NEW JOURNAL OF CHEMISTRY
·
2021
·Vol. 45
·期 16
·7210-7216
·
IF 3.591
Dan Liu,Shanshan Dai,Li Wang,Ya Liu,Hongsheng Lu
Organogelators have received extensive attention in the recovery of leaked organic solvents or oil spills. However, due to the interactions of organogelators with the organic solvents/oil, the separation and recovery of organic solvents/oil and organogelators from organogels is difficult. In this study, we have developed an organogelator with pH-triggered recyclable property, realizing the recovery of oil and organogelator. The organogelator (HSA-N) is synthesized with 12-hydroxystearic acid (HSA) and 3-dimethylaminopropylamine by an amidation reaction. Here, HSA-N can gelate several organic solvents and fuel oils at a low concentration (less than 1 wt%), which is induced by the strong hydrogen bond interaction and van der Waals forces demonstrated by X-ray diffraction (XRD) and infrared spectroscopy (IR). As HSA-N can reversibly transform between hydrophilicity and hydrophobicity by regulating pH, the separation and recovery of organic solvents/oil and organogelator can be achieved at room temperature. Herein, organogelators with pH responsiveness make it promising to recover organic solvents/oil and organogelators from organogels at room temperature.
研究领域:
化学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2019
·
IF 2.931
Yingying Zhang,Yanliang Zhao,Yingnan Wu,Bing Zhao,Liyan Wang,Bo Song
Lysosome as the typical acidic organelle involved in many biological processes, the dysfunction of its pH would alter many diseases. Small-molecule fluorescent probe has been considered as vital tool for monitoring pH fluctuation in living cells. Herein, a hemicyanine based ratiometric fluorescent probe was synthesized, namely, 2,3-trimethy-3-[2-(dimethyl-amino-4-yl) vinyl]-3 H -benzo[ e ]indole ( BiDL ), for rapidly detection pH under acidic conditions. BiDL exhibited ratio fluorescence emission ( F 534nm / F 622nm ) characteristic with p K a 4.25. BiDL showed good linearly response in pH 3.4–4.82, indicating that the probe can be used for quantitative detection pH. The probe also displayed large Stokes shift (112 nm/201 nm) under neutral and acidic conditions, respectively, which could effectively reduce the excitation interference. BiDL had excellent cell membrane permeability , good photo-stability and low toxicity in living cells. The dual-channel confocal fluorescent microscopic ratiometric imaging application of pH in HeLa cells and lysosome were achieved successfully, indicating that BiDL has good potential for investigating lysosome-relevant pathological and physiological processes.
研究领域:
生物化学
·
医学
·
细胞生物学
✓ 已验证
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2020
·
IF 5.162
Junjie Hu,Chaozhang Huang,Anda Gong,Huanle Chen,Shilin Liu,Bin Li,Yan Li
In the present study, we prepared cinnamaldehyde (CA) conjugated chitosan-stabilized emulsions (CSCAEs), and the influence of pH on their properties and lipolysis behavior was investigated. Compared to the emulsions stabilized by chitosan itself (CSEs), CSCAEs had better stability against pH during storage. As pH increased from 2.5 to 6.25, the viscosity and modulus of CSCAEs increased. However, when pH shifted from 6.25 to 6.5, emulsion showed lower viscosity and modulus. Confocal laser scanning microscopy results demonstrated that oil droplets still kept intact and individually distributed, and chitosan homogenously covered on the oil droplets at low pH conditions (pH 2.5, 4.0). At higher pH conditions (pH 5.0, 5.5), a few chitosan aggregates on the oil droplets were observed. At pH 6.0 and 6.25, the compact gel network structure was formed. At pH 6.5, some void was found among the chitosan gel network. In vitro simulated digestion experiments presented that pH had no significant effect on the lipolysis process of emulsions. When the oil content varied from 10% to 50%, emulsions still kept good stability against pHs, but the lipolysis extent after digestion decreased. This knowledge provides a strategy for improving stability of chitosan-stabilized emulsion against harsh pH conditions.
