查找使用阿拉丁产品的科研文献

Biomimetic Cu2+/Zn2+ bimetallic surface with glycocalyx-mimicking polymer for selective vascular cell regulation and enhanced hemocompatibility

Shuaihang Guo,Shengen Gu,Qiulian Wu,Mengying Zhan,Lisha Pan,Dan Li,Yiping Chen,Xiaoli Liu

The vascular endothelium represents the ideal hemocompatible interface, exhibiting unique capabilities to prevent thrombus formation while maintaining vascular homeostasis. To emulate these properties, we have developed a biomimetic surface combining two critical endothelial components: biologically active metal ions that regulate vascular function, and synthetic glycosaminoglycan analogs that replicate the endothelial glycocalyx's antithrombogenic properties. Here, a bimetallic Cu 2+ /Zn 2+ composite coating was developed on polyvinyl chloride (PVC) substrates through dopamine-assisted immobilization, with the surface metal composition being controlled by adjustment of the Cu 2+ /Zn 2+ feeding ratio. The Cu 2+ -rich surface (PC 5 Z 1 ) demonstrated enhanced nitric oxide (NO) catalytic release, effectively suppressing human umbilical vein smooth muscle cell (HUVSMC) proliferation, while the Zn 2+ -enriched surface (PC 1 Z 4 ) promoted human umbilical vein endothelial cell (HUVEC) growth. The optimal Cu 2+ /Zn 2+ (1:1, PC 1 Z 1 ) surface was further functionalized with glycosaminoglycan analog poly(SS- co -OEGMA) (PSO), creating a multifunctional coating that synergistically combines metal ion regulation with glycocalyx-mimicking chemistry. The resulting PC 1 Z 1 -PSO surface achieved a HUVEC/HUVSMC ratio of 2.4 in co-culture, demonstrating its dual capability in promoting endothelialization while inhibiting smooth muscle cell proliferation. Furthermore, platelet adhesion and clotting time assays showed the excellent hemocompatibility of the PC 1 Z 1 -PSO surface. These results demonstrate that strategic integration of bioactive metal ions with glycocalyx-mimicking polymers can effectively mimic key endothelial functions, offering a promising strategy for optimizing the hemocompatibility of blood-contacting materials.

In-situ interfacial engineering in NH2-Zn2(Bim)4/Polyimide mixed matrix membranes for enhanced H2 purification

Qian Wu,Xinping He,Chenyi Cui,Chenchen Jiao,Baojin Qi,Jinjia Wei

Mixed matrix membranes (MMMs) incorporating metal–organic frameworks (MOFs) hold significant promise for gas separation applications. However, the inherent disparity between the organic polymer matrix and the inorganic fillers frequently leads to interfacial incompatibility issues. In this study, we adopted an in-situ interfacial crosslinking strategy to fabricate MMMs incorporating NH 2 -Zn 2 (Bim) 4 nanosheets that simultaneously act as nanofillers and reactive crosslinkers. Specifically, during the thermal imidization reaction process, the amino groups of NH 2 -Zn 2 (Bim) 4 not only establish hydrogen bonding interactions with the carbonyl groups of polyamic acid (PAA) (the precursor of polyimide), but undergo dehydration reactions with carboxyl groups, leading to the formation of stable amide linkages. Meanwhile, the aromatic structure of the BI units, a key monomer of polyimide, closely resembles that of the ligands of NH 2 -Zn 2 (Bim) 4 , which can establish π-π stacking interactions, further improving the interfacial compatibility between the polymer matrix and MOF fillers. Among the prepared samples, MMMs incorporating 33.3 wt% NH 2 -Zn 2 (Bim) 4 nanosheets exhibit the maximum H 2 permeability of 680.5 Barrer, and its H 2 /N 2 and H 2 /CO 2 selectivities were 18.7 and 13.3, respectively, which were close to or even exceeded the Robeson upper bound. The proposed in-situ interfacial engineering based on chemical crosslinking provides a novel and effective route for fabricating high-performance MMMs with enhanced interfacial compatibility, demonstrating great potential for hydrogen separation applications.

