JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2011
·
IF 2.089
Jun Li,Yinmei Ye,Lifang Chen,Zhiwen Qi
The solubilities of CO2 in solvent poly(ethylene glycols) (PEGs) with molecular weights of 150, 200, 300, and 400 were measured over the range of pressure from (100 to 1200) kPa and temperature from (303.15 to 333.15) K. Henry's constant was obtained by linear fitting of the experimental data, and thermodynamic properties of solutions were calculated from the correlation of Henry's constant. It indicates that the solubility of CO2 increases with increasing molecular weights of PEGs. Henry's constant based on mole fraction and the molality of CO2 in PEG400 vary from (4.78 to 7.09) MPa and (1.56 to 2.48) MPa·kg·mol–1 from (303.15 to 333.15) K, respectively.
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DOI
高影响因子
Nanoscale Horizons
·
2025
·
IF 6.6
Si-Ye Tong,Cong-Min Huo,Yu-Cheng Zuo,Shuo Gao,David Tai Leong,Wei Xue,Jing-Yi Zhu
Immunosuppression from the tumor microenvironment plays a key role in the failure of cancer immunotherapy. The presence of potassium ions (K+) from dying tumor cells creates an immunosuppressive environment that encourages tumor-associated macrophages (TAMs) to adopt a pro-tumor M2-like phenotype. Alleviating immune suppression from the high K+ environment might boost innate immunity and fight tumor growth. Herein, disulfide-rich mesoporous silica modified with 18-crown-6 ether was developed as a nanocarrier (D-C) to load ML133, encapsulating with the DiR-embedded macrophage membrane (CM) to create D-C/M@CM/DiR. We first saturated the phagocytosis of the mononuclear phagocyte system (MPS) with blank nanocarriers to enhance the tumor accumulation of D-C/M@CM/DiR, which was coated with the same CM. 18-Crown-6 ether captures K+ to reduce immunosuppression, while ML133 promotes the polarization of TAMs to an anti-tumor M1 phenotype by targeting the K+ channel protein Kir2.1 on their membranes. This strategy activates the anti-tumor immune response and effectively inhibits tumor growth.
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DOI
PubMed
高影响因子
Nutrients
·
2024
·Vol. 16
·期 19
·3351
·
IF 4.8
Haiyan Wang,Zhenyu Yang,Shuxia Wang,Huwei Wu,Xuehong Pang,Yichun Hu,Xiaoguang Yang
Objectives: This study sought to understand the levels of vitamin K in the mature milk of Chinese lactating mothers, thereby providing a foundation for the development of appropriate intake (AI) of vitamin K for infants aged 0–5 months. Methods: Five hundred healthy lactating mothers were selected from the mature milk bank established by the Chinese Maternal and Infant Nutrition and Health Cohort by using a simple random sample procedure. Relevant information about lactating mothers and their infants was obtained by a questionnaire survey. Vitamin K1 and vitamin K2 (MK-4 and MK-7) in mature milk were determined by liquid chromatography–tandem mass spectrometry. Results: The total concentration of vitamin K in mature milk was 4.50 (2.85–6.33) ng/mL. The concentrations of vitamin K1, vitamin K2, MK-4, and MK-7 were 2.81 (1.66–4.39) ng/mL, 1.37 (0.75–2.11) ng/mL, 1.20 (0.58–1.97) ng/mL, and 0.13 (0.08–0.19) ng/mL, respectively. The concentration of vitamin K1 was highest and the concentration of MK-7 was lowest. The concentrations of vitamin K2 and MK-4 in mature milk from the south were significantly higher than those in mature milk from the north. The total vitamin K, vitamin K2, and MK-4 concentrations in mature milk of lactating mothers residing in urban areas were higher than those in rural areas. There was a tendency for the concentration of total vitamin K and vitamin K1 to increase with the mother’s age. Moreover, the concentration of MK-4 in mature milk was highest in summer, followed by spring and winter. The levels of vitamin K1 and MK-4 in mature milk were found to be affected by lactation stage; they were highest at 91–120 days and lowest at 31–60 days. Conclusions: Based on the concentration of vitamin K in mature milk found in this study, it is recommended that the appropriate intake of VK for Chinese infants aged 0–5 months is 3.49 μg/d (2.18 μg/d for VK1 and 1.06 μg/d for VK2).
