JOURNAL OF ELECTROANALYTICAL CHEMISTRY
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2019
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IF 3.218
Haoqing Tang,Chi Chen,Tao Liu,Zhiyuan Tang
Novel N-doped carbon coated Li 2 ZnTi 3 O 8 anode active materials are synthesized via one step high temperature calcination solid state reaction method using chitosan and chitosan oligosaccharide as advanced carbon sources. Coating a nano-thickness conductive N-doped carbon layer between particles is beneficial to enhance the electronic transmission speed. Physical characterization results show that all as-prepared samples have a cubic spinel structure with a P4 3 32 space group without any impurities, and the Li 2 ZnTi 3 O 8 with chitosan additive (molecular weight: 5000) has the best dispersity and smallest particle size in all as-prepared electrode materials . The length of organic compound molecular chain has a direct impact on the agglomeration of particles and reversible lithium intercalation capacity. When tested as the anode for lithium ion batteries , the optimal electrode material shows the largest discharge capacities and remarkable long-term cycling stability at a current density of 1.0, 2.0, and 5.0 A g − 1 over 500 cycles, respectively. Combining structural characterization with electrochemical performance, N-doped carbon layer, high degree of particle dispersibility and larger interface contact area are contributed to the enhancement of both electronic and ionic conductivities and of Li 2 ZnTi 3 O 8 .
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Nanomedicine-Nanotechnology Biology and Medicine
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2024
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IF 4.2
Hongying Zhao,Jiaxin Song,Tian Wang,Xiaodan Fan
Parkinson's disease (PD) is a neurodegenerative disorder and identifying disease-causing pathways and drugs that target them has remained challenging. Herein, selenium nanoparticles decorated with polysaccharides from Sargassum fusiforme (SFPS-SeNPs) were investigated on 6-OHDA-induced neurotoxicity in PC12 cells and rats. 6-OHDA can significantly increase neurotoxicity, oxidative stress and decrease the activity of superoxide dismutase (SOD) and glutathione peroxidase (GPx) both in vitro and vivo. In vitro, treatment with SFPS-SeNPs can significantly decrease 6-OHDA cytotoxicity, reactive oxygen species (ROS) production or malondialdehyde (MDA) levels, and cell apoptosis, significantly increased the activity of SOD and GPx. In vivo, 6-OHDA exposure could also decrease the expression of Nrf2 and OH-1, while treatment with SFPS-SeNPs (1 mg Se/kg) increased. SFPS-SeNPs can protect neurons from 6-OHDA-induced neurotoxicity by regulating apoptosis and Nrf2/ARE pathway. The present study demonstrated that SFPS-SeNPs is a good candidate for developing a new drug against neurodegenerative diseases such as PD.
研究领域:
神经科学
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药理学
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纳米技术
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生物医学工程
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Materials Research Express
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2024
·Vol. 11
·期 5
·055002
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IF 1.8
Siqi Quan,Guoyou Gan,Xiang lei Yu,Xian jie Tang,Hu Sun,Zhuo Qian,Junpeng Li
The investigation of conductive silver pastes and inks has witnessed extensive research within the domain of printed electronics in recent years, primarily owing to the exceptional electrical conductivity and steadfastness intrinsic to silver. This paper introduces an approach for the fabrication of stable, cost-effective, and low-resistance conductive silver paste tailored for flexible printed circuits. This method facilitates the solidification of the conductive silver paste into a highly conductive silver film at a curing temperature of 250 °C. In the process of preparing the conductive silver paste, Ag flakes is subject to modification through the incorporation of Ag NPs, which are subsequently sintered at a low temperature curing setting. The sintering of Ag NPs serves to establish connections between adjacent particles of Ag flakes within the paste, thereby enhancing the conductivity and flexibility of the resulting conductive printed silver film. When the ratio of Ag NPs to Ag flakes is maintained at 10:90, the volume resistivity of the Ag NPs-modified film registers at 2.7 × 10−5 Ω.cm. This demonstrates a substantial 53.45% reduction in the volume resistivity of the conductive printed silver film modified with Ag NPs, compared to its Ag NPs-absent counterpart. Post 200 cyclic bending tests, it becomes evident that the resistance change rate in the Ag NPs-modified conductive printed silver film is a mere 12.5%, whereas the Ag NPs-modified silver film lacking Ag NPs displays a resistance change rate of 21.5%. This discrepancy underscores the capacity of Ag NPs-modified Ag flakes to fortify the bending resistance of the conductive printed silver film. Comprehensive data analysis substantiates that the improvements in electrical conductivity and bending resistance can be attributed to the superior bridging facilitated by the sintering process on the surface of the Ag NPs-modified Ag flakes.
