Advanced Healthcare Materials
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2022
·Vol. 12
·期 1
·2201746
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IF 11.092
Zhihao Zhang,Jinghong Wen,Jie Zhang,Donggang Guo,Quanxi Zhang
Cu-based nanomaterials have been developed to alleviate the problem of antibiotic resistance due to their superior properties and good biocompatibility. Defects in nanomaterials have a major role in improving photocatalytic performance. Herein, two CuS nanospheres with predominant V CuSCu and V CuSS vacancy (abbreviated as CuS and CuS-T150, respectively) characterized by positron annihilation spectra are synthesized. The combination of experimental and theoretical calculation results demonstrates that CuS-T150 exhibits excellent antibacterial, achieving bactericidal rates of 99.9% against to Escherichia coli ( E. coli ) under 808 nm laser irradiation. Compared with CuS, the superior antimicrobial activity of CuS-T150 is mainly attributed to its stronger ability to adsorb oxygen molecules, more easily bind with surface of E. coli , and higher photothermal conversion efficiency (PTCE). This work provides a deeper understanding of nanomaterials with vacancy modulated the antibacterial efficiency by synergistic effect of photodynamic and photothermal therapy.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2022
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IF 4.831
Ciyang Zhang,Xingen Xie,Shasha Feng,Wu Lei,Mingzhu Xia,Fengyun Wang,Hualai Wang
The novel CuMnS nanoflower fluorescent probe based on Mn-doped CuS was developed to achieve the fluorescence detection of oxytetracycline hydrochloride (OTC), the fluorescent sensor has good selectivity and stability. The doping of Mn significantly increased the fluorescence intensity of CuS, which was above 10 times that of CuS. When the predominant species of OTC molecule was zwitterionic OTC +/− at the solution pH of about 5.00, the fluorescence quenching efficiency of CuMnS by OTC reached the highest. Through fluorescence lifetime and UV absorption, the sensing mechanism between CuMnS and OTC was found to be static quenching. Moreover, Multiwfn wavefunction analysis program based on density function theory (DFT) calculation was applied to compare the interactions between different OTC species and CuMnS at different pH, to reveal the micromechanism of fluorescence quenching of CuMnS by OTC from the views of atoms. The molecular surface quantitative analysis and basin analysis of different OTC species demonstrated that the N atom and O atoms of tricarbonylamide moiety of zwitterionic OTC +/− can provide lone pair electrons to form a non-fluorescent ground state complex with CuMnS. Meanwhile, the electrostatic attraction of OTC +/− with negatively charged CuMnS was also beneficial to the interaction, resulting in the effective fluorescence quenching of CuMnS. This work offers a convenient method for sensitively detecting OTC and broadens the application of CuMnS in the field of fluorescence detection.
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RSC Advances
·
2022
·Vol. 12
·期 18
·11119-11127
·
IF 4.036
Bei Liu,Lirong Sun,Xijian Lu,Yuping Yang,Hongshang Peng,Zhaogang Sun,Juan Xu,Hongqian Chu
Real-time monitoring of drug release behaviors over extended periods of time is critical in understanding the dynamics of drug progression for personalized chemotherapeutic treatment. In this work, we report a metal–organic framework (MOF)-based nanotheranostic system encapsulated with photothermal agents (CuS) and therapeutic drug (DOX) to achieve the capabilities of real-time drug release monitoring and combined chemo-photothermal therapy. Meanwhile, folic acid-conjugated polyethylene glycol (FA-PEG) antennas were connected to the MOF through coordination interactions, endowing the MOF with an enhanced active targeting effect toward cancer cells. It is anticipated that such a theranostic agent, simultaneously possessing tumor-targeting, real-time drug monitoring and effective treatment, will potentially enhance the performance in cancer therapy.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2022
·
IF 6.371
Hao Guo,Junye Zhang,Fan Yang,Mingyue Wang,Tingting Zhang,Yanrui Hao,Wu Yang
Metal-organic frameworks (MOFs) have ordered porous structure and intriguing properties for supercapacitors , however, poor conductivity and cycle stability limits their application. To solve these problems, hence, a simple strategy is proposed, by which MOFs are in-situ grown in the porous conductive p-MXene substrate. And then, along with the introduction of CuS, the grown Ni-MOF is derived to Ni 3 S 4 , which is more stable and more electrochemically active. Due to higher contact area, excellent synergistic effect and more exposed active sites, the prepared sandwiched p-MXene@Ni 3 S 4 /CuS nanostructure displays a big specific capacitance (1917 F·g −1 ) and superior cycling performance (91.2%@30000). What’s more, the assembled p-MXene@Ni 3 S 4 /CuS//AC asymmetric device delivers a high energy density of 87.62 Wh·Kg −1 at the power density of 775.02 W·Kg −1 , suggesting that this material provides a brilliant candidate for energy storage.