A Novel Fluorescent Probe for Zn2+ Detection in Aqueous and Application in Environmental Samples and Cells Bioimaging

Huajie Kong,Dandan Li,Yun Yang,Xiangrui Hu,Mingzhe Li,Qiqi Zuo,Kuoxi Xu

A novel salicylaldehyde-benzohydrazide–based fluorescent probe L was designed and synthesized. The probe displayed excellent specificity and sensitivity for Zn 2+ detection in aqueous media (HEPES buffer, pH = 7.40), accompanied by a remarkable colorimetric fluorescence change from colorless to green under a 365 nm UV lamp. The detection mechanism of probe L for Zn 2+ was elucidated by 1 H NMR, HRMS, and DFT calculation. Moreover, the probe was effectively applied in the detection of Zn 2+ in both environmental samples and biological imaging in living cells.

Crystal Water Boosted Zn2+ Transfer Kinetics in Artificial Solid Electrolyte Interphase for High-Rate and Durable Zn Anodes

Hongrun Jin,Simin Dai,Zehao Zhu,Yongxin Luo,Bei Qi,Kaisi Liu,Tao Wu,Xinyan Zhuang,Jun Zhou,Liang Huang

The commercialization of aqueous zinc ion batteries (ZIBs) is seriously hindered by the inferior stability of the Zn anode, which principally originates from water-induced side reactions and dendrite issues. Interfacial engineering has been considered as a cost-effective way to tackle these bottlenecks. However, most artificial solid electrolyte interphase (SEI) suffers from sluggish Zn2+ migration and thus compromises the kinetic merits of aqueous ZIBs especially at ultrahigh rates. Herein, we present a unique H2O molecules-rich zinc phytate (PAZn) interphase for the optimization of Zn anodes. The critical role of crystal water on the Zn2+ transport process is demonstrated. Benefiting from the shielding effect, the Zn2+ diffusion coefficient increases by orders of magnitude in the presence of crystal water. Accordingly, the Zn anode modified by PAZn interphase delivers an impressive lifespan of 1200 h and dramatically reduced voltage hysteresis even under an ultrahigh current density of 10 mA cm–2, and it remains stable even at a higher Zn utilization exceeding 50%. Moreover, the V2O5//PAZn@Zn full cell exhibits remarkable performance with a high capacity retention of 89.3% after 600 cycles. This work provides an effective strategy for rationally designing highly Zn2+-conductive artificial SEI for durable Zn anodes and high-performance commercially available ZIBs.

The NLRX1-SLC39A7 complex orchestrates mitochondrial dynamics and mitophagy to rejuvenate intervertebral disc by modulating mitochondrial Zn2+ trafficking

Yu Song,Huaizhen Liang,Gaocai Li,Liang Ma,Dingchao Zhu,Weifeng Zhang,Bide Tong,Shuai Li,Yong Gao,Xinghuo Wu,Yukun Zhang,Xiaobo Feng,Kun Wang,Cao Yang

Synergistic mechanism of Ag+–Zn2+ in anti-bacterial activity against Enterococcus faecalis and its application against dentin infection