研究领域:
食品科学
·
生物化学
✓ 已验证
DOI
高影响因子
FOOD HYDROCOLLOIDS
·
2019
·
IF 5.839
Yun He,Shishuai Wang,Jing Li,Hongshan Liang,Xianlin Wei,Dengfeng Peng,Zhengqiang Jiang,Bin Li
The objective of this study was to investigate the interaction between tannic acid (TA) and konjac glucomannan (KGM) with different molecular weight at different pHs,temperatures and urea concentration. The different molecular weight of KGM without change in primary structure were obtained by ultrasonic treatment. Turbidity titration showed that TA/KGM complexes could form at lower pH. The dynamic light scattering (DLS) and transmission electron microscopy (TEM) results indicated that the TA/KGM complexes assembled into large and uniform colloidal particles and would lead to precipitate with the increase of TA/KGM weight ratio. Isothermal titration calorimetry (ITC) results further revealed two-step binding behavior: the first stage corresponded to soluble complex formation, while the second stage represented aggregation between complexes. When the molecular increased, the transition of TA/KGM mass ratio between stage 1 and stage 2 changed from 3.5 to 3.0. KGM of higher molecular weight needed to bind more TA to move to the next stage. When the pH was 7 at 25 °C, the pH was 3.8 at 40 °C or urea addition, the ITC signal was completely abolished, the formation of complexes between KGM and TA was shown to be highly dependent on pH, temperature, urea concentration, suggesting the main driving force of TA-KGM complexes formation was hydrogen bond.
研究领域:
食品科学
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生物化学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Environmental Sciences
·
2021
·
IF 5.565
Ji Li,Chenlu Shi,Wenbin Zeng,Yaru Wang,Zebin Hong,Yibing Ma,Liping Fang
Electron shuttles such cysteine play an important role in Fe cycle and its availability in soils, while the roles of pH and organic ligands in this process are poorly understood. Herein, the reductive dissolution process of goethite by cysteine were explored in the presence of organic ligands. Our results showed that cysteine exhibited a strong reactivity towards goethite – a typical iron minerals in paddy soils with a rate constant ranging from 0.01 to 0.1 hr −1 . However, a large portion of Fe(II) appeared to be “structural species” retained on the surface. The decline of pH was favorable to generate more Fe(II) ions and enhancing tendency of Fe(II) release to solution. The decline of generation of Fe(II) by increasing pH was likely to be caused by a lower redox potential and the nature of cysteine pH-dependent adsorption towards goethite. Interestingly, the co-existence of oxalate and citrate ligands also enhanced the rate constant of Fe(II) release from 0.09 to 0.15 hr −1 ; nevertheless, they negligibly affected the overall generation of Fe(II) in opposition to the pH effect. Further spectroscopic evidence demonstrated that two molecules of cysteine could form disulfide bonds (S-S) to generate cystine through oxidative dehydration, and subsequently, inducing electron transfer from cysteine to the structural Fe(III) on goethite; meanwhile, those organic ligands act as Fe(II) “strippers”. The findings of this work provide new insights into the understanding of the different roles of pH and organic ligands on the generation and release of Fe induced by electron shuttles in soils.
研究领域:
土壤科学
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环境化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INORGANIC CHEMISTRY
·
2024
·
IF 4.3
Wenxin Bao,Luyuan Tian,Hao Wang,Aidong Tang,Huaming Yang
Overcoming the intrinsic low activity of most peroxidase mimics under neutral pH is crucial but still extremely challenging for the detection of disease markers in biological samples. Here, we chose nanoclay (i.e., montmorillonite K10, MK10) as a carrier to modulate the structure of Fe1–xS nanozyme components through an interfacial modulation strategy, aiming at breaking the neutral pH limitation of Fe1–xS. MK10 with abundant hydroxyl groups on its surface acts as a carrier to increase the ratio of Fe(II) and S(II−) content in surface Fe1–xS. We verify that Fe(II)-promoted surface hydroxyl radical generation and S(II−)-promoted regeneration of Fe(II) play key roles in endowing peroxidase-like activity to Fe1–xS at neutral pH. As expected, Fe1–xS/MK10 exhibited 11-fold higher Vmax and 52-fold higher catalytic efficiency than bare Fe1–xS. As a proof of concept, the sensor constructed based on Fe1–xS/MK10 achieved colorimetric detection of xanthine under neutral conditions with a linear range of 5–300 μM and a limit of detection of 2.49 μM. Finally, we achieved highly sensitive detection of xanthine in serum using the constructed biosensor. Our contribution is the novel use of a nanoclay-mediated interfacial modulation strategy for boosting the peroxidase-mimicking activity and breaking the pH limitation, which contributes to the in situ detection of disease markers by nanozymes under physiological conditions.
