Advanced Healthcare Materials
·
2025
·
IF 9.6
Jing-Jing Fu,Si-Yi Mei,Qi-Cheng Zhang,Xiang-Yu Fu,Jing-Chu Zhong,Jie Deng,Qiao-Bo Zhang,Xiao-Yang Bai,Fan-Yu He,Jun-Xin Wu,Yue-Wen Chen
Multifunctional hydrogels have aroused great interest in accelerating wound healing. In this study, a hydrogel dressing with antioxidant, antibacterial, anti-inflammatory, and wound healing properties is developed using xylose (Xy) glycated Chinese giant salamander collagen (CGSPXy), curcumin (Cur), sodium alginate (SA), and chitosan (CS). Specifically, the CGSP/CGSPXy-Cur nanoparticle is mixed with SA through hydrogen bonding interactions to form a hydrogel framework. Subsequently, the CGSP/CGSPXy-Cur-SA is immersed in a solution containing Ca 2 ⁺ and CS, forming an ion-crosslinked semi-interpenetrating double-network hydrogel. Notably, CGSPXy synergized with Cur reduced the swelling ratio while enhancing the thermal stability, rheological properties, adhesion performance, and tensile strength of hydrogels. In vitro experiments demonstrated that hydrogels constructed with CGSPXy-Cur nanoparticles exhibited sustained Cur release, along with excellent blood compatibility, clotting properties, antioxidant, and antibacterial activity. Also, CGSPXy synergized with Cur has been proven to effectively promote wound healing by promoting collagen deposition, new blood vessels, myofibroblast generation, and reducing the production of proinflammatory factors (TNF- α and IL-6). This study provided a promising strategy for collagen-based hydrogel as a sustainable solution for wound care.
研究领域:
生物材料学
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组织工程
·
再生医学
·
创伤修复
·
药用高分子
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纳米医学
·
炎症调控
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产品关联
DOI
PubMed
高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
·
2025
·
IF 6.6
Limin Wang,Qianfei Jia,Yuan Li,Hui Zhao,Zijian Wu
This study investigated the chitosan (CS)-octenyl succinic anhydride (OSA) starch complex as a stabilizer for Pickering emulsions. The effects of OSA concentration (0.5wt%-2.5wt%) and viscosity (OSA1, OSA2, OSA3) on the stability and physiochemical properties of emulsion were examined. The results showed that CS-OSA with 2.0wt% concentration OSA stabilized emulsion exhibited optimal emulsifying capacity. Contact angle analysis, Fourier transform infrared spectrometer (FTIR) and X-difference diffractometer (XRD) were utilized to explore the stabilized mechanism of CS-OSA on emulsion, results confirmed the CS and OSA interactions, and strong adsorption of CS-OSA particles at the oil-water interface. Furthermore, CS-OSA stabilized emulsion loading curcumin were assessed, results showed that curcumin loaded emulsion exhibited high stability and better antioxidant capacity than free CS during 10-day storage. The overall study offers valuable insights into the utilization of CS-OSA emulsifiers in delivery application for lipophilic bioactive molecules.
研究领域:
食品科学
·
材料科学
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产品关联
DOI
高影响因子
DALTON TRANSACTIONS
·
2024
·
IF 3.5
Jiayi Qin,Haiyan Zhang,Xianying Cao,Feng Wen,Ke Jiang
Antibiotics are crucial for treating and preventing bacterial infections. However, the widespread use of antibiotics has led to serious antibiotic resistance issues. To address the growing threat of antibiotic-resistant bacterial infections, we designed and synthesized an antibacterial composite material, CCM@ZIF-8@PDA, through a one-pot method and surface modification strategy. This material combines the antibacterial properties of the natural product curcumin, the advantages of ZIF-8, and the photothermal conversion capability of PDA. It exhibits three antibacterial mechanisms against S. aureus: chemical antibacterial, ionic antibacterial, and photothermal antibacterial effects. At a low concentration of 100 ppm, CCM@ZIF-8@PDA achieves a 100% antibacterial rate. This multi-modal antibacterial strategy provides insights for developing new antibacterial materials to combat antibiotic resistance.
