ENVIRONMENTAL TOXICOLOGY
·
2023
·Vol. 38
·期 4
·844-856
·
IF 4.5
Yanting Wang,Yushun Yang,Chenyuan Dang,Bin Lu,Yin Luo,Jie Fu
In this paper, the hepatocytotoxicity and aryl hydrocarbon receptor (AHR) activity of decabromodiphenyl ethane (DBDPE), decabromodiphenyl ether (BDE209) and other 18 analogues were evaluated in vitro using human normal liver cell L02. These dioxin-like compounds showed differential hepatocytotoxicity (EC 50 = 0.38–17.87 mg/L) and AHR activity (EROD activity = 4.53–46.35 U/μg). In silico study indicated the distance of π-π bonds between the benzene ring of compounds and residue Phe234 of AHR played a key role in the binding of AHR, and the substituents on the benzene ring also influenced the activity. Combining molecular biology and bioomics, the comprehensive investigations on the hepatotoxic mechanisms have demonstrated the AHR signaling pathway was the key mediation mechanism for the hepatotoxicity of DBDPE/BDE209. The cytochrome P450s (CYP2 family) mediated formation of reactive oxygenated intermediates might be the dominant toxic mechanism, which could produce oxidative stress or cause genotoxicity. Although the experimental toxicity of DBDPE was smaller relative to BDE209, the health risk of DBDPE may be much greater than we expected, due to the high potential to form a variety of dioxin-like intermediates by microbial oxidation of ethyl group. Therefore, whether it is really safe to replace BDE209 with DBDPE is a debatable question, and more ecotoxicological and health data are needed to clarify this issue.
研究领域:
毒理学
·
环境健康
·
分子生物学
·
生物信息学
✓ 已验证
DOI
PubMed
高影响因子
Applied Materials Today
·
2023
·
IF 8.3
Xiangbo Zhu,Zhiwei Yang,Deqiang Gan,Teng Cui,Honglin Luo,Yizao Wan,Quanchao Zhang
To circumvent the severe cytotoxicity and drug resistance of chemotherapeutics in cancer chemotherapy, we rationally designed an electrospun nanofibrous delivery system for the codelivery of the doxorubicin (DOX) and small interfering ribonucleic acid (siRNA) to improve antitumor activity and mitigate DOX drug resistance. DOX was intercalated into nanolamellar hydroxyapatite (LHAp), which was incorporated into electrospun poly(lactic-co-glycolic acid) (PLGA) nanofibers, and finally, the DOX-intercalated LHAp/PLGA scaffold was coated with polydopamine (PDA) followed by immobilization with siRNA/polyethyleneimine (PEI) complexes. Benefiting from its intrinsic degradability, the scaffold demonstrated pH-responsive release behavior, leading to the simultaneous delivery of DOX and siRNA. Consequently, the codelivery scaffold demonstrated enhanced therapeutic efficiency in vitro and in vivo compared with the scaffold loaded with single drug due to the combined effects of DOX and siRNA and did not show toxicity or side effects in mice. Therefore, it is a safe and effective strategy for preventing postsurgical tumor recurrence.
研究领域:
药学
·
纳米技术
·
癌症研究
·
生物材料
·
药物递送系统
✓ 已验证
DOI
高影响因子
Journal of Composites Science
·
2025
·Vol. 9
·期 1
·15
·
IF 3.7
Anton Mostovoy,Amirbek Bekeshev,Andrey Shcherbakov,Arai Zhumabekova,Zhadira Nurtai,Marina Lopukhova
As a result of the conducted studies, the method of combining components and foaming parameters for obtaining foam epoxides has been selected. The relationship between the structure of the foam epoxide and the amount of the added blowing agent—ammonium carbonate—has been established. This study explores the development of fire-safe foamed epoxy composites by incorporating technogenic waste from ceramic brick production. The optimized composites demonstrated improved compressive strength, enhanced fire resistance (the LOI—35–44%—and successful UL-94 V-0 testing) through the use of flame retardants (Tris(2-methylphenyl) phosphate and Decabromodiphenyl oxide) and low thermal conductivity (0.030–0.042 W/m K), highlighting their potential as sustainable thermal insulation materials.