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VACUUM
·
2023
·
IF 4
Zhihua Liu,Qiaoling Liu,Xiaoyu He,Yihai Zhu,Qunlong Pan,Rongmou Zhang,Haiming Yu
Failure of surgical treatment is usually the result of bacterial colonization around the implant. This subsequently brings about various diseases such as peri-implantitis and sepsis. The purpose of this study was to develop and evaluate the antimicrobial properties of polydopamine adhered eggshell powder-loaded copper sulfide antimicrobial coatings. Here, we used eggshell powder-loaded copper sulfide as an antimicrobial agent to form an antimicrobial coating on the surface of titanium alloy screws using the chelating action of polydopamine. The coating showed good antibacterial effects against both Gram-positive and Gram-negative bacteria represented by Staphylococcus aureus and Escherichia coli . A series of subsequent characterizations confirmed the perfect loading of the material on the screws, and subsequent friction experiments on porcine femurs also demonstrated the good adhesion of the antimicrobial coating. Meanwhile, cytotoxicity assessment was performed by the CCK-8 method, confirming cellular biosafety. This work explores the value of eggshell-loaded CuS nanomaterial coatings in the prevention and treatment of orthopedic endothelial infections, which contributes to the translational application of novel antimicrobial materials in the clinical setting and has important social and economic value.
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ChemMedChem
·
2021
·Vol. 17
·期 3
·e202100570
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IF 3.466
Yan Zhao,Jing-Jing Zhao,Jia-Xin Guo,Shuang-Qing Liu,Yang Li,Xiao-Yi Wang,Rong Li,Hui-Qin Tang,Zhen-Yu Li,Hui-Fen Yang,Bing Chen
Graphical Getting under the skin : BSA-CuS nanoparticles were used as photothermal reagents for depth photothermal therapy (PTT) treatment of subcutaneous abscesses. These nanoparticles exhibited remarkable photothermal conversion and low cytotoxicity combined with tissue-penetrating NIR laser (1064 nm) light. PTT based on BSA-CuS and 1064 nm NIR laser irradiation was found to sterilize drug-resistant pathogens in vitro and to eliminate subcutaneous abscesses in vivo effectively. That is OK, thank you! The treatment of subcutaneous abscess caused by drug-resistant bacteria is facing great difficulties and receiving more attention. In this work, we employed BSA-CuS nanoparticles as a photothermal reagent to apply photothermal therapy (PTT) to combat drug-resistant bacteria in vitro and subcutaneous abscess in vivo . The BSA-CuS nanoparticles were found to be stable and biocompatible without cytotoxicity toward NIH3T3 and 4T1 cells. In vitro experiments showed that three species of drug-resistant pathogens, including Escherichia coli , Staphylococcus aureus , and Candida albicans , could be effectively sterilized under co-incubation with BSA-CuS nanoparticles and then irradiation with 1064 nm NIR laser via tissue penetration. BSA-CuS nanoparticles together with 1064 nm NIR laser irradiation could also effectively diminish subcutaneous abscesses caused by drug-resistant bacteria on mice under PTT and depth PTT without causing any serious side effects and organic damage in vivo .That is OK, thank you!