Fan Wei,Sun Qing,Li Yanyun,Tay Franklin R.,Fan Bing

Background Ag + and Zn 2+ have already been used in combinations to obtain both enhanced antibacterial effect and low cytotoxicity. Despite this, it is still unclear how the Zn 2+ co-works with Ag + in the synergistic antibacterial activity. The main purposes of this study were to investigate the co-work pattern and optimum ratio between Ag + and Zn 2+ in their synergistic antibacterial activity against E. faecalis , the possible mechanisms behind this synergy and the primary application of optimum Ag + –Zn 2+ co-work pattern against the E. faecalis biofilm on dentin. A serial of Ag + –Zn 2+ atomic combination ratios were tested on both planktonic and biofilm-resident E. faecalis on dentin, their antibacterial efficiency was calculated and optimum ratio determined. And the cytotoxicity of various Ag + –Zn 2+ atomic ratios was tested on MC3T3-E1 Cells. The role of Zn 2+ in Ag + –Zn 2+ co-work was evaluated using a Zn 2+ pretreatment study and membrane potential—permeability measurement. Results The results showed that the synergistically promoted antibacterial effect of Ag + –Zn 2+ combinations was Zn 2+ amount-dependent with the 1:9 and 1:12 Ag + –Zn 2+ atomic ratios showing the most powerful ability against both planktonic and biofilm-resident E. faecalis. This co-work could likely be attributed to the depolarization of E. faecalis cell membrane by the addition of Zn 2+ . The cytotoxicity of the Ag + –Zn 2+ atomic ratios of 1:9 and 1:12 was much lower than 2% chlorhexidine. Conclusions The Ag + –Zn 2+ atomic ratios of 1:9 and 1:12 demonstrated similar strong ability against E. faecalis biofilm on dentin but much lower cytotoxicity than 2% chlorhexidine. New medications containing optimum Ag + –Zn 2+ atomic ratios higher than 1:6, such as 1:9 or 1:12, could be developed against E. faecalis infection in root canals of teeth or any other parts of human body.

Efficient synthesis of bis-isoxazole ethers via 1,3-dipolar cycloaddition catalysed by Zn/Zn2+ and their antifungal activities

Zhang Da-Wei,Lin Feng,Li Bo-Chao,Liu Hong-Wei,Zhao Tian-Qi,Zhang Yu-Min,Gu Qiang

An efficient method was developed for synthesising isoxazoles. A series of novel bis-isoxazole ether compounds VI, VII and VIII were synthesised starting from different substituted aldehydes ( I ) via a 1,3-dispolar cycloaddition using Zn/Zn 2+ as a catalyst; these were characterised by FT-IR, HRMS, 1 H NMR and 13 C NMR spectroscopy. In addition, the antimicrobial properties of the synthesised products were investigated. The synthesised compounds exhibited significant antifungal activities in comparison with the standard drugs, fluconazole and itraconazole. It was found that Candida albicans was sensitive to 2-substituted phenyl bis-isoxazole ethers bearing pyridyl.

Preparation of Highly Bioactive Nanolignin via Dopamine Mannich Modification and Its Synergistic Effects With Zn2+ in PVA Hydrogels

Meiling Han,Hui Hui,Yi Yang,Yan Wang,Danli Zhou,Yuebin Xi,Yu Jing,Pingxian Feng,Fan-Gong Kong,Huan Wang,Weijun Yang