研究领域:
材料科学
·
环境科学
✓ 已验证
DOI
高影响因子
Toxics
·
2024
·Vol. 12
·期 1
·40
·
IF 3.9
Aihua Li,Chaofei Wang,Chengjiang Qian,Jinfeng Wen,He Guo
Chemical wastewater has a high concentration of toxic and hazardous antibiotic pollutants, which not only devastates the ecological environment and disrupts the ecological balance, but also endangers human health. This research proposed a non-thermal plasma (NTP) combined with a ZnO-Fe3O4nano-catalyst system to achieve the efficient degradation of ciprofloxacin (CIP) in chemical wastewater. Firstly, ZnO-Fe3O4composite materials were prepared using hydrothermal method and characterized with scanning electron microscopy (SEM), transmission electron microscope (TEM), X-ray diffractometer (XRD), X-ray photoelectron spectroscopy (XPS), etc. With the sole NTP, NTP/ZnO, and NTP/ZnO-Fe3O4systems, the removal efficiency of CIP can reach 80.1%, 88.2%, and 99.6%, respectively. The optimal doping amount of Fe3O4is 14%. Secondly, the capture agent experiment verified that ·OH, ·O2−, and1O2all have a certain effect on CIP degradation. Then, liquid chromatography–mass spectrometry (LC-MS) was used to detect the intermediate and speculate its degradation pathway, which mainly included hydroxyl addition, hydroxyl substitution, and piperazine ring destruction. After treatment with the NTP/ZnO-Fe3O4system, the overall toxicity of the product was reduced. Finally, a cyclic experiment was conducted, and it was found that the prepared ZnO-Fe3O4catalyst has good reusability. The NTP/ZnO-Fe3O4was also applied in practical pharmaceutical wastewater treatment and has practical applicability.
研究领域:
环境科学
·
化学工程
·
生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED CLAY SCIENCE
·
2024
·
IF 5.3
Dan Wang,Yan Wang,Changjiang Li,Junmin Ji
In this work, using various Span series surfactant (Span 40, Span 60, and Span 80) liquor, three types of newly functional palygorskite adsorbents were developed for removing multiple aflatoxins from peanut oil. The palygorskite infiltrated with Span surfactants all showed excellent detoxification ability in the adsorption of aflatoxins. The removal of AFB 1 by palygorskite infiltrated with Span 40, Span 60, and Span 80 was 94.75 %, 93.85 %, and 91.99 %, respectively. Compared with unmodified palygorskite, the removal of aflatoxins by the three adsorbents was increased by 10.05 %, 9.58 %, and 8.40 %, respectively. What's more, the retention of nutrients in peanut oil was enhanced after treatment with modified adsorbents. Among them, the retention rate of sterols in the oil after Span 40-palygorskite detoxification was increased by 18.71 %, and the tocopherol was increased by 11.20 %. Lastly, the adsorption mechanism was further discussed using kinetic, isothermal, and thermodynamic models. The Freundlich isothermal, Dubinin-Radushkevich model, and the pseudo-second-order rate expression all exhibited a strong association with the test results. The adsorption process mainly involved ion exchange, hydrophobic interactions, and pore-filling effects. Thermodynamic analysis ( ΔG 0 < 0, ΔH 0 > 0, ΔS 0 > 0) denoted that the adsorption effect was spontaneous and endothermic. The composite adsorbents could be a suitable candidate for the elimination of multiple aflatoxins with the merits of high detoxification efficiency, low preparation cost, green, and safety, which may open up new ideas for the creation of novel adsorbents in the fats and oils industry.
研究领域:
食品科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
Sustainable Materials and Technologies
·
2024
·
IF 8.6
Jin Qi,Tong Zhang,Ran Zhang,Jinrong Liu,Mingrui Zong,Qingmei Zhang,Yilin Ping,Yajuan Gong,Binbin Zhang,Xiaoming Liu,Jiadi Li,Xiuping Wu,Bing Li
Bacterial infections pose a serious worldwide public health concern and play an important role in slowing or dramatically delaying wound healing. However, traditional antibiotics are faced with obstacles such as bacterial resistance and unsatisfactory biocompatibility, which has impeded further clinical translation. In recent years, antimicrobial nanomaterials have emerged as viable alternatives for combating bacterial infections, and carbon dots (CDs) have received particularly widespread attention due to their superior characteristics. In this work, a simple and eco-friendly one-step hydrothermal method was employed using the natural herbal medicine Eucommia ulmoides as a biomass carbon source to synthesize an Fe-doped CDs nanozyme (Fe-CDs) with good peroxidase-like (POD-like) activity, high biocompatibility, and strong antimicrobial activity for safe and effective antimicrobial therapy and the promotion of wound healing. L929 cells co-cultured with Fe-CDs did not show significant cytotoxicity and favored cell proliferation at appropriate concentrations. In addition, Fe-CDs catalyzed the decomposition of low-concentration H 2 O 2 to ·OH, leading to enhanced antimicrobial activity. Both in vitro and in vivo experiments demonstrated that Fe-CDs exhibit potent antibacterial properties, the ability to promote cell migration and angiogenesis, and significant potential for promoting the healing of infected wounds. In summary, a green and safe antimicrobial nanozyme based on a biomass herbal medicine was developed in this work, offering promising insight into the development of novel antimicrobial materials and tissue regeneration engineering.
