RSC Advances
·
2016
·Vol. 6
·期 91
·88306-88314
·
IF 3.289
Ping Yong,Yuejiao Yang,Zhiyong Wang,Liming Yang,Jie Chen
A thermo- and dual-pH-sensitive ABC triblock copolymer composed of poly(N-isopropylacrylamide)-block-poly(acrylic acid)-block-poly(4-vinyl pyridine) (PNIPAM-b-PAA-b-P4VP, NAV) was synthesized via sequential reversible addition–fragmentation chain transfer (RAFT) polymerization and subsequent hydrolysis. NAV, which had the property of multi-stimuli, containing thermo-sensitive PNIPAM block and opposite pH-sensitive PAA and P4VP blocks, formed diverse nanostructures in an aqueous solution by varying the temperature and pH. Nanostructures including large compound micelles (LCMs), vesicles, spherical micelles and 3D topologies were observed using dynamic light scattering (DLS) and transmission electron microscopy (TEM). More significantly, the solation–gelation behaviour and morphology of the NAV system induced by temperature and pH were investigated by rheology and scanning electron microscopy (SEM), respectively. TEM and SEM revealed that the gelation behaviour of NAV resulted from the bridge effect of the ionized PAA chains between the hydrophobic P4VP cores (V-core) and PNIPAM cores (N-core) over the LCST of PNIPAM. The results obtained from the rheology measurements showed that the gelation temperature was independent of alkaline pH, but slightly tuned by the copolymer concentration or pH (only 6 to 7). Repeated sol–gel transition via temperature changes under alkaline conditions showed the good hydrogel recyclability of NAV.
研究领域:
材料科学
·
高分子化学
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产品关联
DOI
高影响因子
International Journal of Applied Mechanics
·
2024
·
IF 2.9
Hong Sang,Jianying Hu,Erasmo Carrera,Jianke Du
When in an alternating magnetic field, magneto-thermal sensitive hydrogels can absorb solvent molecules, causing the gel network to swell several times to its original size. By conducting experiments with magnetic PNIPAm hydrogels (M-PNIPAm), the parameters of the theoretical model for magneto-thermal sensitive hydrogels were experimentally determined. Subsequently, the mechanical behavior of M-PNIPAm hydrogel was studied through finite element analysis and tensile experiments. The numerical calculations based on the thermodynamic model with specific parameters showed consistency with experimental results. The comparison indicated that the proposed theory for magneto-thermal sensitive hydrogels can accurately predict the mechanical property of M-PNIPAm hydrogel, providing theoretical support for investigating large deformation of magneto-thermal sensitive hydrogels. Furthermore, we discovered that the variation of magnetic particle content significantly influence the mechanics properties of hydrogel. Our findings provide valuable insights for the research and application of magneto-thermal sensitive hydrogels.
研究领域:
材料科学
·
高分子科学
·
机械工程
·
生物医学工程
·
应用物理学
✓ 已验证
DOI
高影响因子
TALANTA
·
2024
·
IF 5.6
Yaran Zhang,Kebing Yi,Feng Gong,Ziwen Tang,Yu Feng,Yilong Tian,Ming Xiang,Fuxiang Zhou,Min Liu,Xinghu Ji,Zhike He
Alpha-fetoprotein (AFP), as a tumor marker, plays a vital role in the diagnosis of liver cancer. In this work, a novel sandwich immunoassay based on a thermosensitive polymer, poly(N-isopropylacrylamide) (PNIPAM), was developed for the detection of AFP. This immunoassay could realize one-step rapid reaction within 1 h, and facilitate the separation of the target molecules by incorporating PNIPAM. In this method, a conjugate of PNIPAM and capture antibody (Ab1) was successfully synthesized as a capture probe and the synthetic method of PNIPAM-Ab1 was simple, while the detection antibody (Ab2) was labeled with fluorescein isothiocyanate (FITC) to form a fluorescent detection probe. By employing a sandwich immunoassay, the method achieved quantitative determination of AFP, exhibiting a wide linear range from 5 ng/mL to 200 ng/mL and a low detection limit of 2.44 ng/mL. Furthermore, it was successfully applied to the analysis of spiked human serum samples and the screening of patients with hepatic diseases in clinical samples, indicating its potential application prospect in the diagnosis of liver cancer.