研究领域:
纳米技术
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生物传感器
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分析化学
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材料科学
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生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED CLAY SCIENCE
·
2015
·
IF 2.467
Honghai Wu,Hanrui Xie,Guangping He,Yufeng Guan,Yanlin Zhang
Tetracycline frequently needs to be detected in the environment; therefore, iron-intercalated montmorillonite (Fe-Mt) was evaluated as a model adsorbent to evaluate tetracycline adsorption behavior . The Fe-Mt sample derived from Na + -montmorillonite (Mt) by the introduction of iron-(hydr)oxides was fully characterized using the techniques of XRD , FTIR , TEM, and SEM as well as N 2 -adsorption/desorption methods. The delaminated structure of Fe-Mt could cause remarkable increases in both the surface area and pore volume. Fe-Mt also showed remarkably distinct behavior from Mt for TC adsorption. The TC adsorption by Fe-Mt was found to be highly influenced by the pH as well as the types and concentrations of background electrolytes. The positive effect of anions on the TC adsorption by Fe-Mt at acidic pH values follows the following adsorption maximum order: PO 4 3 − > SO 4 2 − » NO 3 − > Cl − > ClO 4 − . The solution pH affects the TC adsorption, and the adsorption maximum occurs at a pH around 5.0. The Langmuir and Freundlich equations were shown to fit well to the TC adsorption isotherms on Fe-Mt, and the former equation was a better fit. These adsorption-related performances could be ascribed to Fe-Mt having formed characteristic bulk/surface/pore structures. The multiple potential coexisting efficient mechanisms or pathways responsible for the TC adsorption by Fe-Mt were finally proposed and discussed in comparison with Mt and ferrihydrite .
研究领域:
环境科学
·
化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF THE CHINESE CHEMICAL SOCIETY
·
2022
·Vol. 69
·期 5
·831-839
·
IF 1.753
Tong Yu,Bin Wang,Li-Ping Yu
In this work, a novel pH-responsive hybrid hydrogel namely MOF/PC hydrogel was prepared by incorporating metal–organic framework CDs@UiO-66(OH) 2 into the matrix of photonic crystal hydrogel. MOF/PC hydrogel could display colorful structure colors under visible light and emit blue fluorescence under UV light owing to the stop-bond effect of photonic crystal and fluorescence emission capacity of CDs@UiO-66(OH) 2 , respectively. Benefiting from these two optical phenomena, MOF/PC hydrogel could work as a dual-mode color-changing sensor, in structure color mode and fluorescence mode, for the sensing of pH. When incubating in aqueous solutions with different pH values, MOF/PC hydrogel could adjust its structure color to the corresponding one ranging from green to pink in 10 s, and this visible color-changing can be used to determine the approximate pH values of the sample by naked eyes without any assistance of instruments. As for the fluorescence mode, the fluorescence intensity of MOF/PC hydrogel showed a good linear relationship with pH value in the range of 3.0~7.0, and it can be used to determine the pH value of aqueous solutions quantitatively. Moreover, the as-prepared sensor is reusable and can be applied to the pH sensing of real water samples.
研究领域:
材料科学
·
化学传感器
·
光学材料
✓ 已验证
产品关联
DOI
高影响因子
Optics
·
2020
·Vol. 1
·期 2
·202-212
·
IF 0
Yang Ran,Peng Xiao,Yongkang Zhang,Deming Hu,Zhiyuan Xu,Lili Liang,Bai-Ou Guan
Operando and precisely probing aqueous pH is fundamentally demanded, both in chemical and biological areas. Conventional pH probes, subjected to the larger size, are probably unfit for application in some extreme scenarios, such as a trace amount of samples. In this paper, we have further developed the pH sensor that leverages the microfiber Bragg grating with an ultra-compact size down to an order of magnitude of 10−14m3. Using the electrostatic self-assembly layer-by-layer technique, the functional film consisting of sodium alginate, which harnesses a pH-dependent hygroscopicity, is immobilized on the fiber surface. Consequently, the alteration of aqueous pH could be quantitatively indicated by the wavelength shift of the grating resonance via the refractive index variation of the sensing film due to the water absorption or expulsion. The grating reflections involving fundamental mode and higher order mode exhibit the sensitivities of −72 pm/pH and −265 pm/pH, respectively. In addition, temperature compensation can be facilitated by the recording of the two reflections simultaneously. Furthermore, the modeling and simulation results predict the pivotal parameters of the configuration in sensitivity enhancement. The proposed proof-of-concept enriches the toolbox of pH sensor for catering to the need of detection in some extremely small spaces—for example, the living cells or the bio-tissues.Keywords:fiber optics;microfiber;Bragg grating;sodium alginate;electrostatic self-assembly;pH sensor
研究领域:
生物技术
·
化学工程
✓ 已验证
DOI
ACS Applied Materials & Interfaces
·
2020
·
IF 8.758
Zilong Han,Peng Wang,Guoyong Mao,Tenghao Yin,Danming Zhong,Burebi Yiming,Xiaocheng Hu,Zheng Jia,Guodong Nian,Shaoxing Qu,Wei Yang
As one of the most promising drug delivery carriers, hydrogels have received considerable attention in recent years. Many previous efforts have focused on diffusion-controlled release, which allows hydrogels to load and release drugs in vitro and/or in vivo. However, it hardly applies to lipophilic drug delivery due to their poor compatibility with hydrogels. Herein, we propose a novel method for lipophilic drug release based on a dual pH-responsive hydrogel actuator. Specifically, the drug is encapsulated and can be released by a dual pH-controlled capsule switch. Inspired by the deformation mechanism of Drosera leaves, we fabricate the capsule switch with a double-layer structure that is made of two kinds of pH-responsive hydrogels. Two layers are covalently bonded together through silane coupling agents. They can bend collaboratively in a basic or acidic environment to achieve the “turn on” motion of the capsule switch. By incorporating an array of parallel elastomer stripes on one side of the hydrogel bilayer, various motions (e.g., bending, twisting, and rolling) of the hydrogel bilayer actuator were achieved. We conducted an in vitro lipophilic drug release test. The feasibility of this new drug release method is verified. We believe this dual pH-responsive actuator-controlled drug release method may shed light on the possibilities of various drug delivery systems.
