CHEMICAL ENGINEERING JOURNAL
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2025
·
IF 13.2
Zhijie Feng,Huimin Xue,Xiaoxuan Yin,Hongxiang Li,Chao Zhang,Yinli Bao,Huifang Yin,Cuiqin Huang,Duo Liu,Hanjie Wang
Controllable bacterial therapy in gastrointestinal tract holds therapeutic potential for inflammatory diseases and oncology, but its clinical translation is hindered by insufficient protein expression, inefficient control signal delivery, and lack of adaptability for large-animal models, limiting their practical application. This study proposes an integrated strategy addressing these challenges through two innovations. First, a transcriptional amplifier-optimized optogenetic circuit was engineered in E. coli Nissle 1917, boosting green light-induced protein secretion by up to 41.5 folds compared to dark condition. Second, a wireless LED-emitting electronic capsule was developed, enabling 80 mm deep-tissue wireless signal penetration and smartphone-controlled light delivery. In DSS-induced colitis models, the amplifier-optimized optogenetic strains with 1-h daily light irradiation achieved maximal inflammation alleviation, confirmed by histopathology and disease activity scoring. Pig experiment demonstrated efficient IL-10 accumulation in the rectum after 1-h LED irradiation from the capsule, validating the system's scalability. In conclusion, the dual-optimization strategy combines enhanced optogenetic circuit performance and advanced light irradiation device, enabling programmable and sustained delivery of microbial derived therapeutic proteins. This modular system overcomes limitations of existing approaches, offering adaptable solutions for colorectal disease treatment and gut-axis therapeutics.
研究领域:
合成生物学
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生物医学工程
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胃肠病学
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光遗传学
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微生物治疗
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炎症性肠病
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肿瘤学
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产品关联
DOI
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2019
·
IF 5.589
Ze-Chen Gao,Yi-Li Lin,Bin Xu,Ying Xia,Chen-Yan Hu,Tian-Yang Zhang,Tong-Cheng Cao,Yang Pan,Nai-Yun Gao
This study compared the degradation of dissolved organic matter (DOM) by UV/chlorine advanced oxidation processes (AOPs) with emerging ultraviolet light-emitting diode (UV-LED, 275 nm) and traditional low pressure UV (LPUV, 254 nm) as UV sources. Excitation emission matrix-parallel factor (EEM-PARAFAC) analysis and two-dimensional (2D) correlation gel permeation chromatograph were applied to explore the evolutions of DOM during oxidation processes. The degradation behaviors of DOM indicated by UV absorbance at 254 nm (UV 254 ), dissolved organic carbon (DOC), and fluorophores fitted the pseudo-first-order kinetics well. The removal efficiency of DOM was similar under UV-LED and LPUV irradiation alone. However, UV-LED exhibited much higher degradation rates (increased by 29–160%) than LPUV regardless of the tracking variables during UV/chlorine processes. For three PARAFAC components, humic-like fluorescences were preferentially degraded by UV/chlorine oxidation compared with protein-like fluorescence potentially due to the differences of electronic moieties and molecular weight (MW). The decline in UV 254 , DOC, and fluorophores increased with increasing chlorine dosage; linear correlations between those indicators were observed during the two AOPs. Moreover, UV-LED/chlorine could achieve greater extents of MW change. Our study demonstrated that UV-LED could be a superior alternative for the future selection of UV source in the UV/chlorine process.
研究领域:
环境科学
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水处理
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化学工程
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Qingyun Liu,Boxuan Peng,Jiahui Li,Fangzheng Zhao,Enchang Liu,Huizhen Han,Tong Wu,Jinfeng Xing
To overcome the inherent mechanical limitations of polysaccharide hydrogels for dye adsorption, we developed dual-network hydrogel microspheres via efficient one-step droplet photopolymerization initiated by green LED. The primary network was photopolymerized from sodium acrylate monomers and ethylene glycol dimethacrylate cross-linker, while the secondary network formed through Schiff base conjugation between oxidized chondroitin sulfate and carboxymethyl chitosan. Systematic characterization (FTIR, TGA, SEM, XPS) confirmed the hydrogels' structural and thermal properties. Key operational parameters including contact time, temperature, initial MG concentration, pH, and ionic strength were optimized. At room temperature, adsorption equilibrium was achieved within 3 h, following pseudo-second-order kinetics. The adsorption capacity is 806.51 mg/g and fitted the Langmuir isotherm model. Electrostatic interactions dominated the adsorption mechanism, as verified by pH and ionic strength experiments. After five adsorption-desorption cycles, MG removal efficiency remained more than 80 %.