研究领域:
材料科学
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印刷电子技术
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PLoS Pathogens
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2022
·Vol. 18
·期 11
·e1011009
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IF 7.464
Zhipeng Niu,Shu Ye,Jiaojiao Liu,Mengyu Lyu,Lilan Xue,Muxiao Li,Congcong Lyu,Junlong Zhao,Bang Shen
Many apicomplexan parasites harbor a non-photosynthetic plastid called the apicoplast, which hosts important metabolic pathways like the methylerythritol 4-phosphate (MEP) pathway that synthesizes isoprenoid precursors. Yet many details in apicoplast metabolism are not well understood. In this study, we examined the physiological roles of four glycolytic enzymes in the apicoplast of Toxoplasma gondii . Many glycolytic enzymes in T . gondii have two or more isoforms. Endogenous tagging each of these enzymes found that four of them were localized to the apicoplast, including pyruvate kinase2 (PYK2), phosphoglycerate kinase 2 (PGK2), triosephosphate isomerase 2 (TPI2) and phosphoglyceraldehyde dehydrogenase 2 (GAPDH2). The ATP generating enzymes PYK2 and PGK2 were thought to be the main energy source of the apicoplast. Surprisingly, deleting PYK2 and PGK2 individually or simultaneously did not cause major defects on parasite growth or virulence. In contrast, TPI2 and GAPDH2 are critical for tachyzoite proliferation. Conditional depletion of TPI2 caused significant reduction in the levels of MEP pathway intermediates and led to parasite growth arrest. Reconstitution of another isoprenoid precursor synthesis pathway called the mevalonate pathway in the TPI2 depletion mutant partially rescued its growth defects. Similarly, knocking down the GAPDH2 enzyme that produces NADPH also reduced isoprenoid precursor synthesis through the MEP pathway and inhibited parasite proliferation. In addition, it reduced de novo fatty acid synthesis in the apicoplast. Together, these data suggest a model that the apicoplast dwelling TPI2 provides carbon source for the synthesis of isoprenoid precursor, whereas GAPDH2 supplies reducing power for pathways like MEP, fatty acid synthesis and ferredoxin redox system in T . gondii . As such, both enzymes are critical for parasite growth and serve as potential targets for anti-toxoplasmic intervention designs. On the other hand, the dispensability of PYK2 and PGK2 suggest additional sources for energy in the apicoplast, which deserves further investigation.
The apicoplast is a unique organelle in most apicomplexan parasites, a large group of unicellular pathogens that infect humans and animals. It is essential for parasite growth as it hosts important metabolic pathways and provides critical metabolites. By endogenous gene tagging, here we found four glycolytic isoenzymes localized to the apicoplast of Toxoplasma gondii , including PYK2, PGK2, TPI2 and GAPDH2. Gene inactivation studies demonstrated that the two ATP generating enzymes PYK2 and PGK2 were dispensable for the growth of T . gondii , whereas TPI2 and GAPDH2 were essential. Combined genetic and metabolic analyses suggest that TPI2 generated glyceraldehyde-3-phosphate is critical for the MEP pathway to synthesize isoprenoid precursors, which are essential for parasites proliferation. On the other hand, GAPDH2 is probably a main source of reducing power for metabolic enzymes involved in isoprenoid precursor and fatty acid synthesis in the apicoplast. As such, both enzymes are required for optimal parasite growth.