研究领域:
生物医学工程
·
材料科学
·
微生物学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
·
2024
·
IF 3.6
Xinyu Yang,Dongdong Meng,Ning Jiang,Chaoxing Wang,Jinbo Zhang,Yanqiu Hu,Jiaming Lun,Rui Jia,Xueyun Zhang,Weitong Sun
In this study, the pH-responsive API-CMCS-SA (ACS) polymeric nanoparticles (NPs) based on 1-(3-amino-propyl) imidazole (API), stearic acid (SA), and carboxymethyl chitosan (CMCS) were fabricated for the effective transport of curcumin (CUR) in liver cancer. CUR-ACS-NPs with various degrees of substitution (DS) were employed to prepare through ultrasonic dispersion method. The effect of different DS on NPs formation was discussed. The obtained CUR-ACS-NPs (DSSA=12.4%) had high encapsulation rate (more than 85%) and uniform particle size (186.2 ± 1.42 nm). The CUR-ACS-NPs showed better stability than the other groups. Drug release from the CUR-ACS-NPs was pH-dependent, and more than 90% or 65% of CUR was released in 48 h in weakly acid medium (pH 5.0 or 6.0, respectively). Additionally, the CUR-ACS-NPs increased the intracellular accumulation of CUR and demonstrated high anticancer effect on HepG2 cells compared with the other groups. CUR-ACS-NPs prolonged the retention time of the drug, and the area under the curve (AUC) increased significantly in vivo. The in vivo antitumor study further revealed that the CUR-ACS-NPs exhibited the capability of inhibiting tumor growth and lower systemic toxicity. Meanwhile, CUR, CUR-CS-NPs, and CUR-ACS-NPs could be detected in the evaluated organs, including tumor, liver, spleen, lung, heart, and kidney in distribution studies. Among them, CUR-ACS-NPs reached the maximum concentration at the tumor site, indicating the tumor-targeting properties. In short, the results suggested that CUR-ACS-NPs could act a prospective drug transport system for effective delivery of CUR in cancer treatment.
研究领域:
药学
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癌症研究
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纳米技术
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药物递送系统
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产品关联
DOI
PubMed
高影响因子
CELL BIOLOGY INTERNATIONAL
·
2024
·
IF 3.3
Meng-Wei Zhang,Xu Sun,Yi-Wen Xu,Wei Meng,Qiong Tang,Hui Gao,Ling Liu,Shao-Hui Chen
Oxaliplatin (OXA) has shown high effectiveness in the treatment of cancers, but its anticancer clinical effects often induce neurotoxicity leading to neuropathic pain. Oxidative damage and NLRP3 inflammasome play important roles in neuropathic pain development. Here, neuropathic pain mouse model was constructed by continuous intraperitoneal injection of OXA. OXA administration induced mechanical pain, spontaneous pain, thermal hyperalgesia and motor disability in mice. The spinal cord tissues of OXA mice exhibited the suppressed antioxidative response, the activated NLRP3 inflammasome mediated inflammatory responses, and the increased GSK-3β activity. Next, we injected curcumin (CUR) intraperitoneally in OXA mice for seven consecutive days. CUR-treated mice showed increased mechanical pain thresholds, reduced number of spontaneous flinches, increased paw withdrawal latency, and restored latency to fall. While in the spinal cord, CUR treatment inhibited the NLRP3 inflammasome mediated inflammatory response, increased Nrf2/GPX4-mediated antioxidant responses, and decreased mitochondrial oxidative generation. Additionally, CUR combined with GSK-3β through four covalent bonds and reduced GSK-3β activity. In conclusion, our findings suggest that CUR treatment inhibits GSK-3β activation, increases Nrf2 mediated antioxidant responses, inhibits oxidative damage and inflammatory reaction, and alleviates OXA-induced neuropathic pain.
研究领域:
药理学
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神经科学
·
炎症与免疫
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产品关联
DOI
PubMed
高影响因子
TOXICOLOGY
·
2024
·
IF 4.8
Jianan Zhai,Zhengguo Chen,Qi zhu,Zhifang Guo,Xiance Sun,Liping Jiang,Jing Li,Ningning Wang,Xiaofeng Yao,Cong Zhang,Haoyuan Deng,Shaopeng Wang,Guang Yang
Patulin (PAT), the most common mycotoxin, is widespread in foods and beverages which poses a serious food safety issue to human health. Our previous research confirmed that exposure to PAT can lead to acute kidney injury (AKI). Curcumin is the most abundant active ingredient in turmeric rhizome with various biological activities. The aim of this study is to investigate whether curcumin can prevent the renal injury caused by PAT, and to explore potential mechanisms. In vivo , supplementation with curcumin attenuated PAT-induced ferroptosis. Mechanically, curcumin inhibited autophagy, led to the accumulation of p62 and its interaction with Keap1, promoted the nuclear translocation of nuclear factor E2 related factor 2 (Nrf2), and increased the expression of antioxidant stress factors in the process of ferroptosis. These results have also been confirmed in HKC cell experiments. Furthermore, knockdown of Nrf2 in HKC cells abrogated the protective effect of curcumin on ferroptosis. In conclusion, we confirmed that curcumin mitigated PAT-induced AKI by inhibiting ferroptosis via activation of the p62/Keap1/Nrf2 pathway. This study provides new potential targets and ideas for the prevention and treatment of PAT.
