Drug Design Development and Therapy
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2017
·
IF 2.822
Jingrun Chen,Junjie Liu,Dongxiao Cui,Chaoqun Yan,Liqiang Meng,Liqian Sun,Shurong Ban,Rui Ge,Taigang Liang,Qingshan Li
This study deals with the design and synthesis of a series of novel 4-methoxy-substituted and 5-methyl-substituted (3′S,4′S)-(−)-cis-khellactones. The newly synthesized compounds were characterized by 1H nuclear magnetic resonance (NMR), 13C-NMR, mass spectrometry, and elemental analysis. All the derivatives were subjected to in vitro cytotoxicity screening against HEPG-2 (human liver carcinoma), SGC-7901 (human gastric carcinoma), and LS174T (human colon carcinoma), by using the MTT assay. The results revealed that several of the 4-methoxy-substituted compounds exhibited potent cytotoxicity. Among these, compound 12e showed the highest activity against cancer cells which 50% inhibitory concentration (IC50) values were in the range of 6.1–9.2 μM with low toxicity on normal human hepatocyte. Preliminary investigation of possible mechanisms of action of compound 12e against HEPG-2 cells indicated possible induction of apoptosis, as determined by morphological observations and Annexin V/propidium iodide (PI) double staining, in addition to apparent dissipation of mitochondrial membrane potential (MMP), as measured by 5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethyl-imidacarbocyanine iodide (JC-1) staining in combination with the activation of caspase-9 and caspase-3 by Western blot analysis. Overall, the data suggest that compound 12e may be a promising potential anti-cancer agent that could act primarily by inducing apoptosis through the mitochondria-mediated intrinsic pathway in human hepatoma cells.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2026
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IF 8.3
Longlong Wang,Sirong Sun,Xingyu Jin,Jiayu Cheng,Heng An,Zhou Yang,Xueji Zhang,Haifeng Dong,Xiangdan Meng
Rapid and reliable detection of Staphylococcus aureus ( S. aureus ), a major foodborne pathogen, remains a critical challenge in food safety surveillance. Here, we present a hybrid electrospinning–CHA–SERS biosensing platform that integrates aptamer-functionalized electrospun nanofibers with catalytic hairpin assembly (CHA)-mediated assembly of gold nanoparticles (GNPs) for ultrasensitive detection of S. aureus . The electrospun nanofibers enable efficient bacterial enrichment through their high-surface-area architecture, while CHA-triggered GNPs aggregation generates dense plasmonic “hotspots” for remarkable Raman enhancement. This synergistic design achieves a record-low detection limit of 9.2 CFU/mL, along with high specificity and stability in complex food matrices. Demonstrated in real samples, this work establishes a new signal amplification paradigm that couples enzyme-free nucleic acid assembly with SERS enhancement, offering a powerful strategy for intelligent food safety monitoring and rapid pathogen diagnostics.
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CHINESE JOURNAL OF CATALYSIS
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2026
·
IF 17.2
Xiaoqian Wang,Feifan Zhao,Wantian Mei,Jianjun Zhang,Chuanbiao Bie,Jiaguo Yu,Hermenegildo Garcia,Feiyan Xu
Efficient S-scheme photocatalysis requires not only favorable band alignment but also sufficiently strong interfacial driving forces to direct photogenerated carrier migration across the junction. Local donor-acceptor (D-A) coordination and global Fermi-level equilibration are shown to cooperate in the dark to precondition interfacial energetics and thereby promote subsequent S-scheme charge transfer. A molecularly coupled heterojunction is constructed by integrating a triazine-imine covalent organic framework (TPT-COF) with ZnO quantum dots through interfacial Zn–N coordination. Spectroscopic analyses reveal that D-A-induced local electron redistribution and Fermi-level-equilibration-driven compensating charge redistribution coexist in the dark, cooperatively enlarging the effective interfacial energy offset and reinforcing the internal electric field prior to illumination. Ultrafast spectroscopy further shows that this preconditioned interface accelerates S-scheme charge transfer under light irradiation, enabling efficient spatial charge separation while preserving strong redox potentials. As a result, the optimized COF/ZnO heterojunction achieves selective CO 2 photoreduction to CH 4 without external photosensitizers or sacrificial agents. These findings identify a cooperative mechanism by which local coordination chemistry and interfacial electrostatics jointly regulate S-scheme energetics, offering a molecular strategy for designing adaptive photocatalytic interfaces for solar fuel production.