研究领域:
生物技术
·
医学诊断
·
高分子科学
·
癌症研究
✓ 已验证
产品关联
DOI
PubMed
高影响因子
POLYMER
·
2025
·
IF 4.5
Qinghao Guo,Xuehao Feng,Zhizheng Gao,Xiangyu Teng,Zezheng Qiao,Chuang Zhang,Zhixing Ge,Wenguang Yang
Bioinspired crawling robots fabricated from flexible materials have received considerable attention in recent years. However, existing solutions for crawling robots capable of multi-directional locomotion primarily focus on the complex driving mode. This study explores invertebrate reptiles inspired soft crawling robots driven by near-infrared (NIR) light. A composite hydrogel with excellent photo-responsive properties is prepared by ingeniously combining poly(N-isopropylacrylamide) (PNIPAM) with multi-walled carbon nanotubes (MWCNTs). The crawling robot, when driven by NIR light, achieves an average speed of 0.17 mm/s. It can perform complex tasks such as crawling along a predefined trajectory, crossing obstacles, and traversing mazes via remote control with NIR light. This design holds significant significance for advancing flexible crawling robots and provides valuable insights for the research of bionic robots driven by NIR light.
研究领域:
材料科学
·
生物工程
·
机器人学
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Xinru Wang,Jinyu Shan,Jie Zhang,Dong Yang,Guangming Tian,Yunzhi Dang,Jianhua Ma
Chronic wounds pose significant challenges in clinical treatment due to persistent inflammation, bacterial infections, and prolonged healing cycles. The development of smart dressings with moisture absorption, antibacterial properties, and stimulus responsiveness is particularly important. This work addresses the issues of low rehydration rate, lack of antibacterial activity in bacterial cellulose (BC) films, the complexity of traditional silver nanoparticle (AgNPs) preparation processes, and the varying hydrophilicity/hydrophobicity requirements of dressings at different stages of wound healing. Through a multi-level structural design, a photothermal-thermoresponsive synergistic intelligent antibacterial material was successfully constructed. Firstly, the introduction of glycerol (Gly) as a plasticizer significantly improved the rehydration rate, water vapor permeability, and flexibility of BC films. To endow the dressing with antibacterial properties, the natural antibacterial agent berberine (Ber) was introduced, and the synergistic effect of polydopamine (PDA) and polyethyleneimine (PEI) enabled the in-situ reduction and uniform loading of AgNPs under mild conditions, thereby achieving broad-spectrum antibacterial properties. The outer layer was grafted with thermoresponsive poly(N-isopropylacrylamide) (PNIPAM), leveraging its lower critical solution temperature (LCST) to meet the varying hydrophilicity/hydrophobicity requirements of dressings at different stages of wound healing. Simultaneously, PNIPAM coating effectively regulated the photothermal conversion efficiency of PDA and prevented the early rapid release of silver ions. The antioxidant capacity of Ber not only inhibited the oxidative deactivation of AgNPs but also effectively cleared reactive oxygen species (ROS) generated during wound healing and photothermal processes, thereby reducing tissue oxidative damage. Based on the synergistic antibacterial effects of Ber and AgNPs, the composite films achieved maximum inhibition zones of 4.2 ± 0.12 mm, 5.4 ± 0.16 mm, 1.9 ± 0.04 mm and 1.6 ± 0.04 mm against E. coli , S. aureus , P. aeruginosa and MRSA respectively. The material combines moisture absorption and permeability, biocompatibility, and long-term antibacterial performance, along with environmentally responsive controlled drug release and ROS clearance functions, offering a new solution for chronic wound treatment and promoting the innovative development of smart wound dressings.
研究领域:
生物医学工程
·
材料科学
·
伤口护理
·
纳米医学
·
抗菌材料
✓ 已验证
产品关联
DOI
高影响因子
MATERIALS CHEMISTRY AND PHYSICS
·
2019
·
IF 2.781
Jun Wang,Na Huang,Qi Peng,Xiaoyan Cheng,Wuke Li
In this paper, the luminescent temperature/pH dual-responsive nanoparticles based on lanthanide-polyoxometalates were fabricated as a controllable drug delivery system. In the drug delivery carrier, the mesoporous silica acted as the core, and the poly (N-isopropylacrylamide-co-methacrylic acid) and lanthanide-polyoxometalates served as the dual-responsive shell and luminescent labeling, respectively. Composite hydrogels exhibited red luminescence under UV irradiation, which was visible to the naked eye. The releases of doxorubicin hydrochloride (DOX) from the composites were temperature/pH-dependent. DOX can be quickly released in an acidic environment and at high temperatures. Moreover, the drug delivery carrier showed minimal toxicity to HeLa cells and exhibited good biocompatibility. However, DOX loaded drug-delivery system showed the significant toxicity to HeLa cancer cells in vitro. Cell imaging has shown that lanthanide polyoxometalates composites can be used as bioimaging materials for cell monitoring. As a result, the drug delivery systems based on lanthanide-polyoxometalates have potential applications in the field of biomedical science.
