FOOD CHEMISTRY
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2020
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IF 6.306
Jing Liu,Bin Wang,Huachuan Huang,Dan Jian,Yunan Lu,Yanke Shan,Shouyu Wang,Fei Liu
The ciprofloxacin (CIP) abuse has caused many problems threatening to human health. Here, we design the quantum dot microsphere (QDM) based immunochromatographic quantitative CIP test strip: when the sample under detection contains CIP, the QDM-monoclonal antibody (mAb) probes bound with the CIP and cannot be captured by CIP-bovine serum albumin (BSA) conjugation dispersed on the T lines, reducing the fluorescence intensities. These test strips can provide a low detection limit of 0.05 ng/mL and a wide linear detection range from 0.1 ng/mL to 100 ng/mL in high sensitivity and accuracy as well as good selectivity, reproducibility and stability. Moreover, a smartphone based test strip reader with the size of 85 mm × 48 mm × 44 mm is also fabricated using 3-D printing to automatically and quantitatively detect CIP. The whole process of CIP detection can be finished within 15 min, but only cost ~1 RMB (10 cents).
研究领域:
分析化学
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纳米技术
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生物医学工程
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环境科学
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食品安全
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产品关联
DOI
PubMed
高影响因子
Scientific Reports
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2022
·Vol. 12
·期 1
·1-11
·
IF 4.996
Xu Weikang,Wei Kun,Lin Zefeng,Wu Tingting,Li Guixiang,Wang Liyan
In osteoporosis and diabetes, it is essential to accelerate the bone repair and regeneration process. Trace rare earth elements such as lanthanum (La) ions (La 3+ ) with appropriate concentrations are bioactive and can effectively regulate bone tissue performances. However, few well-established bone tissue engineering scaffolds can precisely and stably release La 3+ to promote bone regeneration significantly. Based on the advantages of biodegradable microspheres and microsphere-based scaffolds for controlled drug release, we developed poly(lactide-co-glycolide) (PLGA)-based microsphere-based scaffolds as both three-dimensional (3D) porous scaffolds and La 3+ storage and release systems for osteogenesis. So far, there is no study about microsphere-based scaffolds to release trace La 3+ to induce osteogenic differentiation of bone marrow mesenchymal stromal cells (BMSCs). PLGA microspheres co-embedded with La-doped mesoporous silica (LMS) with different amounts of doped La were sintered to prepare the LMS/PLGA (LMSP) microsphere-based scaffold. The La 3+ release behavior of LMSP can be controlled by adjusting the doping amount of La in mesoporous silica (MS). All these scaffolds possessed a 3D network architecture. With the increase of La doping, LMSP can better compensate for the pH decrease caused by PLGA degradation. The combination of MS and PLGA can avoid the cytotoxicity of MS alone. All prepared LMSP scaffolds were non-cytotoxic. After BMSCs were implanted on scaffolds, LMSP could promote cells adhesion, proliferation, and osteogenic differentiation. Among these microsphere-based scaffolds, LMSP-3 with stable and higher dose La 3+ release behavior showed the strongest ability to enhance the osteogenesis of BMSCs. The results showed that microsphere-based scaffolds with the ability to store and stably control the release of La 3+ could effectively improve osteogenic performance, which provides a new idea for the construction of bone tissue engineering scaffolds.
