JOURNAL OF CHROMATOGRAPHY A
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2024
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IF 3.8
Chengcheng Yang,Wen Deng,Fei Li,Mengting Gong,Hui Li,Xiaorong Mi,Sitong Ma
A pH/temperature bi-responsive gallic acid magnetic imprinted polymer (PTBG-MIP) was synthesized on a Fe 3 O 4 @SiO 2 @KH570 carrier using methacrylic acid (MAA), p-Vinylphenylboronic acid (p-VPBA), and N-isopropyl-acrylamide (NIPAAm) as complex functional monomers. The density functional theory (DFT) was employed to optimize the molar ratio of multi-functional monomers-template complex, which proved to be an effective tool for predicting complex configuration based on electrostatic potential (ESP) analysis and the lowest binding energy. DFT calculation and analysis determined the optimized molar ratio of 2:1:1:1 for GA-MAA-NIPAAm-p-VPBA, which showed good agreement with experimental results. The PTBG-MIP-4 obtained under the optimized conditions exhibited high pH- and temperature- dependence in rebinding the template, displaying a maximum adsorption capacity ( Q e ) of 62.26 mg g −1 and a highest selection factor (α) of 5.217. Additionally, the PTBG-MIP-4 exhibited exceptional physicochemical properties encompassing magnetization characteristics, morphology, surface sites distribution, and adsorption performance. The application efficiency of this imprinted composite in the extraction and purification of gallic acid from Galla chinensis was remarkably demonstrated.
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JOURNAL OF HAZARDOUS MATERIALS
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2025
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IF 11.3
Wanwan Peng,Jingcheng Wu,Daqing Wu,Yujia Zhang,Tianmi Zhang,Dayong Qing,Yi He
The increasing discharge of complex wastewater, which poses a significant risk to the environment and health, requires the development of an efficient and versatile treatment technology. In this study, we present a more environmentally friendly bifunctional membrane made by in-situ hydrothermal growth of metal-organic frameworks (MOFs) on electrospun nanofibers that can be used for the simultaneous removal of emulsified oils and heavy metal ions. The electrostatically spun fiber substrate consisting of polyacrylonitrile (PAN) and polyimide (PI) provided a high surface scaffold for the uniform deposition of gallic acid biobased MOFs, which ensured highly efficient adsorption and filtration properties as well as the advantage of facilitating secondary recycling. Excellent separation efficiency (>98.4 %) was demonstrated for oil-in-water emulsions and high adsorption capacity (>291 mg·g −1 ) for heavy metal ions. In addition, the membrane exhibited excellent reusability and stability over multiple cycles, highlighting its potential for practical wastewater treatment. This work not only provides scalable strategies in order to design multifunctional filtration materials, but also promotes the understanding of the function of Bio-MOF enhanced nanofibers in the remediation of complex pollutants.
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Polymers
·
2019
·Vol. 11
·期 9
·1464
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IF 3.164
Bin Jiang,Xiaojing Wang,Linlin Wang,Shuang Wu,Dongmei Li,Chunhong Liu,Zhibiao Feng
To develop a novel emulsifier with an antioxidant capacity, a phosvitin-gallic acid (Pv–GA) complex was prepared via a free-radical method. This emulsifier characterizes some key technologies. Changes in the molecular weight of the Pv–GA complex were analyzed by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS–PAGE) and the matrix-assisted laser desorption/ionization time of light mass spectrometry (MALDI-TOF-MS). Fourier transform infrared spectroscopy (FTIR) indicated that C=O, C–N and N–H groups were also likely to be involved in the formation of the complex. A redshift was obtained in the fluorescence spectrogram, thereby proving that the covalent combination of Pv and GA was a free radical-forming complex. The results indicated that Pv and GA were successfully conjugated. Meanwhile, the secondary structure of Pv showed significant changes after conjugation with GA. The antioxidant activity and emulsifying properties of the Pv–GA complex were studied. The antioxidant activity of the Pv–GA complex proved to be much