ACS Nano
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2018
·
IF 13.709
Qing Chen,Yang Du,Kai Zhang,Zeyu Liang,Jinquan Li,Hao Yu,Rong Ren,Jin Feng,Zhiming Jin,Fangyuan Li,Jihong Sun,Min Zhou,Qinggang He,Xiaolian Sun,Hong Zhang,Mei Tian,Daishun Ling
Alzheimer’s disease (AD) remains an incurable disease and lacks efficient diagnostic methods. Most AD treatments have focused on amyloid-β (Aβ) targeted therapy; however, it is time to consider the alternative theranostics due to accumulated findings of weak correlation between Aβ deposition and cognition, as well as the failures of Phase III clinical trial on Aβ targeted therapy. Recent studies have shown that the tau pathway is closely associated with clinical development of AD symptoms, which might be a potential therapeutic target. We herein construct a methylene blue (MB, a tau aggregation inhibitor) loaded nanocomposite (CeNC/IONC/MSN-T807), which not only possesses high binding affinity to hyperphosphorylated tau but also inhibits multiple key pathways of tau-associated AD pathogenesis. We demonstrate that these nanocomposites can relieve the AD symptoms by mitigating mitochondrial oxidative stress, suppressing tau hyperphosphorylation, and preventing neuronal death both in vitro and in vivo. The memory deficits of AD rats are significantly rescued upon treatment with MB loaded CeNC/IONC/MSN-T807. Our results indicate that hyperphosphorylated tau-targeted multifunctional nanocomposites could be a promising therapeutic candidate for Alzheimer’s disease.
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高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2018
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IF 5.091
Ruming Jiang,Meiying Liu,Hongye Huang,Liucheng Mao,Qiang Huang,Yuanqing Wen,Qian-yong Cao,Jianwen Tian,Xiaoyong Zhang,Yen Wei
Ultrasound as a powerful technique has increasingly been used in both industry and academia in recent years. Herein, an efficient approach to the ultrafast preparation of cross-linked fluorescent copolymers (PEGMA-AEMA-TPE) with aggregation-induced emission (AIE) via an ultrasound-assisted multicomponent reaction (MCR) is described. A number of characterization techniques were carried out to certify the successful preparation of these AIE-active copolymers. Due to the introduction of a hydrophilic PEG fragment and a hydrophobic AIE-active dye, the obtained fluorescent copolymers showed amphiphilic properties and could assemble into organic dyed polymer nanoparticles (ODPNs) with great water dispersibility. The final PEGMA-AEMA-TPE ODPNs demonstrated intense fluorescence, strong photostability, a low critical micelle concentration (CMC) of 0.007 mg mL −1 and high biocompatibility. More importantly, the PEGMA-AEMA-TPE ODPNs show obvious AIE characteristics, which could elegantly overcome the quenching effect caused by the aggregation of ODPNs based on conventional organic dyes. Considered the above results, we believe that these AIE-active ODPNs should be promising candidates for biological imaging and other biomedical applications.
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ADVANCED FUNCTIONAL MATERIALS
·
2018
·Vol. 28
·期 14
·1703369
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IF 13.325
Youchen Gu,Heping Shen,Chen Ye,Xuezeng Dai,Qian Cui,Jianbao Li,Feng Hao,Xiaojing Hao,Hong Lin
The thin-film photovoltaic material Cu 2 ZnSnS 4 (CZTS) has drawn worldwide attention in recent years due to its earth-abundant, nontoxic element constitution, and remarkable photovoltaic performance. Although state-of-the-art power conversion efficiency is achieved by hydrazine-based methods, effort to fabricate such devices in a high throughput, environmental-friendly way is still highlydesired. Here a hydrazine-free all-solution-processed CZTS solar cell with Na 2 S self-depleted back contact modification layer for the first time is demonstrated, using a ball-milled CZTS as light absorber, low-temperature solution-processed ZnO electron-transport layer as well as silver-nanowire transparent electrode. The inserting of Na 2 S self-depleted layer is proven to effectively stabilize the CZTS/Mo interface by eliminating a detrimental phase segregation reaction between CZTS and Mo-coated soda lime glass, thus leading to a better crystallinity of CZTS light absorbing layer, enhanced carrier transportation at CZTS/Mo interface as well as a smaller series resistance. Furthermore, the self-depletion feature of the Na 2 S modification layer also averts hole-transportation barrier within the devices. The results show the vital importance of interfacial engineering for these CZST devices and the Na 2 S interface layer can be extended to other optoelectronic devices using Mo contact.
