RSC Advances
·
2015
·Vol. 5
·期 111
·91140-91146
·
IF 3.84
Shuang-Shuang Zhang,Shao-Kui Cao,Su Wang,Qiao-Ling Zhao,Jian-Zhuang Chen,Kun Cui,Zhi Ma
Well-defined α-fluorinated alkyl ester, ω-carboxyl telechelic polystyrenes (PS) were synthesized via combining aminolysis of RAFT-polystyrene and thiol–ene “click” reaction simultaneously. The perfluoroalkyl end groups were –CF3, –(CF2)2–CF3 and –(CF2)7–CF3, respectively. Highly ordered porous films of such telechelic PS with an average pore size about 1.00 μm were fabricated via a static breath-figure process. With the content of fluorine on the surface of porous films increasing from 1.04 wt%, to 1.64 wt% and 2.97 wt%, respectively, the water contact angle (WCA) of such porous films increased from 112° to 116° and 121° ± 0.4°, respectively, indicating their hydrophobicity. Interestingly, microspheres with average diameters of ca. 0.30–0.65 μm can be fabricated via a static BF process using methanol instead of water as the vapor atmosphere in the glass vessel.
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ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Haozhang Xu,Guoan Xi,Wei Chen,Yin Hu,Jun Xia,Weiguo Song,Changyan Cao,Yanhong Zeng,Dan Zhou
The development of hydrogenation catalysts with high performance and stability could decrease the byproducts and simplify the follow-up process in the industrial process. Optimizing supported catalysts through support improvement is a feasible approach to balance effectiveness and cost. In view of this, cubic perovskite NaNbO3 was modified with organosiloxane to form a heterophase junction support consisting of amorphous silica and NaNbO3 crystal. On the basis of this, the supported Ru catalyst displayed superior performance for α-pinene hydrogenation with almost complete conversion, cis-pinane selectivity, and good stability. The relationship between the structure and performance of the catalyst was systematically investigated by comprehensive experiments and multiple characterization technologies. Due to the formation of the heterophase junction, the surface hydrophobicity, specific surface area, and electron properties of the catalyst were optimized, leading to the good dispersity of the catalyst in the hydrogenation mixture and excellent adsorption and charge transfer ability, which should account for the unique performance of the catalyst, as confirmed by a series of experiments, characterizations, and DFT calculations. This work proposes an effective approach to optimize the surface structure and electronic properties of the catalysts through constructing crystallized and amorphous heterophase junction support, which is theoretically significant for the design and development of cost-effective heterogeneous hydrogenation catalysts.
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JOURNAL OF SEPARATION SCIENCE
·
2025
·Vol. 48
·期 5
·e70169
·
IF 2.8
Bing Li,Yidan Lun,Kun Yao,Cheng Tang
In this work, for the first time, a deep eutectic solvent assisted ligand affinity assay was proposed. Several critical parameters affecting the analysis performance were investigated and the optimized DES extract conditions were as follows: the solution of tetrabutylammonium chloride–ethylene glycol (1:2) was prepared as an extract solution. A total of 1.4 mol/L sodium citrate (pH = 6.6) was used for phase separation, and the vortex extraction time was 5 min. Analytes could be enriched in the phase of deep eutectic solvent after phase separation. Then, they could be analyzed by α-glucosidase immobilized magnetic beads affinity assay directly. Results showed the proposed method could detect luteolin (a positive control) from plasma selectively. The LOD was 2 µg/mL. The intraday precision and the interday precision were 7.86% and 6.66%, respectively. By using the proposed method as a tool, plasma of the rats that administrated the extract of Pueraria lobata was analyzed. The bio-active flavonoids absorbed in the body such as puerarin, daidzin, daidzein, and a metabolite of puerarin (puerarin glucuronide) were found. The method has the benefits of a simplified analytic process, high resolution, and is a reliable method.