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DOI
PubMed
高影响因子
Frontiers in Pharmacology
·
2021
·
IF 5.811
Zou Meina,Chen Yanrong,Zheng Zongji,Sheng Shuyue,Jia Yijie,Wang Xiangyu,Ren Shijing,Yang Yanling,Li Xiaomin,Dong Wenhui,Guan Meiping,Zhang Qian,Xue Yaoming
High-salt intake leads to kidney damage and even limits the effectiveness of drugs. However, it is unclear whether excessive intake of salt affects renal tubular energy metabolism and the efficacy of dapagliflozin on renal function in diabetic kidney disease (DKD). In this study, we enrolled 350 DKD patients and examined the correlation between sodium level and renal function, and analyzed influencing factors. The results demonstrated that patients with macroalbuminuria have higher 24 h urinary sodium levels. After establishment of type 2 diabetes mellitus model, the animals received a high-salt diet or normal-salt diet. In the presence of high-salt diet, the renal fibrosis was aggravated with fatty acid metabolism dysregulation. Furthermore, Na+/K+-ATPase expression was up-regulated in the renal tubules of diabetic mice, while the fatty acid metabolism was improved by inhibiting Na+/K+-ATPase of renal tubular epithelial cells. Of note, the administration with dapagliflozin improved renal fibrosis and enhanced fatty acid metabolism. But high salt weakened the above-mentioned renal protective effects of dapagliflozin in DKD. Similar results were recapitulated in vitro after incubating proximal tubular epithelial cells in high-glucose and high-salt medium. In conclusion, our results indicate that high salt can lead to fatty acid metabolism disorders by increasing Na+/K+-ATPase expression in the renal tubules of DKD. High salt intake diminishes the reno-protective effect of dapagliflozin in DKD.
研究领域:
肾病学
·
内分泌学
·
药理学
·
代谢学
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PubMed
高影响因子
SENSORS AND ACTUATORS A-PHYSICAL
·
2020
·
IF 2.904
Xuefei Su,Daqi Chen,Nan Li,Adrian Carl Stevenson,Guang Li,Ruifen Hu
Wireless sensor technology is a facile way of realizing low cost and miniaturized device for the detection of the volatile organic compounds (VOCs). A wireless electrodeless quartz crystal microbalance with dissipation (WE-QCM-D) sensor array was developed by using a single sensor working in a multi-resonance mode, which obtained an acoustic spectra of the quartz crystal at four harmonics (6 MHz, 18 MHz, 30 MHz and 42 MHz). Multi-responses (frequency shift, and energy dissipation) of WE-QCM-D sensor array were obtained via a ring-down mode and employed as discrimination factors for VOCs. The gas discrimination capability of the WE-QCM-D sensor array has been tested by coating a 100 μ g polyvinylpyrrolidone film on the quartz disc and achieved an optimal recognition rate of 97.5 % with K nearest neighbor algorithm. The results indicate that the single element WE-QCM-D sensor array could be a promising way to realize compact and low-cost VOCs monitoring systems.
研究领域:
传感器与执行器
·
环境监测
·
材料科学
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高影响因子
Materials Research Express
·
2022
·Vol. 9
·期 6
·065504
·
IF 2.025
Xin Lin,Chaoyi Chen,Junqi Li,Gangan Wang,Deyang Ning
Brown corundum dust ash(BCFA) is an industrial solid waste from the brown corundum production process. The alkali metal is a key factor limiting its comprehensive use. Currently, BCFA is mainly stockpiled and occupies a large amount of land. Its fine particles are easy to cause air pollution. The addition of NH4HSO4 allows for the effective extraction of K from BCFA and the efficient use of BCFA. Under optimum conditions: NH4HSO4 to BCFA mass ratio of 1.2:1, the roasting temperature of 240 °C, roasting time of 2 h, water leaching time of 90 min, water leaching temperature of 65 °C water leaching liquid to solid ratio of 3:1, the leaching rate of K from BCFA reached 97%. The leachate was crystallised by evaporation to obtain K, N compound fertiliser for agricultural use. The leaching residue is mainly Al and Si, which can be used for the preparation of refractory materials, aluminium and silicon molecular sieves, construction materials and other raw materials.
