ACS Nano
·
2019
·
IF 13.903
Wuyang Yu,Tao Liu,Mingkang Zhang,Zixu Wang,Jingjie Ye,Chu-Xin Li,Wenlong Liu,Runqing Li,Jun Feng,Xian-Zheng Zhang
Hypoxia, a ubiquitously aberrant phenomenon implicated in tumor growth, causes severe tumor resistance to therapeutic interventions. Instead of the currently prevalent solution through intratumoral oxygen supply, we put forward an “O2-economizer” concept by inhibiting the O2 consumption of cell respiration to spare endogenous O2 and overcome the hypoxia barrier. A nitric oxide (NO) donor responsible for respiration inhibition and a photosensitizer for photodynamic therapy (PDT) are co-loaded into poly(d,l-lactide-co-glycolide) nanovesicles to provide a PDT-specific O2 economizer. Once accumulating in tumors and subsequently responding to the locally reductive environment, the carried NO donor undergoes breakdown to produce NO for inhibiting cellular respiration, allowing more O2 in tumor cells to support the profound enhancement of PDT. Depending on the biochemical reallocation of cellular oxygen resource, this O2-economizer concept offers a way to address the important issue of hypoxia-induced tumor resistance to therapeutic interventions, including but not limited to PDT.
研究领域:
肿瘤学
·
生物医学工程
·
治疗学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2019
·
IF 4.084
Kaifeng Wang,Qi Wu,Xiaoming Yan,Jiafei Liu,Li Gao,Lei Hu,Ning Zhang,Yu Pan,Wenji Zheng,Gaohong He
High-performance anion exchange membranes (AEMs) are in need for practical application of AEM fuel cells. Novel branched poly(ether ether ketone) (BPEEK) based AEMs were prepared by the copolymerization of phloroglucinol , methylhydroquinone and 4,4′-difluorobenzophenone and following functionalization. The effects of the branched polymer structures and functional groups on the membrane's properties were investigated. The swelling ratios of all the membranes were kept below 15% at room temperature and had good dimensional stability at elevated temperatures. The branching degree has almost no effect on the dimensional change, but plays a great role in tuning the nanophase separation structure. The cyclic ammonium functionalized membrane showed a lower conductivity but a much better stability than imidazolium one. The BPEEK-3-Pip-53 membrane with the branching degree of 3% and piperidine functionalization degree of 53% showed the best performances. The ionic conductivity was 43 mS cm −1 at 60 °C. The ionic conductivity in 1 M KOH at 60 °C after 336 h was 75% of its initial value (25% loss of conductivity), and the IEC was 83% of its initial value (17% loss of IEC), suggesting good alkaline stability. The peak energy density (60 °C) of the single H 2 /O 2 fuel cell with BPEEK-3-Pip-53 membrane reached 133 mW cm −2 at 260 mA cm −2 .
研究领域:
材料科学
·
能源技术
✓ 已验证
产品关联
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2022
·
IF 7.392
Mengmeng Ni,Lihong Wang,Yao Chai,Bing Wang,Dongmiao Li,Jinni Shen,Zizhong Zhang,Xuxu Wang
The photocatalytic conversion of CO 2 and H 2 O into a series of value-added products is regarded as an important way to mimic natural photosynthesis for solar harvesting. Herein, we prepared CsBi 2 Ta 5 O 16 with a cubic pyrochlore structure via high-temperature molten salt method as a photocatalyst for the first time. The NiO-loaded CsBi 2 Ta 5 O 16 composites could efficiently photocatalyze the conversion of CO 2 into CH 4 and CO, and oxidize H 2 O to O 2 . With 10 wt% NiO loading, the highest yield of CH 4 (7.24 μmol g −1 h −1 ) and O 2 (3.59 μmol g −1 h −1 ) could be achieved. The adsorption and activation of CO 2 molecule on NiO can be attributed to the enhanced CO 2 photocatalytic conversion by the NiO-loaded CsBi 2 Ta 5 O 16 composites. This work provides a design idea of photocatalyst for the full reaction of CO 2 with H 2 O.