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CNS Neuroscience & Therapeutics
·
2025
·Vol. 31
·期 5
·e70437
·
IF 5
Hai‐Qian Zhang,Yan Wang,Xiao Geng,Mingxin Dong,Ziwei Liu,Chengbiao Sun,Kaikai Yu,Wenwen Xin,Ye Xu,Na Xu,Wensen Liu
ANG‐modified liposomes encapsulating α‐melittin and resveratrol increase their blood–brain barrier penetration and GB cell selectivity. The combined treatment of α‐melittin with resveratrol markedly facilitates apoptosis and pyroptosis, and promotes the apoptosis–pyroptosis switch in the GB cells via downregulating the Wnt/β‐catenin signaling.
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Discover Oncology
·
2025
·Vol. 16
·期 1
·1-13
·
IF 2.9
Huang Hai-yi,Lin Lisa Zong Yong,Lu Xin-yi,Jiang Ying
Triple negative breast cancer (TNBC) refers to a molecular subtype of breast cancers (BC) with high rate of distant metastases and poor prognosis. Epirubicin (EPI) is widely used for the therapy of TNBC but it’s limited in clinical use due to cardiotoxicity and chemotherapy resistance. We previously identified F-α-DDB-derivative, a novel synthetic of bifendate, as a potential agent to improve the therapeutic efficacy of TNBC in combination with EPI since F-α-DDB-derivative inhibited MDA-MB-468, but not as much as EPI. In this study, we investigated the antitumor activity of F-α-DDB-derivative in combination with EPI against TNBC in vitro and in vivo and whether co-treatment would induce additional cardiotoxicity. In human TNBC MDA-MB-468 cells, application of F-α-DDB-derivative (11.5, 23.0, 46.0 μg/ml) in combination with EPI (1.5, 3.0, 6.0 μg/ml) exhibited great inhibition on cell viability and cell proliferation. Additionally, F-α-DDB-derivative (5.75, 11.5, 23.0, 46.0 μg/ml) interacted with EPI (0.75, 1.5, 3.0, 6.0 μg/ml) synergistically to induce apoptosis in MDA-MB-468 cells. This suggests that F-α-DDB-derivative may be more sensitive to apoptotic pathways. Furthermore, we revealed that co-administration of EPI and F-α-DDB-derivative (ip, once every other day for 14 days) significantly increased the therapeutic efficacy of EPI (2.0 mg/kg) or F-α-DDB-derivative (20.0 mg/kg) in mice harboring MDA-MB-468 cell xenografts without additional cardiotoxicity compared to that in EPI monotherapy group. These results implicate that co-treatment of EPI and F-α-DDB-derivative may be a potential therapeutic approach for the treatment of TNBC.
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LANGMUIR
·
2025
·
IF 3.9
Zhihao Xu,Cheng Chen,Qizhen Wu,Rui Yang,Chenguang Gao,Mingxue Liu,Ruzhen Xie,Wenyuan Hu,Ying Xiong,Faqin Dong
The α-FeOOH (021) crystal facet has a high density of active sites, and as a reactive facet, it has good adsorption of pollutants and good photocatalytic performance. In this paper, nano α-FeOOH with different (021)/(110) crystal facet ratios was prepared using crystal facet inducers (ethanol, ethylene glycol, and glycerol) via a hydrothermal method, with a (021)/(110) crystal facet ratio reaching 16% in the FG-2 sample. The results of photocatalytic experiments show that this sample’s removal rate of Cr(VI) reaches 60.70% in 4 h, which is 61.00% higher than for FC with unregulated crystal facets, and the apparent normalized photocatalytic reaction rate constant is 8.28 times higher than for FC. Kelvin probe force microscope characterization (KPFM) results and density functional theory (DFT) calculation show that FG-2’s higher rate of removal of Cr(VI) was due in large part to the different electric potentials of the (021) and (110) crystal facets. When the ratio of (021)/(110) crystal facets was changed, different electric fields resulted. Meanwhile, the high site density of the (021) crystal facet created high coordination efficiency and in addition higher reactivity resulted from the chromium ion’s lower adsorption energy that the coupling effect produced.