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ELECTROANALYSIS
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2018
·Vol. 30
·期 11
·2768-2773
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IF 2.851
Xin Feng,Xiaomei Dong,Qingcheng Zhang,Cuixia Cui,JingJing Zhang,Zhen Chen,Changmi Wu,Huile Jin,Shun Wang,Jichang Wang
In this study carbon materials with a hierarchical pore structure have been fabricated through a scalable and template free solvothermal method in the presence of metal catalysts, where the presence of metal catalysts was found to be essential for the initial polymerization process. The as-prepared carbon contained trace amounts of metal residues and exhibited highly efficient catalytic activity toward the oxygen reduction reaction (ORR). Among all the metal catalysts studied, cobalt containing porous carbon exhibited the highest ORR electrocatalytic activity with great tolerance to methanol crossover and excellent long-term cycling stability, outperforming the commercial 30 % ( w / w ) Pt/C catalysts. The great performance may be contributed to the unique porous structure, the large specific surface area of cobalt-doped carbon and chemical activity of cobalt. The result provides useful guidance for the development of carbon-based electrocatalysts.
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ACS Sustainable Chemistry & Engineering
·
2018
·
IF 6.14
Hengchang Ma,Yucheng Ma,Lei Lei,Weidong Yin,Yuan Yang,Tao Wang,Pei Yin,Ziqiang Lei,Manyi Yang,Yanfang Qin,Shaoxiong Zhang
The newly emerged pathogenic bacteria leads to the bactericides generations one by one, which is definitely a long-term and costly process. For the small organic molecule used as antibacterial materials, photostability, biomembrane penetrating ability, and long-term antibacterial ability still are questionable. In this work, we synthesized the multiple-cation-charged aggregation-induced emission (AIE)-active polymer 1,2-diphenyl-1,2-bis(4-(pyridin-4-yl)phenyl) ethane–1,8-dibromooctane (DBPE-DBO). Due to the incorporating the dark toxicity from positively charged polymers, and the phototoxicity from generation of singlet oxygen, as well as AIE-active fluorescence performance, DBPE-DBO could be employed as an efficient bacteria targeting, imaging, and killing materials. Interestingly, DBPE-DBO was less toxic to the normal mammalian cells, which leads us to verify that DBPE-DBO could be used as a very cell-membrane permeable nucleus imaging probes. Thus, our research results may provide a new concept for the designing advanced biomaterials with versatile antibacterial properties and cell imaging ability.
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APPLIED CATALYSIS B-ENVIRONMENTAL
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2018
·
IF 11.698
Pan Li,Tao He
Inspired by the nature photosynthesis, fabrication of Z-scheme system is an effective strategy to enhance the photocatalytic activity, via which photogenerated electrons and holes that take part in the redox reactions can be separated spatially and temporally, while their strong redox capability can still be preserved. It is of great importance to construct good Z-scheme demo systems, and yet a considerable challenge to verify the charge transfer direction, which is vital for designing and fabricating the photocatalytic systems with high efficiency. Here ZnS@ZnO core-shell nanostructures were fabricated via simply annealing ZnS(en) 0.5 precursor, which exhibited superior activity for solar fuel production to ZnS. The Z-scheme mechanism was proposed based on the experimental results of charge transfer study. Direct intimate contact is formed at interface due to in-situ growth with common Zn cation. Specifically, ZnS X O 1–X and/or defects may be formed at the interface, which behave like a mediator in a Z-scheme system. All these account for the observed efficient separation of charge carriers and enhanced activity of photocatalytic reduction.
