COLLOIDS AND SURFACES B-BIOINTERFACES
·
2025
·
IF 5.6
Peixuan Zou,Yusong Pan,Wenjie Luo,Run Huang,Xiuling Lin,Yinghai Xie
Chemo-photothermal synergistic therapy is an effective method for tumor treatment. Herein, the CuS/HKUST-1@PDA drug carrier was successfully prepared by a simple combination of in-situ partial vulcanization and in-situ polymerization technologies. The micro-structure, morphology, and functional groups of the prepared samples were characterized by XRD, SEM, TEM, BET, and FTIR technologies. The drug loading experiment verified that the CuS/HKUST-1@PDA possesses an excellent doxorubicin (DOX) drug loading capacity, whose drug loading capacity is as high as 88.7 %. The drug release indicated that CuS/HKUST-1@PDA drug carrier inherited pH-responsive drug release behavior, which it can release DOX in acidic conditions resembling the tumor microenvironment, while effectively containing the drug within the PDA coating under neutral conditions. The CuS/HKUST-1@PDA drug carrier demonstrated outstanding biocompatibility, sustaining cell viability above 80 % across a concentration range of 1.5–15 μg/mL. Moreover, the drug carrier realized chemo-Photothermal synergistic therapy triggered by near-infrared light in tumor treatment, reducing tumor cell viability to 28 % during in vitro cellular experiments. The innovative design and effective tumor treatment ability of the CuS/HKUST-1@PDA drug carrier highlight its significant potential in anticancer therapy.
研究领域:
材料科学
·
肿瘤学
·
纳米医学
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产品关联
DOI
PubMed
高影响因子
MICROCHIMICA ACTA
·
2020
·Vol. 187
·期 11
·1-11
·
IF 6.232
Cui Ying,Li Junhua,Liu Mengqin,Tong Haixia,Liu Zeng,Hu Jiawen,Qian Dong
A novel hybrid with three-dimensional (3D) hierarchical CuS@Pd core-shell cauliflowers decorated on nitrogen-doped reduced graphene oxide (CuS@Pd/N–RGO) has been prepared by a facile wet-chemical route without utilizing any template molecules and surfactants. The characterization results reveal that the 3D flower-like structure of CuS “core” is composed of interconnecting nanoplates, which is conductive to the loading of Pd nanoparticles’ “shell” and results in the robust interaction between the core and shell for the formation of CuS@Pd cauliflowers. Anchoring such appealing CuS@Pd cauliflowers on the two-dimensional N–RGO can efficaciously inhibit the aggregation of CuS@Pd cauliflowers and accelerate the kinetics of xanthine oxidation. Benefiting from the multi-functional properties and unique morphology, the sensor constructed by CuS@Pd/N–RGO exhibits excellent performance for non-enzymatic detection of xanthine including a wide detection range of 0.7–200.0 μM (0.94 V vs. SCE), a low detection limit of 28 nM (S/ N = 3), high reproducibility (relative standard deviation (RSD) = 4.1%), and commendable stability (retained 90% of the initial electrochemical responses after storage for 30 days), which is amongst the best of various electrochemical sensors reported for xanthine assays till date. Reliable and satisfying recoveries (95–105%, RSD ≤ 4.1%) are achieved for xanthine detection in real samples. The inspiring results make the uniquely structural CuS@Pd/N–RGO greatly promising in non-enzymatic electrochemical sensing applications.
A high-performance non-enzymatic xanthine sensor has been constructed by the three-dimensional hierarchical CuS@Pd core-shell cauliflowers decorated on nitrogen-doped reduced graphene oxide.
