American Journal of Nuclear Medicine and Molecular Imaging
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2022
·
IF 0
Ying Ding,Du Zhang,Min Wang,Li Zhang,Yu Liu,Yinqian Deng,Dawei Jiang,Yuqing Liu,Wei Cao
Positron emission tomography (PET) can accurately locate and quantify radioactivity over traditional single photon emission computed tomography (SPECT), encouraging its application in kidney function evaluation and glomerular filtration rate (GFR) measurement. 68 Ga-ethylenediamine-tetraacetic acid ( 68 Ga-EDTA) is a novel PET tracer for renal scan but a mature GFR calculation method still pending establishment. Herein, we aim to investigate the imaging performance of 68 Ga-EDTA dynamic PET in healthy C57BL/6 mice, establish quantitative methods to calculate GFR, and evaluate its feasibility in mice with kidney dysfunction. Dynamic PET of 68 Ga-EDTA successfully visualized the whole process of tracer elimination. GFR values were measured by the integral method (253.80±40.11 μL/min) and the Patlak Plot method (22.69±9.75 μL/min), while blood clearance rate of the tracer was found at 787.46±70.86 μL/min. The PET-based GFR values correlate well with the GFR blood (R 2 =0.7468, R 2 =0.8793). The Integral method provides better accuracy than Patlak Plot method. Further application of GFR measurement in kidney-diseased mice proves better performance of the Integral method for defining split renal function.
研究领域:
医学成像
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核医学
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肾脏生理学
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PubMed
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
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2026
·
IF 5.2
Bo Mei,Qichao Zhao,Ruifeng Xue,Xiangxi Meng,Yijun Zhou,Zhi Yang,Lei Xia
Although molecular imaging in nuclear medicine has made remarkable progress, the development of tumor-targeted magnetic resonance imaging (MRI) contrast agents based on tumor-cell–specific targets remains a major challenge. Conventional non-targeted gadolinium chelates such as Gd-DTPA are widely used in clinical MRI but often require high doses to achieve diagnostically meaningful enhancement, and their performance is constrained by modest relaxivity and the lack of tumor-targeting capability. Attempts to introduce targeting ligands onto small-molecule gadolinium complexes may increase molecular complexity, alter pharmacokinetics, and raise biosafety concerns. Meanwhile, superparamagnetic iron oxide nanoparticles have been explored as alternative MRI agents due to their high magnetic sensitivity, yet metal deposition, biodegradation, and long-term retention toxicity continue to hinder clinical translation. Current prostate-specific membrane antigen (PSMA)-targeted PET tracers enable highly sensitive lesion detection, yet a corresponding PSMA-targeted MRI agent capable of providing high-resolution anatomical and functional information is still lacking. Therefore, constructing a true PET–MRI dual-modality nanoplatform is expected to overcome the spatial-resolution limitations of PET alone while compensating for the insufficient molecular specificity of conventional MRI contrast agents. In this study, we developed a novel multifunctional organic nanoplatform based on natural melanin nanoparticles (MNPs). By simply integrating nanocarriers, imaging moiety and targeting ligands within one system, a PSMA-targeted MRI contrast agent was obtained. The PSMA ligand was covalently conjugated onto the surface of PEG-modified MNPs, while large numbers of paramagnetic Gd 3+ ions were chelated/adsorbed onto the melanin scaffold, yielding prostate-cancer-targeted PSMA-GMNs. The hydrodynamic diameters of MNPs and PSMA-GMNs were 3.56 ± 2.09 nm and 15.74 ± 1.63 nm, respectively. PSMA-GMNs exhibited a T 1 -enhancing effect more than five-fold stronger than that of Gd-DTPA in vitro . In vivo MRI demonstrated a high T 1 -weighted signal within LNCaP tumors at 4 h and 24 h post-intravenous administration. Furthermore, 64 Cu-labeled PSMA-GMNs achieved peak tumor uptake at 16 h (SUVmax = 4.24 ± 0.50), indicating sustained PSMA-mediated internalization and prolonged tumor retention. The successfully constructed 64 Cu-PSMA-GMN s achieve functional complementarity between the high-sensitivity molecular detection of PET and the high-resolution anatomical visualization of MRI within a single nano-platform. This work addresses the current lack of prostate-cancer-specific MRI contrast agents and the separation of PET and MRI molecular information in clinical practice.