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TALANTA
·
2026
·
IF 6.7
Linzi Huang,Xiaoqian Sun,Kunxiang Deng,Meijun Ni,Xinyi Li,Yixi Xie,Pengcheng Zhao,Junjie Fei
Flutamide (FLU), a nonsteroidal antiandrogen drug for prostate cancer therapy, requires sensitive monitoring due to its narrow therapeutic window. Herein, we constructed a novel photoelectrochemical sensor based on an S-scheme Bi 2 S 3 /FeIn 2 S 4 heterojunction for ultrasensitive FLU detection. This charge transfer mechanism was confirmed through density functional theory calculations and electron paramagnetic resonance tests. FLU can act as a hole scavenger by transforming its nitro group into a nitroso derivative via a 2e − /2H + transfer process, thereby amplifying the photocurrent signal. The sensor outperformed traditional techniques, exhibiting a wide dual-range linear detection capability (0.02 - 20 μM and 20 - 110 μM) with an ultralow detection limit of 10 nM. The designed sensor exhibits good repeatability and long-term storage stability (>92.8%). Moreover, this sensor was successfully applied in human serum and urine, with recovery rates ranging from 96.9% to 100.2%.
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Molecular Catalysis
·
2026
·
IF 4.9
Ting He,Panting Song,Jinshu Wang,Junshu Wu,Jiawei Xiao,Yongli Li
Graphitic carbon nitride (g-C 3 N 4 ) has emerged as a promising metal-free photocatalyst for solar driven hydrogen evolution. However, the rapid recombination of photogenerated electron-hole pairs in pristine g-C 3 N 4 severely limits its opportunities for practical application. Herein, we developed an intramolecular S-scheme with an endogenous built-in electric field (BIEF) via simply ethylenediamine-mediated two-step thermal polycondensation, producing an heteroaromatic-modified g-C 3 N 4 (HA-CN). The experimental results showed this structural innovation achieves dual optimization: (1) molecular-level integration of aromatic ring-modified melon (A-domain) and pristine melon-skeleton (P-domain) establish a BIEF to promote carriers transfer and separation; (2) the aromatic substitution extends π-electron delocalization of the adjacent melon domains, enhancing n→π* transitions and broadening visible-light absorption. The optimized HA-CN exhibited exceptional enhancement of hydrogen evolution (5.99 mmol g⁻¹ h⁻¹, λ ≥ 420 nm), surpassing pristine g-C 3 N 4 by 39-fold, with an apparent quantum efficiency (AQE) of 3.93 % at 420 nm. Time-resolved spectroscopy and electrochemical analysis confirm the suppressed charge recombination and reduced interfacial charge-transfer resistance, corresponding to BIEF-driven directional carrier migration. This research offers valuable insights into junction engineering strategy from molecular level for designing efficient photocatalysts.
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Small
·
2026
·
IF 11.8
Kainan Hong,Yutao Lu,Fuyao Huang,Yichi Zhang,Zihao Zhou,Yuanyuan Zheng,Ya Huang,Huisheng Peng,Peining Chen
Electronic textile is a promising platform for next-generation wearable systems, where transparent conductive fibers are essential building blocks for optoelectronic functions. Current transparent conductive fibers are typically realized by coating conductive nanomaterials onto a polymer fiber substrate. However, this strategy generally suffers from weak interfacial adhesion and thus causes conductivity degradation under mechanical deformations or environmental exposure. In this work, we report a high-performance transparent conductive fiber based on disulfide-functionalized thermoplastic polyurethane. Silver nanowires (AgNWs) react with sulfur atoms in the disulfide groups to form robust Ag-S covalent linkages, thereby stabilizing the AgNWs network. The resulting fibers exhibit a balanced combination of high conductivity (2.7 × 10 3 S/m) and optical transmittance (81%). Their conductivity and optical transmittance can be tuned by adjusting the AgNWs loading, while maintaining high transparency and superior mechanical durability under harsh conditions, including 1000 cycles of bending, twisting, and abrasion. We further integrate these fibers into electroluminescent fibers and display textiles through wrapping or weaving. These devices exhibit high brightness, uniform emission, and long-term operational stability. This interfacial engineering strategy improves compatibility between conductive networks and flexible polymers, enabling high-performance electronic fibers and textiles.