higher than that of the Pv, via assays of the scavenging activities of 2,2-Diphenyl-1-picrylhydrazyl (DPPH) and 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radicals and because of their ability to reduce power. The emulsification activity of the Pv–GA complex was also slightly higher than that of Pv. To function with the most demanding antioxidant and emulsification activities, the optimum conjugation condition was Pv (5 mg/mL) conjugated 1.5 mg/mL GA. Furthermore, the mechanism of Pv–GA conjugation was studied. This study indicated that GA could quench the inner fluorescence of Pv, and this quenching was static. There was a strong interaction between GA and Pv, which was not obviously affected by the temperature. Furthermore, several binding sites were close to 1, indicating that there was an independent class of binding sites on Pv for GA at different temperatures. The conjugation reaction was a spontaneous reaction, and the interaction forces of GA and Pv were hydrogen bonds and van der Waals force.Keywords:phosvitin;gallic acid;conjugation;antioxidant activity;emulsifier;mechanism
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COMPOSITES PART B-ENGINEERING
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2022
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IF 11.322
Ye Li,Min Wang,Meng Sun,Xinxin Wang,Dandan Pei,Bo Lei,Ang Li
Traumatic brain injury (TBI) leads to high rates of morbidity and mortality worldwide with few effective treatments. Excessive oxidative stress and local inflammation at the injury site are considered as the critical factors that determine the therapeutic outcome. In our previous study, stem cells from human exfoliated deciduous teeth-derived exosomes (SHED-Exo) promoted functional recovery of TBI by amelioration of neuro-inflammation. However, the effect was restricted due to unsustainable exosome release and existed oxidative stress that aggravate secondary insult of TBI. To obtain a long-time anti-inflammatory effect of SHED-Exo and attenuate oxidative stress simultaneously, we designed a bioactive antioxidant poly (citrate-gallic acid)-based hybrid hydrogel (FPGEGa) that encapsulate SHED-Exo for treating TBI. The thermosensitive, injectable, self-healing and antioxidant FPGEGa presented ultralong sustained release of SHED-Exo (above 21 days) and significantly decreased the intracellular ROS production of microglia in the central nervous system. FPGEGa carrying SHED-Exo (FPGEGa@SHED-Exo) exhibited better anti-inflammatory potential on microglia, by promoting M2 (anti-inflammatory) polarization and inhibiting M1 (pro-inflammatory) polarization. FPGEGa@SHED-Exo could improve the neuro-regeneration of TBI rats by rescuing damaged motor functions in rats as well as regenerating impaired cortical tissues. The present work suggested that SHED-Exo engineered bioactive antioxidative hydrogel may be promising in achieving satisfactory functional recovery in TBI and other related neurological disorders.
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LWT-FOOD SCIENCE AND TECHNOLOGY
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2020
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IF 4.006
Ting Lu,Yan Shen,Zi-Xuan Wu,Hong-Kai Xie,Ao Li,Yong-Fu Wang,Liang Song,Da-Yong Zhou,Tong Wang
A gallic acid (GA) alkyl ester exerting the best antioxidant effect in flaxseed oil was identified from ten GA alkyl esters with various chain lengths, which was used in combination with other antioxidants including antioxidant of bamboo leaves, ascorbyl palmitate , butylated hydroxytoluene , phytic acid , phospholipid , rosemary extract , tocopherol , tea polyphenols, and tea polyphenol palmitate (TPP) to improve oxidative stability of flaxseed oil. Rancimat induction period, peroxide value , thiobarbituric acid-reactive substances, and electron paramagnetic resonance assays indicate that myristyl gallate (GA-C14) was the best GA ester . The flaxseed oil containing GA-C14 and TPP demonstrated the best oxidative stability among all the composite antioxidants. Through optimizing the mixture ratio, the flaxseed oil containing 34.4 mg/kg GA-C14 and 480 mg/kg TPP showed the best oxidative stability. Its shelf life was predicted by an accelerated shelf life testing using the Arrhenius model, which was prolonged 4.83-fold compared to the control sample under 25 °C.
