QUIMICA NOVA
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2026
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IF 0.9
Sun Mingzhu,Zhao Linlin
Using waste polyethylene terephthalate (PET) as the feedstock, diisooctyl terephthalate (DOTP) was directly synthesized via alcoholysis with isooctanol (2-EH) over an environmentally friendly choline chloride-zinc acetate (the ChCl-Zn(Ac)2 catalyst)-deep eutectic solvent (DES). This approach overcame the limitations of traditional methods by offering simplicity, low cost, tunable composition, excellent environmental compatibility, and superior chemical stability. The study systematically investigated the effects of reaction temperature, catalyst dosage, molar ratio of 2-EH to PET, and reaction time on the synthesis process. Response surface methodology (RSM) was employed to optimize the process conditions, with the optimal parameters determined as follows: reaction temperature of 180 °C, catalyst dosage of 5.19%, molar ratio of 2-EH to PET of 4.89 mol mol-1, and reaction time of 87.30 min. Under these optimal conditions, PET was completely degraded, and the DOTP yield reached as high as 87.59%. The ChCl-Zn(Ac)2 catalyst exhibited stable performance, significantly enhanced both the PET degradation rate and the DOTP yield. This study provides a feasible technical solution for the efficient resource utilization of waste PET, offers a reference for developing green catalytic synthesis processes of DOTP, and expands the application potential of DES catalysts in polyester degradation.
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Food & Function
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2022
·Vol. 13
·期 11
·6166-6179
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IF 6.317
Hongxia Li,Xin Xu,Mengyu Cai,Yicui Qu,Zifu Ren,Chuyang Ye,Hui Shen
The aim was to investigate whether the combination of hydroxytyrosol acetate (HT-ac) and ethyl β-hydroxybutyrate (HBET) can improve the cognition of heat-stressed mice, meanwhile exploring the mechanism of action. Mice were divided into 5 groups: control, heat-stressed, HT-ac, HBET, and HT-ac + HBET. Mice were gavaged for 21 days and exposed to heat (42.5 ± 0.5 °C, RH 60 ± 10%, 1 h day-1) on days 15–21, except for the control group. Results showed that the combination of HT-ac + HBET improved the cognitive and learning abilities of heat-stressed mice, which were tested by Morris water maze, shuttle box, and jumping stage tests. The combination of HT-ac + HBET maintained the integrity of neurons and mitochondria of heat-stressed mice. Likewise, this combination increased the mitochondrial membrane potential, the ATP content, the expression of phosphorylated PKA, BDNF, phosphorylated CREB and Bcl-2, and decreased the expression of Bax, caspase-3, and intracytoplasmic Cyt C in heat-stressed mice.
研究领域:
神经科学
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药理学
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生理学
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JOURNAL OF CHEMICAL THERMODYNAMICS
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2021
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IF 3.178
Yaqi Ding,Neng Gao,Nian Li,Guangming Chen,Yongmei Xuan
The vapour-liquid equilibrium (VLE) data of four ternary solutions HCOOK + [Emim]Ac /[Emim]Br / [Emim]Cl / [Emim]NO 3 + H 2 O were measured using the boiling method at the temperatures from 305.78 K to 387.08 K, at solute (HCOOK + IL) mass fractions ( w ) between 0.2 and 0.5. A total of 234 data points ( w = 0 included) were obtained and correlated with empirical Antoine-type equations. The absolute average relative deviations (AARD %) between calculated and measured vapour pressures were 0.58%, 0.50%, 0.49%, 0.63%, respectively, which showed good agreement. The comparison of the experimental and standard data and combined uncertainties of the experimental data confirmed good reliability of the experimental method and apparatus. The four ternary solutions with ILs as additives have lower vapour pressure compared to the corresponding binary solutions without ILs. The results showed that the four ternary solutions of HCOOK + [Emim]Ac / [Emim]Br / [Emim]Cl / [Emim]NO 3 + H 2 O can be the alternatives for traditional dehumidification and absorption media. [Emim]Cl has the best ability to reduce the vapour pressure of HCOOK + H 2 O at the solute (HCOOK + IL) mass fraction of 0.4 and 0.5. The [Emim]Ac has the most effect reducing the vapour pressure of HCOOK + H 2 O at the solute (HCOOK + IL) mass fraction of 0.3.