研究领域:
纳米技术
·
材料科学
·
生物医学工程
·
药学
·
微生物学
·
伤口愈合
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Fan Zhang,Chao Wang,Xiaona Huang,Xiaotong Dong,Hui Chi,Kun Xu,Yungang Bai,Pixin Wang
Porous polymers have many industrial applications, but their pore structures (open or closed) are usually fixed during polymerization. In this study, polymers with reversible and controllable pore structures, namely, thermosensitive porous hydrogels with regulated volume phase transition temperature, were prepared using a Pickering high-internal-phase emulsion as the template. Upon heating, the hydrogels transformed not only in their wettability (between hydrophilicity and hydrophobicity with water contact angles of 21.8 and 100.9°) but also their pore structure (between open through-holes and closed holes with pore throat sizes of 15.58 and 0 μm, respectively) in a short time (<10 s). When the hydrogel was used as a separator in smart supercapacitors (SCs), this behavior effectively limited the path of electrolyte migration, reducing the chance of conflagration accidents. Moreover, by utilizing the highly reversible pore structures and wettability of the porous hydrogel, reversible charging and discharging were restored after the system cooled down. This work not only provides great guidance for preparing porous polymers with reversible pore structures but also paves the way for designing smart SCs with enhanced safety.
研究领域:
材料科学
·
能源技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
·
2024
·
IF 11.2
Ting Sai,Xiaodi Ye,Bingtao Wang,Zhenghong Guo,Juan Li,Zhengping Fang,Siqi Huo
A series of transparent, intrinsically flame-retardant, and impact-resistant poly(carbonates- b -siloxanes) were synthesized by incorporating Schiff-base modified polysiloxanes (DMS-Schiff) and naphthalene-sulfonate units into the polycarbonate (PC) chain. In addition to high transparency, the resultant copolymers (SS-co-PC5, SS-co-PC9, SS-co-PC14, and SS-co-PC20) exhibited remarkable improvements in fire safety and mechanical performance. Compared to pure PC, these copolymers demonstrated significantly enhanced limiting oxygen index (LOI, up to 34.5%) and a UL-94 V-0 rating under a thickness of only 1.6 mm. The incorporation of the polysiloxane blocks not only improved flame retardancy but also enhanced the impact strength, with SS-co-PC9 showing a 48% increase in elongation at break and a 38% rise in impact toughness compared to pure PC. In addition, SS-co-PC9 presented high mechanical strength. The synergistic effects between the naphthalene-sulfonate and polysiloxane blocks, along with the well-controlled polysiloxane phase separation (sulfonate units enabled lower processing viscosity of copolymers), led to superior comprehensive performance. These findings provide a promising pathway to create high-performance copolycarbonates for real-world applications.
研究领域:
材料科学
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2026
·
IF 7.8
Congcong Li,Haojie Sui,Yongqi Xie,Xuan Wang,Jinhao Dong,Haoyu Zhao,Hai Zhong,Yonghong Hu,Shufang Zhang,Changlin Yao,Qi Zhang
The commercialization of perovskite solar cells (PSCs) is severely limited by interfacial charge losses, poor stability, and lead leakage, with few strategies to address all issues simultaneously. We design 1,5-naphthalenedisulfonic acid sodium salt (NSA) as a multifunctional buried interface modifier for SnO2-based PSCs. NSA features sulfonate groups, a rigid π-conjugated naphthalene backbone, and localized SO3––Na+ ion pairs, enabling an ion-pair-induced electrostatic gating effect beyond conventional chemical passivation: (i) sulfonate groups coordinate with undercoordinated Pb2+ defects to reduce trap density; (ii) the SO3–-Na+ network generates a local electrostatic field to promote directional electron extraction and suppress hole backflow; (iii) the uniform NSA layer guides perovskite crystallization, producing larger grains and higher crystallinity. As a result, NSA-modified n-i-p PSCs reach a champion efficiency of 25.82%, with improved charge extraction and suppressed nonradiative recombination. Notably, the NSA layer acts as a robust lead-lock barrier, reducing lead leakage and boosting operational stability. This work presents a facile molecular design for buried interface engineering that synergistically optimizes efficiency, stability, and environmental safety in PSCs.
