Materials Today Bio
·
2025
·
IF 10.2
Dong Yan,Guoqi Cao,Yikai Gao,Yiping Wang,Wenqiang Zhang,Kun Wang,Shumei Mao,Chengde Li,Guangdong Zhou,Huitang Xia,Wufei Dai,Xiaoyu Yan,Yibing Wang
Conventional wound dressings for infected diabetic wounds (IDWs) typically target only the wound surface, often neglecting the need for multifunctional therapies that address deeper tissue layers, resulting in less effective treatment outcomes. Emerging research suggests that a comprehensive approach to IDW therapy should involve the transdermal delivery of therapeutic agents capable of staged bacterial eradication, reactive oxygen species (ROS) scavenging, and angiogenesis. This study introduces a novel metal-phenolic nanozyme, CuTA@MnO 2 nanoflake, designed for transdermal delivery in IDW therapy. The nanozyme is synthesized by loading copper ions (Cu 2+ ) onto manganese dioxide (MnO 2 ) via in-situ polymerization, with tannic acid (TA) as a linker, and encapsulated in a hyaluronic acid (HA) solution to form a photothermally controlled microneedle system. In a IDW rat model, this system effectively delivered photothermal therapy, eliminating bacteria under 808 nm near-infrared light. The heat-induced HA degradation released the CuTA@MnO 2 nanoflake, where MnO 2 and TA reduced ROS levels, providing antioxidant effects. Concurrently, released Cu 2+ promoted angiogenesis, significantly accelerating wound healing. Whole transcriptome RNA sequencing confirmed that the CuTA@MnO 2 microneedle enhanced angiogenesis and collagen remodeling, along with reduced inflammation. The CuTA@MnO 2 microneedle offers a promising platform for the staged treatment of IDWs through bacterial eradication, oxidant scavenging, and angiogenesis promotion.
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PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Haining Chen,Xin Tao,Jinbo Liu,Qian Kong,Li Wang,Yiwen Zhao,Chao Jiang,Yu Song,Xu Xu,Jialin Zhu,Yiyang Wang,Fengyi Du,Baoding Chen,Jun Wu
Cartilage injury repair remains challenging because of its unique physical structure and pathological micro-environment, including vascular invasion and inflammatory environment. In this study, inflammatory responsive hydrogels (TA-Mg@Bev iHGs) reinforced by bevacizumab (Bev)-loaded infinite coordination nanopolymer (TA-Mg@Bev) were fabricated for accelerated cartilage repair via anti-angiogenic and anti-inflammatory effects. The incorporation of TA-Mg@Bev iHGs enhanced the mechanical strength of TA-Mg@Bev via phenolic hydroxyl group-mediated hydrogen bond, enabling a sustained drug release under inflammatory environment. Moreover, the released TA-Mg@Bev greatly accelerated chondrogenic proliferation and differentiation from bone marrow mesenchymal stem cells but inhibited the hypertrophy of chondrocytes. The TA-Mg@Bev iHGs inhibited the proliferation of human umbilical vein endothelial cells and corresponding angiogenesis. In a rabbit model of full-layer cartilage defect, the TA-Mg@Bev iHGs promoted in situ cartilage regeneration through immunohistochemistry (type I collagen, type II collagen, and aggrecan). Overall, our study presents a cooperative induction system for accelerated cartilage regeneration.
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高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Cheng Dai,Qian Wang,Hun Huang,Ye Hu,Junlin Chen,Chuhan Lv,Hongbo Yu,Yun Li,Hua Dong
Rapid and efficient hemostasis of massive bleeding wounds remains a major challenge in clinical practice. Self-gelling powders are now emerging as the new-generation hemostatic materials due to their capability to form hydrogels via a self-gelling process and thus integrate the merits of powders and hydrogels. However, they still face several unsettled issues, such as complex components, tedious synthesis, and poor compatibility with hemostatic powders on sale. Herein, we propose a universal strategy to enhance the hemostatic, antibacterial, and wound healing performance of polysaccharide powders via a water-soluble assembly macromolecule (tannic acid-grafted carboxymethyl chitosan, CCTA). When CCTA is blended with polysaccharide hemostatic powders and exposed to blood, the abundant ortho-phenolic hydroxyl groups of CCTA can build a dense hydrogen bonding network with swollen powders (i.e., microgels), erythrocytes, and platelets, leading to the in situ formation of microgel assembly with excellent mechanical strength, tissue adhesion, and thus sealing performance. In addition, CCTA also endows hemostatic powders with good antibacterial activities. The as-formed porous microgel assembly facilitates cell migration and ingrowth, leading to accelerated wound healing and tissue repair in vivo. Three types of polysaccharide powders and three bleeding models (rat femoral artery, rabbit liver, pig liver, and spleen) are used to validate our strategy.
