BIOLOGICAL & PHARMACEUTICAL BULLETIN
·
2026
·Vol. 49
·期 3
·525-537
·
IF 1.8
Tingting Zhang,Sirui Mo,Hongcheng Luo,Guangbin Ye,Qing Qin,Minli Jiang,Yingkai Wang,Jingjing Bi,Zhengmian Zhang,Zhongquan Qi
Multiple sclerosis is a chronic inflammatory disease characterized by demyelination in the central nervous system (CNS). The existing drugs for multiple sclerosis treatment carry significant side effects. The aim of this study was to investigate the safety and effect of a new compound N, N′-dicyclohexyl-N-linoleic acylurea (DCLAA) on experimental autoimmune encephalomyelitis (EAE), the principal multiple sclerosis animal model. Results showed that DCLAA had low toxicity, and DCLAA significantly inhibited the EAE progression and reduced the dosage requirements of methylprednisolone. After DCLAA treatment, the activation of microglia and astrocytes in the CNS was reduced. The expression of proinflammatory cytokines decreased, whereas the expression of anti-inflammatory cytokines increased. DCLAA reduced the number of peripheral T cells and CNS infiltration in EAE mice. Moreover, DCLAA attenuated the proliferation and induced the apoptosis of myelin oligodendrocyte glycoprotein (MOG)-specific T cells. These results indicate that DCLAA exhibit low toxicity and is able to alleviate the clinical symptoms of EAE by reducing neuroinflammation and suppressing the survival of peripheral T cells.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2018
·Vol. 30
·期 2
·1699-1705
·
IF 2.324
Teng Fei,Chen Dong,Ma Yuzhe,Ji Shaohua,Liu Jiaojiao,Wang Tianhua,Tang Jie,Cao Lifeng,Teng Bing
N,N -dimethylamino-4′-N′-methylstilbazolium 2,4,6-trimethylbenzenesulfonate (DSTMS)-graphene ex-situ and in-situ composite films with 2% concentration of graphene were first prepared and systematically investigated. The crystallinity of DSTMS-based composite films were confirmed by XRD analysis, and the functional groups of composite films can be obtained by FT-IR. Optical absorptions were recorded using UV–Vis-NIR spectral analysis, and the band gap and extinction coefficient of the films were calculated. The thermal stability of the composite films were analyzed by TG/DSC. The pressure sensitive resistance test showed that the pressure sensitive signal of the composite films were significantly increased after graphene added, while the signal of DSTMS film eventually disappears. This work expands the application of organic nonlinear crystal DSTMS in optics and electricity by doping graphene.
研究领域:
材料科学
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凝聚态物理
·
功能材料
·
非线性光学
·
纳米复合材料
·
电学性能
·
光学性能
·
热分析
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TOXICOLOGY AND APPLIED PHARMACOLOGY
·
2022
·
IF 4.46
Suizhi Cheng,Li Che,Qingqing Yang,Rongjing Sun,Yuhong Nie,Haoyue Shi,Yiwen Ding,Li Wang,Zuo Du,Zhenzhong Liu
N -methyl- N′ -nitro- N -nitrosoguanidine (MNNG) is a common alkylating agent , which can be experimentally used as a chemical mutagen and carcinogen, extensively existing in the environment. Folic acid (FA), part of the B group of vitamins, plays an important role in defending against inflammation and reducing the risk of cancers. Nevertheless, there is little research on the protective effects of FA against MNNG-induced esophageal inflammation, and its underlying mechanism still remains elusive. Hence, in the present study, we exposed MNNG to SD rats and esophageal cells to establish the esophageal inflammation models. Our research aims to explore the protective roles of FA against esophageal inflammation induced by MNNG via NF-κB pathway by CCK-8, EdU, RT-qPCR, ELISA , H&E, Western blot . Our results revealed that MNNG decreased the viability of esophageal cells, which was restored under FA intervention. Besides, FA relieved the elevation of IL-6, IL-8 and TNF-α in MNNG-induced esophageal inflammation. Moreover, histopathological analysis showed that epithelial spinous cells proliferated in mucous layer, and inflammatory cells were locally infiltrated in the submucosa after MNNG exposure, while the pathological damage of esophageal tissues was gradually alleviated along with increasing FA doses. And Western blot results demonstrated that FA could relieve the rise of phosphorylated IκBα (p-IκBα) and phosphorylated p65 (p-p65) proteins induced by MNNG. Therefore, it is reasonable to believe that FA has a crucial role in preventing MNNG-induced esophageal inflammation through inhibiting the NF-κB pathway, thereby down-regulating the expressions of IL-6, IL-8 and TNF-α.