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DYES AND PIGMENTS
·
2023
·
IF 4.5
Xiumin Liu,Hengwei Zhang,Fengting Hu,Yi Wang,Xu Fei,Jing Tian
In this paper, an efficient and novel 1,3-bis(2-pyridylimino)-4,7-dihydroxyisoinndole scaffold-based two-site fluorescent probe 1,3-bis(2-pyridylimino)-4,7-phenylene diacrylate isoindole (BPI-AC) for the sensing of cysteine (Cys) has been designed and synthesized. We have studied the chemical structure and its fluorescent properties for the novel fluorescent probe with double recognition group by means of theoretical calculations and experimental measurements, which were carried out using density functional theory (DFT) and time-dependent density functional theory (TDDFT) calculations and experiments on organic chemical synthesis. Firstly, geometries have been recorded for the fluorescent probe. Theoretical research parameters including spectroscopic parameters, molecular orbitals , reaction sites and energy barrier Δ were obtained by fitting the electron density in a multiparticle system. Additionally, the spectral characteristics , selectivity and anti-interference performance of the probe were systematically investigated and verified by in vitro experiments. The experimental results showed that by using this probe, it was possible to quantitatively detect Cys in 1% dimethyl sulfoxide-containing water solution (pH 7.4). Super large Stokes shift (265 nm) endowed the probe low background signal. Finally, according to our theoretical calculations and the available experimental data, the probe BPI-AC with dual recognition sites could distinguish the biothiols with similar structure through series recognition reaction, and the Stokes shift was large, realizing the efficient detection of Cys specificity.
研究领域:
分析化学
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理论化学
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生物化学
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2025
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IF 9.7
Feifei Pei,Jiqing Lu,Lin Li,Jie Yan,Tian Bai,Haijiao Yu,Dong Wang,Guangping Han,Wanli Cheng
Sorption-based atmospheric water harvesting (SAWH) offers a promising solution to address freshwater scarcity. Although many solid sorbents exhibit high water uptake capacities, their ability to achieve continuous, all-day water production still depends on complex system configurations. Here, a 24-h SAWH system is presented, enabled by wood-based ionogel (WIG) with simultaneous sorption-desorption functionality. The WIG is prepared by encapsulating 1-ethyl-3-methylimidazolium acetate ([EMIM][Ac]) into the natural wood channels, functioning as a sorption module. Meanwhile, carbonized wood, with photothermal and Joule heating properties, serves as the desorption module. Adjusting the sorption/desorption area ratio enables dynamic kinetic balance, allowing simultaneous moisture uptake and release within a single ionogel. The WIG leverages the water transport capability of wood channels and the fluidity of [EMIM][Ac] to shorten the sorption equilibrium time to 3 h and sustain directional water transfer from the sorption to the desorption zone. This system, driven by solar heating during the day and Joule heating at night, achieves 24-h continuous water production, yielding 47.62 g water per day under natural conditions, equivalent to 2.38 L water m solar − 2 day − 1 ( L water m solar − 2 day − 1 , defined as liters of water produced per solar absorbing area per day). This work demonstrates a sustainable and efficient SAWH strategy, highlighting the unique advantages of wood and offering a new avenue toward mitigating the global water crisis.
研究领域:
环境科学
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材料科学
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水资源管理
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能源工程
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化学工程
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可持续技术
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2024
·
IF 9.4
Zhilong Zhang,Xingyu Zhan,Bo Hong,Xinqing Wang,Peisong Tang,Yangbin Ding,Yingchun Xia,Yunxiong Zeng
Peroxymonosulfate (PMS) is widely employed to generate oxygen-containing reactive species for ciprofloxacin (CIP) degradation. Herein, cobalt oxyhydroxide @activated carbon (CoOOH@AC) was synthesized via a wet chemical sedimentation method to activate PMS for degradation of CIP. The result suggested AC can support the vertical growth of CoOOH nanosheets to expose high-activity Co-contained edges, possessing efficient PMS activation and degradation activity and catalytic stability. In the presence of 3.0 mg of optimal CoOOH@AC and 2 mM PMS, 96.8 % of CIP was degraded within 10 min, approximately 11.6 and 9.97 times greater than those of CoOOH/PMS and AC/PMS systems. Notably, it was disclosed that the optimal CoOOH@AC/PMS system still exhibited efficient catalytic performance in a wide pH range, different organics and common co-existing ions. Quenching experiments and electron paramagnetic resonance indicated that both radical and non-radical processes contributed to the degradation of CIP, with 1 O 2 and direct electron transfer accounting for the non-radical pathway and SO 4 •− and •OH serving as the main radical active species. Finally, possible CIP degradation pathways were proposed based on high-performance liquid chromatography-mass spectrometry. This study provided an alternate method for wastewater treatment based on PMS catalyzed by cobalt-based hydroxide.
