ADVANCED FUNCTIONAL MATERIALS
·
2024
·
IF 18.5
Yiyue Hong,Mengyang Wang,Daorun Hu,Yujia Wang,Shuaifei Ji,Jiangbing Xiang,Hongliang Zhang,Huating Chen,Yan Li,Mingchen Xiong,Wei Pi,Qianyi Wang,Xinling Yang,Yingying Li,Chaochen Shui,Xiaolei Wang,Xiaobing Fu,Xiaoyan Sun
Efficient wound repair with skin appendage regeneration following severe trauma poses a challenge due to the scarcity of skin grafts and decreased drug effectiveness in protease-rich wound microenvironments. Here, a multifunctional artificial skin (NIR-mFAS) with photothermal-triggered drug delivery capabilities is designed to actively and comprehensively improve the regenerative potential of full-thickness wounds. The antibacterial chitosan/silk fibroin hydrogel matrix of artificial skin, cross-linked by electrostatic interactions, effectively encapsulates and sustains the release of epidermal growth factor (EGF) to accelerate re-epithelialization and neovascularization by promoting the migration and proliferation of repair cells. Subsequently, the photothermal responsive polydopamine nanoparticles (PDA-NPs) dispersed in the matrix enable precise control over the release of BMP4 under the irradiation of 1064 nm NIR, thereby inhibiting scarring by reducing myofibroblasts during the proliferative stage. Importantly, the concurrent controlled release of CHIR99021 can modulate cell fate by inducing the conversion of myofibroblasts into dermal papilla-like cells, leading to hair follicle and sebaceous gland regeneration. The NIR-mFAS functions as an advanced delivery system for achieving high-quality wound healing with appendage regeneration and offers a smart therapeutic approach that can be applied to other treatments requiring coordinated delivery of multiple pharmacological agents.
研究领域:
生物医学工程
·
再生医学
·
药学
·
材料科学
·
组织工程
✓ 已验证
产品关联
DOI
高影响因子
Polymers
·
2024
·Vol. 16
·期 8
·1152
·
IF 4.7
Shijun Long,Chang Liu,Han Ren,Yali Hu,Chao Chen,Yiwan Huang,Xuefeng Li
Shape-shifting polymers are widely used in various fields such as intelligent switches, soft robots and sensors, which require both multiple stimulus-response functions and qualified mechanical strength. In this study, a novel near-infrared-light (NIR)-responsible shape-shifting hydrogel system was designed and fabricated through embedding vinylsilane-modified carbon nanotubes (CNTs) into particle double-network (P-DN) hydrogels by micellar copolymerisation. The dispersed brittle Poly(sodium 2-acrylamido-2-methylpropane-1-sulfonate) (PNaAMPS) network of the microgels can serve as sacrificial bonds to toughen the hydrogels, and the CNTs endow it with NIR photothermal conversion ability. The results show that the CNTs embedded in the P-DN hydrogels present excellent mechanical strength, i.e., a fracture strength of 312 kPa and a fracture strain of 357%. Moreover, an asymmetric bilayer hydrogel, where the active layer contains CNTs, can achieve 0°–110° bending deformation within 10 min under NIR irradiation and can realise complex deformation movement. This study provides a theoretical and experimental basis for the design and manufacture of photoresponsive soft actuators.
研究领域:
材料科学
·
智能材料
·
软体机器人
·
传感器技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Small
·
2024
·
IF 13
Jun Zhu,Leyuan Tian,Dingyuan Yan,Dong Wang,Ben Zhong Tang
Exploiting single molecular species synchronously affording powerful second near-infrared (NIR-II) fluorescence, superior photoacoustic output, prominent reactive oxygen species generation, and satisfactory photothermal conversion is supremely appealing for phototheranostics, yet remains formidably challenging. In this work, electron donor/π-bridge engineering is implemented on the basis of 6,7-di(thiophen-2-yl)-[1,2,5]thiadiazolo[3,4- g ]quinoxaline moiety. The optimal molecule, namely TPATO-TTQ, is demonstrates to exhibit those notable features requested by exceptional phototheranostics, which are systematically elucidated through the depictions of excited-state energy dissipation pathways and the influence of intramolecular motion on the photophysical properties, with assistances of quantum chemical calculation and molecular dynamic simulation. By utilizing TPATO-TTQ nanoparticles, unprecedented performance on NIR-II fluorescence-photoacoustic-photothermal trimodal imaging-navigated type I photodynamic-photothermal synergistic therapy to orthotopic breast cancer is authenticates by the precise tumor diagnosis and complete tumor ablation.
