TALANTA
·
2025
·
IF 6.1
Feng Tang,Bin Luo,Le Zhang,Ke Liu,Wenxin Yu,Peichen Hou,Tianyang Liu,Aixue Li,Chunjiang Zhao
Rutin, a natural flavonoid with anti-inflammatory and antioxidant properties, is widely found in plants and foods. To meet the demand for in situ detection of Ru in soft plant tissues, in this paper, a thin laser-induced graphene (LIG) electrode was prepared on polyimide (PI) and transferred to Ecoflex substrate, obtaining LIG/Ecoflex electrodes with good flexibility and tensile resistance. To further improve the electrochemical catalytic performance, nanocomposites of hafnium diselenide (HfSe 2 ), carboxylated single-walled carbon nanotubes (COOH-SWCNT), carboxylated graphene (COOH-GR) and nafion were also modified on the surface of LIG by a one-step dropping method. The HfSe 2 -COOH-SWCNT-COOH-GR-nafion/LIG/Ecoflex sensor could detect Ru in the range of 1 μM–700 μM under different pH values (4.5–7.4). It was also successfully used to in situ detection of Ru content in tomato leaves under different salt stress. The as-prepared sensor has important practical application prospects in the monitoring of plant physiological information in situ.
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PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2023
·
IF 8.4
Yaqi Yang,Jiejun Li,Zhiwang Luo,Xingnian Li,Jiayi Zou,Chunyan Li,Chao Chen,Yixi Xie,Pengcheng Zhao,Junjie Fei
One-dimensional (1D) ordered mesoporous carbon hybrid nanotubes loaded with bimetallic oxide hollow nanospheres are expected to be very attractive electrocatalysts . In this study, through high-temperature pyrolysis , we generated Mo 2 C@C PNTs with outstanding electrical conductivity , a significant surface area , and effective catalytic activity by wrapping ordered mesoporous polypyrroles on the surface of 1D MoO 3 nanotubes using block polymers that self-assembled. FeMnO 3 hollow porous nanospheres have a large specific surface area, many electroactive sites, and excellent molecular/charge diffusion properties, which can be compounded with 1D ordered mesoporous nitride-rich carbon to solve the problem of poor electrical conductivity of metal oxides and to prevent the accumulation of 1D nanotubes. The composite showed excellent electrocatalytic activity towards rutin due to the synergistic interaction between Mo 2 C@C PNTs and FeMnO 3 . In the best case, rutin has a limit of detection (LOD) as low as 0.35 × 10 −9 M and a wide linear range (3 × 10 −9 to 3.1 × 10 −6 M). The sensor displays a remarkable level of selective response to rutin in the presence of other co-interfering species. Furthermore, it has superb repeatability and reproducibility. The sensor has shown outstanding recovery (95.7–104.1 %) in the practical viability of detecting rutin in beverages. This work not only provides a new candidate for the accurate detection of rutin but also provides insight into the exploration of advanced sensing materials.
研究领域:
材料科学
·
电化学
·
纳米技术
·
分析化学
·
传感器
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DOI
高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Hailin Wang,Leiwen Xiang,Zhuangwei Zhang,Guoqiang Li,Peng Li,Wentao Chen,Yu Fang,Xinyan Lin,Shufen Lin
Polyphenol-protein interactions are crucial for food processing, nutrition, and functional properties. This study investigates the interaction between rutin and β-casein (β-CAS) or β-lactoglobulin (β-LG) using multispectral analysis, molecular docking, and molecular dynamics (MD) simulations. Fluorescence spectroscopy reveals that rutin binds spontaneously (ΔG < 0) to β-CAS and β-LG, forming complexes with binding constants (Ka) at 298 K of 42.500 × 10 3 and 2.101 × 10 3 L·mol −1 , respectively, and at 308 K of 5.814 × 10 3 and 4.350 × 10 3 L·mol −1 . Multispectral analysis and microscopy reveal complex formation and changes in the proteins' secondary, crystalline, and microstructures. Molecular docking and MD simulations verify complex stability, showing heightened binding affinity between rutin and β-CAS. These results validate hydrophobic interactions and hydrogen bonding as the main forces between rutin and the two proteins. These findings offer insights for using milk proteins as rutin carriers and support potential food industry application.