en This link goes to a English section zh This link goes to a Chinese section Lignin is a natural non-toxic polyphenolic macromolecule, which shows inherent antioxidant and broad-spectrum antibacterial activities. However, due to the low content and the high bond dissociation energy of phenolic hydroxyl groups (Ar-O·H), its antioxidant and antibacterial activities are relatively weak, which limits its application as a highly bioactive biomaterial. In this study, different contents of dopamine (DA) were grafted onto the lignin nanoparticles (LNP) via a simple Mannich reaction to prepare LNP- x DA nanomaterial. LNP-1DA has an antibacterial rate of up to 99% against Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ), and the antioxidant activity is 40% higher than that of LNP. Meanwhile, both LNP and LNP-DA have excellent blood and cell compatibility, whereas the hemolysis rate was less than 1% ( p < 0.001) and the cell viability for CCK-8 was higher than 95% ( p > 0.05). In order to further investigate its potential application as the bioactive wound-dressing additive, PVA/LNP-DA/Zn hydrogels were prepared by uniformly dispersing LNP-1DA in the Polyvinyl Alcohol (PVA) aqueous solution via the freezing-thawing approach, followed by immersing into the ZnCl 2 solution via an equilibrium method. The synergistic effects of LNP-1DA and Zn 2+ coordination endowed the hydrogels with improved mechanical properties (tensile strength up to 37.9 KPa) and antibacterial activity (antibacterial rate of 99%). This work will be of significance for the high-value utilization of lignin and the development of a novel bioactive material. 摘要 en This link goes to a English section zh This link goes to a Chinese section 木质素是一种天然无毒的多酚类大分子 , 具有固有的抗氧化和广谱抗菌活性。然而 , 由于其含量较低以及酚羟基 ( Ar-O·H ) 键解离能较高 , 导致其抗氧化和抗菌活性相对较弱 , 限制了其作为高生物活性生物材料的应用。本研究通过简单的曼尼希反应 , 将不同含量的多巴胺 ( DA ) 接枝到木质素纳米颗粒 ( LNP ) 上 , 制备出LNP-xDA纳米材料。LNP-1DA 对大肠杆菌 ( E. coli ) 和金黄色葡萄球菌 ( S . aureus ) 的抗菌率高达99% , 其抗氧化活性比LNP高出40%。同时 , LNP和LNP-DA均表现出优异的血液和细胞相容性 , 溶血率低于1% ( p < 0.001 ) , CCK-8检测的细胞存活率高于95% ( p > 0.05 ) 。为进一步探究其作为生物活性敷料添加剂的应用潜力 , 采用冷冻-解冻法将LNP-1DA均匀分散于聚乙烯醇 ( PVA ) 水溶液中 , 再通过平衡法浸入ZnCl₂溶液 , 制备了PVA/LNP-DA/Zn水凝胶。LNP-1DA与Zn²⁺配位产生的协同效应显著提升了水凝胶的力学性能 ( 拉伸强度达37.9 kPa ) 和抗菌活性 ( 抗菌率达99% ) 。本研究对木质素的高值化利用及新型生物活性材料的开发具有重要意义。

Zn2+/Na+ Co-Intercalation Chemistry Enabled by a Hybrid Hydrogel Electrolyte for High-Voltage Flexible Aqueous Zinc Batteries

Shibo Meng,Dongshu Liu,Jiang Liu,Jiayi Zhang,Hanlin Li,Wenxian Liu,Fangfang Wu,Wenhui Shi,Zhiyuan Zeng,Xiehong Cao

Flexible aqueous zinc-based batteries (ZBs) are promising for wearable electronics but are hindered by low operating voltage and poor cycling stability. While zinc hexacyanoferrate (ZnHCF) represents a promising cathode candidate, its practical application is limited by rapid capacity decay. This failure is conventionally attributed to irreversible structural collapse. Herein, our findings depart from the prevailing view by demonstrating that degraded cathodes retain their structural integrity and recover capacity in specific media. We identify the primary failure mechanism as Zn 2+ entrapment induced by strong electrostatic interactions, distinct from lattice dissolution. Leveraging this insight, a dual-regulation strategy is proposed utilizing Na + co-intercalation to mitigate ion trapping and a quasi-solid composite hydrogel to suppress water activity. Consequently, a high full-cell voltage (1.8 V) Zn//ZnHCF battery is developed delivering exceptional stability over 4000 cycles. This work not only revises the fundamental understanding of ZnHCF degradation but also provides a robust pathway for high-performance aqueous energy storage. Graphical Departing from the prevailing view that ZnHCF degradation arises from irreversible structural collapse, this work identifies Zn 2+ entrapment induced by strong electrostatic interactions as the primary failure mechanism. By introducing Na + co-intercalation to mitigate ion trapping, ZnHCF reversibility is markedly enhanced, enabling a flexible 1.8 V Zn//ZnHCF battery with exceptional cycling stability supported by a quasi-solid composite hydrogel.