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高影响因子
MACROMOLECULAR CHEMISTRY AND PHYSICS
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2023
·
IF 2.5
Zhe Xu,Wang Yin,Yong Guan,Meidong Lang
Polyethylene terephthalate (PET) is a widely used plastic, but its short service life and non-degradable features make it a major source of white pollution. In this context, the efficient recycling and rational reuse of PET have become a global research priority. In this paper, a deep eutectic solvent（DES）is prepared using methylurea and zinc chloride to catalyze the efficient PET glycolysis, which produces a high purity product bis(2-hydroxyethyl) terephthalate (BHET), in 83.75% of yield. The product is condensed with diethyl adipate to produce Poly (ethyleneadipate-co-terephthalate) (PEAT). The relationships between the structural, thermal, mechanical, and degradation properties of PEAT with different intrinsic viscosities and composition ratios are studied. The addition of benzene ring improves the thermal properties and tensile strength of PEAT, but also makes them stiffer and less degradable. An increase in intrinsic viscosity can improve the thermal and mechanical properties to some extent but has little effect on the degradation. In general, the PEAT produced by the above process has good thermal properties, controllable degradation properties, and better mechanical properties than Poly (butyleneadipate-co-terephthalate) (PBAT). This work achieves the conversion of waste PET to high value-added PEAT and has potential development prospects in recycling of PET.
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高影响因子
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
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2019
·
IF 4.978
Que Kong,Zhiguang Li,Zuoliang Zhang,Xuehong Ren
In this paper, silica dioxide nanoparticles (SiO 2 ) were synthesized and functionalized with n -octadecyltriethoxysilane (OD) through a modified Stöber method for the preparation of organic–inorganic hybrid micro-nanoparticles. Organic–inorganic hybrid micro-nanoparticles were applied onto the polyester (PET) fabric via a conventional “dipping–drying” process for the fluoro-free water-repellent textile materials. The coated PET fabric surface showed micro/nano-structures and exhibited hydrophobic behavior with water contact angle of 141°. The surface morphologies, surface chemical composition and contact angles of the coated fabrics surface were measured. Furthermore, the dynamic hydrophobic behavior of water droplet impact on the fabric was investigated. By analyzing the energy change, D(t)/D 0 value and H(t)/D 0 value during water droplet impact were measured. The water droplet showed an obvious effect of the dynamic rebound behavior on the coated fabric surface, further confirming that the coated PET fabric had hydrophobicity. After the rubbing and washing durability, mechanical and chemical stability treatment, the coated PET fabrics still maintained high hydrophobicity and displayed good water-repellent durability. Last but not least, PET hydrophobic fabrics exhibited excellent self-cleaning properties with dyes on the fabric surface.
研究领域:
材料科学
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纺织工程
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高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2016
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IF 3.782
Yanfang Wang,Jian Shen,Jiang Yuan
Zwitterionic surface has been proven to be a good candidate for improving hemocompatible and antibiofouling properties. However, it can only passively repel the adsorption of microbes and is unable to kill the adherent or trapped microbes. The purpose of our study is to develop a facile method based on synergy “repel and kill” strategy and prepare dual antifouling and antibacterial surface. Herein, the poly(2-(dimethylamino) ethyl methacrylate) (PDMAEMA) was first constructed via surface-initiated activators regenerated by electron transfer atom transfer radical polymerization (ARGET-ATRP) method, followed by partial quaternization in order to form polycarboxybetaine and polysulfobetaine. The conversion rates of PDMAEMA to polyzwitterions were evaluated by X-ray photoelectron spectroscopy analysis (XPS). Surface characterizations by ATR-FTIR, XPS, and AFM demonstrated that zwitterionic polymer brushes were successfully grafted. The remained PDMAEMA(weak cationic) and formed zwitterions(neutral) endowed the surface with the synergetic antibacterial and antifouling properties. The resulting PET sheets showed outstanding antifouling property featured by the reduced adhesion of 3T3 fibroblast cells and E. coli . Additionally, these sheets displayed excellent hemocompatibility such as non-cytotoxicity, repelled protein adsorption, reduced platelet adhesion, and prolonged blood blotting time. These synergistic surfaces with neutral zwitterions and weak cations are promising for biomedical applications.
研究领域:
生物医学工程
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材料科学
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DOI
PubMed
高影响因子
TETRAHEDRON
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2016
·
IF 2.645
Xinyue Zhu,Hong Gao,Wenyan Zan,Yan Li,Jianjian Zhang,Xiaoyan Liu,Xuan Wei,Fengchao Qi,Xiaojun Yao,Haixia Zhang
It was reported here a devised and synthesized thiol fluorescent probes ortho -Z3 , meta -Z3 and para -Z3 based on photoinduced electron transfer (PET) pathway utilizing fluorophore naphthalimide as the electron donor and responsive group maleimide as the electron acceptor . The fluorescence intensity of these probes varied significantly depending on the position of the maleimide toward the naphthalimide fluorophore. Comparing to the meta and para isomers, the ortho isomer displayed the best fluorescence response performances upon addition of thiols. The results indicated that relative position of the electron acceptor played key role in the PET process, and probe ortho -Z3 could detect endogenous biothiols in serum samples and live cells successfully.
