang,Yu Yan,Haiyang Wang,Zhixuan Sun,Wen Chen,Hongtao Kang,Yi Han,Wenquan Zahng,Xiaohua Sun,Zhenxing Li
A novel copper/copper(I) oxide@carbon (Cu/Cu2O@C) core–shell nanocomposite monodispersed on the surface of reduced graphene oxide (defined as Cu/Cu2O@C-rGO) was synthesized using a one-step calcination of Cu-based metal organic frameworks (MOFs)/graphene oxide (GO) composite structure. The size of the resultant Cu/Cu2O@C core–shell nanoparticles (NPs) on the rGO layers were mainly distributed in range of about 90–100 nm with good dispersion, which was characterized using transmission electron microscopy. X-ray diffraction, Raman spectroscopy, Fourier transform infrared spectroscopy, nitrogen adsorption–desorption isotherms, X-ray photoelectron spectrometry and thermogravimetric analyses were also carried out to characterize the structure and composition of the Cu/Cu2O@C-rGO. The catalytic performance of the Cu/Cu2O@C-rGO composite was evaluated using a reduction reaction from 4-nitrophenol to 4-aminophenol. It was demonstrated that the Cu/Cu2O@C-rGO composite exhibited an excellent catalytic performance, which can reach a nearly 100% conversion rate in 90 s with 0.1 mg of catalyst. This catalyst also showed a good performance for the degradation of other organic dyes such as methylene blue, methyl orange and rhodamine B. Additionally, the core–shell structure exhibited good stability and reusability for the reduction reaction, which was because of its relatively better oxidation resistance than that of the bare Cu NPs. This research provided an efficient and stable non-noble metal-based catalyst derived from the MOF/GO structure.
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ChemCatChem
·
2018
·Vol. 10
·期 18
·4143-4153
·
IF 4.674
Xinyu Wang,Jing Lu,Yunlong Zhao,Xiaopeng Wang,Zhang Lin,Xueming Liu,Ronglan Wu,Chao Yang,Xintai Su
Graphical SuperHUMATE performance : A novel catalyst, carbon anchored nickel/heazlewoodite nanoparticles (Ni/Ni 3 S 2 @C nanosheets), was fabricated by facile pyrolysis of solid precursor with potassium humate as carbon source and sulfur source. The Ni/Ni 3 S 2 @C nanocatalyst exhibited superior catalytic performance towards 4-nitrophenol reduction with excessed sodium borohydride as reactant, which the K /m value up to 166 s −1 g −1 . A facile molten salt method was utilized for the synthesis of carbon anchored nickel/heazlewoodite nanoparticles (Ni/Ni 3 S 2 @C nanosheets) with potassium humate as the carbon and sulfur source and NaCl as template. The morphology, particle size and crystallinity of the products were characterized by various techniques containing TEM, FE-SEM and XRD. Furthermore, the mesoporous Ni/Ni 3 S 2 @C own easy accessibility of active sites and high surface area (149.04 m 2 g −1 ). Thus, the as-prepared Ni/Ni 3 S 2 @C exhibited prominent performance for catalytic reduction of 4-nitrophenol (4-NP). Catalytic reduction of other nitrophenols (NPs) were also tested which can prove that the catalyst own selectivity on reduction of NPs. For durability, the property of the catalyst does not decrease obviously after five cycles. More significant correlations concerning effect of activation parameters ( E a =37.21 kJ mol −1 ) on 4-NP reduction were scrutinized and discussed. Hence, we provide a facile method for fabrication of metal/metal sulfide@C which own better dispersity, small dimension and excellent catalytic performance for further studies.
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Journal of Environmental Chemical Engineering
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2018
·
IF 0
Chirag B. Godiya,Xiao Cheng,Guozhe Deng,Dawei Li,Xiaolin Lu
The indiscriminate disposal of heavy metal ions poses serious threat to the environment and public health. Herein, we report a sustainable and low-cost silk fibroin (SF)/polyethyleneimine (PEI) composite hydrogel for the remediation of heavy metal ions in the aqueous solutions. The SF/PEI hydrogel demonstrated excellent adsorption capacities for the Cu(II), Pb(II), Cd(II), Zn(II), Ni(II), and Ag(I) ions, which are 163.9, 185.2, 169.5, 125.0, 140.8, and 200.0 mg g −1 , respectively. Via a stepwise adsorption, reduction and utilization procedure, the as-prepared hydrogel shows versatile functionalities depending on the pristine adsorbed metal ion(s), for example, catalytical activity and antibacterial property. Based on the functional SF/PEI hydrogel, engineering the cascaded treatment procedure will provide an effective and practical paradigm for the treatment and recycling of heavy metal ions in the wastewater.
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ENVIRONMENTAL POLLUTION
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2018
·
IF 4.358
Xue Cao,Xiaoli Wang,Haibo Chen,Hui Li,Muhammad Tariq,Chen Wang,Yuanyuan Zhou,Yongdi Liu
The present study was performed to evaluate the neurobehavioural deficit induced by nonylphenol (NP), a well-known xenobiotic chemical. The neurotoxic mechanism from oxidative stress and serotonin-related progress was also investigated. Caenorhabditis elegans was exposed at different levels of NP ranging from 0 to 200 μg L −1 for 10 days. The results revealed that from a relatively low concentration (i.e., 10 μg L −1 ), significant effects including decreased head thrashes, body bends and forging behaviour could be observed, along with impaired learning and memory behaviour plasticity. The level of reactive oxygen species (ROS) in head was significantly elevated with the increase of NP concentrations from 10 to 200 μg L −1 . Through antioxidant experiment, the oxidative damage caused by NP restored to some extent. At a NP concentration of 200 μg L −1 , the significant increased expression of stress-related genes, including sod-1 , sod-3 , ctl-2 , ctl-3 and cyp-35A2 gene, was observed from integrated gene expression profiles. In addition, in comparison with wild-type N2 worms, the ROS accumulation was increased significantly with the mutation of sod-3 . Tryptophan hydroxylase (TPH) in ADF and NSM neurons sharply decreased at the concentrations of 10–200 μg L −1 . The transcription of TPH synthesis-related genes and serotonin-related genes were both suppressed, including tph-1 , cat-1 , cat-4 , ser-1 , and mod-5 . Overall, these results indicated that NP could induce neurotoxicity on Caenorhabditis elegans through excessive induction of ROS and disturbance synthesis of serotonin. The conducted research opened up new avenues for more effective exploration of neurotoxicity caused by NP.
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