A ratiometric fluorescence probe toward Zn2+ detection in acidic gastric juice sample based on quinoline/carbonized polymer dot

Haiyue Yu,Zimin Yao,Guoliang Zheng,Yan Zhao,Dantong Zhu,Fanxu Bu

The Zn 2+ level in gastric juice serves as a powerful reference for the distinction of benign/malignant lesions. However, its accurate detection remains challenging due to the complex and highly acidic samples. Herein, a ratiometric fluorescence probe was developed based on quinoline-functionalized carbonized polymer dots (CPDs) for Zn 2+ accurate detection. The probe has two emission bands at 410 nm and 490 nm. The quinoline groups on the CPDs can form coordination bonds with Zn 2+ , enabling specific recognition of zinc ions. Zn 2+ addition can lead to fluorescence quenching of quinoline component of quinoline/CPD probes in simulated gastric fluid samples, while the emission of the CPDs remains almost unchanged. This ratiometric response between emission intensity at 410 nm and 490 nm enables accurate quantitative detection of Zn 2+ . The probe exhibited a detection sensitivity of 4.56 nM for Zn 2+ and demonstrated outstanding selectivity against other metal ions, attributed to its self-calibration capability. This work offers a novel strategy for designing ion sensing platforms and holds great potential for aiding the diagnosis of gastrointestinal diseases.

Synergistic Zn2+–Sb3+ Doping Enables Unity Photoluminescence Quantum Yield in Zero-Dimensional Manganese Halide toward Flexible Temperature Sensing

Liangyi Gu,Daxi Pan,Jiahong Li,Xiaoshuang Li,Jian Wang,Bingtao Liu,Bo Wang,Youchao Kong,Qingguang Zeng

Zero-dimensional manganese halides offer distinctive luminescence but are limited by nonradiative losses, constraining their efficiency and tunability. Herein, we demonstrate a synergistic Zn2+ and Sb3+ doping strategy in (C8H20N)2MnCl4 to overcome these limitations. Initial Zn2+ alloying optimized the inter-Mn2+ distance, suppressing nonradiative energy transfer and boosting the inherent green Mn2+ emission (525 nm) to a 92.5% PLQY. Subsequent incorporation of trace Sb3+ ions created dual emissive centers, enabling broad white-light emission and a record PLQY of 98.4%. Combined spectroscopic and computational studies confirm that Sb3+ occupies both Mn2+ and Zn2+ sites, introducing specific defect states that steer energy into both triplet and singlet self-trapped exciton channels, alongside the Mn2+ transition. The optimized material exhibits superior thermal stability with a high activation energy barrier. Leveraging these properties, we fabricated a mechanically durable fluorescent film that serves as a highly sensitive temperature sensor (maximum relative sensitivity of 5.190% K–1), withstanding rigorous folding tests. This work establishes a potent doping paradigm for engineering high-performance 0D emissive halides and showcases their viable integration into flexible optoelectronic devices for advanced sensing applications.

Synergistic strategy for enhancing the thermoelectric properties of Mg2+-Zn2+ co-doped high-entropy fluorite-structured oxide ceramics

Weihua Ji,Ziqian Meng,Yang Miao,Yijie Wang,Chao Ma,Jeremy Heng Rao

The inherent contradiction between electrical and thermal transport has restricted the development of thermoelectric materials. However, high-entropy ceramics with complex structures exhibit unique properties and are expected to overcome this limitation. Herein, the thermoelectric properties of high-entropy fluorite oxides (Zr 0.194 Ce 0.194 Pr 0.194 Y 0.194 Ho 0.194 Mg x Zn 0.03-x )O 2-δ (0 ≤ x ≤ 0.03) are systematically tuned through the Mg-Zn co-doping strategy. The optimal composition (x=0.015) achieves a ZT of 0.46 at 773   K, which was approximately 119% higher than the undoped sample, and about 58% and 41% over Mg-only and Zn-only doped samples. This enhancement results from Zn increasing electrical conductivity as a charge donor while Mg reduces thermal conductivity through point defect scattering, enabling the synergistic optimization of electrical/thermal performance. First-principles calculations reveal Zn induces band convergence and gap contraction, increasing the density-of-states effective mass and promoting electron delocalization. This work validates high-entropy design combined with defect engineering as an effective strategy for developing high-performance thermoelectric materials.