研究领域:
毒理学
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药理学
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分子生物学
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食品安全
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产品关联
DOI
PubMed
高影响因子
FOOD HYDROCOLLOIDS
·
2024
·
IF 11
Hao Xu,Qianhan Ma,Chao Qiu,Jinpeng Wang,Zhengyu Jin,Yao Hu
Low aqueous dispersibility and poor stability severely restrict the bioaccessibility of curcumin in health-related products. Constructing highly effective delivery carriers is essential to overcome the limitation. In this study, a novel and simple self-assembly process driven by electrostatic interaction was developed to prepare cyclodextrin succinate/chitosan (SACD/CS) nanoparticles. Spherical SACD/CS nanoparticles were obtained by adjusting the ratio of SACD:CS to obtain an average size and ζ-potential of around 500 nm and 20 mV, respectively. By analyzing the intermolecular interactions and crystalline structure of SACD/CS nanoparticles, it is indicated that SACD could act as crosslinking nodes, and contributed to transformation of molecular arrangement in the nanoparticles. The noncytotoxic SACD/CS nanoparticles were further used as curcumin carriers and showed significant improvement on curcumin stability, with the retention index of curcumin under physiological conditions increased from 19% to 62%. Moreover, the Cur-SACD/CS nanoparticles displayed controlled release behavior of curcumin during in vitro digestion, with 9%, 22%, and 44% of curcumin released at the end of the oral, stomach, and small intestine stage, respectively. This study developed a novel and effective strategy for oral delivery of curcumin, showing promising potential for improving the bioaccessibility and bioavailability of bioactive compounds like curcumin.
研究领域:
食品科学
·
药物递送
·
生物材料
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产品关联
DOI
高影响因子
Regenerative Biomaterials
·
2024
·
IF 5.6
Zhang Wenya,He Yuxin,Chu Yun,Zhai Yuanxin,Qian Song,Wang Xinhui,Jiang Pengju,Cui Pengfei,Zhang Yin,Wang Jianhao
The incidence of intrauterine adhesions (IUA) was raised accompanied by the increasing utilization of intrauterine surgery. The postoperative physical barrier methods commonly used, such as balloons and other fillers, have limited effectiveness and may even cause further damage to the remaining endometrial tissue. Herein, we developed an injectable thermosensitive hydrogel using Pluronic F127/F68 as pharmaceutical excipients and curcumin as a natural active molecule. The hydrogel effectively addresses solubility and low bioavailability issues associated with curcumin. In vitro, drug release assays revealed that the amorphous curcumin hydrogel promotes dissolution and sustained release of curcumin. In vitro experiments reveal high biocompatibility of the hydrogel and its ability to enhance vascular formation while inhibiting the expression of fibrotic factor TGF-β1. To assess the effectiveness of preventing intrauterine adhesions, in vivo experiments were conducted using IUA rats and compared with a class III medical device, a new-crosslinked hyaluronic acid gel (NCHA). According to the study, curcumin hydrogel is more effective than the NCHA group in improving the regeneration of the endometrium, increasing the blood supply to the endometrium, and reducing the abnormal deposition of fibrin, thus preventing intrauterine adhesion more effectively. This study provides a promising strategy for treating and preventing IUA.
研究领域:
药剂学
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生物医学工程
·
妇科学
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产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2024
·
IF 8.5
Bao Zhang,Shen Long,Ran Feng,Meng-Jie Yu,Bao-Cai Xu,Han Tao
To achieve the effective loading and delivery of curcumin, novel disulfide-crosslinked nanoparticles based on modified dextrin were developed for the encapsulation of curcumin. Thiolated dextrin (Dt-SH) was obtained via sodium periodate oxidation and cysteamine grafting. The Dt-SH exhibited a rough, flake-like morphology, was classified as an amorphous material and demonstrated enhanced enzyme resistance. Subsequently, spherical nanoparticles with sizes ranging from 92.52 to 157.12 nm and zeta potentials between +23.59 and + 29.90 mV were self-assembled in an aqueous solution. Thiol modification promoted interconnection and aggregation of the nanoparticles. These nanoparticles exhibited pH-dependent size variations. Taking curcumin as a hydrophobic model, nanoparticles showed intestinal targeted release in vitro . Fluorescence spectroscopy and thermodynamic analysis indicated that curcumin bound to Dt-SH nanoparticles primarily through hydrogen bonding and van der Waals forces, with hydrophobic interactions contributing. These findings supported the potential of thiolated dextrin nanoparticles in the effective delivery of hydrophobic compounds.