研究领域:
食品科学
·
生物化学
·
营养学
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DOI
PubMed
高影响因子
Antioxidants
·
2023
·Vol. 12
·期 3
·552
·
IF 7
Abid Naeem,Chengqun Yu,Zhenzhong Zang,Weifeng Zhu,Xuezhen Deng,Yongmei Guan
Oxidants play a significant role in causing oxidative stress in the body, which contributes to the development of diseases. Rutin—a powerful antioxidant—may be useful in the prevention and treatment of various diseases by scavenging oxidants and reducing oxidative stress. However, low solubility and oral bioavailability have restricted its use. Due to the hydrophobic nature of rutin, it cannot be easily loaded inside hydrogels. Therefore, first rutin inclusion complexes (RIC) with hydroxypropyl-β-cyclodextrin (HP-βCD) were prepared to improve its solubility, followed by incorporation into xanthan gum-based (hydroxypropyl methylcellulose-grafted-2-acrylamido -2-methyl-1-propane sulfonic acid) hydrogels for controlled drug release in order to improve the bioavailability. Rutin inclusion complexes and hydrogels were validated by FTIR, XRD, SEM, TGA, and DSC. The highest swelling ratio and drug release occurred at pH 1.2 (28% swelling ratio and 70% drug release) versus pH 7.4 (22% swelling ratio, 65% drug release) after 48 h. Hydrogels showed high porosity (94%) and biodegradation (9% in 1 week in phosphate buffer saline). Moreover, in vitro antioxidative and antibacterial studies (Staphylococcus aureus,Pseudomonas aeruginosa, andEscherichia coli) confirmed the antioxidative and antibacterial potential of the developed hydrogels.Keywords:hydrogels;flavonoids;anti-oxidants;inclusion complexes;oral formulations
研究领域:
药剂学
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生物材料
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药物化学
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PubMed
高影响因子
MICROCHIMICA ACTA
·
2018
·Vol. 185
·期 9
·1-10
·
IF 5.705
Liu Chaoqiao,Huang Jianzhi,Wang Lishi
The authors describe a method for electrochemical synthesis of a nanocomposite consisting of carboxylated multi-walled carbon nanotubes, polythionine and platinum nanoparticles (denoted as cMWCNT@pTh@Pt). The composite was placed on a glassy carbon electrode (GCE) to obtain a sensor for simultaneous determination of myricetin and rutin by differential pulse voltammetry, with typical peak voltages of 0.16 and 0.34 V (vs. SCE). Under optimal conditions, the modified GCE has a linear response in the range of 0.01–15 μM myricetin concentration range, and a 3 nM lower detection limit. For rutin, the data are 0.01–15 μM and 1.7 nM, respectively. The sensor is selective, stable and reproducible. It was successfully applied to the simultaneous determination of myricetin and rutin in spiked juice samples, and satisfactory results were obtained.
A nanocomposite consists of carboxy multi-walled carbon nanotube (cMWCNT), polythionine (pTh) and platinum nanoparticles (Pt) was presented for the simultaneous determination of myricetin and rutin. The nanocomposite shows excellent electrochemical determination performances based on a synergistic effect among cMWCNT, pTh and Pt.