研究领域:
材料科学
·
环境科学
·
化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2018
·Vol. 165
·期 5
·A757
·
IF 3.662
Shijia Mu,Ding Zhu,Wei Liu,Shengrong Cai,Kaifang Zhang,Yungui Chen
Due to the sluggish oxygen reduction reaction (ORR) process of an O2 cathode, the power delivery of aprotic Li-O2 batteries (A-LOBs) is widely considered to be very poor. However, this work demonstrates the transient high-power output of A-LOBs based on the capacitive feature of the O2 cathode, including the intrinsic capacitance of cathode material and the ORR pseudocapacitance of the absorbed O2 on the cathode surface, by using graphene with high specific surface area. The O2 cathode delivers a high specific power of 12 026 W kggraphene−1 while also providing a large specific energy of 1216 Wh kggraphene−1. Pulse-discharge tests show that A-LOBs can achieve the transient high power output at high current via the "capacitor-type", while maintaining the high energy output at low current due to the "battery-type" (ORR). This work indicates that A-LOBs can deliver both high energy density and high transient power, which may be an appeal for the next-generation electric vehicles.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
FUEL PROCESSING TECHNOLOGY
·
2017
·
IF 3.752
Ting Lu,Yucui Hou,Weize Wu,Muge Niu,Yupeng Wang
Direct conversion of raw biomass to fine chemicals is of significant conceptual and practical interest. Up to now, the direct conversion of raw biomass to fine chemicals is still a big challenge. The oxidation of biomass to formic acid (FA) and acetic acid (AA) is a promising industrial process in the future. In this work, we reported that a binary catalyst system of Keggin-type heteropoly acid H 5 PV 2 Mo 10 O 40 + H 2 SO 4 was efficient to directly convert corn cob , a highly abundant renewable agricultural waste, to FA and AA using O 2 as the oxidant in aqueous solutions. The effects of catalyst amount, H 2 SO 4 concentration, reaction temperature, reaction time and initial O 2 pressure on the conversions of corn cob were investigated. Under optimized reaction conditions, corn cob was transformed with a FA yield of 42.5% and an AA yield of 9.1% (based on carbon) after 30 min of reaction at 170 °C. In the oxidation, the pH of the aqueous solution plays a key role. The influences of pH on solid degradation, reaction pathway and oxidation of the components of corn cob were discussed. Hemicellulose is oxidized rapidly followed by partly oxidation of lignin, and cellulose is the most difficult converted part. Products FA and AA mainly come from polysaccharides (hemicellulose and cellulose) and pH has a major influence on cellulose. The recycling of the catalyst system is demonstrated and shows good reusability .
研究领域:
生物化学
·
可再生资源利用
✓ 已验证
产品关联
DOI
高影响因子
Small
·
2022
·Vol. 18
·期 15
·2107467
·
IF 15.153
Jia-Qi Huang,Lin-Ping Zhao,Xiang Zhou,Ling-Shan Liu,Rong-Rong Zheng,Fu-An Deng,Yi-Bin Liu,Xi-Yong Yu,Shi-Ying Li,Hong Cheng
Abnormal tumor metabolism causes the hypoxic microenvironment, which greatly limits the efficacy of photodynamic therapy (PDT). In this work, a strategy of metabolic reprogramming is proposed to economize O 2 for enhanced PDT against hypoxic tumors. The carrier-free O 2 -economizer (designated as LonCe) is prepared based on the metabolic antitumor drug of Lonidamine (Lon) and the photosensitizer of chlorin e6 (Ce6). By virtue of intermolecular interactions, Lon and Ce6 self-assemble into nanosized LonCe with favorable stability and high drug contents. Compared with Ce6, LonCe exhibits an improved cellular uptake and photodynamic property for tumor treatment. Moreover, LonCe is capable of inhibiting cell metabolism and mitochondrial respiration to remit the tumor hypoxia, which would promote reactive oxygen species (ROS) production and elevate the PDT efficacy on tumor suppression. In vivo experiments indicate that intravenously injected LonCe prefers to accumulate at the tumor site for highly efficient PDT regardless of the hypoxic environment. Besides, the self-delivery LonCe is fabricated without any carriers, which avoids the excipients induced system toxicity and immunogenicity in vivo. This carrier-free nanomedicine with cell respiratory inhibition mechanism would expedite the development and clinical translation of photodynamic nanoplatforms in tumor treatment.