研究领域:
材料科学
·
分析化学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICA CHIMICA ACTA
·
2020
·
IF 5.977
Jun-Tao Cao,Yu-Xiang Dong,Yan Ma,Bing Wang,Shu-Hui Ma,Yan-Ming Liu
Photoactive materials with high photo-electron transfer efficiency and stable signal output hold a key role in constructing the photoelectrochemical (PEC) biosensing systems. In this study, the ternary [email protected] 3 N 4 heterojunction was first prepared and characterized, and its application in PEC bioanalysis was explored. The gold nanoparticles sandwiched between CdS and g-C 3 N 4 , acting as both plasmonic photosensitizer and electron relay, significantly boosted the light absorption and accelerated the charge transfer from g-C 3 N 4 to CdS, both of which contributed to the enhancement of photoelectric conversion efficiency. Signal quenching with graphene oxide-CuS efficiently weakened the photocurrent from [email protected] 3 N 4 . The combination of the excellent PEC properties of [email protected] 3 N 4 and the remarkable quenching effects of graphene oxide-CuS enabled construction of a sandwich-type PEC immunosensor for prostate specific antigen (PSA) detection. This immunosensor achieved sensitive PSA analysis by multiple signal amplification mechanisms, with a detection limit of 0.6 pg mL −1 and a wide linear range from 1.0 pg mL −1 to 10 ng mL −1 . This work not only demonstrates the great potential of noble metal sandwiched ternary heterojunctions in the PEC field, but also lays a foundation for developing the general PEC immunoassays .
研究领域:
光电化学
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生物传感器
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分析化学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Yanni Jiang,Zhongjuan Wang,Jianbo Huang,Feng Yan,Ye Du,Chuanshu He,Yang Liu,Gang Yao,Bo Lai
Singlet oxygen ( 1 O 2 ) is an effective reactive oxygen species in disinfection due to its long lifetime and sensitivity to bacteria. This study tried to develop a 1 O 2 dominated process for bacterial inactivation by visible light (vis) photocatalysis assisted by PMS. A novel CuS-modified MIL-101(Fe) (CSMF) photocatalyst was synthesized for the first time. Compared with MIL-101(Fe), CuS-modified MIL-101(Fe) enhanced the photocatalytic performance by increasing absorption of visible light, narrowing down the bandgap and promoting photo carrier separation efficiency. 7.5-log Gram-negative Escherichia coli (E. coli) could be inactivated by Vis/CSMF/PMS system within 40 min, showing much better performance of 3.5-log E. coli inactivated by Vis/PMS system. The Vis/CSMF/PMS system is applicable in a broad pH range from 3.0 to 9.0, remaining quite steady disinfection efficiency after regenerations of the catalyst. Quenching experiments and electron paramagnetic resonance (EPR) analysis demonstrated 1 O 2 was the dominated ROS rather than OH • and SO 4 •− . Three pathways, including photo-generated electrons (e − ) and O 2 dependent pathway, photo-generated holes (h + ) dependent pathway and CSMF enhanced PMS dissociation pathway, were evidenced to responsible for 1 O 2 formation by aeration experiments and specific 1 O 2 fluorescence probe. 1 O 2 in water attacked the bacterial cell membranes first, got inside the cell and up-regulated the level of intracellular ROS, which further led to cell membrane damage and DNA degradation so as to irreversible cell death. In addition, the developed Vis/CSMF/PMS system could also efficiently inactivate gram-positive bacteria Staphylococcus aureus and fecal coliform bacteria in practical wastewater, suggesting its wide applicability as a promising alternative to conventional disinfection process.
研究领域:
环境科学
·
化学工程
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材料科学
·
微生物学
✓ 已验证
DOI
高影响因子
JOURNAL OF NANOPARTICLE RESEARCH
·
2024
·Vol. 26
·期 11
·1-13
·
IF 2.1
Ye Qianyun,Wang Wenhao,Jiang Mingxin,Sun Xiaohuan,Han Jie
The peroxidase (POD)-like nanozymes are regarded as facile and convenient toolkits for the quantification of ascorbic acid (AA). Nevertheless, their insufficient specificity for AA in comparison to other biological antioxidants, such as glutathione (GSH) and cysteine (Cys), severely hindered the discrimination of AA in complex systems. To attain simultaneous quantification and discrimination of AA from GSH and Cys, a CuS nanoparticles-based sensor array with multichannel output signals is constructed in this study. The CuS nanoparticles exhibit superior POD-like activity and can effectively initiate the oxidation of 3, 3′, 5, 5′-tertamethylbenzidine (TMB) to oxidized TMB (oxTMB), accompanied by a measurable change in UV–Vis absorption, solution color and photothermal performance. However, in the presence of antioxidants, the aforementioned process is inhibited and the oxTMB is reduced back to TMB, resulting in signal (UV–Vis absorption, RGB and photothermal heating temperature) changes corresponding to the identity and concentration of antioxidants. As a consequence, by creating a finger print pattern using the multichannel output signals through linear discriminant analysis (LDA) and principal component analysis (PCA), the CuS nanoparticle-based sensor array enables the simultaneous quantification and discrimination of AA from GSH and Cys both in aqueous solution and human serum. This study presents a novel approach for the precise quantification and differentiation of AA and shows great potential in practical application.