研究领域:
生物医学工程
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材料科学
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组织工程
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生物材料
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产品关联
DOI
PubMed
高影响因子
Catalysts
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2022
·Vol. 12
·期 5
·479
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IF 4.501
Xiangxiang Li,Shuling Chang,Yanting Wang,Lihong Zhang
The selective and effective conversion of CO2into available chemicals by electrochemical methods was applied as a promising way to mitigate the environment and energy crisis. Metal silver is regarded as an efficient electrocatalyst that can selectively convert CO2into CO at room temperature. In this paper, a series of coral-like porous Ag (CD-Ag) catalysts were fabricated by calcining silver-carbonaceous microsphere (Ag/CM) precursors with different Ag content and the formation mechanism of CD-Ag catalysts was proposed involving the Ag precursor reduction and CM oxidation. In the selective electrocatalytic reduction of CO2to CO, the catalyst 15 CD-Ag showed a stable current density at −6.3 mA/cm2with a Faraday efficiency (FE) of ca. 90% for CO production over 5 h in −0.95 V vs. RHE. The excellent performance of the 15 CD-Ag catalysts is ascribed to the special surface chemical state and the particular nano-coral porous structure with uniformly distributed Ag particles and pore structure, which can enhance the electrochemical active surface areas (ECSA) and provide more active sites and porosity compared with other CD-Ag catalysts and even Ag foil.Keywords:carbon dioxide reduction;silver;carbonaceous microsphere;carbon monoxide;electrochemical
研究领域:
环境科学
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材料科学
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电化学工程
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产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2022
·
IF 8.025
Ya Li,Xi-xiang Shuai,Ming Zhang,Fei-yue Ma,Jun Chen,Jian Qiao,Rong-hao Chen,Li-qing Du
As a common macromolecular carbohydrate, pectin has a strong affinity for Pb 2+ . An ethylenediamine modified pectin (EP 48 ) with 48 % of amidation was prepared and exhibited great removal efficiency towards Pb 2+ in our previous study. However, the EP 48 has drawbacks in adsorption including low mechanical strength and difficulty in separation. In this study, EP 48 was compounded with sodium alginate (Alg) and Fe 3 O 4 to synthesize EP 48 /Alg/Fe 3 O 4 microsphere. The physicochemical properties and Pb 2+ adsorption characteristics of microsphere were analyzed. It was found that the microsphere exhibited good thermal stability, mechanical strength, porous structure, as well as acid tolerance. The pseudo-second-order model well described the kinetics of adsorption process, indicating the chemical adsorption is dominant. The Langmuir model fitted the experimental data well, and the maximum adsorption capacity reached 175.19 mg/g. Adsorption-desorption experiments showed that the removal rate of the microsphere maintained over 98.9 % after 10 cycles. The X-ray photoelectron spectroscopy (XPS) analyses revealed that the potential adsorption mechanism included ion-exchange and chelation. The above results suggested its potential use for the removal of Pb 2+ from wastewater.
研究领域:
环境科学
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材料科学
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化学
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产品关联
DOI
PubMed
高影响因子
Advanced Fiber Materials
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2022
·Vol. 4
·期 5
·1209-1218
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IF 12.958
Guo Jiahui,Zhang Han,Zhang Hui,Chen Hanxu,Gu Zhuxiao,Zhang Dagan,Zhao Yuanjin
Tactile sensors with distinctive ability to imitate skins have attracted considerable attention from researches for applications in a variety of sensing fields. Here, inspired by the tentacles of jellyfish, biomimetic hydrogel microfibers were fabricated to be implanted with discrete structural color microsphere units for spatial tactile sensing. By employing a microfluidic spinning technology, the generated microfibers were with high microsphere encapsulation features and controllable morphologies because of the density match of microspheres and the pre-hydrogel solution. In addition, benefitting from the easy manipulation of the microfluidics, microfibers implanted with different structural color microspheres could also be realized. It was demonstrated that the resultant microfibers would show synchronous shifts of photonic bandgaps as well as structural color when a local force like pressure or tension was applied to the microsphere part. Based on the localization of finger bending experiments, the practical values of the bioinspired microfibers have also been proved as spatial tactile sensors. Thus, it is believed that the proposed bioinspired hydrogel microfibers are greatly significant in diverse sensing application fields. Graphical Abstract
研究领域:
材料科学
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生物医学工程
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传感器技术
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产品关联
DOI
高影响因子
Current Research in Food Science
·
2022
·
IF 6.269
Yongjian Cheng,Bo Xie,Yifan Liang,Xinmei Liu,Haojie Chen,Jiadong Li,Hongtao Lei,Zhili Xiao
Paclobutrazol (PBZ) is a plant growth inhibitor and fungicide, but it is also carcinogenic and teratogenic, and has potential harm to human health. In this study, two PBZ haptens (PBZ-1, PBZ-2) were synthesized and conjugated with carrier proteins to get artificial antigens. A highly specific monoclonal antibody (mAb) against PBZ was prepared. The antibody subtype was IgG 1 and the concentration was 11.03 mg/mL. A sensitive and rapid time-resolved fluorescence microsphere lateral flow immunoassay (TRFMs-LFIA) was established based on the mAb. The activated pH, the mAbs diluents, the mAb reacting concentration and the probe amount were optimized. The visual limit of detection (vLOD) and quantitative limit of detection (qLOD) of the TRFMs-LFIA for PBZ were 50 and 1.72 ng/mL respectively, and the 50% inhibiting concentration (IC 50 ) was 9.38 ng/mL. The pretreatment procedures are simple and rapid, and the detection time of TRFMs-LFIA strip is 6 min. Qualitative and quantitative analysis of PBZ could be achieved under a UV light or with a portable fluorescence immunoassay analyzer. The average recovery rates ranged from 96.2% to 111.9% and the corresponding coefficients of variation (CV) were 4.0%–11.2% in spiked wheat and rice samples. Twenty real wheat and rice samples were measured by the TRFMs-LFIA and compared with Ultra-performance liquid chromatography/tandem mass spectrometry (UPLC-MS/MS). The measured values showed a good accordance. These results indicated that the proposed assay will provide a novel effective strategy for on-site detection of PBZ.