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INORGANIC CHEMISTRY
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2025
·
IF 4.7
Li Deng,Linfeng Zhang,Ruikai Qi,Jiaming Chen,Wei Song,Xiaofeng Lu
The accurate monitoring of gallic acid (GA) in foodstuffs is crucial for safeguarding human health. The application of nanozymes in colorimetric assays offers a promising route for assessing the GA level. However, the development of high-efficiency and cost-effective nanozymes for quick GA detection holds a substantial challenge. In this study, copper (Cu) nanoparticles (NPs) immobilized on N-doped carbon nanotubes (NCNTs) have been prepared, exhibiting exceptional peroxidase (POD)-like activity for GA detection in food. The anchoring of Cu nanoparticles with NCNTs enables their excellent antioxidant capacity. Then, the obtained Cu NPs/NCNTs show remarkable POD-like activity in catalyzing TMB oxidation, with the attributes of long-term storage stability and reproducibility. Electrochemical assays and radical scavenging experiments reveal a dual mechanism action (involving reactive oxygen species and electron transfer) for the POD-mimicking activity. Furthermore, the developed colorimetric catalytic platform is applied to detect GA in actual tea samples, demonstrating high reliability and potential utility for GA monitoring in the food industry.
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INORGANIC CHEMISTRY COMMUNICATIONS
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2025
·
IF 5.4
Zhuangzhuang Tian,Linping Rui,Xuan Han,Wei Wei
Nanocrystalline chlorapatite (nClAP) has recently gained great interest in adsorptive removal of various contaminants. However, the adsorption of phenolic acids by nClAP remains poorly understood. This study combines experimental and computational approaches to systematically investigate the adsorption mechanisms of two representative phenolic acids, gallic acid (GA) and tannic acid (TA), onto nClAP. Comprehensive characterization confirmed the synthesized nClAP possessed a mesoporous structure with high surface area (153 m 2 /g) and crystalline stability. The batch adsorption experiments of GA and TA onto nClAP were examined as a function of pH, ionic strength, contact time and initial GA/TA concentration. The experimental results indicated that GA/TA adsorption on nClAP reached equilibrium within 120 min, and solution pH and ionic strength exhibited a complex influence on the adsorption process. The experimental data were well fitted by the Elovich model and the Langmuir/Hill isotherm model, indicating monolayer adsorption in the non-homogeneous system. Molecular dynamics (MD) simulations unveiled atomic-scale interactions, showing TA exhibited 8.6-fold stronger binding energy (236.64 kcal/mol) than GA (27.44 kcal/mol), attributed to synergistic Ca 2+ coordination and hydrogen bonding with surface phosphate groups. Notably, nClAP achieved ∼100 % TA removal from eucalyptus leaf leachate at 2.5 g/L dosage, underscoring its practical potential. This work advances fundamental understanding of phenolic acid-mineral interactions and highlights nClAP's efficacy in mitigating plant-derived organic pollution.
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FOOD HYDROCOLLOIDS
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2025
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IF 12.4
Chaoran Yang,Caoyu Guo,Boyan Gao,Marcin A. Kurek,Yuge Niu,Liangli Yu
Natural polymer hydrogels formed by polysaccharides and proteins can be protective carriers for Monascus pigment (MPs) in the food industry. In this study, in order to enhance the mechanical properties of the hydrogel and its ability to protect MPs, we introduced polyphenols as bifunctional components into the hydrogel carrier. This hydrogel carrier consisted of gallic acid (GA) grafted pectin (LPG) and gelatin. The results showed that the grafting of GA enhanced the affinity between MPs and pectin. A more compact network structure formed by pectin under the interaction of MPs with GA improved the mechanical properties of the hydrogel carriers. With the combination of GA with MPs, the gelation rate of the hydrogel carrier was accelerated, the gel strength increased from 550.07 g to 937.67 g and its water swelling rate decreased significantly from 447.87 % to 311.76 %. Moreover, the multiple pigment protection produced by the GA in the hydrogel greatly reduced the degradation rate of MPs under continuous light expose conditions. The findings provide new insights into developing hydrogel carriers for pigment protection with ideal mechanical properties.