研究领域:
生物医学工程
·
肿瘤学
·
光学成像
✓ 已验证
DOI
PubMed
高影响因子
Nano Research
·
2021
·Vol. 14
·期 11
·4046-4055
·
IF 8.897
Xu Yue,Zhao Chenxi,Zhang Xi,Xu Jingwen,Yang Lingling,Zhang Zhechen,Gao Zhida,Song Yan-Yan
Infectious diseases caused by bacteria are a global threat to the human health. Here, we propose a solvent “irrigation” technique to endow TiO 2 nanotubes (NTs) to precisely modify with functional nanomaterials, and apply them in constructing a near-infrared (NIR) light controlled drug-delivery system for rapid necrosis of bacteria. In this design, the NIR stimuli-responsive functional shell is located on the external tube wall of TiO 2 NT; the internal tube wall offers sufficient binding sites for drug loading. Using kanamycin as a model drug, we demonstrate that the reactive oxygen species generated in photocatalysis not only controllably release the loaded drug by scissoring the linked chains, but also effectively compromise bacteria membrane integrity by damaging the cell wall. Benefiting from the damages, antibiotics rapidly enter the bacteria and reach ≥99.9% reduction in Escherichia coli colony within only 2 h. Importantly, such a covalently conjugation-based delivery system can efficiently relieve radical-induced inflammation and cytotoxicity. This study provides an innovative design strategy for engineering delivery systems with tailorable components, enduring stimuli-response by multiple triggers.
研究领域:
生物材料学
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纳米医学
·
抗菌研究
✓ 已验证
产品关联
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2018
·
IF 3.057
Yongji Yao,Liangmiao Zhang,Zhang Chen,Chuanxiang Cao,Yanfeng Gao,Hongjie Luo
A simple two-step route is developed to fabricate hexagonal Cs x WO 3 nanoparticles . The core of this route is the preparation of the precursor by drying the mixture of WO 3 sol and CsCl , which leads to a higher Cs/W (0.32) ratio at low temperature in a short time. During reaction, oleic acid, used as a solvent, can be adsorbed on the surface of Cs x WO 3 nanoparticles, which results in small particle size (20 nm × 10 nm) and mild agglomeration. In addition, oleic acid also plays a role as a reducing agent in forming Cs x WO 3 nanoparticles without any further post-treatment. Furthermore, the film prepared from as-synthesized Cs 0.32 WO 3 nanoparticles shows excellent NIR-shielding properties (approximately 99% of the near-infrared radiation is cut off over a wavelength range of 780–2600 nm and the visible-light transmittance at 465 nm is 78.9%) when covering on an ordinary sheet of glass. A model which simulates the real environment is applied to evaluate heat-shielding performance of the Cs 0.32 WO 3 film while comparing with that of ordinary glass and commercial ITO glass (10 Ω □ −1 ). Results revealed that the Cs 0.32 WO 3 film showed superior performance than others.
研究领域:
材料科学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2019
·
IF 8.456
Chi Huang,Zhengbo Sun,Haodong Cui,Ting Pan,Shengyong Geng,Wenhua Zhou,Paul K. Chu,Xue-Feng Yu
Near-infrared-II (NIR-II) biowindow is appealing from the perspectives of larger maximum permissible exposure in comparison with the near-infrared-I biowindow, so the NIR-II-responsive drug-delivery nanoplatform is highly desirable. In this work, two-dimensional InSe nanosheets (InSe NSs) are modified with poly(ethylene glycol) and evaluated as an effective NIR-II-responsive cancer treatment nanoplatform. The InSe NSs synthesized by liquid exfoliation exhibit prominent NIR-II-responsive photothermal conversion efficiency (39.5%) and photothermal stability. Moreover, the InSe NSs have a doxorubicin (DOX) loading capacity as high as 93.6%, along with excellent NIR-II-responsive DOX release characteristic. The superior synergistic chemo/photothermal effects have also been demonstrated by the in vitro experiments in killing cancer cells. In combination with good biocompatibility, the InSe NSs have great potential in therapeutic applications.
研究领域:
生物医学工程
·
纳米技术
·
癌症治疗
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Optical Materials
·
2014
·Vol. 2
·期 7
·670-678
·
IF 0
Enhai Song,Sha Ding,Ming Wu,Shi Ye,Fen Xiao,Shifeng Zhou,Qinyuan Zhang
An anomalous near-infrared (NIR) upconversion (UC) emission band at approximately 770 nm is demonstrated in KZnF 3 :Yb 3+ ,Mn 2+ nanocrystals with heavy Mn 2+ doping. This band would enable advanced biological imaging with improved resolution and enhanced penetration depth. Careful studies based on structure analysis, excitation and emission spectra, and luminescence decay curves indicate that this unusual NIR emission (770 nm) originates from the 6 A 1g (S) 4 T 1g (G)→ 6 A 1g (S) 6 A 1g (S) transitions of the Mn 2+ –Mn 2+ dimers. The influence of Mn 2+ concentration and temperature on the Stokes and UC luminescence properties are also investigated. The proposed mechanism for the observed NIR UC emission involves ground state absorption and excited state absorption processes. The present results not only provide a useful and effective approach to achieving pure NIR UC emission, and also new insights into the development of advanced photonic devices and technologies.