研究领域:
生物医学
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材料科学
·
药理学
✓ 已验证
产品关联
DOI
高影响因子
ENVIRONMENTAL RESEARCH
·
2020
·
IF 5.715
Fei Sun,Hai-Tao Ren,Ting-Ting Li,Shih-Yu Huang,Yue Zhang,Ching-Wen Lou,Jia-Horng Lin
Inspired by fish scales, this study prepares a thermo-responsive underwater oleophobic PNIPAM/PAN/TiO 2 nanofibrous membranes by traditional electrospinning technique using poly-N-isopropylacrylamide (PNIPAM) and polyacrylonitrile (PAN). Thermal properties, mechanical properties, surface chemical composition, wettability , photocatalysis , and oil/water separation of PNIPAM/PAN/TiO 2 membrane are explored compared to pure PNIPAM membrane. Result reveals that PAN/TiO 2 compounds make PNIPAM membrane with a smaller fiber diameter of 141 nm and high tensile stress of 7.4 MPa, and also decompose 98% of rhodamine B after UV light radiation . This bioinspired design structure endows the membrane with superhydrophilicity with a low water contact angle, and underwater superoleophobicity with a high oil contact angle of 157° (petroleum ether) and 151° (dichloromethane). This membrane can efficiency separate oil/water mixture with a high separation efficiency. Moreover, the resultant PNIPAM/PAN/TiO 2 membrane has the bionic fish scale structure, and has wettability respond at lower critical solution temperature making the water flux decreased from 10013 ± 367 L m −2 ·h −1 to 7713 ± 324 L m −2 ·h −1 , and thus has a potential to be used in purification of reclaimed water and separation of oil from water.
研究领域:
材料科学
·
环境工程
·
纳米技术
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
·
2018
·
IF 4.439
Li Li,Tianyi Zhang,Jianhua Lü,Changli Lü
Carbon dots (CDs), the youngest member in the carbon nanomaterial family, have drawn considerable attention due to their interesting optical, physicochemical and electronic properties as well as broad promising applications. Here, we developed a facile and effective strategy for the preparation of Au nanoparticles stabilized by thermo-responsive poly(N-isopropylacrylamide) (PNIPAM) functionalized carbon dots (Au@CD@P) under the gentle water media. The as-designed dopamine(DA)-terminated PNIPAM can be easily anchored to CDs via mussel-inspired chemistry route. Both CD@P and CDs could well stabilize the Au nanoparticles with interesting assembled structure. The as-prepared Au@CD and Au@CD@P nanohybrids with good dispersibility and stability exhibited the intriguing catalytic activity for reduction of p -nitrophenol ( p -NP). Especially, Au@CD@P as catalyst also played a switching role in regulating the catalytic rate by temperature. In addition, Au@CD@P exhibited excellent recyclability which may have potential in green chemical industry for developing high-activity catalysts and easy production methods.
研究领域:
材料科学
·
纳米技术
·
催化
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2021
·Vol. 45
·期 13
·5925-5932
·
IF 3.591
Cheng Zhou,Yan Chen,Mingjun Huang,Yi Ling,Liming Yang,Guochen Zhao,Jie Chen
A dual temperature-responsive triblock polymer (poly(N-isopropyl acrylamide)-block-poly(N,N-dimethyl acrylamide)-block-poly(acrylamide-co-acrylonitrile)) (P(AM-co-AN)-b-PDMA-b-PNIPAM) (NDAA) was obtained by sequential reversible addition–fragmentation chain transfer (RAFT) polymerization,with the uncharged UCST temperature-sensitive block P(AM-co-AN) and the classic LCST-type temperature-sensitive block PNIPAM. This well-defined thermo-responsive copolymer with tunable compositions exhibits a dual thermal response behavior in water. Properly designing the length of the block can make the block copolymer undergo a phase transition within the envisaged temperature range. When the concentration is 5 wt%, the UCST of the NDAA polymer is around 20 °C, and the LCST is around 31 °C. All three blocks of these polymers are soluble in water within 20–31 °C. At high temperature, PNIPAM hydrophobically aggregates into a core, and NDAA self-assembles into a core1 (PNIPAM)–shell (PDMA)–corona1 (P(AM-co-AN)) structure. In contrast, at low temperatures, P(AM-co-AN) forms hydrogen bonds and is insoluble in water, and NDAA self-assembles into a core2–shell–corona2 structure. In this way, it is possible to prepare spontaneously reversible micellar aggregates in water. After the concentration reaches the lowest critical concentration, the NDAA polymer can undergo a reversible gel behavior, that is, a phase transition occurs near the UCST and LCST. This change in the polarity of the micelle core opens up the possibility of dissolving different compounds in water just by changing the temperature.