研究领域:
高分子科学
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环境工程
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材料科学
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化学工程
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吸附技术
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产品关联
DOI
PubMed
高影响因子
ACS Biomaterials Science & Engineering
·
2019
·
IF 4.511
Shilei Wang,Qiaomu Huang,Xiangyu Liu,Zhao Li,Hao Yang,Zhong Lu
The integration of nanomaterials with clinical therapeutic instruments is a promising approach to improve the effects of nanomaterials. We reported an efficient synergistic antibacterial strategy formed through the combination of Ag/ZnO nanocomposites with a light-emitting diode (LED) curing light, which is a commonly used small instrument in dental clinics. The as-designed integration depicted a significantly enhanced bactericidal effect on facultative anaerobic oral pathogen Streptococcus mutans (S. mutans) both in planktonic and biofilm phases over a very short irradiation time (≤5 min). Further study showed that the combination of LED and Ag/ZnO nanocomposites induced more ·OH and ·O2– generation, which is responsible for the enhanced antibacterial activity. Moreover, this combination could destroy S. mutans biofilm by killing the bacteria embedded within biofilm, inhibiting exopolysaccharide production and down-regulating the biofilm-related gene expression. Therefore, it is proposed that this combination could be applied in dental clinics to realize dental caries prevention and dental restoration simultaneously.
研究领域:
牙科学
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纳米技术
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微生物学
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产品关联
DOI
PubMed
高影响因子
Water Reuse
·
2024
·Vol. 14
·期 3
·342-354
·
IF 4.3
Liu Z.,Xu M. Y.,Yin H.,Xie C. W.,Liu Q.,Liu H. T.,Liang S. Y.,Li J. K.,Zhang T. Y.,Li T.,Hu H. Y.,Xu B.
Membrane fouling is a prominent issue that affects the stable and efficient operation of reverse osmosis (RO) in reused water treatment. In this study, a zero-discharge RO system was adopted to treat the ultrafiltration permeate from a steel plant with the combined multi-wavelength UV-LED/chlorine process, focusing on organic structure modification and membrane fouling control. The results showed that the UV-LED/chlorine process could not only efficiently remove the dissolved organic carbon and the total nitrogen of the RO influent but also alter the organic substances from large molecules to small ones. In addition, the longer wavelength of a 295 nm UV-LED/chlorine process exhibited a greater RO permeate flux of 158 LMH, as compared to the shorter wavelength of 255 nm with the flux of 152 LMH. Moreover, compared to the single-wavelength, the dual-wavelength UV-LED/chlorine process played a more significant role in RO filtration performance, which induced a looser and thinner foulant structure, resulting in an 8% larger permeate flux and recovery at 275 + 295 nm than at 295 nm. This study demonstrated that the combined UV-LED/chlorine process could effectively alleviate RO membrane fouling. Our findings can provide theoretical and technical support for the sustainable development of membrane-based reused water treatment in the steel industry. Multi-wavelength UV-LED/chlorine process was effective for the pretreatment of RO for steel reused water treatment. UV-LED/chlorine process could oxidize organics to enhance RO filtration. Longer wavelength UV-LED/chlorine process was more favorable for organics removal and RO fouling control. Dual-wavelength UV-LED/chlorine pretreatment can induce less RO membrane fouling as compared to single wavelength.
研究领域:
环境工程
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水处理技术
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膜科学
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2022
·
IF 16.744
Mohsin Pasha,Saier Liu,Minjing Shang,Min Qiu,Yuanhai Su
Photochemical transformations are mobilized by traceless photons of narrow or broad visible light wavelength and have been proven as a green and sustainable synthesis route for organic compounds. However, most of such investigations were restricted to only parametric studies, lacking in examining a synergistic involvement of actinometric, kinetics and mass transfer mechanisms on product yield. To address this vital issue, we executed the synthesis of natural product juglone via the photooxidation of 1,5-dihydroxynapthalene (DHN) mediated through singlet oxygen, which was produced by triplet–triplet energy transfer from three porphyrin-based photosensitizers to triplet oxygen upon irradiation from UV–Vis LED. Compared to the other two photosensitizers, m-TcPP ( meso -tetracarboxyphenylporphyrine) showed a higher molar extinction coefficient and remarkable energy transfer, resulting in higher DHN conversion and juglone yield. Full DHN conversion and 82% yield were obtained at the m-TcPP loading of 2.0 mol% and the residence time of 22.1 min. Actinometric investigation showed that the photon flux was significantly improved by rising m-TcPP and DHN concentrations. The maximum radiant power absorbed by the DHN photooxidation could reach 17.3% of the total input power of UV–Vis LED strip. The detailed reaction mechanism of the DHN photooxygenation was discussed through the Jablonski diagram and rate constants of intermediate steps were determined. A positive relationship between the photon flux and the apparent rate constant was found by rising m-TcPP concentration from 0.01 to 0.05 mM, while the rise in DHN concentration from 5.0 to 10.0 mM resulted in a negative correlation between these parameters. Consequently, a synergistic improvement of photon flux and apparent rate constant was necessitated to attain complete DHN conversion and high juglone yield.