研究领域:
分析化学
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纳米技术
·
电化学
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DOI
PubMed
高影响因子
Foods
·
2023
·Vol. 12
·期 5
·951
·
IF 5.2
Xinxin Ding,Xiaoping Li,Qiling Cai,Zhen Ma,Tian Ren,Xinzhong Hu
This study examined the effect of calcium hydroxide (Ca(OH)2, 0.6%,w/w) on structural, physicochemical and in vitro digestibility properties of the complexed system of Tartary buckwheat starch (TBS) and rutin (10%,w/w). The pre-gelatinization and co-gelatinization methods were also compared. SEM results showed that the presence of Ca(OH)2promoted the connection and further strengthened the pore wall of the three-dimensional network structure of the gelatinized and retrograded TBS-rutin complex, indicating the complex possessed a more stable structure with the presence of Ca(OH)2, which were also confirmed by the results of textural analysis and TGA. Additionally, Ca(OH)2reduced relative crystallinity (RC), degree of order (DO) and enthalpy, inhibiting their increase during storage, thereby retarding the regeneration of the TBS-rutin complex. A higher storage modulus (G′) value was observed in the complexes when Ca(OH)2was added. Results of in vitro digestion revealed that Ca(OH)2retarded the hydrolysis of the complex, resulting in an increase in values in slow-digestible starch and resistant starch (RS). Compared with pre-gelatinization, the complex process prepared with the co-gelatinization method presented lower RC, DO, enthalpy, and higher RS. The present work indicates the potential beneficial effect of Ca(OH)2during the preparation of starch-polyphenol complex and would be helpful to reveal the mechanism of Ca(OH)2on improving the quality of rutin riched Tartary buckwheat products.Keywords:Tartary buckwheat;starch-rutin complex;calcium hydroxide;pre-gelatinization;co-gelatinization;physicochemical properties;digestibility
研究领域:
食品科学
·
化学
·
营养学
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DOI
PubMed
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2021
·
IF 5.279
Ningning Zhao,Junpeng Xing,Zhong Zheng,Zifeng Pi,Fengrui Song,Zhiqiang Liu,Shu Liu
The boronate affinity-based oriented and double-shelled surface molecularly imprinted polymers on 96-well microplates (BDMIPs) were designed and applied to high-specific and high-throughput pharmacokinetic (PK) study of rutin and its metabolites from rat plasma without concentration and redissolution. It integrated the advantages of covalent effects-based boronate affinity, noncovalent effects of ethylene imine polymer (PEI) dendrimer, multiple cavities-based double-shelled layers, and multiparallel wells-based 96-well microplates. Furthermore, ultrahigh-performance liquid chromatography triple quadrupole tandem mass spectrometry (UHPLC–MS/MS) was used to accurately quantify targets. It showed lower limits of detection (LODs) up to 100-fold than the conventional method. And PKs of rutin and trace isoquercetin (IQC) were first reported at the same time. The platform can provide a fast, simple, low-cost, high-selective, high-effective, and high-throughput methodological reference for analysis of large-scale samples in the fields of agriculture and food.
研究领域:
分析化学
·
药理学
·
生物医学工程
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DOI
PubMed
高影响因子
CARBON
·
2018
·
IF 7.082
Huiyu Li,Yuan Xu,Li Zhao,Jie Ding,Mengyang Chen,Guangrui Chen,Yi Li,Lan Ding
The solid-phase pyrolysis method is widely used in the synthesis of fluorescent carbon dots (CDs) because of its large scale and solvent-saving advantages. However, CDs are inclined to agglomerate during the synthesis process, resulting in low quantum yield (QY) and inhomogeneous distribution of particle sizes. Here, a simple and effective solid dispersion surface pyrolysis method was used for the synthesis of tiny-carbon dots (T-CDs) with a high QY. Multi-walled carbon nanotubes (MWCNTs) were used as a support and 2-( N -morpholino)ethanesulfonic acid (MES) as a precursor. MES was uniformly dispersed on the surface of MWCNTs by hydrogen bonding and π-π interactions. Due to the excellent thermal conductivity and rigidity of MWCNTs, the precursor is carbonized without agglomeration. Compared with the CDs obtained by the direct pyrolysis method without the use of a solid support, the particle size of the T-CDs is small (0.69 ± 0.14 nm) and the QY increased from 17.8 to 42.8%. It is anticipated that this method will lead to the improvement of the QY of CDs. Applications of the T-CDs included fluorescence detection of rutin in pharmaceuticals, human urine, and human serum samples, and determination of Al 3+ in tap water samples.