研究领域:
寄生虫学
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分子生物学
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细胞生物学
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高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2018
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IF 3.412
Yao Pan,Ze-yuan Deng,Shi-lian Zheng,Xuan Chen,Bing Zhang,Hongyan Li
The hydrophilic extracts of mulberry (HEM) and blueberry (HEB) and lipophilic extracts of mango (LEM) and watermelon (LEW) were mixed in different ratios to assess the antioxidant interactions by chemical-based (DPPH and ABTS assays) and H9c2 cell-based models. There were both synergistic and antagonistic antioxidant interactions among these fruits. Some groups with combinational extracts showed stronger synergistic antioxidant effects than the individual groups, and others (HEM–LEW F1/10, LEW–LEM F5/10, and HEB–LEM F3/10) showed stronger antagonistic effects than the individual groups based on the indicators [the values of DPPH, ABTS, and MTT; the expression of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT), and malondialdehyde (MDA); the release of lactate dehydrogenase (LDH); and the quantification of cellular antioxidant activity]. The principal component analysis (PCA) showed that samples could be defined by two principal components: PC1, the main phenolic acids and anthocyanins, and PC2, carotenoids. From our results, primarily, carotenoids were in the majority in antagonistic groups, and phenolics and anthocyanins were in the majority in synergistic groups. However, the combinational groups containing only hydrophilic compounds did not always show synergistic effects. Therefore, the compatibility of diets indicates balancing the ratios of hydrophilic and lipophlic compounds in our daily food. In addition, the expression of enzymes (SOD, GSH-Px, and CAT) may not be sensitive to the changes of antioxidant activity caused by the combinations with different ratios of hydrophilic and lipophilc compounds. The different structures of lipophilic compounds (β-carotene and lycopene) could influence the antagonistic effects.
研究领域:
营养学
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生物化学
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食品科学
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细胞生物学
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高影响因子
Journal of Soil Science and Plant Nutrition
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2026
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IF 3.6
Li Siyao,Guo Naijia,Zhao Haiying,Liu Zhiyuan,Fan Chengheng,Li Fengying,Cao Jiling
Purpose: Silver nanoparticles (AgNPs) are becoming emerging contaminants, raising increasing interests and concerns regarding their effects on plants and soil microbes. Understanding these effects from a cultivar-specific perspective is crucial for ensuring crop production and food safety. Methods: Pot experiments were performed to evaluate the effects of AgNPs (1.0 mg kg − 1 , 10.0 mg kg − 1 , and 50.0 mg kg − 1 ) on the growth, Ag accumulation, and rhizosphere microbial community of two maize cultivars: waxy maize and sweet maize. Results: AgNPs exerted hormetic effects on plant growth of waxy maize and sweet maize. Low concentrations (1.0 and/or 10.0 mg kg − 1 ) increased plant shoot, root and total biomass as well as chlorophyll content but increased superoxide dismutase (SOD) activity and hydrogen peroxide (H 2 O 2 ) contents, whereas high concentrations (50.0 mg kg − 1 ) decreased plant shoot, total biomass, chlorophyll content, and increased malondialdehyde (MDA) content. The stimulatory effect occurred at 1.0 and 10.0 mg kg − 1 AgNPs for waxy maize but only at 10.0 mg kg − 1 for sweet maize, indicating that waxy maize might respond more positively to AgNPs. Additionally, with increasing AgNP doses, waxy maize seedlings accumulated lower Ag in leaves, stems, and roots relative to sweet maize. The waxy maize rhizosphere was enriched with Proteobacteria (Sphigomonas) and Actinobacteria (Arthrobacter) under lower doses (1.0 and 10.0 mg kg − 1 ) of AgNPs, especially under 10.0 mg kg − 1 AgNPs, which could increase plants resistance and adsorb Ag in soil, respectively. In contrast, the sweet maize rhizosphere contained comparable Actinobacteria and Proteobacteria under control and lower doses (1.0 and 10.0 mg kg − 1 ) of AgNPs. Soil Ag content and plant biomass were found to be highly correlated with bacterial community composition in the maize rhizosphere. Conclusions: Taken together, these findings suggest that the hormetic effects of AgNPs on maize growth are cultivar-dependent, which may be closely linked to the differential shifts in rhizosphere microbial communities.