研究领域:
化学工程
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光化学
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有机合成
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绿色化学
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产品关联
DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
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2021
·
IF 5.268
Juan Zhao,Lixian Xu,Hao Zhang,Yuhong Zhuo,Yanan Weng,Shuang Li,Dinghua Yu
Recently, increased attention has been focused on antibacterial photodynamic therapy (APDT) to treat multidrug-resistant bacterial infection due to the antibiotic abuse. Methylene blue has been used as a kind of efficient and cheap commercial photosensitizer in APDT. However, due to high hydrophilicity, methylene blue is not able to be transcellular intaken and accumulated efficiently. To promote accumulation and APDT efficiency of methylene blue, lipopeptide surfactin-methylene blue complex has been prepared through electrostatic interaction. The complex under LED irradiation was found to effectively reduce 5.0 Log 10 CFU and 7.6 Log 10 CFU for P. aeruginosa and S. aureus , respectively. The bacterial reduction efficiency is slightly higher than free methylene blue. The photosensitizers accumulation and APDT targeting protein have been characterized by fluorescence spectroscopy, fluorescence microscopy and protein electrophoresis techniques. These results demonstrated that more surfactin-methylene blue complex could be accumulated more into the cell, and inactivate bacteria through destroying intracellular protein under LED illumination. In comparison, free methylene blue under light could inactivate bacteria through destroying membrane protein and lipid structures. These results would provide valuable insight for developing advanced clinical medicine and designing photo-drug for photodynamic therapy.
研究领域:
药学
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微生物学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
Surfaces and Interfaces
·
2025
·
IF 6.3
Xiyu Zou,Yuzhe Hua,Xiangyang Du,Yunan Shen,Zilong Chen,Huachong Chen,Hui Sui,Guangmin Ren,Qingjie Guo,Man Wu,Hongjing Tian
Addressing such limitations of traditional photocatalysts as poor visible light absorption, substantial electron-hole recombination, and inefficient reactive oxygen species (ROS) generation is crucial. In this paper, oxygen vacancies (OVs) rich Bi 2 MoO 6 (BMO)/ZnSe S-scheme heterojunction was successfully prepared using a simple and mild solvothermal method. The introduction of OVs effectively shortened the band gap and increased the visible light absorption range. The mechanism of inducing OVs into BMO by adapting the concentration of surfactants was uncovered using both experimental and DFT simulation results. OVs-BMO/ZnSe exhibited an enhanced charge transfer capacity because OVs facilitated the formation of a rapid electron transfer pathway at the heterojunction interface. The synergistic effect of OVs and S-scheme heterojunction could effectively inhibit the recombination of photogenerated carriers. Its degradation efficiency and turnover frequency per wattage of light (TOF/P) reached 92.1% and 854.98 × 10 -10 (mol·g −1 ·J -1 ), respectively, during the low power LED white light-driven photocatalytic degradation of 50mg/L TC. The high value of TOF/P demonstrated its practical application potential in comparison with some other reported photocatalysts. Liquid Chromatography-Mass Spectrometry (LC-MS) characterization and ECOSAR simulation results indicated that OVs promoted the generation of ROS, in which ·O–2, 1 O 2 and h + significantly reduced the toxicity of intermediate products.
研究领域:
环境科学
·
材料科学
·
化学工程
·
纳米技术
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产品关联
DOI
高影响因子
OPTICAL MATERIALS
·
2018
·
IF 2.32
Hong Ming,Junfei Zhang,Shuifu Liu,Jiaqing Peng,Fu Du,Jianhui Huang,Libin Xia,Xinyu Ye
Lack of red-light of current w-LEDs restricts their applications in the field of high color rendering index warm solid-state lighting. Fluoride phosphors doped with Mn 4+ provide an efficient way to resolve the problem. Unfortunately, these excellent Mn 4+ activated fluoride red phosphors are generally synthesized in highly toxic HF solution. In this paper, we report a novel green synthetic route to prepare a non-rare-earth and nonequivalent doping type of K 2 NbF 7 :Mn 4+ red phosphor with micro-rod-like morphology. The results of XRD and its Rietveld refinement reveal that all the samples possessed only a single phase with monoclinic P21/c structure and the Mn 4+ ions were successfully incorporated into the crystal lattice . The Mn 4+ ions in K 2 NbF 7 matrix have a highly distorted octahedral environment, which strengthen the intensity of zero phonon line (ZPL). The strongest absorption and excitation bands appear in blue region of diffuse refection spectra (DRS) and the photoluminescence excitation (PLE) of K 2 NbF 7 :Mn 4+ sample, which demonstrates the product perfectly match with the most popular GaN-based blue chip. Under blue light illumination, the as-prepared K 2 NbF 7 :Mn 4+ sample exhibits intense sharp-line red fluorescence (∼628 nm) with internal quantum yield (QY) of 71.3%, an extreme narrow full width at half-maximum (FWHM) of ∼2.8 nm, and an ultra-high-color purity of 99.2%. Impressively, by incorporating K 2 NbF 7 :Mn 4+ as a red component, a warm w-LED with high CRI of 83.8, low color temperature of 3010 K and high luminous efficiency of 115.91 lm/W is obtained, demonstrating great validity of K 2 NbF 7 :Mn 4+ red phosphor for white LED devices.