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2021
·
IF 8.128
Enhui Ma,Ke Wang,Zhenqi Hu,Hong Wang
Antibiotics as emerging pollutants in water pose great risks to human health. Due to their persistence in the environment, advanced oxidation processes (AOPs) have been proposed for the degradation of antibiotics. Therefore, developing efficient catalysts for AOPs becomes critical for the removal of antibiotics. Herein, we develop self-propelled CuS-based micromotors (CuS@Fe 3 O 4 /Pt) as active heterogenous catalysts for efficient photo-Fenton degradation of antibiotics. Combining the merits of conventional heterogenous and homogenous catalysts, the prepared micromotors are easy to recycle and free of secondary pollution risks, while demonstrating high degradation efficiency due to self-induced intensification of mass transfer via autonomous motion and microbubble generation. The H 2 O 2 in the Fenton reagents can serve as the fuel for the micromotors to drive their self-propulsion by bubbles generated from catalytic decomposition of H 2 O 2 by the platinum layer. The dual-stimuli-responsiveness of the micromotors to magnetic field and light irradiation allows multi-modes of propulsion and guidance in different systems. The efficient photothermal effect of CuS enables the micromotors to achieve collective phototactic motion toward light, whereas magnetic responsiveness facilitates the recovery and collection of the micromotors. The synergistic effect of CuS and Fe 3 O 4 NPs in H 2 O 2 under visible light irradiation generates a large amount of OH · and · O 2 – to effectively degrade tetracycline within several minutes. With these advantages, the dual-stimuli-responsive CuS-based micromotors provide a new strategy for enhanced degradation of antibiotics in water purification applications.
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RSC Advances
·
2020
·Vol. 10
·期 25
·14670-14678
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IF 3.119
Yang Yang,Junting Liang,Wenwen Jin,Yingyue Li,Menghui Xuan,Shijie Wang,Xiaoqian Sun,Chuanliang Chen,Jianhua Zhang
In this study, the CuS/BiVO4-X (where X represents the mass percentage of CuS associated with CuS/BiVO4; X = 2%, 5% and 7%) p–n heterostructures were fabricated using a two-step hydrothermal method. The structural and morphological features were ascertained in great detail using several physical characterization processes. According to the results of the photoelectrochemical (PEC) experimental processes, the PEC properties of CuS/BiVO4-5% were much more obvious as compared to those of pure BiVO4, CuS and CuS/BiVO4-X. Moreover, the photoluminescence (PL) and UV-vis diffuse reflection spectra (DRS) affirmed that the CuS/BiVO4-5% demonstrates an excellent capacity for absorbing visible light and low electron recombination rate as compared with the other composites. Accordingly, PEC sensors with CuS/BiVO4-5% were fabricated for the detection of dopamine (DA) and bisphenol A (BPA) with outstanding selectivity and stability. For DA, it implied a broad linear range from 0.01–10 μM and 10–120 μM, and for BPA, the broad linear range was 0.01–90 μM. Thus, the PEC sensor has significant potential application when it comes to DA and BPA detection.
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MICROCHIMICA ACTA
·
2020
·Vol. 187
·期 8
·1-10
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IF 6.232
Zou Lina,Yang Lingxi,Zhan Yi,Huang Di,Ye Baoxian
A photoelectrochemical platform for thrombin determination was developed based on Au-rGO-CuS as multiple signal amplification elements. CuInS 2 QDs was used to sensitize burr-shape TiO 2 (b-TiO 2 ) to obtain a strong photocurrent. Under the specific recognition between aptamer and thrombin, a sandwichlike structure was formed and the Au-rGO-CuS-labeled aptamer (S2@Au-rGO-CuS) was immobilized on the electrode surface. This induced a sharp decrease in photocurrent. The phenomenon is mainly due to the fact that CuS NPs can competitively consume the light energy and electron donor with CuInS 2 /b-TiO 2 . The rGO can increase the amount of CuS NPs and the Au NPs can accelerate charge transferring which depress the recombination of photogenerated electrons and holes in CuS to further enhance the competitive capacity of CuS. The sandwichlike structure has a steric hindrance effect. Therefore, the S2@Au-rGO-CuS has a multiple signal amplification function for thrombin determination. Under optimal conditions, the PEC aptasensor exhibited a wide linear concentration range from 0.1 pM to 10 nM with a low detection limit of 30 fM (S/ N = 3) for thrombin. Besides, the designed aptasensor performed well in the assay of human serum sample, indicating good potential for the determination of thrombin in real samples.