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JOURNAL OF HAZARDOUS MATERIALS
·
2022
·
IF 14.224
Linlu Shen,Zhonglin Chen,Jing Kang,Pengwei Yan,Jimin Shen,Binyuan Wang,Shengxin Zhao,Lanbo Bi,Shuyu Wang,Yizhen Cheng
This study found that peroxymonosulfate (PMS) oxidation without activation has the potential to generate a suspected human carcinogen, N-nitrosodimethylamine (NDMA), in water containing N,N-dimethylhydrazine compounds. Considerable amounts of NDMA formed from three compounds by PMS oxidation were observed. 1,1,1′,1′-Tetramethyl-4,4′-(methylene-di-p-phenylene) disemicarbazide (TMDS), which is an industrial antiyellowing agent and light stabilizer, was used as a representative to elucidate the kinetics, transformation products , mechanism and NDMA formation pathways of PMS oxidation. TMDS degradation and NDMA formation involved direct PMS oxidation and singlet oxygen ( 1 O 2 ) oxidation. The oxidation by PMS/ 1 O 2 was pH-dependent, which was related to the pH-dependent characteristics of the reactive oxygen species and intermediates. The degradation mechanism of TMDS mainly included the side chain cleavage, dealkylation, and O-addition. NDMA was generated from TMDS mainly via O-addition and 1,1-dimethylhydrazine (UDMH) generation. The cleavage of amide nitrogen in O-addition products and primary amine nitrogen in UDMH are likely the key steps in NDMA generation. The results emphasized that the formation of harmful by-products should be taken into account when assessing the feasibility of PMS oxidation.
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MOLECULES
·
2024
·Vol. 29
·期 16
·3812
·
IF 4.2
Yongwei Li,Zhihao Fang,Lijuan Feng,Fangfang Liu,Yucui Shi,Jiao Li,Chao Zhao
A series of Zr-TiO2catalysts were prepared using a facile sol-gel method and were used for N-methylmorpholine (NMM) oxidation to N-methylmorpholine-N-oxide (NMMO). The structure features of Zr-TiO2catalysts were studied in detail through a variety of characterization methods, such as XRD, SEM, N2adsorption-desorption isotherms, XPS, EPR, and O2-TPD. As-obtained 5%Zr-TiO2catalysts had superior catalytic performance and stability with a 97.6% NMMO yield at 40 °C, which related to Zr doping, a higher surface area, more oxygen vacancies, and oxygen chemisorption on the catalytic surface. This work provides an efficient preparation strategy of TiO2-based catalysts for selective oxidation reactions by a facile method.
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MINERALS ENGINEERING
·
2021
·
IF 4.765
Huiqi Duan,Xiaoping Huang,Xiaoyu Cao,Zhanfang Cao,Hong Zhong,Jianxian Zeng,Hu Zhou,Jianrong Xue,Yuan Liu
Flotation collectors with strong collecting ability and superior selectivity have important application prospects for recovering complex and refractory copper sulfide resources. Herein, a novel surfactant of N-benzoyl-N’,N’-diethyl thiourea (BDETU) with C O and C S groups is synthesized for separation of chalcopyrite and pyrite. The flotation performance and adsorption mechanism of BDETU to chalcopyrite and pyrite were evaluated by flotation experimental, adsorption experimental, contact angle measurements, UV–vis spectroscopy, as well as FTIR analyses and DFT calculation. By comparing the flotation performances with the traditional flotation collector of O-isopropyl-N-ethyl thionocarbamate (IPETC), it becomes evident that BDETU exhibit stronger collecting ability and excellent selectivity for chalcopyrite against pyrite. These results might be attributed to the facts that BDETU can selectively adsorb on the surface of chalcopyrite and strengthen its surface hydrophobicity, while the hydrophobicity of pyrite surface is not improved with the weak adsorption of BDETU on its surface. The analyses of adsorption mechanism reveal that BDETU is chemically adsorbed on the surface of chalcopyrite by the reactions of the functional groups (C O and C S) to the copper species with the formation of C O Cu and C S Cu structures.