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Chinese Physics B
·
2018
·Vol. 27
·期 6
·066108
·
IF 1.321
Qing Yu,Jiangjian Shi,Pengpeng Zhang,Linbao Guo,Xue Min,Yanhong Luo,Huijue Wu,Dongmei Li,Qingbo Meng
A study of the self-healing phenomenon of Cu2ZnSn(S, Se)4 (CZTSSe) solar cells has shown more than 10% enhancement in cell performance after storage at room temperature for a week, with a significant improvement in the open-circuit photovoltage (Voc) and fill factor (FF). In addition, up to 10.45% power conversion efficiency (PCE) has been achieved. No obvious change in crystallinity, crystal phase, optical absorption or elemental distribution in the CZTSSe films was detected on examining the x-ray diffraction (XRD) pattern, Raman spectrum, ultraviolet-visible (UV-Vis), and TOF-SIMS. Further investigations on the charge carrier concentration, charge radiative recombination, and band structure suggest that the enhancement in PCE stems mainly from a reduction in deep defects of the CZTSSe semiconductor film.
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EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
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2018
·Vol. 2018
·期 18
·1891-1901
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IF 2.507
Saisai Yan,Zhinong Gao,Yan Xia,Xueming Liao,Jia Han,Chenchen Pan,Yingfang Zhang,Wenzhong Zhai
Graphical Shape-controlled hollow aggregation-induced emission (AIE) silica nanoparticles (SNs) and mesoporous silica nanoparticles (MSNs) are prepared. Proper balance of the structure-directing effects of cetyltrimethylammonium bromide (CTAB) and C 16 -tetraphenylethene (TPE)-C 16 allows the morphologies of AIE-SNs and AIE-MSNs to be adjusted from nonfluorescent CTAB-SNs to fluorescent nanostructures. The development of particles that possess different properties has been a long-thought goal for producing multifunctional materials owing to their combination of performance. Herein, aggregation-induced emission (AIE) gemini surfactant-assisted preparation of shape-controlled fluorescent hollow silica nanoparticles (AIE-SNs) is performed directly in water through a one-pot method. The incorporated AIE gemini surfactant (C 16 -TPE-C 16 ) not only provides a fluorophore for the AIE-SNs but also participates in the structure-directing process with cetyltrimethylammonium bromide (CTAB) to regulate their construction. By properly tuning the molar ratio of CTAB and C 16 -TPE-C 16 , AIE-SNs with different morphologies and fluorescence properties can be produced. Their mesoporous silica nanoparticle (AIE-MSN) derivatives can also be fabricated by subsequent extraction owing to the inherent structural differences between CTAB and C 16 -TPE-C 16 . Importantly, fluorescent hollow mesoporous silica nanorods and nanospheres with ordered channels, thin shell thicknesses (~ 13 and ~ 7 nm), high accessible surface areas (599.2 and 573.9 m 2 g –1 ), and uniform pore sizes ~ 2.8 nm) can be facilely prepared at CTAB/C 16 -TPE-C 16 molar ratios of 30:1 and 15:1, respectively. This facile and straightforward method for creating tunable hollow AIE-MSNs may open viable opportunities and inspire the preparation of particles with multiple properties.
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ANALYTICA CHIMICA ACTA
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2018
·
IF 5.123
Yang Li,Qingfen Niu,Tao Wei,Tianduo Li
A novel bifunctional thiophene-based Schiff base TS as a colorimetric and fluorescent turn-on sensor for rapid and simultaneous detection of Al 3+ and Zn 2+ ions with high selectivity and sensitivity has been developed. The sensor shows remarkable fluorescence enhancement response for Al 3+ and Zn 2+ over a broad pH range with good anti-interference capability, which accompanied with an obvious color change easily detected by naked eyes. Sensor TS can detect as low as 3.7 × 10 −9 M for Al 3+ and 3.0 × 10 −8 M for Zn 2+ , whereas respective association constants are 1.16 × 10 4 M −1 and 2.08 × 10 4 M −1 . With the help of fluorescence titration and Job's plot, the stoichiometric ratio of TS with Al 3+ /Zn 2+ was determined to be 1:1. The sensing mechanism of sensor TS with Al 3+ /Zn 2+ based on the chelation-enhanced fluorescence (CHEF) was analyzed in detail through 1 H NMR titration, FTIR, HRMS and DFT studies . Moreover, sensor TS has been applied to the detection of Al 3+ and Zn 2+ in real environmental water and food samples as well as the filter paper-based test strips. Furthermore, sensor TS has good cell-permeability and can be used to selectively sense intracellular Al 3+ and Zn 2+ by bioimaging.