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PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Yuan Tian,Pan Wu,Xiong Yang,Yafei Shi,Gary Owens,Kewu Pi
Tailoring interfacial architectures in porous photothermal materials is critical for advancing solar-driven desalination technologies. Herein, we present a fully bio-based aerogel engineered through an iron-polyphenol coordination strategy inspired by the traditional Chinese “iron-tannin dyeing” method. Liquid-phase tannic acid (TA) extract and solid-phase cellulose from Chinese gallnut were co-assembled with sodium alginate, followed by Fe 3+ /Ca 2+ dual-ion crosslinking and freeze-drying, yielding a TA@SA@Fe 3+ aerogel with hierarchical porosity and adaptive interfacial characteristics. The tailored coordination network enhances light absorption (95.7 %), hydrophilicity, and a high solar evaporation rate of 2.0 kg·m –2 ·h –1 under 1 sun illumination. Its interconnected pores promote salt diffusion, ensuring long-term outdoor operation. Furthermore, the material exhibits strong adhesion on diverse substrates—including melamine sponges and geotextiles—supporting modular integration into scalable desalination systems. A comprehensive life cycle assessment (LCA) confirms the sustainability advantage of this system, with a total emission of only 2.4 kg CO 2 -equivalent per kilogram of material, significantly lower than conventional alternatives. This work offers a green, cost-effective, and application-ready strategy for designing interfacial aerogels, providing a promising platform for next-generation solar-thermal water purification technologies.
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TRANSACTIONS OF THE INDIAN INSTITUTE OF METALS
·
2025
·Vol. 78
·期 4
·1-11
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IF 1.6
Chen Qijie,Liu Chencheng,Han Jiaxin,Cheng Yong,Chen Qingyun,Xiong Zhonggang
A new high-entropy MAX phase (V 0.2 Nb 0.2 Ta 0.2 Mo 0.2 W 0.2 ) 2 AlC was successfully synthesized at 1500 ℃ by nonpressure sintering one-step solid phase reaction method. The microstructure, crystal structure and oxidation behavior of high-entropy (V 0.2 Nb 0.2 Ta 0.2 Mo 0.2 W 0.2 ) 2 AlC MAX phase were investigated. Using thermogravimetry analysis to investigate the oxidative stability of (V 0.2 Nb 0.2 Ta 0.2 Mo 0.2 W 0.2 ) 2 AlC in air environment at high temperature from 0 to 1000 °C, there is no volume change from 0 to 400 °C, and the morphology still exhibits a typical layered structure, demonstrating thermal stability. Oxidation rate gradually decreases with the increase in temperature, and the K p3 value decreases to 0.86 × 10 –4 kg 2 m −4 s 2 at 1000 ℃. The microscopic morphology analysis at different temperatures shows that the surface defects of the matrix gradually form under high-temperature conditions, in which the formation of carbide and Al 2 O 3 layers hinds the further oxidation of the sample. The research provides a reference for the synthesis and thermal stability of new two-dimensional layered high-entropy MAX ceramics.
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CEMENT AND CONCRETE RESEARCH
·
2025
·
IF 13.1
Minghui Jiang,Xiao Liu,Shiyu Li,Yurui Xu,Simai Wang,Lei Lu,Xinxin Li,Xinru Sun,Chunlei Xia,Ziming Wang,Suping Cui
The internal water migration within calcium silicate hydrate (C-S-H) in dry environments is considered to be the primary factor affecting the volume stability of cementitious materials. In this research, the in-situ polymerization product of plant polyphenol tannic acid (TA) was applied to modify C-S-H based on an organic-inorganic composite modification method. The chemical structure, microstructure, composition, dimensional changes and water migration characteristics of modified C-S-H were analyzed. Experimental results showed that TA improved the polymerization degree of siloxane chains in the C-S-H nanostructure, with a maximum improvement of 80.70%, and increased the interlayer spacing in the C-S-H structure, confirming the modification of C-S-H at the nanoscale, exhibited by 29 Si Nuclear Magnetic Resonance (NMR), X-ray diffraction (XRD) and Transmission Electron Microscopy (TEM). This modification by TA optimized the C-S-H nanostructure and microscopic pores, and increased the interlayer and gel pore water content, especially gel pore water increased by 56.53% compared to that of the unmodified C-S-H, revealed by nitrogen adsorption and 1 H LF-NMR. In the dry environment, the blocking and cladding effects of TA on C-S-H effectively inhibited the gel water loss and reduced the drying shrinkage, especially at low TA concentration. This research aims to improve the volume stability of C-S-H by in-situ polymerization product of plant polyphenol, which provides new insights into improving the volume stability of cementitious materials.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Feiyan Huang,Zhuoting Zhao,Zhiqin Yang,Fang He,Hongguang Sun,Yuexiang Li,Zhenxing Wang
Rare earth mining produces a large amount of acidic oily wastewater, which causes serious environmental pollution. Developing an acid-resistant oil–water separation membrane is an effective way to solve the above problems. In this work, we successfully construct a protein-induced silica coating on polyvinylidene fluoride (PVDF) membrane with the aid of adhesion protein for highly efficient separation of acid emulsion. The obtained coating is composed of ovalbumin (OVA), tannic acid (TA), TiO 2 , and SiO 2, which can endow the PVDF membrane with excellent underwater superoleophobicity and desirable acid resistance. Moreover, the modified membrane has excellent anti-oil-adhesion property, which can keep withstand fouling even an oil droplet is continuously squeezed into the membrane for 2 h under acidic conditions. The outstanding anti-oil-adhesion property is due to the bound water of the multilayer coating, which is confirmed by low field-nuclear magnetic resonance (LF-NMR). The flux recovery can reach up to 98 % and oil rejection rate can reach up to 99.7 % toward strongly acidic emulsion. In addition, the multilayer coating also possesses good stability, which can withstand ultrasonic treatment and washing. Considering the mild preparation process without expensive/complex equipment and the desirable performance, this strategy may become a powerful tool for preparing acid-resistant membranes for efficient treatment of acidic emulsion.