Graphical abstract
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Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy
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2024
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IF 1.4
Xie Huilong,Fu Yunrong,Lin Zhisheng,Wang Jiayi,Wu Jingyu,You Xiuhua,Xie Jieming
This study explores the synergistic effect of T-CUS 245C combined with cyclosporin A, and its possible mechanism. T-CUS 245C is an immunotoxin conjugated with tastuzumab and recombinant cucurmosin 245C (CUS 245C ). Cyclosporin A is a calcium antagonist mainly used as an immune-suppressive agent, which enhances the cytotoxicity of immunotoxins through an unknown mechanism. The sulforhodamine B assay, flow cytometry, DNA fragmentation apoptosis assay, and western blot analysis were used to evaluate the synergistic effects of cyclosporin A combined with T-CUS 245C on proliferation inhibition and apoptosis induction in SK-OV-3 ovarian cancer cells with HER-2-overexpressing. Meanwhile, using confocal microscopy and flow cytometry, the effect of cyclosporin A on the intracellular distribution of T-CUS 245C was observed and quantified. The results of this study showed that the combination index of cyclosporin A combined with T-CUS 245C is less than 0.7, indicating that cyclosporin A significantly enhances the proliferation inhibition and apoptosis induction induced by T-CUS 245C in SK-OV-3 cells. The confocal microscopy and flow cytometry results show that cyclosporin A effectively increases the dispersion of T-CUS 245C in the cytoplasm by promoting the endolysosomal escape. This study demonstrates that cyclosporin A combined with T-CUS 245C has a synergistic anticancer effect, by facilitating the release of T-CUS 245C in the intracellular space. Graphical Abstract
研究领域:
肿瘤学
·
细胞生物学
·
药理学
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Journal of Physical Chemistry C
·
2025
·
IF 3.2
Dan Wang,Yunhong Xie,Lingfan Xu,Yixuan Zhou,Kai Li,Zhongfeng Li
The development of bifunctional nanoplatform-based theranostics has garnered considerable attention in cancer therapy research. In this study, we engineer Gd2O3@SiO2-CuS nanorods as an integrated diagnostic-therapeutic system, simultaneously harnessing photothermal conversion and paramagnetic properties for MRI-assisted photothermal intervention. Hydrothermally synthesized Gd2O3 nanorods demonstrate superior T1-weighted contrast performance, achieving a longitudinal relaxivity (r1) of 4.2 mM–1·s–1, which compares favorably with that of commercial contrast agents. Furthermore, the strategically integrated CuS component exhibits remarkable photothermal conversion efficiency (19.6%) and sustained therapeutic stability. These attributes pave the way for achieving the application objective of magnetic resonance imaging-assisted photothermal therapy. Critically, comprehensive biosafety evaluations, including hemocompatibility assays and cytotoxicity profiling, confirm the nanocomposite’s favorable biocompatibility. The findings underscore the substantial potential of Gd2O3@SiO2-CuS nanorods for image-guided photothermal therapy applications.
研究领域:
医学影像学
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纳米医学
·
癌症治疗
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MACROMOLECULAR MATERIALS AND ENGINEERING
·
2017
·Vol. 302
·期 11
·1700213
·
IF 2.863
Kai Hou,Weijie Wu,Mengge Xia,Meifang Zhu
Thermosensitive nanocomposite (NC) hydrogels are considered as a significant kind of intelligent material to be utilized as sensor, biomaterial, drug carrier, etc. Recently, preparation of remotely controlled NC hydrogel with high-performance attracts more and more concern. To produce facile remote-stimuli thermosensitive NC hydrogel, a novel near-infrared (NIR) laser switched CuS/clay/poly(OEGMA- co -MEO 2 MA) hydrogel is demonstrated, which can be precisely remote-stimulated by NIR irradiation based on the excellent NIR photothermal conversion property of CuS nanoparticle. The temperature change of hydrogel is related to the NIR intensity, CuS content, and crosslinking density. Moreover, the influences on dimensional variation of hydrogel on macroscale are systematically studied, and the hydrogel as smart liquid valve is further utilized which can be remotely controlled by NIR switch on/off successfully. Cyclic test illustrates that this novel CuS/clay/poly(OEGMA- co -MEO 2 MA) hydrogel exhibits stable cyclic volume transition property which has promising applications in the areas of sensors, valves, and intelligent switches.
研究领域:
材料科学
·
生物医学工程
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