研究领域:
材料科学
·
光学
·
生物医学工程
✓ 已验证
产品关联
DOI
ACS Applied Nano Materials
·
2023
·
IF 5.9
Meili Guo,Gang Zhang,Ruoli Zhao,Huizhen Ma,Yuxing Yan,Shuyu Yang,Jian Meng,You Huang,Xiao-Dong Zhang,Hao Wang,Ruiping Zhang
Near-infrared-II (NIR-II) imaging has shown great potential in medical diagnosis and surgical navigation, but developing safe, photostable, high-brightness molecular probes remains a great challenge. Due to their ultrasmall size resulting in highly efficient renal clearance, gold nanoclusters have shown great clinical potential. In this work, we systematically explored the effect of different ligands on the luminescence and bioactivity of gold nanoclusters. Our results show that gold nanoclusters protected by thioglycolic acid (TGA) and 6-mercaptohexanoic acid (MHA) exhibit the strongest fluorescence, while 3-mercaptopropionic acid (MPA)- and sodium sulfide (Na2S)-protected gold nanoclusters show the weakest NIR-II signal. Further doping showed that the Cd-doped MPA and MHA-protected gold nanoclusters exhibited enhanced fluorescence, but the cysteine (Cys)-, glutathione (GSH)-, and Na2S-protected gold nanoclusters showed fluorescence quenching after doping, indicating significant ligand selectivity. Because of the unique multi-energy structure and the large number of electronic states at the highest occupied molecular orbital energy level, MPA- and MHA-protected gold nanoclusters exhibit high stability and photostability. In addition, gold nanoclusters with different ligands exhibited different selective enzyme-mimicking activities of peroxidase (POD), superoxide dismutase (SOD), and catalase (CAT). Imaging in vivo showed that gold nanoclusters could accomplish reliable imaging of cerebral vasculature, hindlimb vessels, and spine as well as monitor renal clearance. The stable nanoclusters allow the time window of imaging to reach 125 min for hindlimb imaging and 270 min for spinal imaging. The gold nanoclusters exhibit a high signal-to-noise ratio of up to 11 for whole-body imaging and show efficient renal clearance and low toxicity at an injected dose of 50 mg/kg.
研究领域:
生物医学工程
·
纳米技术
·
医学成像
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2025
·
IF 5.6
Xiaohong Li,Jiming Dai,Xiaozhen Zhang,Huafeng Liu,Chengzhi Zhou,Renhua Chen
Non-rare earth ion-activated Yb 3+ -rich fluoride matrix luminescent materials exhibit higher absorption efficiency under near-infrared (NIR) laser excitation, and are more suitable for upconversion (UC) photoluminescence and optical heating applications. These materials are highly promising fluorescent self-labeling nano-heaters. In this work, Bi 3+ -codoped β-NaYbF 4 :Tm 3+ UC nanomaterials were synthesized by combining the hydrothermal reaction with the molten salt method. The effects of Bi 3+ doping on the crystalline phase composition, micromorphology, upconversion luminescence (UCL) properties, spectral characteristics , and optical heating performance of the synthesized materials were investigated in detail. The co-doping of 5–20 mol% Bi 3+ was found to significantly enhance the near-infrared (NIR) UCL intensity of NaYbF 4 : Tm 3+ . In particular, t he sample doped with 15 mol% Bi 3+ emitted nearly pure 801 nm monochromatic near-infrared light under 980 nm optical excitation , and its I NIR /I Blue ratio increased dramatically from 0.97 without Bi 3+ doping to 1599. This material exhibited efficient photothermal conversion capability, and the center temperature of the sample can reach ∼147.6 °C under 10 s laser irradiation, achieving a high photothermal conversion efficiency of 129.53 °C W −1 , together with excellent photothermal conversion stability. The mechanism behind the enhanced NIR emission of Bi 3+ -doped nanomaterials was also elucidated based on the energy level transition strategy.