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JOURNAL OF APPLIED ENTOMOLOGY
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2026
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IF 1.8
Shasha Yang,Xiaofei Yu,Keming Wang,Maofa Yang,Xuli Zhu,Huizi Wu,Hanjie Guan,Chunyang Huang,Xiang Yang
Although Aphidoletes aphidimyza (Rondani) is a predator of aphids, its biocontrol efficacy depends largely on oviposition behaviour. Previous studies have shown that spider webs can attract A. aphidimyza and enhance its oviposition. It has been hypothesized that sex pheromones from spider webs and A. aphidimyza itself may affect its mating and oviposition, but this remains unconfirmed. In our study, we selected (2 R ,7 S )-diacetoxytridecane (sex pheromone of A. aphidimyza ), ( R )-3-hydroxybutyric acid (sex pheromone of Linyphia triangularis (Clerck)), and a mixture of these pheromones (at a 10:1 concentration ratio) to investigate their overall response on A. aphidimyza in terms of electroantennogram, behaviour, fecundity, attraction, and aphid control. Our results indicated that these pheromones elicited antennal responses in A. aphidimyza . Specifically, (2 R ,7 S )-diacetoxytridecane significantly attracted males, while ( R )-3-hydroxybutyric acid significantly attracted females; their mixture attracted both sexes. These compounds did not affect oviposition and lifespan of A. aphidimyza . The pheromone mixture attracted significantly more A. aphidimyza than the control group. The number of aphids in the mixture group began to decline 1 day earlier than that in the control group and ultimately achieved a 100% control effect against aphids in a greenhouse. Our findings provide evidence for further exploration of the relationship between L. triangularis and A. aphidimyza . The studied pheromone blend shows potential as an attractant for A. aphidimyza , which could enhance aphid biological control in greenhouses.
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ENVIRONMENTAL RESEARCH
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2026
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IF 8.2
Xiao Li,Xiaoyu Tan,Guiying He,Yuheng Chen,Mengting Yang,Guan Zhang,Baiyang Chen
While dissolved organic nitrogen (DON) is traditionally considered a crucial precursor of nitrogenous disinfection byproducts (N-DBPs) like dichloroacetonitrile (DCAN), the present study hypothesizes that dissolved inorganic nitrogen (DIN) and nitrogen-free organic matter (NFOM) can also serve as important precursors of DCAN. To validate this hypothesis, this study compared the DCAN yields from DIN coupled with NFOM versus those from DON during the ultraviolet (UV)/chlorine process. Under identical carbon, nitrogen, and chlorine dosage conditions, the levels of DCAN formation followed the order: NFOM + ammonia (NH 4 + ) > DON ≫ NFOM + NO x − (nitrate and nitrite), highlighting the significance of DIN and NFOM in DCAN formation. Among NFOMs, compounds with benzene rings generated more DCAN than those without benzene structures, indicating that the former should be prioritized for control. Among model DON compounds, the DCAN yields decreased with increasing number of carbon, suggesting a dilemma in regulation compliance and control efficiency. Hydroxyl radicals together with reactive chlorine species, reactive nitrogen species, and monochloramine contributed 57%, 37%, and 6% to DCAN formation, respectively, whereas UV alone had negligible effects. The evolutions of parent compounds and intermediate products showed various relations with DCAN formation, suggesting that the process might involve multiple pathways for N-DBPs. Overall, this study provides new insights into the formation mechanisms of DCAN and highlights the necessity to re-evaluate precursor control strategies by controlling DIN and aromatic NFOM alongside DON.
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ANNALS OF BOTANY
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2025
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IF 3.6
Gao Yan,Phan Thi Kim Lien,Zhang Jiawei,Yu Ying,Wang Chao
Backgrounds and AimsFasciclin-like arabinogalactan proteins (FLAs) function in diverse plant physiological processes, particularly cell wall biosynthesis and tension wood (TW) formation. This study aimed to identify Betula platyphylla FLA genes associated with secondary xylem and TW development, thereby elucidating molecular mechanisms underlying xylogenesis to facilitate molecular improvement strategies.MethodsTissue-specific expression of two FLA genes (BpFLA1, BPFLA2) was analyzed via quantitative real-time PCR. BpFLA1/2-overexpressing transgenic lines and bpfla1 knockout mutants were generated using the pROKⅡ vector and CRISPR-Cas9 technology. Anatomical phenotypes, cell wall composition, and TW development were subsequently investigated.Key ResultsTwo FLA genes (BpFLA1, BpFLA2) were identified in the birch TW transcriptome. Phylogenetically, BpFLA1 and BpFLA2 exhibit conserved evolutionary relationships and structural domains. Both genes were highly expressed in mature stems but suppressed by mechanical stimuli. BpFLA1/2-overexpressing (OE) transgenics displayed slightly suppressed growth, reduced cell wall thickness, enlarged xylem vessel area, and notably inhibited TW formation following artificial bending. Conversely, bpfla1 knockout mutants exhibited significant thickening of xylem fiber cell walls—a phenotype contrasting sharply with OE lines.ConclusionBpFLA1/2 functions as a critical regulator of cell wall development and a negative regulator of xylem fiber and TW formation in birch. Therefore, this study identifies BpFLA1/2 as a novel target for genetic improvement. BpFLA1/2 overexpression potentially enhances wood straightness and quality, whereas its suppression or knockout may benefit cellulose production for pulpwood applications.