研究领域:
药剂学
·
生物材料科学
·
药物化学
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产品关联
DOI
PubMed
高影响因子
Polymers
·
2024
·Vol. 16
·期 24
·3451
·
IF 4.7
Caixia Wu,Xiaoqun Ning,Qunfeng Liu,Xiaoyan Zhou,Huilong Guo
Biological tissue defects are typically characterized by various shaped defects, and they are prone to inflammation and the excessive accumulation of reactive oxygen species. Therefore, it is still urgent to develop functional materials which can fully occupy and adhere to irregularly shaped defects by injection and promote the tissue repair process using antioxidant and anti-inflammatory mechanisms. Herein, in this work, phenylboronic acid modified oxidized hyaluronic acid (OHAPBA) was synthesized and dynamically crosslinked with catechol group modified glycol chitosan (GCHCA) and guar gum (GG) into a hydrogel loaded with curcumin liposomes (Cur-LPs) which were relatively uniformly distributed around 180 nm. The hydrogel possessed rapid gelation within 30 s, outstanding injectability and tissue-adaptive properties with self-healing properties, and the ability to adhere to biological tissues and adapt to tissue movement. Moreover, good biocompatibility and higher DPPH scavenging efficiency were illustrated in the hydrogel. And a more sustainable release of curcumin from Cur-LPs-loaded hydrogels, which could last for 10 days, was achieved to improve the bioavailability of curcumin. Finally, they might be injected to fully occupy and adhere to irregularly shaped defects and promote the tissue repair process by antioxidant mechanisms and the sustained release of curcumin for anti-inflammation. And the hydrogel would have potential application as candidates in tissue defect repair.
研究领域:
生物材料学
·
组织工程
·
药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
·
2024
·
IF 5.6
Yuhao He,Zhenpeng Cao,Chenyang Deng,Lei Zheng,Jingzhou Xu,Zaicheng Zhang,Hongyu Zhao,Song Hu,Kuanjun Fang,Yawei Song
Lyocell fiber is an important choice for functional apparel textiles because of its advantages of comfort, high strength, sustainable source and pollution-free spinning process. However, current methods for functionalization Lyocell fibers, such as blend spinning or surface modification using inorganic and synthetic materials, are generally complex, less environmentally friendly and easy to lose functionality. In this study, for the first time, we innovatively loaded the natural functional material curcumin into cationic polymer nanospheres and applied them in Lyocell fiber functionality through a simple one-step dyeing process. The fabricated curcumin@polymer nanospheres had a uniform particle distribution of approximately 148.03 nm, and exhibited a positive surface potential of +25.3 mV. Under the action of cationic polymer nanospheres, the interaction between curcumin and Lyocell fiber was obviously enhanced, and the mechanism was analyzed. The colored fibers possessed high antibacterial efficacy of 99.99 % against Staphylococcus aureus due to the synergistic antibacterial activity of curcumin and the quaternary ammonium salt groups in polymer sturcture. Furthermore, the application of the prepared curcumin@polymer nanospheres could realize the one-step process for coloration and functionalization of Lyocell fibers. Therefore, from the measurement of antibacterial activity, stability, and coloration depth, curcumin@PMBD showed great potential in the manufacture of greener antibacterial textile.
研究领域:
纺织材料学
·
生物医学工程
·
环境科学
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING & TECHNOLOGY
·
2024
·Vol. 47
·期 10
·e202400203
·
IF 1.8
Jinwei Qi,Jihui Li,Kaili Liu,Huixin Zhang,Jian Han,Jianxin Chen
The curcumin-malic acid-aspartic acid polymer (PCMA) as a new water treatment agent was prepared by solid phase synthesis of curcumin, malic acid and aspartic acid. The static scale inhibition experiments showed that PCMA can inhibit CaCO 3 and CaSO 4 scale formation by 100.0 % and had excellent scale inhibition effect under various experimental conditions. The mechanism of action of PCMA was obtained by X-ray diffraction, scanning electron microscope and molecular dynamics simulation. Electrochemical test showed that PCMA is an anodic corrosion inhibitor that achieves 93.1 % corrosion inhibition by forming a protective film on the surface of Q235 carbon steel. Besides, fluorescence spectra proved that PCMA has stable fluorescence intensity.
研究领域:
材料科学
·
化学工程
·
电化学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）