研究领域:
材料科学
·
纳米技术
·
光学
·
发光学
·
光热治疗
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2021
·
IF 6.953
Zheng Wu,Jun Shi,Pingan Song,Jingguo Li,Shaokui Cao
Ti 3 C 2 MXenes, a novel two-dimensional material, have attracted lots of attention in biomedical filed for its large surface area and excellent near-infrared (NIR) responsiveness. In this paper, a pH/near-infrared (NIR) multi-responsive drug delivery platform consisted of hollow hydroxyapatite (HAP), chitosan (CS)/hyaluronic acid (HA) multilayers, gold nanorods (AuNRs) and MXene had been fabricated via a layer-by-layer (LbL) approach. Chitosan/hyaluronic acid multilayers were deposited on the surface of hollow HAP to retard the burst release of DOX in the initial delivery stage. MXenes and AuNRs equipped on the surface of hybrid matrix greatly enhanced the photothermal conversion efficiency of the microcapsules. Due to the collapse of electrostatic force among chitosan/hyaluronic acid multilayers and the dissolution of HAP under acidic condition, as well as the synergistically enhanced photothermal effect between MXene and AuNRs, HAP/CS/HA/MXene/AuNRs microcapsules exhibited outstanding pH-/NIR-responsive drug delivery properties. The present paper provides an attractive method to prepare chitosan/hyaluronic acid based pH/NIR multi-responsive hybrid microcapsules with excellent photothermal conversion efficiency and biocompatibility, which has great potential in the field of remotely controlled drug delivery.
研究领域:
生物医学工程
·
材料科学
·
纳米技术
·
药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOMATERIALS
·
2016
·
IF 8.387
Maoquan Chu,Wangxi Hai,Zheyu Zhang,Fangjie Wo,Qiang Wu,Zefei Zhang,Yuxiang Shao,Ding Zhang,Lu Jin,Donglu Shi
The use of non-toxic or low toxicity materials exhibiting dual functionality for use in sentinel lymph node (SLN) mapping and cancer therapy has attracted considerable attention during the past two decades. Herein, we report that the natural black sesame melanin (BSM) extracted from black sesame seeds ( Sesamum indicum L.) shows exciting potential for SLN mapping and cancer photothermal therapy. Aqueous solutions of BSM under neutral and alkaline conditions can assemble into sheet-like nanoparticles ranging from 20 to 200 nm in size. The BSM nanoparticles were encapsulated by liposomes to improve their water solubility and the encapsulated and bare BSM nanoparticles were both non-toxic to cells. Furthermore, the liposome-encapsulated BSM nanoparticles (liposome-BSM) did not exhibit any long-term toxicity in mice. The liposome-BSM nanoparticles were subsequently used to passively target healthy and tumor-bearing mice SLNs, which were identified by the black color of the nanoparticles. BSM also strongly absorbed light in the near-infrared (NIR) range, which was rapidly converted to heat energy . Human esophagus carcinoma cells (Eca-109) were killed efficiently by liposome-BSM nanocomposites upon NIR laser irradiation. Furthermore, mouse tumor tissues grown from Eca-109 cells were seriously damaged by the photothermal effects of the liposome-BSM nanocomposites, with significant tumor growth suppression compared with controls. Given that BSM is a safe and nutritious biomaterial that can be easily obtained from black sesame seed, the results presented herein represent an important development in the use of natural biomaterials for clinical SLN mapping and cancer therapy.
研究领域:
医学
·
食品科学
·
癌症研究
·
纳米技术
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2017
·Vol. 7
·期 60
·37929-37937
·
IF 3.108
Yang Luo,Sinan Du,Wei Zhang,Zhengfang Liao,Fang Zuo,Shengtao Yang
Core@shell structures of Fe3O4@Mn2+-doped NaYF4:Yb/Tm nanoparticles (NPs) with multifunctional properties were prepared using a hydrothermal route with a seed-growth procedure. The effect of Mn2+ ions on the phase, shape, and upconversion luminescence (UCL) of Fe3O4@Mn2+-doped NaYF4:Yb/Tm NPs was explored using X-ray diffraction, transmission electron microscopy, dynamic light scattering, and photoluminescence spectroscopy. Furthermore, hydrophobic to hydrophilic surface modification of the Fe3O4@Mn2+-doped NaYF4:Yb/Tm NPs was achieved by coating the NPs with an amphiphilic polymer (poly(maleic anhydride-alt-1-octadecene) (C18PMH)) modified with amine-functionalized methyl ether poly(ethylene glycol). Then, the NIR-to-NIR UCL ascribed to the Tm3+ ions, T1-weighted MRI ascribed to the Mn2+ ions, and T2-weighted MRI ascribed to the Fe3O4 core of the hydrophilic Fe3O4@Mn2+-doped NaYF4:Yb/Tm NPs were evaluated. The results indicate that Mn2+ doping is an effective method to control the size/shape and improve the UCL intensity of Fe3O4@Mn2+-doped NaYF4:Yb/Tm NPs, which are promising as imaging agents for NIR-to-NIR UCL and T1/T2-weighted MRI in biomedical research.
研究领域:
生物医学工程
·
材料科学
·
影像医学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）