研究领域:
材料科学
·
分析化学
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DOI
高影响因子
ANALYTICAL LETTERS
·
2021
·
IF 2.329
Ping-Rong Zhou,Zhang-Feng Tang,Ke-Su Wei,Ya Wan,Yu-Meng Gao,Yan-Mei Liang,Xiu-Fang Yan,Jun Bin,Chao Kang
Ultraviolet-visible absorption spectrometry is used for the determination of many inorganic, organic, and biological species. However, poor selectivity limits its applications for quantitative analysis in complex mixtures. In this work, its mathematical selectivity was explored using trilinear decomposition on spectral-pH measurements for the selective determination of two flavonoids in three Chinese herbal medicines. Through introducing a pH mode, second-order spectral pH data were constructed per sample. By using trilinear decomposition on the calibration and prediction samples, the rutin signals were extracted from lonicerae japonicae flos, perillae folium, and perillae fructus samples, respectively. Novel second-order calibration was developed for interference-free determination of rutin in these medicines followed by univariate regression of the decomposed intensity versus concentration. The predicted 95% confidence intervals for the concentration of rutin in these samples were 5.19 ± 0.16, 5.81 ± 0.10, and 7.00 ± 0.36 μg mL−1, respectively. These results were validated by high performance liquid chromatography (HPLC). Similarly, interference-free determination of isorhamnetin was achieved in these materials. By increasing the selectivity of ultraviolet-visible spectroscopy with trilinear decomposition, the requirements for sample preparation and chemical separation are reduced. The developed spectral pH second-order calibration allows direct analysis of complex samples by ultraviolet-visible absorption spectrometry due to the mathematical selectivity.
研究领域:
分析化学
·
药物分析
·
光谱学
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DOI
高影响因子
Surfaces and Interfaces
·
2023
·
IF 6.2
Yulin Xu,Zhiqiang Xu,Congcong Chen,Weihao Ye,Baoyan Guo,Jiemin Qiu,Jianle Zhuang,Chaofan Hu,Bingfu Lei,Guangqi Hu,Yingliang Liu
In this paper, a kind of novel fully UV absorbing carbon dots (R-CDs) were prepared as UV absorbers by a one-step hydrothermal method using natural renewable rutin as raw material. R-CDs can achieve multifunctional applications under acid-base amphoteric conditions. Under acidic conditions, R-CDs have high absorption efficiency (over 98%) in the whole ultraviolet region (200–400 nm) which have wider UV absorption range than commercial water-soluble organic UV absorbers (BP-4) and are almost completely transmitted in the visible light region. The UV absorption mechanism of R-CDs be investigated to the UV absorption systems of degradable cellulose coating (CMC) and the R-CDs@CMC coating was applied to prevent UV leakage of the 395UV chip. Under alkaline conditions, R-CDs remain fully UV absorbing and good absorption stability, but BP-4 loses its function as a UV absorber. Finally, R-CDs was applied to the UV absorption and anti-blue light systems of PU . The R-CDs@PU are more effective than commercially available anti-blue light lenses. At present, the preparation process of R-CDs is simple and rutin is a natural renewable energy source. So, R-CDs have the potential to become a new generation of water-soluble UV absorbers and be applied to prevent blue light.