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ACS Omega
·
2026
·
IF 4.3
Bingjie Chen,Zhenrun Wu,Qingbo Zhu,Hong Wang,Shuai Yuan,Arlan Z. Abilmagzhanov,Svetlana A. Tungatarova,Xingcai Lu,Zhandong Wang
C7–C10 aromatics are indispensable components of aviation fuels to meet the swelling need for sealing rings in aero engines. Aromatics with a short and single substituent have weak low-temperature reactivity, yet this may be enhanced under a fuel blend environment. In this work, we investigated low-temperature oxidation chemistry of n-propylbenzene, a representative C9 aromatic in a blend with n-heptane, in a jet-stirred reactor. Time-of-flight molecular beam mass spectrometry using synchrotron vacuum ultraviolet radiation as a photon ionization source was used for product analysis and species identification. Thirty-six species were identified by comparison of measured photoionization efficiency curves and calculated species ionization energies, and six of them are key reaction intermediates of n-propylbenzene oxidation. Kinetic model simulations captured the measured mole fractions of reactants, main products, and intermediates with some discrepancies. Furthermore, many oxygenated aromatics are missing in the model, reflecting insufficient understanding of n-propylbenzene low-temperature chemistry. Low-temperature oxidation pathways were proposed based on molecular structures of reaction intermediates. This work explored low-temperature oxidation of n-propylbenzene under a fuel blend environment, which might be useful to unravel the low-temperature chemistry of C7–C10 aromatics in practical jet fuels.
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JOURNAL OF CHEMICAL THERMODYNAMICS
·
2016
·
IF 2.196
Maogang He,Sanguo Peng,Ying Zhang,Shi Zhang,Xiangyang Liu
The mutual diffusion coefficients of isopropanol + n-heptane and isobutanol + n-heptane were measured at different concentrations and in the temperature range from (283.15 to 323.15) K. The measurements were carried out using a digital holographic interferometry system. For all the mixtures investigated, the mutual diffusion coefficient increases as the temperature increases. At the same concentration and temperature, the mutual diffusion coefficients of isobutanol + n-heptane were lower than those of isopropanol + n-heptane due to the fact that the molecular weight of isobutanol is larger than that of isopropanol. A new correlation is proposed for the mutual diffusion coefficients of isopropanol + n-heptane and isobutanol + n-heptane. The absolute average relative deviation between the correlation and experiment is less than 1.90%.
研究领域:
热力学
·
化学工程
·
物理化学
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ACS Biomaterials Science & Engineering
·
2018
·
IF 4.432
Rong Bai,Jing Kang,Oudjaniyobi Simalou,Wenxin Liu,Hui Ren,Tianyi Gao,Yangyang Gao,Wanjun Chen,Alideertu Dong,Ran Jia
N-Halamine compounds have attracted great attention because they are recognized as promising antibacterial agents to control microbial contamination; however, most of the research interests were focused on N-halamines that contain N–Cl bond(s) rather than N–Br bond(s). In this contribution, we report the facile fabrication of N–Br bond-containing N-halamine nanofibers using the electrospinning method for antibacterial usages. The as-produced N–Br bond-containing N-halamine nanofibers (i.e., DBDMH/PAN nanofibers) comprise an antibacterial component of 1,3-dibromo-5,5-dimethylhydantoin (DBDMH) and a support component of polyacrylonitrile (PAN). When systematic characterizations were carried out, the as-obtained DBDMH/PAN nanofibers were proven to exhibit well-defined fiber-like morphology and be highly efficient in the killing of the selected model bacteria (Escherichia coli). Their morphology and size could be well governed by tuning the concentration of electrospinning precursor and the mass ratio of PAN to DBDMH. The antibacterial mechanism of the DBDMH/PAN nanofibers and their stabilities under dry, wet, and bacterial conditions were confirmed as well. Facile synthesis and antibacterial activity allow the feasibility of the final N–Br bond-containing N-halamine nanofibers for antibacterial-related clinical applications in practice. Our work highlights the development of the N–Br bond-containing N-halamine nanofibers as promising antibacterial agents for biomedical applications.