研究领域:
肿瘤学
·
药理学
·
纳米技术
·
治疗学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Therapeutics
·
2023
·Vol. 6
·期 4
·2200237
·
IF 4.6
Yan-Mei Li,Xiang Zhou,Xin-Yu Li,Jia-Qi Huang,Zi-Wen Qiu,Ren-Jiang Kong,Ni Yan,Shi-Ying Li,Hong Cheng
Oxygen-dependent photodynamic therapy (PDT) holds unique advantages on tumor treatment by inducing cell apoptosis, but it is often limited owing to the unfavorable tumor microenvironments. In this study, a self-delivery O 2 -ecomonizer (designated as CeTam) is prepared to relieve hypoxia and reverse antiapoptotic pathway for enhanced photodynamic tumor therapy. Based on Chlorin e6 (Ce6) and Tamoxifen (Tam), CeTam is assembled through intermolecular hydrophobic interaction without any vehicles. Nanosized CeTam has an enhanced stability and improved drug delivery efficiency, which prefers to accumulate at tumor tissue for effective cellular uptake. More importantly, CeTam can effectively inhibit mitochondrial respiration to relieve hypoxia and reduce Bcl-2 expression to reverse antiapoptotic pathway. As a result, this self-delivery O 2 -ecomonizer successfully regulates the unfavorable tumor microenvironments to enhance the PDT efficacy on tumor elimination. Taken together, this work reports a multifunctional nanoplatform by a simple self-assembly strategy to remedy the deficiencies of PDT on hypoxic tumor treatment, which can advance the development of individualized biomedicine for precise tumor therapy.
研究领域:
癌症治疗
·
药理学
·
纳米技术
·
分子生物学
✓ 已验证
产品关联
DOI
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2023
·
IF 22.1
Xinjian Li,Yanhui Su,Yong Ma,Le Wei,Ying He,Yuting Gu,Shiwei Mei,Qiaoqiao Mu,ChengYuan Peng,Yang Peng,Zhao Deng
Photo-assisted charge/discharge has witnessed marked success in Li-O 2 batteries (LOBs) to overcome the sluggish kinetics of triphasic reactions at the cathode, but challenges remain to develop high-efficiency but low-cost photocathode catalysts. Herein, a photoactive electron mediator is applied, for the first time, as bifunctional photocathode catalyst in solar-assisted LOBs. The facilely synthesized tris(2,2-bipyridine) cobalt(II) complex (Co-bpy) manifests good electrocatalytic activity in dark and high photoactivity under illumination, concertedly affording an superior charge/discharge voltage gap of 0.12 V and round-trip efficiency of 97%. Moreover, a significantly enhanced charge/discharge reversibility was attained under illumination and attributed to the light-induced amorphization of Li 2 O 2 that further extends the cycle life. A two-circuit model is proposed to rationalize the better reduction of charge/discharge polarization at lower operating current density. This work not only extends the family of photocathode catalysts to small-molecule complexes, but also offers new insights into the mechanism of photoenergy storage in LOBs.
研究领域:
材料科学
·
电化学
·
能源存储
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2022
·
IF 10.383
Hanhao Huang,Yulian Shang,Haofei Li,Qi Feng,Yang Liu,Junlin Chen,Hua Dong
Pancreatic islets transplantation is an optimal alternative to exogenous insulin injection for long-term effective type 1 diabetes treatment. However, direct islets transplantation without any protection can induce cell necrosis due to severe host immune rejection. Insufficient O2 supply induced by the lack of capillary network at the early stage of islets transplantation is another critical constraint limiting islets survival and insulin-secretion function. In this paper, we design a novel co-transplantation system composed of islets-laden nanocomposite microgels and O2-generating microspheres. In particular, nanocomposite microgels confer the encapsulated islets with simultaneous physical protection and chemical anti-inflammation/immunosuppression by covalently anchoring rapamycin-loaded cyclodextrin nanoparticles to microgel network. Meanwhile, O2-generating microspheres prepared by blending inorganic peroxides in biodegradable polycaprolactone and polylactic acid can generate in situ O2 gas and thus avoid hypoxia environment around transplanted islets. In vivo therapeutic effect of diabetic mice proves the reversion of the high blood glucose level back to normoglycemia and superior glucose tolerance for at least 90 days post co-transplantation. In brief, the localized drug and oxygen codelivery, as well as physical protection provided by our co-transplantation system, has the potential to overcome to a large extent the inflammatory, hypoxia, and host immune rejection after islets transplantation. This new strategy may have wider application in other cell replacement therapies.