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REACTIVE & FUNCTIONAL POLYMERS
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2025
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IF 5.1
Tengfei Han,Shufen Zhang,Benzhi Ju
Stalk is an important biomass resource and converting it directly into high value-added products is a major challenge. Herein, we have cleverly utilized three novel techniques, mechanochemistry, Deep eutectic solvents (DES), and dynamic cross-linking, to achieve one-step in-situ plasticization of virtually worthless corn stalk into reprocessable thermoset plastics. This preparation strategy has many advantages, such as cheap and easy availability of raw materials, no need for catalysts, no need for pretreatment of raw materials, and no need for separation and purification of products. The stalk plastics have good mechanical strength, thermal stability, plasticity and reprocessability. In addition, cellulose plastic was prepared as a control experiment for stalk plastic, and the constitutive relationship between the structure of various components in stalk and the performance of plastic was deeply investigated. This strategy of developing new plastics from agricultural and forestry waste in a simple and environmentally friendly way will open up a whole new avenue for the production of more competitive bio-based plastics.
研究领域:
材料科学
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高分子科学
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绿色化学
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生物质利用
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农业废弃物管理
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Journal of Media Business Studies
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2021
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IF 0
Dam Hee Kim
Although the film industry is high risk, sequels and films adapted from novels or comic books can be financially successful because they can capitalise on the established brands of their parent work. Focusing on sequels and adaptations as extended lines and brands, this paper analysed 2,490 films released between 2010 and 2013 in the U.S. to examine what types of films were successful in terms of opening weekend gross and non-opening gross. During opening weekends, while sequels generated higher grosses than non-sequels, sequels adapted from existing work generated even higher grosses. Brand strategies involving stars and title novelty further helped adaptation sequels generate higher grosses mostly during opening weekends. Sequels and adaptations may work together to garner line and brand extension benefits upfront.
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ENVIRONMENTAL POLLUTION
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2026
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IF 7.3
Shushu Song,Qinghao Wei,Ying Tu,Shun Zhou,Jiaojiao Zhou,Junyan Tao,Yun Chen,Hao Zhou,Mingdan You
The risk of autism spectrum disorder (ASD) is elevated by exposure to the organophosphate pesticide chlorpyrifos (CPF) during pregnancy and lactation. As a neurodevelopmental disorder, ASD often co-occurs with depression, exacerbating the social isolation experienced by affected individuals. Trehalose (Tre), a naturally occurring non-reducing sugar, has neuroprotective properties. Nevertheless, the mechanisms by which it exerts protective effects against CPF-induced ASD and depression-like behaviors remain unclear. The objective of study was to investigate the mechanisms underlying Tre combating CPF-induced ASD and depression through network pharmacology and toxicology analyses. In animal studies, Tre was administered to offspring mice exposed to CPF during pregnancy and lactation. Behavioral assessments revealed that Tre alleviated CPF-induced repetitive and stereotypic behaviors, social deficits, and depression-like behaviors in offspring mice. Findings from network pharmacology and toxicology analyses and animal experiments supported the notion that mammalian target of rapamycin-related autophagy and TLR4-related necroptosis signaling may contribute to the protective effects of Tre against CPF-induced hippocampal damage. This research offers valuable information regarding the potential protective effects of Tre against neurodevelopmental disorders linked to environmental chemicals.
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