研究领域:
生物化学
·
分析化学
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DOI
高影响因子
Journal of Water Process Engineering
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2023
·
IF 7
Zaichao Guo,Yujing Wang,Zhihao Liang,Zhenhua Zhang,Jianjun Xie,Xiaoyu Gui,Borui Hou,Dan Mo,Liang Lu,Huijun Yao
Due to the increase in oil spills and the high organic contamination of the marine environment, it is necessary to develop an oil/water separation technology with low cost and high efficiency. Membrane separation technology has been proven to be an important technology used in the oil/water separation area. Herein, PET ion track-etched membranes with channel sizes of 310 nm, 650 nm, 1050 nm, and 1950 nm were hydrophobically modified by chemical grafting using propyltrichlorosilane and o-xylene as modifier and solvent, respectively. The modified PET ion track-etched membranes were found to exhibit a maximum water contact angle of 140.81° and possessed excellent hydrophobic property with modifying conditions of 80 mM modifier and 24 h modification time. It demonstrated the grafted propyl groups on the PET ion track-etched membrane played a key role in the increase of hydrophobic property. After modification, the PET ion track etched membrane had a high oil/water separation ratio of 99.87% and a flux of 12,158.24 L/m 2 ·h with good running stability. This work provided a cost-effective and facile approach to distinctly improve the ion track-etched membrane performance on durable oil/water separation.
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高影响因子
Materials
·
2023
·Vol. 16
·期 6
·2362
·
IF 3.4
Kuntong Song,Yi Li,Ruiqi Zhang,Nan Wang,Junhong Liu,Wenxia Hou,Qing Zhou,Xingmei Lu
Compared with conventional pyrolysis, steam-assisted pyrolysis of polyethylene terephthalate (PET) can effectively eliminate char and upgrade terephthalic acid (TPA). However, during steam-assisted pyrolysis of PET, the degree of cracking still varies greatly, and while some of the product is excessively cracked to gas, the other part is still insufficiently cracked. In addition, these two types of products seriously affect the yield and purity of TPA. To further enhance the TPA, an attempt was made to reduce these impurities simultaneously by synergistic catalysis among the different components of the metal–acid catalyst. Through a series of experiments, Pt@Hzsm-5 was screened as the optimal catalyst. In the catalytic steam-assisted pyrolysis of PET, the optimum reaction temperature decreased to 400 °C, the calculated yield of TPA increased to 98.23 wt%, and the purity increased to 92.2%. The Pt@Hzsm-5 could be recycled three times with no significant decrease in the obtained yield of TPA. The catalytic mechanism of the Pt@Hzsm-5 was investigated through the analysis of the products and isotope tracing experiments. The Pt catalyzed the hydrogen transfer reaction between the water molecules and PET molecules, which inhibited the excessive cracking of TPA by improving the hydrogen transfer efficiency, reduced the generation of gaseous products, and improved the calculated yield of TPA. In contrast, the Hzsm-5 catalyzed the reaction of monovinyl ester cracking to TPA, effectively reducing the impurities in the solid product, increasing the olefin yield, and improving the purity of TPA. This discovery not only clarifies the synergistic catalytic effect of the Pt@Hzsm-5 in the steam-assisted pyrolysis of the PET reaction but also lays the foundation for further screening of other inexpensive metal–acid catalysts. This is of great significance to realize the industrial application of TPA preparation by PET pyrolysis.Keywords:PET;metal–acid catalyst;steam-assisted pyrolysis;TPA
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PubMed
高影响因子
Journal of Environmental Chemical Engineering
·
2022
·
IF 7.968
Pengtao Fang,Shuqian Xia,Xingmei Lu
The development of catalysts with high thermal stability, high catalytic activity and high cycling performance has been an important challenge in PET alcoholysis research. PET degradation is a surface interface controlled process, but PET as a dense solid with lower specific surface area severely reduces its degradation rate. Here, the high specific surface area (0.4–3.3 m 2 /g) and the large number of pores (0–17.5 nm) formed by the swelling of PET at high temperature were used to break the interfacial confinement between the reactants; then the rapid and complete degradation of PET was achieved under the multi-hydrogen bonding microenvironment formed by the multi-active site polyoxometalate (POM) catalysts K 10 [M 4 (H 2 O) 2 (PW 9 O 34 ) 2 ]-H 2 O (M = Zn, Mn, Cu, Ni, Co) and EG. Finally, accompanied by the attack of the transition metal active site on C O of PET, 1.0 g of PET could be completely degraded in 5 min under the optimal reaction conditions (2.0 wt% of catalyst to PET, 240 °C) and the bis(hydroxyethyl) terephthalate (BHET) yield of 92.8% was achieved within 8 min. Moreover, the catalyst could be recycled more than 30 times, which is very meaningful. In the same time, the mechanism of PET alcoholysis was investigated and proposed a mechanism of PET alcoholysis.