研究领域:
高分子化学
·
材料科学
✓ 已验证
DOI
高影响因子
COMPOSITES PART B-ENGINEERING
·
2025
·
IF 14.2
Yuze Zhou,Guang Yang,Yumeng Wang,Jiaying Lei,Tengling Ye,Ruipeng Huang,Shaohao Zhan,Dongyan Tang
To address oily wastewater pollution, a dual-responsive composite membrane with switchable superwettability was fabricated by in situ growth of MnO 2 microflowers on carbon fiber cloth (CFC), followed by coordination-driven self-assembly of catechol-functionalized poly(N-isopropylacrylamide) (PNIPAM). The abundant oxygen vacancies (O v ) on MnO 2 microflowers enhanced photothermal conversion efficiency (24.99% for optimal MC 4 ) and provided active sites for robust PNIPAM anchoring via C-O-Mn coordination bonds. The resulting membrane (PMC) exhibited switchable superwettability: underwater superoleophobicity (150.10°) at 25 o C and underoil superhydrophobicity (150.27°) at 45 o C under heating or NIR irradiation. This enabled efficient separation of diverse oily pollutants, including light/heavy oil-water mixtures and emulsions, with high separation efficiency (> 99.5% for mixtures, > 99.2% for emulsions) and exceptional water flux (25239.89 L m −2 h −1 ). Taking advantages of the in situ grown of MnO 2 on CFC and strong chemical anchoring of PNIPAM on MnO 2 , the photo and thermal dual-responsive PMC membrane maintained excellent stability after mechanical (rubbing, bending, soaking) and chemical (acid/alkaline/saline) challenges, demonstrating superior reusability and durability for practical water purification applications.
研究领域:
材料科学
·
化学工程
·
环境科学
·
纳米技术
·
高分子科学
·
表面工程
✓ 已验证
产品关联
DOI
高影响因子
Materials Horizons
·
2023
·Vol. 11
·期 3
·835-846
·
IF 13.3
Xiaoyong Zhang,Haoran Ding,Zhaozhao Li,Yongping Bai,Lidong Zhang
Poly(N-isopropylacrylamide) (PNIPAM) is capable of improving the reversibility and responsiveness of flexible electronics. However, its phase transition-induced volume variation and poor adhesiveness remain limitations for expending its applications. Herein, a pressure-sensitive adhesive (PSA), which is a type of mesh scaffold, is constructed inside the network of PNIPAM, providing the hydrogel with a constant volume in response to different temperatures, in situ tunable mechanical properties, and superior adhesiveness. The reversible density of the mesh scaffold adjusts the aggregation state of the hydrogel chains, whereupon it is capable of changing its mechanical modulus from 6.7 kPa to 45.3 kPa. This mechanical mechanism contributes to hydrogel-based flexible devices for multiple applications, especially in pressure-related sensors. The mesh scaffold restricts the phase-transition-induced volume variation, which allows the hydrogel sensor to stably monitor the external pressure at various temperatures. The high adhesion enables the effective interfacial interaction with the skin, avoiding the loss of sensing signals during the detection of human body movements. When it is assembled into an electronic device, it can transmit information and recognize sign language via Morse code. Thus, herein, we report a hydrogel sensor that is promising for pressure detection in temperature-unstable environments, especially for managing the health of patients who require emergency medical care through sign language recognition.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
·
2024
·
IF 2.8
Guohua Teng,Hezhao Bai,Chen Zhang,Jingyi Yang,Xiaoye Wang,Yu Zhu,Fei Tian
A magnetic composite (Fe 3 O 4 @SiO 2 @PNIPAM-co-NHMA) with high adsorption capacity and recoverability was developed for the enrichment and determination of flavonoids in Scutellaria Radix ( SR ). A magnetic solid-phase extraction (MSPE) technique using Fe 3 O 4 @SiO 2 @PNIPAM-co-NHMA absorbent in combination with high-performance liquid chromatography (HPLC) was developed for selectively enrichment and determination of the biologically active flavonoids in the aqueous extract of SR , including baicalein, baicalin, wogonoside and wogonin. Under the optimized experimental conditions, the magnetic adsorbent could adsorb up to 77.0 ± 0.98 % − 98.15 ± 0.15 % of four representative flavonoids from SR , with elution rates varying from 55.10 ± 0.25 % to 91.94 ± 1.85 %. The limits of detection (LOD) and limits of quantitation (LOQ) were 0.01–0.35 μg/mL and 0.03–0.98 μg/mL, respectively. In addition, it remained effective after six replicates, demonstrating its potential as a recoverable adsorbent for enriching flavonoids in traditional Chinese medicine.
研究领域:
分析化学
·
药学
·
纳米技术
·
中医药
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）