研究领域:
分析化学
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纳米技术
·
生物化学
·
传感器
✓ 已验证
DOI
高影响因子
Journal of Materials Chemistry A
·
2025
·
IF 9.5
Guangqi Zhang,Congcong Dang,Yiping Liu,Rouyan Guo,Lingti Kong,Liancheng Zhao,liming Gao
Li-O2 batteries have emerged as promising contenders for advanced energy storage systems, leveraging their exceptionally high theoretical energy density. Nevertheless, their practical deployment is substantially hindered by rapid capacity degradation and restricted operational durability, primarily attributed to sluggish oxygen reaction kinetics. Here, to modulate kinetic barriers, we propose an approach synergizing structural and electronic advantages by integrating heterointerface engineering and hierarchical nano structuring. A hollow nanobox MoSe2@CuS core-shell heterostructure is developed as a bifunctional oxygen electrode. Such heterostructure could induce a built-in electric field to modulate charge transfer dynamics and the hollow architecture could optimize triple-phase interfacial reactions. Leveraging the synergistic attributes of its components, the MoSe2@CuS-based Li-O2 battery achieves an excellent specific capacity of 16,000 mAh g-1 at 100 mA g-1. Moreover, it demonstrates remarkable cycling durability, sustaining high performance for over 190 cycles at 200 mA g-1 with a restricted capacity of 600 mAh g-1. Density functional theory (DFT) calculations further illustrate the lowered energy kinetic barrier for Li2O2 formation/decomposition induced by MoSe2@CuS core-shell heterostructure. This work pioneers a universal heterointerface engineering strategy through rational design of hierarchical hollow architectures, providing new insights for developing high-performance Li-O2 battery cathodes.
研究领域:
储能
·
纳米材料
·
电化学
·
电池技术
·
材料科学
·
理论化学
✓ 已验证
DOI
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2019
·
IF 9.518
Di Huang,Lu Wang,Yi Zhan,Lina Zou,Baoxian Ye
A novel signal on-off type photoelectrochemical (PEC) biosensing system was designed for sensitive detection of carcinoembryonic antigen (CEA) based on tin disulfide nanosheets loaded on reduced graphene cxide (SnS 2 -GR) as the photoactive material and gold nanoparticles coated on reduced graphene oxide-functionalized copper sulfide ( [email protected] ) for signal amplification . It's the first time for SnS 2 -GR was exploited as a sensing matrix. Here, the photocurrent signals of SnS 2 were amplified attributed to the sensitization effect of graphene. As signal amplifier, [email protected] could quench the photocurrents of SnS 2 -GR not only through the p-n type semiconductor quenching effect as well as the steric hindrance effect, but also as peroxidase mimetics to catalyze the oxidation of 4-Chloro-1-naphthol (4-CN) to produce insoluble product on the electrode surface . Based on the multiple signal amplification ability of [email protected] , CEA was detected sensitively with a linear range from 0.1 pg mL −1 to 10 ng mL −1 and limit of detection down to 59.9 fg mL −1 (S/N = 3). Meanwhile, the PEC biosensor displayed excellent performance in the assay of human serum sample, showing good application prospects for various target analysis.