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高影响因子
Frontiers in Chemistry
·
2020
·
IF 3.693
Liu Qingyao,Fang Hanyi,Gai Yongkang,Lan Xiaoli
Natural melanin nanoplatforms have attracted attention in molecular imaging. Natural melanin can be made into small-sized nanoparticles, which penetrate tumor sites deeply, but unfortunately, the particles continue to backflow into the blood or are cleared into the surrounding tissues, leading to loss of retention within tumors. Here, we report a pH-triggered approach to aggregate natural melanin nanoparticles by introducing a hydrolysis-susceptible citraconic amide on the surface. Triggered by pH values lower than 7.0, such as the tumor acid environment, the citraconic amide moiety tended to hydrolyze abruptly, resulting in both positive and negative surface charges. The electrostatic attractions between nanoparticles drove nanoparticle aggregation, which increased accumulation in the tumor site because backflow was blocked by the increased size. Melanin nanoparticles have the natural ability to bind metal ions, which can be labeled with isotopes for nuclear medicine imaging. When the melanin nanoparticles were labeled by 68Ga, we observed that the pH-induced physical aggregation in tumor sites resulted in enhanced PET imaging. The pH-triggered assembly of natural melanin nanoparticles could be a practical strategy for efficient tumor targeted imaging.
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高影响因子
RSC Advances
·
2016
·Vol. 6
·期 54
·48737-48744
·
IF 3.289
Danfeng Hou,Jiayu Xin,Xingmei Lu,Xiaonan Guo,Huixian Dong,Baozeng Ren,Suojiang Zhang
1,4-Cyclohexanedimethanol (CHDM) is a highly valued and widely used monomer in the polymer industry. Bis(2-hydroxyethylene terephthalate) (BHET), the product of glycolysis of waste PET, is an excellent raw material for the preparation of CHDM. Herein, a series of monometallic, bimetallic and trimetallic supported catalysts were prepared for the one-pot conversion of BHET into CHDM by the impregnation method and good performance was found over trimetallic RuPtSn/Al2O3 catalysts containing various active sites to catalyze the hydrogenation of the phenyl and carbonyl groups. The influences of various reaction parameters including temperature, pressure and time on the hydrogenation reaction were studied, and 100% conversion and 87.1% yield of CHDM were obtained with the trimetallic supported catalyst with Ru/Sn 1.5. Moreover, through the comparison between various methods for the preparation of CHDM, the conversion of BHET into CHDM by the one-pot method is considered one of the most competitive methods.
研究领域:
化学工程
·
材料科学
·
催化反应
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DOI
高影响因子
Surfaces and Interfaces
·
2025
·
IF 6.3
Ze-Long Bao,Wen-Hao Geng,Song-Yi Zhang,Peng-Fei Qian,Li-Chao Jing,Xuan-Chen Liu,Tong-Yu Li,Yu-Long Guo,Ru-Yu Chang,Hong-Zhang Geng
Ubiquitous electromagnetic waves have a negative effect on precision instruments and damage human health. Therefore, multifunctional and versatile flexible transparent conductive films, which can solve the challenge of microelectronic device encapsulated and protected in harsh conditions (e.g., extreme temperature) in specific scenarios, are demanded to process electromagnetic shielding and electric heating properties. Herein, AgNWs/MXene@Ni/PET films were fabricated by MXene template-guided electrochemical deposition of nickel nanosphere as flexible transparent conductive films. The films exhibit excellent optoelectrical properties (9.8 Ω/sq @ transparency 80.3%), splendid EMI shielding performances (35.1 dB), outstanding electric heating performance (85°C at 4 V), and rapid heating capability (reaching the saturation temperature with 40 s), which are potential to be widely applied under the complex surrounding as electromagnetic shielding and electric heating. Noticeably, nickel nanosphere are regarded as resistor-capacitor circuit model on the surface of MXene, forming the structure of the capacitor. Furthermore, magnetic nickel nanospheres have synergistic effect with dielectric MXene and AgNWs, defined Dielectric-Magnetic-Dielectric synergistic absorption. In addition, Ni nanosphere generate dielectric dipole interactions with MXene, to enhance the capability of absorbing EMW. Finally, this work has the potential to be conducive to practical and commercial applications as flexible transparent electromagnetic interference and electric heating devices.
研究领域:
材料科学
·
电子工程
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高影响因子
危险品化学品经营许可证（带存储）