研究领域:
农业科学
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免疫学
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食品安全
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产品关联
DOI
PubMed
高影响因子
OPTICAL FIBER TECHNOLOGY
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2023
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IF 2.7
Yiting Liu,Huaping Gong,Xiao Lu,Kai Ni,Chunliu Zhao,Changyu Shen
An optical fiber humidity sensor based on vernier effect of Fabry-Perot(F-P) interferometers constructed by microsphere and polyvinyl alcohol (PVA) film is proposed. A hollow capillary fiber (HCF) is spliced with the single-mode fiber (SMF), and the barium titanate ball is inserted into the HCF. A layer of PVA film is coated on the end face of the HCF to construct multiple F-P cavities, and two F-P cavities act as the reference cavity and sensing cavity. The lengths of the two cavities are relatively close to form the vernier effect. The experimental results show that the humidity sensitivity of the sensor is 0.316 nm/%RH in the range of 35 %RH-85 %RH. The fluctuation of the sensor in 60 min is less than 0.27 %RH. And the response time of the sensor is about 12 s. The sensor has the merits of high sensitivity, compact size and good stability.
研究领域:
光学传感
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材料科学
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产品关联
DOI
高影响因子
Science Advances
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2024
·Vol. 10
·期 26
·
IF 11.7
Ruifeng Luo,Jinwei Liu,Qian Cheng,Mitsuhiko Shionoya,Cheng Gao,Ruibing Wang
Oral medication for ulcerative colitis (UC) is often hindered by challenges such as inadequate accumulation, limited penetration of mucus barriers, and the intricate task of mitigating excessive ROS and inflammatory cytokines. Here, we present a strategy involving sodium alginate microspheres (SAMs) incorporating M2 macrophage membrane (M2M)–coated Janus nanomotors (denominated as Motor@M2M) for targeted treatment of UC. SAM provides a protective barrier, ensuring that Motor@M2M withstands the harsh gastric milieu and exhibits controlled release. M2M enhances the targeting precision of nanomotors to inflammatory tissues and acts as a decoy for the neutralization of inflammatory cytokines. Catalytic decomposition of H2O2 by MnO2 in the oxidative microenvironment generates O2 bubbles, propelling Motor@M2M across the mucus barrier into inflamed colon tissues. Upon oral administration, Motor@M2M@SAM notably ameliorated UC severity, including inflammation mitigation, ROS scavenging, macrophage reprogramming, and restoration of the intestinal barrier and microbiota. Consequently, our investigation introduces a promising oral microsphere formulation of macrophage-biomimetic nanorobots, providing a promising approach for UC treatment.
研究领域:
药学
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纳米技术
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胃肠病学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF LUMINESCENCE
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2020
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IF 3.28
Chao Zhang,Tingting Li,Weijia Wen,Xiangdong Luo,Lijuan Zhao
Perovskite-semiconductor composites formed by high quality CsPbBr 3 nanocrystals embedded in ZnSe microsphere were prepared. The optical properties of pure CsPbBr 3 and composites were studied in detailed. Highly enhanced luminescence from CsPbBr 3 -ZnSe composites was observed and the excitation power-dependent photoluminescence of samples showed that the recombination in all samples involves excitons . The recombination lifetimes of composites for both fast and slow decays increased compared with pure perovskite, indicating that the nonradiative combination was suppressed which may be possibly due to the decrease of both bulk and surface defects , owing to the passivation of ZnSe. Besides, the visible light absorption range of composites was extended, which suggests increasing efficiency of photoelectric conversion and the utilization of sunlight.