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INORGANIC CHEMISTRY
·
2018
·
IF 4.7
Saisai Yan,Zhinong Gao,Yan Xia,Xueming Liao,Yifan Chen,Jia Han,Chenchen Pan,Yingfang Zhang
Nanoparticles that possess unique structures and properties are highly desired in the production of multifunctional materials because of their combinational performance. In this study, a facile and effective fabricating strategy is developed to controllably prepare fluorescent hollow mesoporous silica nanorods via the cetyltrimethylammonium bromide (CTAB) and tetraphenylethene (TPE) luminogen-functionalized gemini surfactant (CTPE–C6–CTPE) guided dual-templating approach. Because of its unique chemical structure, water solubility, surface activity, and fluorescent properties, the designed CTPE–C6–CTPE will not only provide an anchored fluorophore for silica nanoparticles but also serve as an intimate partner of CTAB to regulate their construction in the structure-directing process. By properly tuning the molar ratio of CTAB/CTPE–C6–CTPE, the shape-controlled aggregation-induced emission hollow mesoporous silica nanoparticles (AIE-MSNs) can be prepared directly, producing two kinds of silica nanorods (AIE-MSNs-15 and AIE-MSNs-7). In particular, the incorporated bulky TPE luminogens will not only endow AIE-MSNs-7 with enhanced fluorescence intensity (2.3-fold) after the removal of CTAB but also bring about high accessible surface area (606.6 m2/g) and larger pore size (3.2 nm) and pore volume (0.634 cm3/g) for effective loading and sustained release of the hydrophobic anticancer drug camptothecin. CTPE–C6–CTPE enriches the family of gemini surfactants and provides important insights into the convenient fabrication of advanced fluorescent mesoporous materials.
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APPLIED SURFACE SCIENCE
·
2018
·
IF 4.439
Ying Xu,Shengnan Wang,Xiaoyan Hou,Zhe Sun,Yong Jiang,Zhongbing Dong,Quanbao Tao,Jun Man,Yan Cao
N, P, S co-doped graphene quantum dots (NPS-GQDs) were prepared via a one-step wet chemical plus dialysis method directly using anthracite coal as raw material. This facile oxidation process simultaneously synthesized graphene quantum dots (GQDs) and doped N, P and S atoms on edges or forming functional groups of GQDS. X-ray photoelectron spectroscopy (XPS) proved that the involved heteroatoms were successfully doped on GQDs. The local doping of N, P and S on GQDs can reach high levels as 5.6%, 3.7% and 3.7% (by atomic) during XPS detection, respectively. Raman spectra showed that the amount of defects or disorders of prepared GQDs increased during the transition of the coal hunk toward the nano-GQDs. The effect of graphitizing degree of applied coals (varied coal ranks) on the formation of GQDs implied that raw coals with too high or too low graphitizing degree were not optimizing for the formation of high-quality GQDs. The prepared NPS-GQDs showed excellent properties on the excitation-dependent fluorescence and the quench by some trace metals. Thus, the NPS-GQDs were applied to detect of Pb 2+ in both a DI water and a multi-elements analysis matrix, exhibited wide linear detection range (1–20 μM) and a detection limit of 0.75 μM.
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CHEMICAL ENGINEERING JOURNAL
·
2018
·
IF 6.735
Youchen Gu,Chen Ye,Xuewen Yin,Jianhua Han,Yu zhou,Heping Shen,Jianbao Li,Xiaojing Hao,Hong Lin
Cadmium sulfide (CdS) is the most widely used buffer material for a variety of thin-film solar cells including Cu 2 ZnSnS 4 . However, reports have shown that CdS film obtained by chemical bath deposition (CBD) is not the ideal buffer layer for pure sulfide CZTS solar cell. Zinc doping is a viable approach to modifying the CdS buffer film, but the present methods are far from satisfactory. Here, we innovatively developed an effective way of Zinc doping using partial electrolyte (PE) treatment, resulting in state-of-the-art buffer layer for solar cells based on high-surface-waviness CZTS light absorber. Our study shows that this Zn PE-treated CdS film improved the properties including coverage, full-range light transmittance and conduction band alignment with CZTS. Ultimately, the resultant modified CdS film boosted the open-circuit voltage of our devices by more than 100 mV, yielding power conversion efficiency (PCE) of 3.30%. We note that this is the highest efficiency that has been reported for all solution-processed CZTS solar cells.
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