研究领域:
生物医学工程
·
药学
·
糖尿病研究
·
细胞治疗
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Catalysis Science & Technology
·
2023
·Vol. 14
·期 1
·83-89
·
IF 5
Yong Tang,Jianhao Qiu,Dingliang Dai,Guanglu Xia,Lu Zhang,Jianfeng Yao
Defect engineering has recently received much attention as an effective approach for improving photocatalytic performances. Herein, UiO-66-NH2 with missing ligand defects (DUiO-66-NH2) wrapped by ZnIn2S4 was investigated for photocatalytic H2O2 production under visible light. The defects in DUiO-66-NH2 enable efficient charge separation and O2 capture, which are the key factors in accelerating H2O2 production. Specifically, the O2 adsorption capacity over ZnIn2S4/DUiO-66-NH2 was improved by a factor of 3.1 as compared to its counterpart without defects. As a result, in ambient air and pure water without any sacrificial agents, the H2O2 yield of ZnIn2S4/DUiO-66-NH2 was 340 μmol L−1, which was significantly higher than that of ZnIn2S4/UiO-66-NH2 (150 μmol L−1). The main H2O2 formation pathway over ZnIn2S4/DUiO-66-NH2 is an indirect oxygen reduction reaction with ·O2− as the intermediate, and the defects in UiO-66-NH2 could act as active sites to adsorb and activate O2 to produce ·O2−. However, the H2O2 generation over ZnIn2S4/UiO-66-NH2 undergoes both indirect and direct oxygen reduction reactions. This work could provide new insights and inspire further research into defect engineering of MOFs and photocatalytic H2O2 synthesis.
✓ 已验证
产品关联
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2023
·
IF 5.2
Bo Ma,Zhiqin Wen,Jiedong Qin,Zhenyu Wu,Junxiao Liu,Yunming Lv,Junjie Yu,Yuhong Zhao
In this work, single-phase (Ce 0.2 Zr 0.2 La 0.2 Sm 0.2 Nd 0.2 )O 2-δ high-entropy fluorite oxides (HEFOs) were successfully prepared by conventional solid-phase reaction method and crystal structure and microstructure were studied in-depth. Single-phase (Ce 0.2 Zr 0.2 La 0.2 Sm 0.2 Nd 0.2 )O 2-δ is formed at 1600 °C for 12 h, and five cationic elements are uniformly distributed without any segregation at the micrometer and nanometer scales. And the XRD patterns with Rietveld refinement reveal the formation of single-phase fluorite structure of (Ce 0.2 Zr 0.2 La 0.2 Sm 0.2 Nd 0.2 )O 2-δ . The SAED patterns on the [0 1 ‾ 1] band axes are similar to the diffraction patterns of face-centered cubic fluorite structure, and the standard deviation of the cation radius (coordination VIII) distribution of the specimens is 0.1277, which is again identified as forming a single-phase fluorite structure. The bulk specimens are solid compacts free of obvious cracks with randomly distribution porosity at a rare level, and the powder specimens are irregular fragmented shapes with an average particles size of 5.41 μm. The average cation radius and interplanar spacings becomes larger compared with standard fluorite structure of CeO 2 due to the cation radius of La 3+ , Sm 3+ and Nd 3+ are larger than that of Ce 4+ , leading to an increase in lattice parameters of the HEFOs. In addition, the concentration of Ce 3+ in the Ce cation is only 8.1 %, and the δ -value is calculated to be 0.3081 based on the content of all cations per mole of the substance, which indicates that the composition of the prepared specimen is (Ce 0.2 Zr 0.2 La 0.2 Sm 0.2 Nd 0.2 )O 1.6919 .
研究领域:
材料科学
·
无机化学
✓ 已验证
产品关联
DOI
高影响因子
Nature Communications
·
2024
·Vol. 15
·期 1
·1-10
·
IF 14.7
Fan Yamei,Li Rongtan,Wang Beibei,Feng Xiaohui,Du Xiangze,Liu Chengxiang,Wang Fei,Liu Conghui,Dong Cui,Ning Yanxiao,Mu Rentao,Fu Qiang
Sintering of active metal species often happens during catalytic reactions, which requires redispersion in a reactive atmosphere at elevated temperatures to recover the activity. Herein, we report a simple method to redisperse sintered Cu catalysts via O 2 -H 2 O treatment at room temperature. In-situ spectroscopic characterizations reveal that H 2 O induces the formation of hydroxylated Cu species in humid O 2 , pushing surface diffusion of Cu atoms at room temperature. Further, surface OH groups formed on most hydroxylable support surfaces such as γ-Al 2 O 3 , SiO 2 , and CeO 2 in the humid atmosphere help to pull the mobile Cu species and enhance Cu redispersion. Both pushing and pulling effects of gaseous H 2 O promote the structural transformation of Cu aggregates into highly dispersed Cu species at room temperature, which exhibit enhanced activity in reverse water gas shift and preferential oxidation of carbon monoxide reactions. These findings highlight the important role of H 2 O in the dynamic structure evolution of supported metal nanocatalysts and lay the foundation for the regeneration of sintered catalysts under mild conditions.
研究领域:
催化
·
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）