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COLLOIDS AND SURFACES B-BIOINTERFACES
·
2026
·
IF 5.9
Yi Wang,Teng Xiao,Meijiao Wu,Qiang Zhao,Jianhua Zhou,Yu Zhang
GA-CDs impart durable antioxidant and anticoagulant activity to polyethersulfone (PES) membranes. • GA-CDs promote macrophage Nrf2 nuclear translocation and reduce ROS and endothelial TF expression. • The membrane showed 83% DPPH and 97% ABTS⁺ scavenging, APTT of ~420 s, and reduced platelet adhesion and PF4 release. Conventional hemodialysis membranes exhibit suboptimal blood compatibility, predisposing patients to thrombotic events and oxidative stress-associated complications that accelerate disease progression. To address this challenge, we developed a gallic acid carbon dots (GA-CDs)-functionalized polyethersulfone (PES) membrane via polydopamine-assisted co-deposition of nitrogen-doped GA-CDs and a heparin-mimetic polymer. The resulting membrane features stable surface immobilization of GA-CDs, conferring durable hemocompatibility and intrinsic dual functionality: (i) sustained ROS-scavenging-driven antioxidant activity for long-term oxidative stress mitigation; and (ii) enhancement of anticoagulant performance through suppression of oxidative stress-mediated tissue factor (TF) activation, thereby synergistically preventing thrombosis. Mechanistically, GA-CDs activated the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling cascade to upregulate endogenous antioxidant enzymes, efficient reactive oxygen species (ROS) clearance, and protection against oxidative cellular damage. Concurrently, by scavenging ROS, GA-CDs suppressed oxidative stress–induced tissue factor activation, establishing a functional link between redox homeostasis and coagulation regulation. In vitro evaluation demonstrated outstanding dual functionality: potent free radical scavenging capacity (83% DPPH and 97% ABTS⁺ scavenging), significantly prolonged activated partial thromboplastin time (APTT 420 s, 8.4-fold increase vs. control), excellent cytocompatibility, and markedly improved hemocompatibility. Collectively, these findings highlight the translational promise of this rationally designed dual-action hemodialysis membrane, where localized durable ROS scavenging and surface-confined anticoagulation operate in concert to mitigate key pathophysiological drivers of dialysis-associated complications. Download: Download high-res image (270KB) Download: Download full-size image Polydopamine (PDA)-assisted co-deposition of poly(sodium 4-styrenesulfonate) (PSSNa) and gallic acid carbon dots (GA-CDs) enabled multifunctional surface modification of polyethersulfone (PES) hemodialysis membranes. Furthermore, cellular experiments demonstrated that GA-CDs promoted the nuclear accumulation of nuclear factor erythroid 2-related factor 2 (Nrf2), reduced intracellular reactive oxygen species (ROS) levels, and suppressed oxidative stress-induced upregulation of endothelial tissue factor (TF). The modified membrane exhibited excellent antioxidant activity, achieving DPPH and ABTS⁺ radical scavenging rates of 83% and 97%, respectively. It also prolonged coagulation times, reduced platelet adhesion and platelet factor 4 (PF4) release, and improved hemocompatibility.
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COMPOSITES COMMUNICATIONS
·
2026
·
IF 8.6
Biaobiao Yan,Yihang Li,Chengxi Du,Xiaojie Shi,Sensen Lu,Guolin Zheng,Lingling Hu,Ping Wang
GA molecules promote the ordered deposition of MXene on fibers, forming a continuous and stable conductive network. • ST-MG offers excellent flexibility, breathability, moisture permeability, and environmental stability. • Textiles with an EMI SE T value close to 50 dB, can shield 99.999% of incident electromagnetic waves. • Covering the surface of a heat source with textiles can lower the temperature measured by an IR detector by approximately 20°C. Personal protective textiles often face the challenges of complex manufacturing processes and poor comfort while striving to achieve functionality. Herein, through this simple and scalable strategy mediated by the natural polyphenolic compound gallic acid (GA), MXene nanosheets were deposited in situ onto the surface of silk textiles, successfully fabricating a personal protective textile (ST-MG) that combines exceptional functionality with wearability. The GA molecules can play a critical adhesive-like role, effectively promoting the uniform deposition of MXene nanosheets on the fiber surface, thereby forming a continuous and stable conductive network. The ST-MG textiles produced not only retain the excellent softness, breathability, and moisture permeability of natural silk but also demonstrate significantly improved conductivity stability. Importantly, when folded into four layers, the ST-MG achieves a shielding efficiency of nearly 50 dB, blocking 99.999% of incident electromagnetic waves; When placed over the surface of a heat source, it can reduce the infrared-detected temperature by approximately 20°C compared to the original fabric, demonstrating excellent potential for infrared thermal camouflage. This work provides a new approach to developing next-generation advanced textiles that combine wearability with multifunctional protection.