✓ 已验证
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Longchao Ma,Genmiao Wan,Yan Wang,Chenkai Dou,Danhe Liu,Yue Jiao,Hao Sun,Xinzhou Wang,Yi Chen,Qiliang Fu,Yanjun Li
Bamboo surface is engineered with a synergistic modification of metal ions–silane. • Coordinated alginate network provides flame retardancy and mold resistance. • Silane layer confers hydrophobicity and self-cleaning properties. • Crosslinked structure imparts excellent mechanical robustness. Flattened bamboo board (FB) characterized by its high raw-material utilization, large dimensions, and appealing aesthetics, holds potential for indoor furniture applications. However, its inherent hygroscopicity and flammability severely restrict its performance in humid or fire-sensitive environments. Herein, a multifunctional nanostructured coating system integrating metal-ion coordination and silane modification was developed to enhance the durability of FB. Specifically, Ca 2+ /Zn 2+ ions were first coordinated with sodium alginate to construct a bio-based alginate salt (AS) coating, followed by silane modification (PSO) to form an integrated AS/Ca-Zn@PSO coating, where the metal ion–silane synergy enabled concurrent improvements in flame retardancy, mold resistance, water repellency, and interfacial durability. The resultant FB functionalized with AS/Ca-Zn@PSO exhibited high flame retardancy (LOI = 32.3) with superior anti-mold performance, reaching the highest grade of level 0. Compared with untreated FB, the peak heat release rate and total smoke production of AS/Ca-Zn@PSO FB were reduced by 56% and 55%, respectively. Furthermore, the modified FB also maintained high hydrophobicity and flame retardancy after mechanical abrasion. This environmentally benign modification approach enables an effective route to valorize renewable bamboo into a sustainable material with favorable water resistance, anti-mold performance, and flame retardancy for indoor furniture applications. Download: Download high-res image (101KB) Download: Download full-size image
✓ 已验证
DOI
高影响因子
ACS Nano
·
2025
·
IF 16
Xiaobin Chen,Sili Qiu,Zhenhua Jian,Yan Hu,Dazhu Chen,Zhouguang Lu,Chen Liu
The thermal runaway issue of polymer electrolytes (solid polymer electrolytes (SPEs)) at high temperatures, particularly the irreconcilable contradiction between thermal safety and electrochemical performance, remains a great challenge for SPEs that can be applied to solid-state lithium batteries. Here, an intelligent self-extinguishing system originating from the core–shell structure of microcapsules is designed to snuff out the possibility of thermal runaway and provides a high-performance solid-state Li metal battery. The polymer shell of the microcapsules not only serves as a barrier to eliminate detrimental interactions of the flame retardant with the electrolyte or the active lithium metal anode but also acts as a thermoresponsive agent to release the flame retardant. The ion hopping points on the shell of the microcapsules further contribute to the ion conducting nature of the SPE, boosting the ionic conductivity to be 9.3 × 10–4 S cm–1. Significantly, the Li//Li symmetric cells exhibit stable long-term cycling for over 3400 h, and the solid-state Li metal battery shows a capacity retention of 87.4% after 500 cycles. Meanwhile, the SPE displays superior flame retardancy with a self-expansion time of 3 s g–1. This work offers a versatile strategy for designing truly safe and high-performance solid-state Li–metal batteries.
研究领域:
材料科学
·
能源存储
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2025
·
IF 11.5
Kunpeng Liu,Binbin Jiao,Guan Zhang,Zhihua Gan,Shicong Lai,Zhenshan Ding,Qingsong Yu
Bladder cancer remains a significant clinical challenge, necessitating the development of innovative therapeutic strategies. Recent advancements have highlighted the potential of reactive oxygen species (ROS)-responsive drug delivery systems in cancer therapy. In this study, we introduce a novel treatment approach utilizing a ROS-responsive camptothecin (CPT) prodrug encapsulated within a chitosan nanocarrier, named CACPT. Cinnamaldehyde (CA), acting as a ROS generator, forms thioketal bonds with CPT to create a prodrug that responds selectively to the elevated ROS levels within the tumor microenvironment. Upon exposure to high ROS conditions, these thioketal bonds are cleaved, resulting in the simultaneous release of CPT and CA. The liberated CA further enhances ROS production, establishing a positive feedback loop that amplifies the therapeutic effect. The use of amphiphilic chitosan nanocarriers enhances the retention and penetration of the prodrug within bladder tissue, optimizing its therapeutic potential. Our experimental findings demonstrate that this self-enhanced ROS-responsive release promotes increased cellular uptake and significantly enhances the anticancer efficacy of CACPT. These results position CACPT as a promising candidate for intravesical therapy in bladder cancer, potentially overcoming current limitations in treatment options. The innovative combination of ROS-responsive mechanisms and chitosan nanocarriers represents a paradigm shift in bladder cancer therapeutics, offering a multifaceted approach with substantial promise for clinical translation.
研究领域:
肿瘤学
·
药剂学
·
生物材料学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）