研究领域:
环境科学
·
材料科学
·
化学工程
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高影响因子
Inorganic Chemistry Frontiers
·
2019
·Vol. 6
·期 8
·2118-2125
·
IF 5.934
Xianglong Huang,Wei Wang,Jianhua Deng,Wei Gao,Dingyu Liu,Qianru Ma,Maowen Xu
In this study, a novel hollow carbon matrix was designed and prepared using a facile NaCl crystal template for the effective encapsulation of Se. This superior carbon electrode plays a significant role in facilitating sufficient energy storage and conversion of Se-based cathode materials. A large specific surface area of 416 m2 g−1 was obtained, and the matrix provided numerous hollow spheres for the storage of Se. The thermogravimetric analysis and electrochemical results show that the as-prepared Se-hollow porous carbon composite with an ideal Se content of 42% can make excellent capacity contribution. The hollow porous structure not only effectively accommodates the volumetric expansion during the discharge–charge process but also makes the composite have a good contact with the electrolyte. In addition, the 3D open framework structure can be conducive to fast electron transportation. As a result, the Se-hollow porous carbon composite exhibited outstanding electrochemical performance when evaluated as a cathode material for rechargeable K–Se batteries.
研究领域:
材料科学
·
能源存储与转换
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高影响因子
JOURNAL OF MOLECULAR STRUCTURE
·
2023
·
IF 3.8
Jing-Yi Cao,Ze-Dong Yu,Guang Yang,Xue-Can Wang,Lu Jiang,Xi Wang,Wen-Xuan Zhao,Shu-Hai Chen,Carl Redshaw,Chuan-Zeng Wang,Takehiko Yamato
In recent years, fluorescence sensors have been widely used in explosive detection due to their portability and high efficiency. In the present work, two K-region tetrasubstituted deep-blue pyrene-based luminogens were designed and synthesized by introducing electron-donating groups. The optical properties were investigated by experimental and density functional theory (DFT) methods. Reasonable luminescence efficiency and electron rich characteristic allowed for the possible detection of nitro-explosives. Both luminogens, especially TFPy , exhibit a sensitive response towards nitroanilines ( NA ), with a limit of detection (LOD) for p -NA as low as 2.75 × 10 –8 M, which is mainly attributed to the electron-donating substituents on the periphery of the pyrene core and the extended π-conjugated structure. These research results establish a low-cost and simple strategy for the detection of trace nitroaniline.
研究领域:
化学传感器
·
材料科学
·
环境监测
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高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2016
·
IF 1.835
Hongjie Xu,Zuoxiang Zeng,Weilan Xue,Kun Li
The solubility of ethyl p-aminobenzoate (EPAB) was measured in six different alcohols (methanol, ethanol, n-propanol, n-butanol, isobutyl alcohol, isoamyl alcohol) within (283.15 to 327.15) K by the last solid disappearance method. The solubility increases with increasing temperature. The decreasing order satisfies the following sequence: methanol > ethanol > n-propanol > n-butanol > isoamyl alcohol > isobutyl alcohol. Four models, including modified Apelblat equation, λh model, NRTL model, and Wilson model, were used to correlate the experimental data of EPAB. It is found that the modified Apelblat equation, NRTL model, and Wilson model were suitable to correlate the solubility of EPAB in the selected solvents with an overall RAD less than 2%. In addition, the changes of thermodynamic properties of solution [standard molar enthalpy (ΔdisHo), standard molar entropy (ΔdisSo), and standard molar Gibbs energy (ΔdisGo)] were obtained. The results indicate that the dissolution process of EPAB in these alcohols is endothermic and an entropy-driven process.