研究领域:
材料科学
·
光电技术
·
照明技术
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DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2023
·
IF 5.2
Dongsheng Chen,Xiangyang Xu,Pengtao Lei,Jianyu Ge,Yuanlin Tong,Chenyu Huang,Xianghui Fu
Morphology control and heterostructure construction are two essential aspects in designing and synthesizing photocatalysts . Herein, hollow microsphere heterojunctions of CeO 2 and Ce 3+ doped BiOBr (Ce-BiOBr) were fabricated adopting a facile one-pot solvothermal approach. Owing to the positively charged Ce species, the interlamellar repulsion can be reduced and the specific surface area of these microsphere can be increased. The as-generated Ce 4+ /Ce 3+ redox centers can synergistically improve the transfer and separation efficiency of photogenerated carriers. When used to treat Congo red (CR), 0.1CBOB with a Ce/Bi molar ratio of 0.1:1 exhibits the best photodegradation efficiency (94.63%) and kinetic rate (0.01119 min −1 ) under visible light-emitting diode (LED) light irradiation , which are remarkably superior to pure BiOBr and CeO 2 . The results of radical capture experiment show that photogenerated hole (h + ), superoxide radical (·O 2 − ) are the main active species in the process of photocatalytic degradation.
研究领域:
材料科学
·
环境科学
·
化学
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产品关联
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2025
·
IF 5.6
Xin Yang,Wei Lü,Jin Xiang Lim,Biao Wang
There is strong demand of exceptional efficiency for near-infrared (NIR) phosphors for next-generation integrated and intelligent multifunctional light-emitting diode (LED) devices. Designing NIR phosphors with excellent efficiency that simultaneously meet multiple application requirements is challenging. Hence, this work focuses on the NIR optical properties and the corresponding multifunctional applications for Cr 3+ activated LaMgAl 11 O 19 (LMAO) phosphors. The blue light excitable LMAO:Cr 3+ phosphors can produce intense NIR emission ranging from 630 to 1000 nm with an 95.8% internal quantum efficiency as well as excellent thermal stability (I 423 K /I 303 K = 75.9%). Additionally, benefiting from the strong correlation between fluorescence lifetime and ambient temperature, the LMAO:Cr 3+ phosphors were showed promising potential for application in temperature sensing. Notably, the NIR phosphor-converted LED devices based on LMAO:Cr 3+ phosphors and commercial blue LED chip were self-built, which exhibiting great potential for indoor plant cultivation, night vision, and nondestructive detection. This study describes the highly efficient LMAO:Cr 3+ phosphors preparation and the corresponding multifunctional applications in the fields of optical thermometry, indoor plant cultivation, night vision, and nondestructive detection, which is crucial for the next-generation integrated and intelligent multifunctional LED devices.
研究领域:
材料科学
·
光学工程
·
固态照明
·
温度传感技术
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植物生长技术
·
无损检测
✓ 已验证
产品关联
DOI
高影响因子
EUROPEAN POLYMER JOURNAL
·
2022
·
IF 5.546
Shujie Liu,Zhen Wang,Jinfeng Xing
Hydrogels have been widely used in wound dressings due to their excellent moisture retention and biocompatibility. In this study, a poly(N-[tris(hydroxymethyl)methyl]acrylamide-co-acrylamide) (P(THMA-co-AAM)) hydrogel was rapidly prepared by photopolymerization under green LED irradiation within 5 s. The P(THMA-co-AAM) hydrogel exhibits excellent mechanical properties, self-healing properties, adhesion ability and prominent biocompatibility. Moreover, the tunable multifunctional hydrogel (P-QCS) prepared by adding quaternary chitosan to the P(THMA-co-AAM) hydrogel exhibits attractive antibacterial properties. Notably, our strategy provides a universal platform to combine various functional substances to generate multifunctional hydrogels for the application of hydrogels in wound dressing.
研究领域:
材料科学
·
生物医学工程
·
伤口愈合
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）