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BioDesign Research
·
2025
·
IF 4.7
Peiling Wu,Haofeng Chen,Guojun Yang,Haoyu Qin,Qian Zhang,Yuxin Chen,Dongjiang Lin,Yang Zhang,Shuyong Lin,Shizhen Wang,Jifeng Yuan
2-Hydroxyisovalerate (2-HIV) is a value-added chemical that is widely applied in the synthesis of bioactive compounds and polymers. Here, we report an underexplored metabolic route for the de novo production of S -type 2-HIV ( S -HIV) in Escherichia coli . In particular, we identified promiscuous activity of 4-hydroxymandelate synthase (HmaS) from Amycolatopsis orientalis towards the conversion of 2-keto-4-methyl-pentanoate (2-KMP, an immediate precursor for L-leucine) to S -HIV. Next, we designed a variant HmaS (S201F) with abolished activity for mandelate and 4-hydroxymandelate synthesis, thereby minimizing byproduct formation. Coupled with systematic optimization of the L-leucine biosynthetic pathway, we achieved de novo production of S -HIV at 8.1 mM (0.95 g/L) in shake flasks and 33.9 mM (4.0 g/L) in 2-L fed-batch fermentation. In summary, this work represents the first time to realize the efficient synthesis of S -configuration 2-HIV in metabolically engineered E. coli .
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POLYMERS FOR ADVANCED TECHNOLOGIES
·
2023
·Vol. 34
·期 10
·3125-3136
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IF 3.4
Longwei Shi,Zheng Zhao,Lishuai Zong,Jinyan Wang,Xigao Jian
Limiting molecules' polarized motion effectively reduces the dielectric loss of materials. This article synthesized side chains with different lengths using p-ethoxyphenol, p-hydroxybenzoic acid, and long-chain halohydrins through a two-step process. These chains' movement was almost unaffected by the main chain of polymers, so they can fill up the free volume of polymers under certain conditions. 1,2-dihydro-4-(4-hydroxyphenyl)phthalazine-1-(2H)-one(DHPZ), 4,4'-Difluorophenyl sulfone(DFS), and 4,4-Bis(4-hydroxyphenyl) valeric acid(HPV) obtained three polymers with different carboxyl groups (10%, 30%, and 50%) through nucleophilic substitution. They were then grafted and treated with hot-pressing. The introduction of side chains could reduce the free volume of polymers under hot-pressing conditions, so further reducing the dielectric loss of materials. Polymer with the shortest and least (10%) side chains showed the most obvious dielectric loss tangent, the reduction rate of the film's dielectric loss tangent was 13.11% (at T g + 15°C, while the non-grafted one was only 3.69%) and 20.70% (at T g + 80°C, while the non-grafted one was only 8.35%), respectively. In addition, WXRD and DMA tests showed that films' intermolecular chain spacing (“ d ”) and T g changed after the hot-pressing process, respectively. The change law of both was consistent with that of dielectric loss tangent. Confirm that grafting high-motility side chains can significantly reduce polymer's dielectric loss by enhancing the free volume reduction effect after hot-pressing.
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ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Zhili Li,Jiye Zhang,Pengfei Luo,Jiayi Chen,Bowen Huang,Yuzhe Sun,Jun Luo
Silver chalcogenides demonstrate great potential as flexible thermoelectric materials due to their excellent ductility and tunable electrical and thermal transport properties. In this work, we report that the amorphous/crystalline phase ratio and thermoelectric properties of the Ag2SxTe1–x (x = 0.55–0.75) samples can be modified by altering the S content. The room-temperature power factor of the Ag2S0.55Te0.45 sample is 4.9 μW cm–1 K–2, and a higher power factor can be achieved by decreasing the carrier concentration as predicted by the single parabolic band model. The addition of a small amount of excessive Te into Ag2S0.55Te0.45 (Ag2S0.55Te0.45+y) not only enhances the power factor by decreasing the carrier concentration but also reduces the total thermal conductivity due to decreased electronic thermal conductivity. Owing to the effectively optimized carrier concentration, the thermoelectric power factor and dimensionless figure of merit zT of the sample with y = 0.007 reaches, respectively, 6.2 μW cm–1 K–2 and 0.39, while the excellent plastic deformability is well maintained, demonstrating its promising potential as a flexible thermoelectric material at room temperature.