研究领域:
物理化学
·
药学
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高影响因子
JOURNAL OF SOLUTION CHEMISTRY
·
2018
·Vol. 48
·期 3
·367-378
·
IF 1.401
Li Hongxia,Guo Lijiang,Li Jianqiang
The water activities of the MgCl 2 –RbCl–H 2 O ternary system and its sub-binary systems have been measured with the isopiestic method at 323.15 K. The measured water activities for the MgCl 2 –H 2 O and RbCl–H 2 O sub-binary systems agree well with the results reported in literature. The measured equal water activity lines of the MgCl 2 –RbCl–H 2 O ternary system are not straight lines, which means the mixing behavior of the solutions do not obey Zdanovskii’s rule. The solubility of the MgCl 2 –RbCl–H 2 O ternary system has been determined with the Flow-Cloud-Point method at 323.15 K, and the measured results are roughly consistent with values reported in the literature. The Pitzer model was selected to correlate the water activity and solubility data measured in this work. The predicted water activities and solubility isotherm for the MgCl 2 –RbCl–H 2 O ternary system at 323.15 K, with binary solution parameters only, both deviated from the experiment values. The ternary solution Pitzer model parameters were obtained by fitting the measured water activities in the ternary system. The water activities and solubility isotherms of the MgCl 2 –RbCl–H 2 O ternary system at 323.15 K were calculated including both binary and ternary solution parameters. The calculated water activities are consistent with the experimental values. The calculated solubility isotherms are roughly consistent with experiment values, except they deviate somewhat in the RbCl crystallization region.
研究领域:
化学
·
物理化学
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高影响因子
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2015
·Vol. 162
·期 4
·C197
·
IF 3.266
Gong Chen,Zhongning Shi,Jiangyu Yu,Junli Xu,Xianwei Hu,Zhaowen Wang,Bingliang Gao
The passivation of a graphite electrode in LiF–KF molten salt at 773 K was studied using cyclic voltammetry and electrochemical impedance spectroscopy. The anodic cyclic voltammogram showed that there are two oxidation current peaks at approximately 1.2 and 4.8 V vs. Pt quasi-reference electrode. We confirmed that carbon fluoride compounds are formed at the first current peak, while the last current peak was predominantly attributed to F2 evolution. The surfaces of the anodes used for electrolysis were analyzed at the potential of 1.0 V by X-ray photoelectron spectroscopy and Raman spectroscopy, and the anode atmosphere during the experiments was analyzed by gas chromatography. The results show that solid carbon fluoride compounds were formed in the graphite surface and no trace of gaseous carbon fluoride was detected. In addition, the active–passive transition of graphite electrode was observed in the EIS spectra recorded at 1.5 V. We confirmed the reason for the passivation of a graphite anode in LiF–KF molten salt: the formed carbon fluoride compounds layer blocks the transmission of F− anion from the electrolyte to the graphite electrode.
研究领域:
电化学
·
材料科学
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高影响因子
JOURNAL OF SOLID STATE ELECTROCHEMISTRY
·
2026
·
IF 3.1
Ye Sifei,Li Yingnan,Liu Peng,Deng Jianghao,Tang Qiuhua,Lei Xiaoting,Zeng Xiangrong,Wen Yangping
The abnormal accumulation of purine metabolites, such as adenine (A) and hypoxanthine (Hx), is closely associated with the pathogenesis of hyperuricemia and gout, underscoring the urgent need for precise methodologies enabling their simultaneous detection. To overcome the inherent limitations of conventional analytical techniques and resolve the challenge of overlapping voltammetric signatures in electrochemical sensing, this study presents an integrated analytical strategy encompassing an advanced sensing platform, sophisticated signal processing, and intelligent data analytics. A glassy carbon electrode modified with carboxymethyl cellulose-functionalized multi-walled carbon nanotubes (CMC-fMWCNTs/GCE) serves as the foundation for highly sensitive detection. Crucially, the application of half-order derivative voltammetry effectively resolves the overlapping oxidation peaks of A and Hx, thereby enhancing analytical selectivity. Complementing this, a K -means clustering algorithm is employed to enable automated, data-driven assessment of sensing stability. These components are integrated into a web-based intelligent system that automates the complete analytical workflow, from raw data ingestion to quantitative concentration readout. The proposed system exhibits a broad linear dynamic range (0.08–80 μM), low limits of detection (0.062 μM for A and 0.075 μM for Hx), and high analytical reproducibility (relative standard deviation < 5%), while streamlining the analytical process. Collectively, this work not only achieves the precise synchronous quantification of A and Hx but also establishes a transferable analytical framework for the intelligent analysis of small molecules with analogous structural features.
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