Catalysis Science & Technology
·
2019
·Vol. 9
·期 13
·3380-3387
·
IF 5.726
Xiaochao Zhang,Jiabing Wei,Guangmin Ren,Changming Zhang,Zhanfeng Zheng,Caimei Fan
This work reported for the first time a systematic investigation on a BiOBr photocatalyzed oleic acid isomerization process in different (air, N2 and O2) atmospheres and proposed the cis–trans isomerization mechanism to effectively restrain the formation of trans fatty acids with deleterious effects on human health. The phase structures, optical properties, and morphologies of as-prepared BiOBr were characterized by XRD, UV-vis DRS, SEM and TEM. Besides, the photocatalyzed isomerization products over BiOBr in different atmospheres were analyzed with FT-IR and 1H NMR for comparison. The results demonstrate that there are significant differences in the photocatalytic isomerization process of oleic acid in different atmospheres, and especially the N2 atmosphere is the most favorable atmosphere, while the presence of O2 will inhibit the formation of elaidic acid. Moreover, density functional theory (DFT) was employed to calculate the charge density and energy difference of ground states between cis- and trans-isomers of oleic acid. Combining the theoretical and experimental findings, the radical cation and photo-induced h+ action mechanisms in the photocatalytic isomerization process were discussed and proposed. Our findings should provide new insights and basic data for understanding the photocatalytic isomerization of unsaturated fatty acids.
研究领域:
食品科学
·
化学工程
·
生物化学
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DOI
高影响因子
CANCER SCIENCE
·
2018
·Vol. 109
·期 4
·1185-1194
·
IF 4.372
Hai-Ning Liu,Tao-Tao Liu,Hao Wu,Yan-Jie Chen,Yu-Jen Tseng,Can Yao,Shu-Qiang Weng,Ling Dong,Xi-Zhong Shen
Recently, many new diagnostic biomarkers have been developed for colorectal cancer. We chose 2 methods with high diagnostic efficiency, the detection of serum microRNA and metabolomics based on gas chromatography/mass spectrometry (GC/MS), and aimed to establish appropriate models. We reviewed the diagnostic value of all microRNA identified by previous diagnostic tests. We selected appropriate microRNA to validate their diagnostic efficiency, and determined the optimal combination. We included 85 patients with colorectal cancer (CRC) and 78 healthy controls (HC) and detected the expression of the microRNA. GC/MS analysis was conducted, and we used 3 multivariate statistical methods to establish diagnostic models. The concentrations of carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) were detected for comparison with the novel models. Ultimately, 62 published studies and 63 microRNA were included in this review. MiR-21, miR-29a, miR-92a, miR-125b and miR-223 were selected to further validate their diagnostic value. The serum levels of the 5 microRNA in CRC patients were significantly higher than those in the HC. The combination of miR-21, miR-29a, miR-92a and miR-125b had the highest area under the curve (AUC) at 0.952, with a sensitivity of 84.7% and a specificity of 98.7%. The GC/MS analysis exhibited an excellent diagnostic value and the AUC reached 1.0. With regard to traditional biomarkers, the AUC of CEA and CA19-9 were 0.808 and 0.705, respectively. The application prospects are good for microRNA and metabolomics as new diagnostic methods because of their high diagnostic value compared with traditional biomarkers.
研究领域:
医学
·
分子生物学
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DOI
PubMed
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2021
·Vol. 19
·期 1
·1-17
·
IF 10.435
Lan Biyun,Zhang Liming,Yang Liqun,Wu Junfeng,Li Na,Pan Chenglin,Wang Xiaoyi,Zeng Lexiang,Yan Li,Yang Chuan,Ren Meng
AbstractExcessive expression of matrix metalloproteinase 9 (MMP-9) impedes healing of diabetic chronic wounds, thus wound dressing that could effectively inhibit the expression of MMP-9 offers significant clinical translation for diabetic wound healing. Herein, a hybrid hydrogel dressing was developed for localized and sustained delivery of MMP-9 siRNA (siMMP-9). siMMP-9 was complexed with Gly-TETA (GT), the GT/siMMP9 complex was then loaded into a thermosensitive hydrogel based on Pluronic F-127 (PF) and methylcellulose (MC). In vitro, this hybrid hydrogel dressing exhibited negligible cytotoxicity, prolonged the release of GT/siMMP-9 for up to 7 days, and significantly reduced MMP-9 expression. In vivo assessment in diabetic rats demonstrated that hydrogel provided localized and sustained delivery via the thermosensitive controlled release of entrapped GT/siMMP-9 into wound tissues for 7 days, resulting in dramatic MMP-9 silencing which significantly improved diabetic wound closure. This hybrid hydrogel dressing exhibited excellent biocompatibility, with no observed systemic toxicity in rats. Taken together, the hybrid hydrogel dressing may constitute an effective and biocompatible means of enhancing diabetic wound healing through effective silencing of the MMP-9 gene, and this hydrogel delivery system also offers a platform for in vivo delivery of siRNA for the treatment of other diseases.