研究领域:
材料科学
·
抗菌材料
·
纳米技术
·
生物医学工程
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JOURNAL OF PHYSICAL CHEMISTRY B
·
2019
·
IF 2.923
Xueqian Guan,Zhiyu Huang,Hongsheng Lu,Dejun Sun
Binary mixtures of water and organic solvents are described as the aqueous solutions of organic solvents, which are usually spatially heterogeneous on the scale of a few molecular sizes but homogeneous on longer length scales, that is, microheterogeneity. For the water–organic solvent binary mixtures with microheterogeneity, most organic solvents are miscible with water at any ratio. Interestingly, some slightly water-miscible organic solvents can also be used to prepare binary mixtures with microheterogeneity. In this study, N,N-dimethylcyclohexylamine (DMCHA) was used to prepare binary mixtures with microheterogeneity and CO2 switchability. With the help of conductivity, Fourier–transform infrared spectroscopy, ultraviolet–visible spectroscopy, and dynamic light scattering measurements, we found that water molecules are hydrogen-bonded together to form clusters over the water content range of 9 to 27 wt %, exhibiting microheterogeneity in the binary mixture. The size of the water clusters increases slightly with increasing water content. What is more, the DMCHA–water mixtures can be reversibly split into two phases by alternate bubbling of CO2 and N2, exhibiting excellent CO2 switchability. The binary mixtures can be used as reaction media for the synthesis of CaCO3 nanoparticles. Binary mixtures with microheterogeneity can also be formed under high salinity or high temperature conditions or be prepared using other slightly water-miscible organic solvents, opening up more interesting possibilities for binary mixtures with microheterogeneity.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Xueli Zhou,Qingyuan Song,Jing Chen,Chunhong Chen,Yuhuan Chen,Fang Yang
Blended amine mixtures show great superiorities in CO 2 absorption capacity and energy efficiency. This work focuses on the absorption-desorption performance of CO 2 capture by mixed amine solutions based on N, N-diethylethanolamine (DEEA). Four bi-solvent blends consisting of DEEA and 2-amino-2-methyl-1-propanol (AMP)/1-(2-hydroxyethyl) piperazine (HEPZ)/1-ethylpiperazine (N-1EPZ)/piperazine (PZ) are studied. The CO 2 loading, absorption rate, average absorption rate, desorption loading, average desorption rate, desorption efficiency and relative heat duty are comprehensively investigated to explore the performance of blended absorbents. Experimental investigations on concentration reveal that blended 20 wt% DEEA +10 wt% PZ solution demonstrates outstanding CO 2 equilibrium loading, absorption rate and average absorption rate, and 20 wt% DEEA +10 wt% AMP system exhibits excellent CO 2 desorption performance. The average desorption rate, desorption loading and desorption efficiency increase by 91.47 %, 91.09 % and 122.30 % in contrast to the single amine solution, i.e. aqueous 30 wt% MEA, respectively. Therefore, mixed amine solutions can largely reduce the energy requirement for CO 2 regeneration, which confirms blended amine mixtures are energy-efficient. Additionally, 13 C NMR and FT-IR spectra are conducted to elucidate the mechanism of DEEA-based mixed amine systems for CO 2 capture.
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ACTA PHYSICO-CHIMICA SINICA
·
2013
·Vol. 29
·期 10
·2157-2161
·
IF 0.869
LI Chang-Ping,LI Zhuo,ZOU Ben-Xue,LIU Qing-Shan,LIU Xiao-Xia
The density, viscosity, and conductivity of protic ionic liquid (PIL) N,N-dimethylethanolammonium propionate (DMEOAP) were determined in the temperature range of 283.15-333.15 K. The influence of temperature on density, viscosity, and conductivity is discussed. The thermal expansion
coefficient, molecular volume, standard molar entropy, and lattice energy of DMEOAP were calculated using empirical and semiempirical equations. The molar conductivity of DMEOAP was determined fromdensity and conductivity data. The temperature dependence of viscosity and conductivity data
was fitted using the Vogel-Fulcher-Tammann (VFT) equation. The relationship between molar conductivity and viscosity was determined by the Walden rule.
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