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CARBOHYDRATE POLYMERS
·
2022
·
IF 10.723
Qingxia Yuan,Hong Li,Qian Wang,Shujing Sun,Ziyu Fang,Hao Tang,Xiaohuo Shi,Jing Wen,Lianghua Huang,Meng Bai,Shengping Zhong,Yonghong Liu,Chenghai Gao,Longyan Zhao
Stichopus monotuberculatus is a tropical sea cucumber species and used as a folk medicine and tonic food . In this study, a fucosylated glycosaminoglycan (SmFG), the depolymerized SmFG (dSmFG) and its oligosaccharide fractions were prepared. The SmFG and its depolymerized products were comprised of a chondroitin-sulfate-E backbone, and various sulfated fucose side chains, including an unusual disaccharide side chain connected to the C-3 position of D-glucuronic acid (GlcA) or GlcA-ol. A peeling reaction occurred during the deaminative depolymerization process. The dSmFG and its fractions showed strong anticoagulant activity by selectively inhibiting intrinsic tenase complex, and had no anti-factor IIa, Xa and VIIa activity. The anticoagulant activity reduced with the decrease of molecular weight , and the unusual branch and novel reducing end may enhance the anticoagulant activity. These findings can provide significant information for development and utilization of depolymerized products from SmFG in food and pharmaceutical industries .
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Coatings
·
2022
·Vol. 12
·期 9
·1263
·
IF 3.236
Honggang Xia,Dongbin Wang,Aixian Tian,Yingde Xu,Hao Gong,Zhaoyang Li,Jun Miao
Medical tools and implants used in clinics can be contaminated with bacteria even with disinfection treatment. To avert this situation, titanium (Ti) plates modified with a MoS2(S)–Ag3PO4coating were designed to killStaphylococcus aureus(S. aureus) andEscherichia coli(E. coli) effectively under near-infrared (NIR) light irradiation. The introduction of Ag3PO4nanoparticles (NPs) reduced the bandgap of MoS2and suppressed the recombination of the photogenerated electron–hole pairs. Therefore, Ti–MoS2(S)–Ag3PO4exhibited a higher photocatalytic performance, leading to the generation of more radical oxygen species (ROS). Furthermore, cooperating with the good photothermal performance of MoS2, the MoS2(S)–Ag3PO4coating exhibited a high antibacterial efficacy of 99.76 ± 0.15% and 99.85 ± 0.09% againstS. aureusandE. coli, respectively, for 15 min in vitro. Moreover, the MoS2(S)–Ag3PO4coating had no apparent toxicity to cells. The proposed strategy may provide new insights for rapidly eradicating bacteria on medical tools and superficial implants.Keywords:bacteria-killing;Ag3PO4;MoS2;photocatalytic;photothermal
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2022
·
IF 7.139
Xiaojun Dai,Sheng Feng,Wei Wu,Yun Zhou,Zhiwei Ye,Xun Cao,Yang Wang,Chengdeng Yang
In this study, ZnCo 2 S 4 (ZCS) nanoparticles were coupled on the surface of TiO 2 by simple solvothermal method to form S-scheme heterojunction. Compared with ZCS and TiO 2 , the photocatalytic performance of ZCS/TiO 2 under simulated sunlight is significantly improved, and its hydrogen evolution efficiency reaches 5580 μmol·g −1 ·h −1 with the apparent quantum efficiency (AQY) up to 11.5% at 420 nm, which is 88.3 times and 54.3 times that of TiO 2 and ZCS, respectively. Moreover, ZCS/TiO 2 also has excellent performance in the photocatalytic degradation of tetracycline (TC). The enhancement of photocatalytic performance of ZCS/TiO 2 is mainly due to S-scheme heterojunction. On the one hand, the S-scheme electron transfer path not only improves the electron-hole separation efficiency, but also improves the charge transfer efficiency. On the other hand, ZCS significantly enhances the visible light absorption of ZCS/TiO 2 . The photocatalytic mechanism and S-scheme heterojunction structure is confirmed by XPS , EPR , ultraviolet photoelectron spectroscopy (UPS) and energy band structure . This work provides a new idea for designing and constructing S-scheme heterojunction to improve the performance of photocatalytic hydrogen evolution and TC degradation.
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