研究领域:
药学
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生物医学工程
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伤口愈合
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糖尿病
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DOI
PubMed
高影响因子
RSC Advances
·
2026
·Vol. 16
·期 26
·23915-23921
·
IF 6.1
Taoran Yan,Xinying Ma,Fengna Xi
Matrix metalloproteinase-9 (MMP-9) detection is crucial for the early screening and treatment monitoring of infantile hemangioma. Herein, a nanoconfinement catalysis-enhanced electrochemiluminescence (ECL) aptasensor was fabricated for the sensitive detection of MMP-9. Co3O4 nanoparticles were electrochemically deposited onto an ordered silica nanochannel film (SNF), which not only exhibited electrocatalytic oxidation activity toward luminol and H2O2 but also possessed peroxidase (POD)-like activity. The synergistic effect between Co3O4 and the confinement effect of SNF remarkably amplified ECL from the luminol–H2O2 system. After functionalizing the electrode surface with epoxy groups, MMP-9 aptamers were covalently immobilized to construct the aptasensor. ECL signal quenching, attributable to the spatial hindrance and elevated interfacial resistance following the specific MMP-9/aptamer binding, served as the basis for the quantitative detection of MMP-9. The sensor displayed a wide linear response range (0.001 to 100 ng mL−1), a low detection limit of 0.1 pg mL−1, and high selectivity, reproducibility, and stability.
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DOI
PubMed
高影响因子
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
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2016
·
IF 3.902
Hui Yang,Hao-Wen Wang,Teng-Wei Zhu,Le-Mao Yu,Jian-Wen Chen,Lu-Xia Wang,Lei Shi,Ding Li,Lian-Quan Gu,Zhi-Shu Huang,Lin-Kun An
In our previous research, 9-bromo indolizinoquinoline-5,12-dione 1 has been found to be a good anti-MRSA agent. However, it had very low bioavailability in vivo possibly due to its low solubility in water. In order to obtain the derivatives with higher anti-MRSA activity and good water solubility, twenty eight bromo-substituted indolizinoquinoline-5,12-dione derivatives were synthesized in the present study. The antibacterial activity of the synthesized compounds was evaluated against one gram-negative and some gram-positive bacterial strains including 100 clinical MRSA strains. The UV assays were carried out to determine the solubility of six active compounds 16, 21, 23 and 27–29 . The most potent compound 28 exhibited strong activity against clinical MRSA strains with both MIC 50 and MIC 90 values lower than 7.8 ng/mL. Compound 27 had good water solubility of 1.98 mg/mL and strong activity against clinical MRSA strains with MIC 50 value of 63 ng/mL and MIC 90 value of 125 ng/mL, 16-fold higher than that of Vancomycin .
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DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2016
·
IF 4.758
Jun Qin,Xiaomei Li,Zezhong Chen,Feng Feng
Commercially available 9-bromophenanthrene (9-BrP) was used as fluorescence probe for determination of trace palladium (Pd). Under the catalysis of Pd 2+ , 9-BrP is converted to phenanthrene, which can emit stronger fluorescence. Consequently, fluorescence of Pd sample is greatly enhanced, and the enhancement is positively correlated with the concentration of Pd 2+ . The catalytic reaction exhibits excellent selectivity and specificity, which enables a simplification on the pre-treatment of real sample. The method has a wide linear range of 0.07–18 μM and a detection limit of 50 nM for Pd 2+ . Detection and recovery experiments of Pd in lake water, Pd-carbon catalyzer and surface soil are also satisfactory, indicating that the method has better feasibility and application potential in routine determination of Pd.