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JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
·
2026
·
IF 4
Xu Guo,Jinghan Yu,Qian Wang,Chuan Li,Weiyuan Niu,Xinmiao Wang,Dayong Zhou,Fawen Yin
BACKGROUND Alkyl gallates (A-GAs) are widely used as antioxidants but suffer from poor oral bioavailability. This study investigates whether complexation with phosphatidylcholine (PC) can enable a controlled two-step release of gallic acid (GA) from A-GAs, and how the acyl chain length of A-GAs modulates this process. RESULTS PC complexes with A-GAs (methyl to stearyl gallates) were prepared by thin-film dispersion. FTIR, UV, and 1 H-NMR confirmed hydrogen bonding between the phenolic hydroxyl of A-GAs and the phosphate group of PC. In an everted rat gut sac model, short-chain A-GAs (C1–C4) and GA showed efficient intestinal permeation. The hydrolysis of A-GAs to GA followed first-order kinetics. As the acyl chain length increased, the hydrolysis rate constant ( k DH ) first increased (methyl: 0.9681 × 10 −5 min −1 ; ethyl: 1.278 × 10 −5 ; propyl: 1.852 × 10 −5 ; butyl: 1.905 × 10 −5 ; octyl: 3.154 × 10 −5 ) and then decreased (dodecyl: 1.699 × 10 −5 ; tetradecyl: 0.9911 × 10 −5 ; hexadecyl: 0.6323 × 10 −5 ; stearyl: 0.4074 × 10 −5 ). Octyl and longer esters were not transported across the intestinal mucosa due to self-association. CONCLUSION PC–A-GA complexes enable a two-step sustained release of GA: release of intact A-GAs, followed by enzymatic hydrolysis to GA. The release kinetics can be tuned by varying the acyl chain length of the A-GA, providing a rational design strategy for improving the oral bioavailability of phenolic compounds. © 2026 Society of Chemical Industry.
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MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Xiangyu Sun,Li Han,Xiaoqiang Qiao,Tao Zhu
IL-to-PIL transformation enabled distinct interfacial reconstruction in HsGY/MWCNTs composites. • Polymerization reorganizes PIL interfaces into cooperative multivalent ionic networks. • The PIL5@HsGY/MWCNTs sensor achieved sensitive and stable GA detection. To investigate the distinct interfacial roles of ionic liquids (ILs) and polymerized ionic liquids (PILs), IL- and PIL-functionalized hydrogen-substituted graphyne/multi-walled carbon nanotube (HsGY/MWCNTs) composite electrodes were constructed, with gallic acid (GA) employed as a model analyte and density functional theory (DFT) calculations used to elucidate interfacial interaction mechanisms. After IL functionalization and in situ polymerization, distinct surface morphologies and electrochemical characteristics were observed for the resulting composite electrodes, while different electrochemical responses toward GA were obtained for the IL- and PIL-based composites, highlighting the influence of the modified sensing layers on electrode performance. Under optimized conditions (pH 3.0 and 150 s accumulation), the PIL5@HsGY/MWCNTs/GCE exhibited a linear range of 0.3–10 μM and a detection limit of 0.077 μM. Acceptable repeatability, reproducibility, and stability were achieved by the sensor, and its anti-interference performance was preliminarily evaluated through interference tests. Satisfactory recoveries of 97.68–103.33% were obtained in strawberry and green tea beverage samples. Overall, the distinct interfacial mechanisms of IL and PIL functionalization were elucidated, providing valuable insights for the rational design of high-performance electrochemical sensor interfaces. Download: Download high-res image (145KB) Download: Download full-size image
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危险品化学品经营许可证（带存储）