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INTERNATIONAL JOURNAL OF REFRACTORY METALS & HARD MATERIALS
·
2025
·
IF 4.6
Shuailing Ma,Yufei Ge,Wang Chen,Min Lian,Xingbin Zhao,Qiang Tao,Kuo Bao,Pinwen Zhu,Tian Cui
It is widely acknowledged that strong electron-phonon coupling in conventional superconductors predominantly arises from the high vibrational frequencies of light elements. In this work, we report an anomalous superconducting system where the superconducting behavior in the covalent metallic compound TaC originates predominantly from heavy transition metal atoms. Polycrystalline samples of the ‘covalent metal’ TaC (space group Fm-3 m) were synthesized using a high-pressure high-temperature (HPHT) technique. Comprehensive characterization through direct magnetic susceptibility and electrical resistivity measurements confirms that TaC exhibits characteristics of a weakly-coupled type-II superconductor, demonstrating both a remarkably high upper critical magnetic field and a superconducting transition temperature ( T c ) of 9.0 K. Intriguingly, the material displays exceptional mechanical properties as evidenced by its asymptotic Vickers hardness values, which significantly surpass these of conventional superconducting materials. The composition with Ta:C = 1:0.9 demonstrates optimal performance balance, achieving a maximum Vickers hardness of 18.7 GPa while maintaining robust superconducting transition characteristics. First-principles calculations reveal that the elevated T c primarily stems from substantial electronic contributions from tantalum atoms. Our findings demonstrate that controlled introduction of carbon vacancies serves as an effective strategy for tailoring these dual functional characteristics, providing novel design principles for developing specialized superconducting devices capable of operating under extreme mechanical and electromagnetic conditions.
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高影响因子
ADVANCED MATERIALS
·
2025
·
IF 26.8
Haoyu Yue,Zhongnan Guo,Wenjing Guo,Ruonan Yao,Shuang Zhen,Qiansu Ma,Ming Chen,Jiawei Lin,Wenxia Yuan
The high-entropy strategy offers a viable pathway to activate the inert basal plane of transition metal dichalcogenides (TMDs) for electrocatalysis. This work demonstrates that the “lattice distortion effect”, one of the core effects of high-entropy materials, plays a crucial role in activating the basal plane of TMDs. A high-entropy diselenide (ReNbTaMoW)Se 2 (denoted as HESe 2 ) is synthesized via solid-state reaction. Single-crystal X-ray diffraction and atomic resolution scanning transmission electron microscopy reveal a unique fivefold-modulated structure in HESe 2 , which unexpectedly distorts the rigid trigonal prismatic motif. HESe 2 exhibits exceptional activity for hydrogen evolution reaction (HER), showing a low overpotential of 31 mV at a current density of 10 mA cm −2 , comparable to state-of-the-art precious metal catalysts. In situ X-ray photoelectron spectroscopy indicates that the distorted structure of HESe 2 remains stable during the HER process. A proton exchange membrane (PEM) electrolyser assembled with HESe 2 cathodic catalyst shows competitive performance and durability with negligible degradation over 400 h. Density functional theory calculations reveal the electron accumulation regions induced by lattice distortion as high-activity sites, thereby driving the augmented HER performance of HESe 2 . This work presents a universal strategy for boosting the basal plane activity of layered materials through unique lattice distortion effect.
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