研究领域:
材料科学
·
药学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MOLECULES
·
2022
·Vol. 27
·期 2
·520
·
IF 4.927
Le Xu,Xi Liu,Jiao Jia,Hao Wu,Juan Xie,Yongtang Jia
Accurately and sensitively sensing and monitoring the pH in the environment is a key fundamental issue for human health. Nanomaterial and nanotechnology combined with fluorescent materials can be emerged as excellent possible methods to develop high-performance sensing membranes and help monitor pH. Herein, a series of fluorescent nanofiber membranes (NFMs) containing poly-1,8-naphthimide derivative-3-[dimethyl-[2-(2-methylprop-2-enoyloxy)ethyl]azaniumyl]propane-1-sulfonate (PNI-SBMA) are fabricated by electrospinning the solution of PNI-SBMA blended with poly(vinyl alcohol) (PVA). The surfactant-like functionalities in side chains of PNI-SBMA endow the NFMs with outstanding hydrophilicity, and the naphthimide derivatives are sensitive to pH by photoinduced electron transfer effect, which contribute to highly efficient pH fluorescence sensing applications of NFMs. Specifically, the PNI-SBMA/PVA NFM with a ratio of 1:9 (NFM2) shows high sensitivity and good cyclability to pH. This work demonstrates an effective strategy to realize a fluorescent sensor NFM that has a fast and sensitive response to pH, which will benefit its application of pH sensor monitoring in the water treatment process.Keywords:electrospinning;nanofibers;fluorescence;sensors;pH
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2017
·
IF 4.164
Yayuan Guan,Yuling Su,Lili Zhao,Fancui Meng,Quanxin Wang,Yongchao Yao,Jianbin Luo
Polyurethane micelles with disulfide linkage located at the interface of hydrophilic shell and hydrophobic core (PU-SS-I) have been shown enhanced drug release profiles. However, the payloads could not be released completely. The occurrence of aggregation of hydrophobic cores upon shedding hydrophilic PEG coronas was considered as the reason for the incomplete release. To verify the above hypothesis and to develop a new polyurethane based micelles with dual stimuli respond properties and controllable location of pH and reduction responsive groups in the PU main chains, a tertiary amine was incorporated into the hydrophobic core PU-SS-I, which resulted polyurethane with both reduction and pH sensitive properties (PU-SS-N). Biodegradable polyurethane with only disulfide linkages located between the hydrophilic PEG segment and the hydrophobic PCL segments (PU-SS-I) and polyurethane with only pH sensitive tertiary amine at the hydrophobic core (PU-N-C) were used as comparisons. Paclitaxel (PTX) was chosen as mode hydrophobic drug to evaluate the loading and redox triggered release profiles of the PU micelles. It was demonstrated that PU-SS-N micelles disassembled instantly at the presence of 10 mM GSH and at an acidic environment (pH = 5.5), which resulted the nearly complete release (~ 90%) of the payloads within 48 h, while about ~ 70% PTX was released from PU-SS-I and PU-SS-N micelles at neutral environment (pH = 7.4) with the presence of 10 mM GSH. The rapid and complete redox and pH stimuli release properties of the PU-SS-N nanocarrier will be a promising anticancer drug delivery system to ensure sufficient drug concentration to kill the cancer cells and to prevent the emergency of MDR. The in vitro cytotoxicity and cell uptake of the PTX-loaded micelles was also assessed in H460 and HepG2 cells.
研究领域:
材料科学
·
药学
·
肿瘤学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）