研究领域:
分析化学
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环境科学
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DOI
高影响因子
Journal of Materials Chemistry B
·
2019
·Vol. 7
·期 45
·7141-7151
·
IF 5.047
Jun Zhang,Tiantian Zuo,Xiao Liang,Yingxin Xu,Yifan Yang,Tianxu Fang,Jing Li,Daijie Chen,Qi Shen
Triple-negative breast cancer (TNBC) is characterized by a high metastatic rate, which can seriously threaten women's health. ROS play an important role in tumor development and metastasis. Excessive ROS can induce tumor cell apoptosis and inhibit tumor cell metastasis. This study investigated Fenton-reaction-stimulative nanoparticles (P@P/H NPs) containing ROS-responsive molecular switches for antitumor metastasis by amplifying the ROS and activating the cascade biological reaction of ROS in tumor cells. Spheroidal P@P/H NPs exhibited a uniform size of 68.18 ± 0.29 nm, high drug cumulative release of 97.59% in response to H2O2 at 24 h, and satisfactory cytotoxicity with the IC50 value of 0.50 ± 0.02 μg mL−1. The markedly elevated ROS level caused by P@P/H NPs generated an evident antitumor metastasis effect in vitro by facilitating the expressions of cytochrome c, caspase-9, and caspase-3 and blocking that of matrix metalloprotein 9 (MMP-9). Moreover, P@P/H NPs engendered an excellent tumor inhibition rate of 56.37% and antitumor metastasis effect in vivo. Therefore, P@P/H NPs could respond to H2O2 in tumor cells to rapidly disassemble and further increase the ROS to induce antitumor metastasis via the Fenton reaction.
研究领域:
纳米技术
·
癌症治疗
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生物医学工程
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药学
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产品关联
DOI
PubMed
高影响因子
Journal of Pharmaceutical Innovation
·
2022
·
IF 2.538
Sun Yu
Purpose In this study, we fabricated a nanoplatform to target tumor sites via active and passive targeting effects, thus avoiding the toxic side effects of nanocarriers and improving the efficacy of chemotherapeutic drug delivery. Methods A sequential stimulus-responsive nanoparticle that targeted the tumor microenvironment and exhibited dual sensitivity to the reduction condition and matrix metalloproteinase-9 (MMP-9) enzyme was fabricated based on a self-assembled polypeptide-paclitaxel conjugate. Results The nanoparticles (48.9 ± 2.1 nm) transformed into rod-like nanostructures (297.1 ± 3.2 nm) in the presence of MMP-9. The rod-like nanostructures were taken up by tumor cells and then sensitive bonds were broken in response to highly expressed GSH in tumor cells to release drugs. This platform showed a tumor inhibition rate of 71.8% in S180-bearing mice and a more effective tumor inhibition rate than Taxol in 4T1-bearing mice. Conclusion This platform facilitates the design of enhanced safe and efficient chemotherapy drug delivery.
研究领域:
药学
·
肿瘤学
·
纳米医学
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产品关联
DOI
高影响因子
APPLIED ORGANOMETALLIC CHEMISTRY
·
2024
·Vol. 38
·期 12
·e7696
·
IF 3.7
Xueze Wang,Huawei Zhou,Xianxi Zhang
Bi-based organic halides have attracted widespread attention as potential substitutes for lead-based organic halide perovskites and have been explored and applied in many optoelectronic devices. The rational design of organic Bi-based halides is a popular research topic. In this work, we used benzylammonium (BA) cations to synthesize BA 3 Bi 2 I 9 (BBI) perovskite material and FA 3 Bi 2 I 9 (FBI, FA [formamidinium]) as control. We observe that the benzene rings in BA cations overlap with each other due to the benzene rings Π-Π conjugation in the crystal structure of BBI, which exhibits large interplanar spacing due to large BA ions. BBI has preferential orientation along the (020) crystal plane. Due to conjugation, scanning electron microscopy (SEM) and energy dispersive spectrometer (EDS) mapping images indicate that the surface of the BBI thin film is smoother and more uniform than that of the FBI thin film. We fabricated the device by growing thin films of BBI and FBI on ITO interdigital electrodes. The photodetector based on BBI SC exhibits stability and regularity with turning on/off of the light at different intensities (10, 20, 30, and 40 W m −2 ) and wavelengths (386, 397, 405, and 433 nm). The ultraviolet–visible (UV–vis) absorption and reflection spectrum analysis shows that BBI has a slightly wider bandgap than FBI. This study can provide some ideas for the design Π-Π conjugation in organic metal halides.