研究领域:
环境科学
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化学工程
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材料科学
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废水处理
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高影响因子
JOURNAL OF ANALYTICAL CHEMISTRY
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2026
·
IF 1.5
Sha Ou,Wu Yunfan,Xu Yuan,Yao Yang,Zhang Kaixuan,Fan Guangyu
In this study, an eco-friendly and dependable method based on magnetic solid-phase extraction and high-performance liquid chromatography equipped with ultraviolet detection was established to extract and determine chlorpromazine in milk. A novel composite material, Fe 3 O 4 @CS@AC, used as a magnetic adsorbent, was successfully synthesized via the chemical co-precipitation method and characterized. Various factors influencing the recovery of chlorpromazine were discussed and optimized. Moreover, Fe 3 O 4 @CS@AC for chlorpromazine exhibits a large adsorption capacity of 17.82 mg/g, and its mass transfer mechanism aligns more closely with the quasi-second-order kinetic model, dominated by chemisorption. Under optimal conditions, the linearity of chlorpromazine was investigated in the range of 0.01–5.00 mg/L, with a coefficient of determination greater than 0.9995, and the limit of detection was 2.47 × 10 –3 mg/L. The feasibility of the developed method was evaluated by analyzing and detecting chlorpromazine in different milk samples, with recoveries of 90.76–96.72% and relative standard deviation of 2.01–4.23%. This method, with straightforward operation and good reproducibility, was successfully applied for the analysis and determination of trace chlorpromazine in milk, providing a promising avenue for the development and application of novel adsorbents in milk analysis.
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高影响因子
JOURNAL OF PHYSICAL CHEMISTRY B
·
2017
·
IF 3.177
Wangqin Song,Jie Zhu,Lvdan Liu,Guangming Liu
Macromolecular crowding could influence the binding affinity of the polyzwitterion-conjugated proteins. Herein, the hydrolysis of N-succinyl-Ala-Ala-Pro-Phe p-nitroanilide by the poly(carboxybetaine) conjugated α-chymotrypsin (PCT) was employed as a model system to investigate the modulation of the binding affinity of the polyzwitterion-conjugated proteins by the ion-specific effects in the crowded environments. In comparison with the bare α-chymotrypsin (BCT), the binding affinity of the PCT to the peptide is stronger in the dilute solutions but becomes weaker in the crowded environments. Our study demonstrates that the kosmotropic Ac– anion is incapable of achieving a stronger enzymatic binding affinity of the PCT than the BCT in the highly crowded environments. By contrast, the binding affinity of the PCT can be enhanced to be stronger than that of the BCT by the chaotropic SCN– anion in the crowded environments.
研究领域:
生物物理学
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生物化学
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分子生物学
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高影响因子
TISSUE & CELL
·
2024
·
IF 2.7
Xiuchao Shang,Yesheng Jin,Yuan Xue,Xiaoyun Pan,Haiquan Zhu,Xiangsheng Meng,Zhihai Cao,Yongjun Rui
This study aimed to investigate the effects of E26-transformation-specific variant-2 (ETV2) overexpression on wound healing in a cutaneous wound (CW) model and clarify associated mechanisms. pLVX-ETV2 lentivirus expressing ETV2 was constructed and infected into BMSCs to generate ETV2-overexpressed BMSCs (BMSCs+pLVX+ETV2). The RT-PCR assay was applied to amplify ETV2, VE-cadherin, vWF, ARG-1, IL-6, iNOS, TGF-β, IL-10, TNF-α. Western blot was used to determine expression of VE-cadherin and vWF. ETV2 induced differentiation of BMSCs into ECs by increasing CDH5/CD31, triggering tube-like structures, inducing Dil-Ac-LDL positive BMSCs. ETV2 overexpression increased the gene transcription and expression of VE-cadherin and vWF (P<0.01). Transcription of M1 phenotype specific iNOS gene was lower and transcription of M2 phenotype specific ARG-1 gene was higher in the RAW264.7+BMSCs+ETV2 group compared to the RAW264.7+BMSCs+pLVX group (P<0.01). ETV2 overexpression (RAW264.7+BMSCs+ETV2) downregulated IL-6 and TNF-α, and upregulated IL-10 and TGF-β gene transcription compared to RAW264.7+BMSCs+pLVX group (P<0.01). ETV2-overexpressed BMSCs promoted wound healing in CW mice and triggered the migration of BMSCs to the wound region and macrophage activation. ETV2-overexpressed BMSCs promoted collagen fibers and blood vessel formation in the wound region of CW mice. In conclusion, this study revealed a novel biofunction of ETV2 molecule in the wound healing process. ETV2 overexpression in BMSCs promoted wound healing in CW mice by triggering BMSCs differentiation into endothelial cells and modulating the transformation of M1 pro-inflammatory and M2 anti-inflammatory macrophages in vitro and in vivo .
研究领域:
细胞生物学
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分子生物学
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伤口愈合
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干细胞研究
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免疫学
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高影响因子
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