研究领域:
生物传感
·
纳米技术
·
分析化学
·
癌症诊断
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
·
2024
·
IF 6.3
Li Liu,Jing Mo,Jie Xu,Yangxi Liu,Ruoxi Yang,Xiaohui Yang,Xinguo Ma,Wensheng Fu
Heterojunction has the characteristics of adjusting catalyst structure, improving oxygen evolution kinetics and breaking the elevated reaction barrier of oxygen evolution process. In this paper, a heterostructure catalyst of NiCo-LDHs nanosheets encapsulated CuS hollow nano-octahedrals has been reported, which has better stability and higher mass transfer efficiency compared with two-dimensional nanosheets. Density functional theory (DFT) calculations indicate that the heterostructure strengthens the orbital hybridization of metal 3 d and O 2 p , at the same time, the heterointerface coupling induces the directional movement of electrons from NiCo-LDHs to CuS, which together provide abundant high-valence Ni and Co active sites, promote the conversion of *OH to *O species, thus reducing the energy required for the reaction. Hence, CuS@NiCo-LDHs exhibits excellent OER performance and good stability in 1 M KOH. When the current density is 10 mA/cm 2 , the overpotential and Tafel slope of this catalyst is only 253 mV and 56 mV/dec, respectively. This study furnishes the construction of heterogeneous structures and the catalyst exploitation with serviceable insights.
研究领域:
催化
·
材料科学
·
电化学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
Acta Biomaterialia
·
2018
·
IF 6.383
Hua Shi,Runqi Yan,Luyan Wu,Yidan Sun,Song Liu,Zhengyang Zhou,Jian He,Deju Ye
Precise diagnosis of lymph node metastasis to guide lymphadenectomy is highly important for gastric cancer therapy in clinics. Though surgical dissection of regional metastatic lymph nodes remains the only way for gastric cancer therapy, the extended dissection may cause unavoidable postoperative risk of complications. It is still lack of effective method enabling the accurate removal of metastatic gastric cancer cells in lymph nodes with minimum injuries to normal tissue. Herein, we report a new fluorescent copper sulfide (CuS) nanoparticle (RGD-CuS-Cy5.5) enabling both non-invasive multimodality imaging and targeting photothermal therapy (PTT) of metastatic gastric cancer cells in lymph nodes. We demonstrate that RGD-CuS-Cy5.5 can easily drain into sentinel lymph nodes (SLN) after injection into primary tumors, and selectively enter into metastatic gastric MNK45 tumor cells via α v β 3 integrin-mediated endocytosis . The resulting strong near-infrared (NIR) fluorescence and computed tomography (CT) contrast in metastatic SLN compared to normal SLN can precisely differentiate SLN metastasis of gastric cancers. Guided by the imaging, localized PTT with RGD-CuS-Cy5.5 is conducted upon irradiation with an 808 nm laser , resulting in complete removal of metastatic gastric tumor cells in SLN without obvious toxicity. Moreover, RGD-CuS-Cy5.5 can also allow for the rapid and non-invasive self-monitoring of PTT efficacy against metastatic SLNs in living mice. This study highlights the potential of using RGD-CuS-Cy5.5 for imaging-guided and targeting PTT of SLN metastasis in vivo , which may be applicable for the metastatic gastric cancer therapy in clinics. Statement of Significance RGD-CuS-Cy5.5 nanoparticles possess NIR fluorescence and CT signals for in vivo bimodality imaging of lymph node metastasis. Strong photothermal property under irradiation at 808 nm for efficient PTT. Easy drain into sentinel lymph nodes and selective enter metastatic gastric cancer cells via α v β 3 integrin-mediated endocytosis. Rapid and non-invasive monitoring of therapeutic efficacy against lymph node metastasis.