研究领域:
材料科学
·
光电学
·
化学
·
物理学
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产品关联
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2024
·
IF 6.3
Zhikun Wang,Zhuo Chen,Ayesha Yousaf,Lan Wu,Guixin Jin,Zhigang Shao,Zhihua Zhao
Herein, a resistive gas sensor based on Molybdenum tri oxide (MoO 3 )/ 9 % mass fraction of multi-walled carbon nanotubes (MWCNTs-9) nanocomposites was developed by hydrothermal method to detect NH 3 gas at room temperature. According to the findings, outstanding resistance change rate of 187.5 % was observed in MoO 3 /MWCNT-9 sensor when exposed to 100 ppm NH 3 at room temperature (25 °C). In contrast, 8.2 % response rate was recorded for pure MoO 3 sensor when exposed to same condition and the response value of newly fabricated sensor was improved by about 22.9 times to unalloyed MoO 3 . In addition, the nanocomposite sensor consisting of MoO 3 /MWCNT-9 had demonstrated excellent selectivity, repeatability, and a high level of sensitivity in detecting low concentrations of NH 3 at low temperature. During experiment when the sensor desorbed NH 3 gas at room temperature, a certain instantaneous voltage was applied, which greatly reduces the sensor’s resistance recovery time to 90 s. MWCNTs’s doping decreased the operating temperature of MoO 3 and showed good gas sensitivity at room temperature. Finally, the results reveal that MoO 3 /MWCNT-9 nanocomposite-based sensor can be fruitful in the field of NH 3 monitoring.
研究领域:
材料科学
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传感器技术
·
纳米科技
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产品关联
DOI
高影响因子
Journal of Advanced Dielectrics
·
2020
·
IF 0
Liang Shi,Cheng Liu,Huaiwu Zhang
Low temperature sintered Ce 2 Zr 3 ( Mo 0 . 9 W 0 . 1 O 4 ) 9 (marked as CZMW) ceramics were synthesized via the conventional solid-state reaction method. X-ray diffraction results showed that the CZMW ceramics belonged to a Trigonal system with R-3C space group, and without any impure phase formation. The experimental facts revealed that the density and grain morphology greatly affected the microwave dielectric properties. The samples sintered at 825 ∘ C exhibited good microwave dielectric properties: ε r = 9 . 8 5 , Q × f = 2 2 , 9 8 0 GHz (at 11.3 GHz) and a satisfactory τ f ( − 1.5 ppm/ ∘ C) value. It is suggested that the CZMW ceramics are suitable for low-temperature co-fired ceramic (LTCC) applications in microwave devices.
研究领域:
材料科学
·
电子工程
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DOI
CHINESE JOURNAL OF CHEMICAL PHYSICS
·
2020
·Vol. 33
·期 3
·296-302
·
IF 1.067
Zhang Hang,Li Yan-bo,Zhu Long,Chen Jun,Yu Ye-peng,Li Zhao-hui,Lin Xuan,Shan Xiao-bin,Liu Fu-yi,Sheng Liu-si
Vacuum ultraviolet (VUV) photoionization and photodissociation of methylcyclohexane have been studied utilizing a reflectron time-of-flight mass spectrometer (RTOF-MS) with synchrotron radiation source. Photoionization efficiency curves (PIEs) of molecule ion C 7 H 14 + and fragment ions C 7 H 13 + , C 6 H 11 + , C 6 H 10 + , C 5 H 10 + , C 5 H 9 + , C 4 H 8 + , C 4 H 7 + , and C 3 H 5 + were observed. The ionization energy of methylcyclohexane was measured to be (9.80±0.03) eV, and appearance energies of fragment ions were determined from the PIEs. Optimized structures of transitional states, intermediates and product ions were characterized at the B3LYP/6-31G(d) level and the energies were calculated using G3B3 method. Formation channels of dominating fragment ions were proposed. Intramolecular hydrogen migrations and carbon ring-opening were the foremost processes in fragmentation pathways of methylcyclohexane.
研究领域:
物理化学
·
分子光谱学
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DOI
高影响因子
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