研究领域:
材料科学
·
化学工程
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DOI
高影响因子
Foods
·
2023
·Vol. 12
·期 12
·2302
·
IF 5.2
Yuanfei Li,Huadi Mei,Yanchen Liu,Zhenming Li,Hammad Qamar,Miao Yu,Xianyong Ma
Consumer demand for tasty and quality meat has been quickly increasing. This study investigated how dietary supplemented rutin affects meat quality, muscle fatty acid profile, and antioxidant capacity in the Chinese indigenous Qingyuan partridge chicken. A cohort of 180 healthy 119-day-old chickens was subjected to a randomized assignment into three groups, identified as the control, R200, and R400 groups, with respective supplementation of 0, 200, and 400 mg/kg of rutin. The results revealed insignificance in growth performance, namely, average daily gain, average daily feed intake, and feed-to-gain ratio, across the various treatment groups (p> 0.05). Nevertheless, dietary rutin supplementation increased (p< 0.05) breast muscle yield and intramuscular fat content in breast muscle and decreased (p< 0.05) drip loss in breast muscle. Rutin supplementation increased (p< 0.05) the content of high-density lipoprotein but decreased (p< 0.05) the contents of glucose, triglyceride, and total cholesterol in serum. Rutin supplementation increased (p< 0.05) the levels of DHA (C22:6n-3), total polyunsaturated fatty acids (PUFAs),n-3 PUFAs, decanoic acid (C10:0), the activity of Δ5 + Δ6 (22:6 (n− 3)/18:3 (n− 3)), and the ratio of PUFA/SFA in breast muscle but decreased (p< 0.05) the level of palmitoleic acid (C16:1n-7), the ratio ofn-6/n-3 PUFAs, and the activity of Δ9 (16:1 (n− 7)/16:0). Rutin treatment also reduced (p< 0.05) the contents of malondialdehyde in serum and breast muscle, and increased (p< 0.05) the catalase activity and total antioxidant capacity in serum and breast muscle and the activity of total superoxide dismutase in serum. Additionally, rutin supplementation downregulated the expression ofAMPKαand upregulated the expression ofPPARG,FADS1,FAS,ELOVL7,NRF2,andCATin breast muscle (p< 0.05). Convincingly, the results revealed that rutin supplementation improved meat quality, fatty acid profiles, especiallyn-3 PUFAs, and the antioxidant capacity of Qingyuan partridge chickens.Keywords:rutin supplementation;antioxidant capacity;fatty acid profile;lipid metabolism;meat quality;Chinese yellow-feathered broiler;Qingyuan partridge chickens
研究领域:
动物营养学
·
食品科学
·
分子生物学
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PubMed
高影响因子
MICROCHIMICA ACTA
·
2011
·Vol. 173
·期 3
·337-345
·
IF 2.578
Yin Huanshun,Zhou Yunlei,Cui Lin,Liu Tao,Ju Peng,Zhu Lusheng,Ai Shiyun
The electrochemical behavior of rutin was investigated in pH 6.0 buffer solution using a glassy carbon electrode coated with graphene nanosheets, chitosan and a poly (amidoamine) dendrimer in pH 6.0 buffer solution. The results indicate that the modified electrode displays electrochemical redox activity towards rutin, and that the oxidation peak current of rutin increases significantly compared to that at other electrodes. The amount of immobilized graphene and dendrimer, pH value, scan rate, accumulation time and accumulation potential were optimized. The kinetic parameters, charge transfer coefficient, transfer electron number, proton transfer number, standard rate constant, were calculated. Under the optimized conditions, the oxidation peak current is proportional to the concentration of rutin in the range between 0.001 and 2.0 μmol L −1 ( R = 0.9991). The detection limit is 0.6 nmol L −1 (at S/N = 3). The electrode exhibits satisfactory selectivity and reproducibility and was applied to the determination of rutin in pharmaceutical preparations, spiked human serum, and traditional Chinese medicine, with recoveries between 97.2 and 104.67%.
1. Preparation of graphene nanosheets and PAMAM modified glassy carbon electrode. 2. Graphene nanosheets and PAMAM improve the electrochemical redox of rutin. 3. The prepared electrode determines rutine with high sensitivity and selectivity. 4. The developed method can determine rutin in pharmaceutical formulations, human serum, and traditional Chinese medicine.
研究领域:
分析化学
·
药学
·
生物医学工程
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DOI
高影响因子
危险品化学品经营许可证（带存储）