研究领域:
生物医学工程
·
纳米技术
·
癌症治疗
·
成像科学
·
诊疗一体化
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Nano
·
2024
·
IF 15.8
Xiaoyu Chen,Ning Huang,Danyang Wang,Miao Zhang,Xuyang Deng,Fangze Guo,Bingcheng Yi,Changqing Yuan,Qihui Zhou
Periodontitis, a prevalent chronic inflammatory disease worldwide, is triggered by periodontopathogenic bacteria, resulting in the progressive destruction of periodontal tissue, particularly the alveolar bone. To effectively address periodontitis, this study proposed a nanoformulation known as CuS@MSN-SCS. This formulation involves coating citrate-grafted copper sulfide (CuS) nanoparticles with mesoporous silica (MSNs), followed by surface modification using amino groups and sulfated chitosan (SCS) through electrostatic interactions. The objective of this formulation is to achieve efficient bacteria removal by inducing ROS signaling pathways mediated by Cu2+ ions. Additionally, it aims to promote alveolar bone regeneration through Cu2+-induced pro-angiogenesis and SCS-mediated bone regeneration. As anticipated, by regulating the surface charges, the negatively charged CuS nanoparticles capped with sodium citrate were successfully coated with MSNs, and the subsequent introduction of amine groups using (3-aminopropyl)triethoxysilane was followed by the incorporation of SCS through electrostatic interactions, resulting in the formation of CuS@MSN-SCS. The developed nanoformulation was verified to not only significantly exacerbate the oxidative stress of Fusobacterium nucleatum, thereby suppressing bacteria growth and biofilm formation in vitro, but also effectively alleviate the inflammatory response and promote alveolar bone regeneration without evident biotoxicity in an in vivo rat periodontitis model. These findings contribute to the therapeutic effect on periodontitis. Overall, this study successfully developed a nanoformulation for combating bacteria and facilitating alveolar bone regeneration, demonstrating the promising potential for clinical treatment of periodontitis.
研究领域:
纳米技术
·
牙科科学
·
材料科学
·
生物医学工程
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Energy Storage
·
2023
·
IF 9.4
Sijia Hao,Yongjin Zou,Cuili Xiang,Lixian Sun,Fen Xu,Zhicong Hu
The single function and leakage of organic phase change materials (OPCMs) used alone considerably limit the scope of their large-scale applications. An efficient method of addressing this issue is by adding functional fillers and porous scaffolds to OPCMs. In this study, a novel CuS-coated carbonized melamine foam (CMF)/reduced graphene oxide (rGO) framework (CMF/rGO/CuS) was developed for the preparation of stable multifunctional OPCMs. The functional materials rGO and CuS were used as reinforcing materials, and CMF was used as a supporting material. Paraffin wax (PW), a thermal storage substance, was encapsulated in the CMF/rGO/CuS framework by vacuum-assisted impregnation to obtain a PW@CMF/rGO/CuS composite with excellent comprehensive properties. When the concentration of the conductive filler CuS was 2.0 wt%, the conductivity of the PW@CMF/rGO/CuS 2.0was 73.7 % more than that of pure PW, and its photothermal conversion efficiency exceeded 90 %. Meanwhile, CMF/rGO/CuS endowed the composite with a thermal conductivity of 0.2525 W m −1 K −1 , which was 33.6 % higher than that of pure PW. Finally, PW@CMF/rGO/CuS demonstrated high thermal cycling and thermal cycling stability with good application prospects in various fields.
研究领域:
材料科学
·
能量转换与存储
·
纳米技术
·
热工程
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2018
·Vol. 8
·期 31
·17489-17496
·
IF 2.936
Xiaodong Sun,Mingxu Sui,Guangzhen Cui,Ling Li,Xiaopeng Li,Xuliang Lv,Fan Wu,Guangxin Gu
Electromagnetic irradiation has caused environmental pollution and harmful effects on human health. The use of effective materials to attenuate electromagnetic energy is urgently required. In this study, Fe3O4 nanoparticles (NPs) decorated on a CuS platelet-based sphere (CuS/Fe3O4) with popcorn chicken-like micromorphology were synthesized through a solvothermal deposition method. The effects of reaction temperature and quantity of Fe3O4 NPs on the heterostructures, morphologies and electromagnetic absorption (EA) properties of the heterostructures were investigated. CuS/Fe3O4 heterostructures exhibited remarkable enhancement in comparison with pure Fe3O4 NPs and the CuS platelet-based sphere. With the contribution from dielectric and magnetic losses, a CuS/Fe3O4 heterostructure-loaded composite could achieve a minimum reflection loss (RL) of −61.32 dB at 14.00 GHz and an effective EA bandwidth (≤−10 dB) of 4.15 GHz at a thickness of only 1.5 mm simultaneously. The current study indicates that the CuS/Fe3O4 heterostructures can potentially be applied as advanced electromagnetic absorbers.
研究领域:
材料科学
·
电磁工程
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）