研究领域:
材料科学
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光学
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DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Yong Li,Lin Zhang,Ziyi Zhang,Tongdong Shen,Kun-Yi Andrew Lin,Shaoping Tong
Cobalt-magnesium oxide–carbon microsphere composite (Co-MgO-CMS), Cobalt-carbon nanosheet composite (Co-CNS), and magnesium oxide–carbon nanorod composite (MgO-CNR) were synthesized by the MOFs self-sacrificing template method. And they were used as the catalysts for catalytic ozonation of thiamphenicol (20 mg/L) in water at an initial pH of 7.0. The phase of Co-MgO-CMS is mainly composed of metallic cobalt, magnesium oxide and carbon according to X-ray diffraction and transmission electron microscopy analyses. Thiamphenicol removal efficiency is enhanced through Co-MgO-CMS catalytic ozonation (75.4 %, in 6 min), compared with those in ozonation alone (39.8 %), Co-CNS catalytic ozonation (43.2 %), MgO-CNR catalytic ozonation (65.1 %) and Mg-Co binary oxide (Mg 2 CoO y ) catalytic ozonation (69.0 %). Self-increasing of solution pH, protonated hydroxyl groups and electron transfer on metallic Co and lattice Co 2+ are advantageous for the ozone decomposition into reactive oxygen species in Co-MgO-CMS catalytic ozonation. Owing to the metallic Co in Co-MgO-CMS, the electron transfer ability of Co-MgO-CMS is better than that of Mg 2 CoO y according to the in situ electrochemical test. Moreover, electron transfers directly from metallic Co to ozone. While protonated hydroxyl groups are the key for electron transfer on lattice Co 2+ . A possible degradation pathway for thiamphenicol in Co-MgO-CMS catalytic ozonation is proposed according to the detected intermediates. This work provides insight into improvement on electron transfer ability of concerted acid-base catalyst in heterogeneous catalytic ozonation.
研究领域:
环境科学
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催化化学
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产品关联
DOI
高影响因子
Heliyon
·
2022
·
IF 3.776
Suwei Jiang,Hailiang Hu
In this paper, we explore the adsorption potential of catechin (CT) loaded composite microspheres and provide a new micron scale carrier of functional factor. Chitosan (CS) modified rice porous starch (RPS/CS) was used as a CT adsorption carrier to prepare bioactive CT-loaded composite microspheres (CT@RPS/CS). The adsorption kinetics, storage characteristics, and biological activity maintenance of CT@RPS/CS were studied in an aqueous solution, and the sustained-release characteristics of CT@RPS/CS were studied in vitro during simulated gastrointestinal digestion. An aqueous solution further studied the removal characteristics of adsorbed heavy metal ion Pb 2+ . RPS/CS can significantly improve the ability to adsorb CT. RPS/CS can also significantly improve CT's storage stability, antioxidant stress, and slow-release characteristics, and the sustained release effect in gastric and intestinal juice. CT@RPS/CS can be removed Pb 2+ by adsorbing in the solution, and their adsorption was physical adsorption and chemisorption, but the primary interaction is chemisorption. CT@RPS/CS can be used as a micron carrier of new food functional factors, which has potential space for improving and expanding the functional characteristics of its loaded functional factors and the endowing of new functions.
研究领域:
食品科学
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生物化学
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环境科学
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DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
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2021
·
IF 5.316
Yanguang Zhang,Jing Tian,Detong Tian,Weibing Li,Zhenze Liu,Fenghui Tian,Yuyu Bu,Shaoping Kuang
In order to solve the problem of low efficiency of existing photocatalyst in wastewater treatment, BiOCl and Bi x In y OCl solid solution photocatalysts with different indium element content were prepared by one-step solvothermal method. The solid solution of indium element greatly affects the porous structure and specific surface area of BiOCl, and the specific surface area of BiInOCl-0.5 is 9.26 times that of BiOCl, which provides abundant active sites for photocatalytic reaction. Furthermore, after indium element solid solution, the conduction band and valence band potentials of BiOCl shift towards negative and positive, respectively, enhancing the redox capacity of the photogenerated electrons and holes. Thus, BiInOCl shows excellent photocatalytic performances for reduction of Cr(VI), degradation of norfloxacin, dyes and even industrial cotton pulp wastewater. This provides a possibility for the practical application of photocatalytic technology in industrial wastewater treatment.
研究领域:
材料科学
·
环境科学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）