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INTERNATIONAL IMMUNOPHARMACOLOGY
·
2014
·
IF 2.711
Xiaomin Xia,Chuanyang Su,Juanli Fu,Pu Zhang,Xiaoji Jiang,Demei Xu,Lihua Hu,Erqun Song,Yang Song
This study investigated the protective effect of α-lipoic acid (LA) on lipopolysaccharide (LPS)/ d -galactosamine ( d -GalN)-induced fulminant hepatic failure in mice. First, we found that LA markedly reduced LPS/ d -GalN-induced increases in serum ALT and AST activities, which were supplemented with histopathological examination, suggested that LA has a protective effect on this model of hepatic damage. Livers challenged with LPS/ d -GalN exhibited extensive areas of vacuolization with the disappearance of nuclei and the loss of hepatic architecture. On the contrary, these pathological alterations were ameliorated by LA treatment. Next, we found that ROS and TBARS levels were increased in LPS/ d -GalN treated liver homogenates , which were attenuated by LA administration. Consistently, decreases in hepatic CAT and GPx activities were observed in LPS/ d -GalN group and were significantly restored by LA administration. Moreover, pretreatment with LA markedly reduced LPS/ d -GalN-induced iNOS , COX-2, TNF-α, NF-κB, IL-1β and IL-6 expressions. Furthermore, our data showed that TUNEL-positive cells increased in LPS/ d -GalN-treated mice liver which was counteracted by LA administration. LPS/ d -GalN induced apoptosis of hepatocytes, as estimated by caspase 3, caspase 8 and caspase 9 activations. Also, the increasing of Bax and the decreasing of Bcl-2 expressions also supported LPS/ d -GalN induced apoptosis. Interestingly, LA marked relieved these apoptotic features. Taking together, our results indicated that LA plays an important role on LPS/ d -GalN-induced fulminant hepatic failure through its antioxidant, anti-inflammatory and anti-apoptotic activities.
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APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
·
2018
·Vol. 102
·期 18
·7891-7900
·
IF 3.34
Pei Xiaolin,Wang Jiapao,Wu Yifeng,Zhen Xiaoting,Tang Manman,Wang Qiuyan,Wang Anming
Nitrile hydratase (NHase) has attracted considerable attention since it can efficiently catalyze the hydration of nitriles to valuable amides. However, the poor stability of NHase is one of the main drawbacks in the industrial application. In this study, we compared the structural difference between Fe-type and Co-type NHase and found that an extra α helix existed at the β-subunit surface of Co-type NHase (defined as the β-6th helix). Then, the effects of the β-6th helix were investigated on the thermal stability and the catalytic kinetics of a Co-type NHase from Aurantimonas manganoxydans ATCC BAA-1229 (NHase1229). When the β-6th helix was deleted or disrupted, the thermal stability of NHase1229 was reduced to 17.6 and 12.9% of that of wild NHase1229, respectively. Thus, the β-6th helix is important for the thermal stability of Co-type NHase. Based on the structural characteristics of Co-type NHase, the β-6th helix may be interacted with another helix at the α-subunit (defined as the α-2nd helix) by hydrophobic network just as a “magnetic suction buckle” on the enzyme surface to stabilize the binding of α- and β-subunits. The β-6th helix is located at the mouth of the substrate and product tunnel, so it plays crucial roles in catalytic process. Furthermore, the β-6th helix in NHase1229 was swapped with a thermophilic NHase fragment from Pseudonocardia thermophila JCM3095 (NHase1229-Swap). The thermal stability of NHase1229-Swap was significantly improved, and the half-life was approximately 2.4-fold at 40 °C than that of the wild NHase1229. The knowledge is useful for improving the stability of NHases by restriction fragment swapping.
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Marine Drugs
·
2021
·Vol. 19
·期 8
·416
·
IF 5.118
Xiaoshuang Gou,Danmei Tian,Jihua Wei,Yihan Ma,Yixue Zhang,Mei Chen,Wenjuan Ding,Bin Wu,Jinshan Tang
Marine fungi-derived natural products represent an excellent reservoir for the discovery of novel lead compounds with biological activities. Here, we report the identification of two new drimane sesquiterpenes (1and2) and six new polyketides (3–8), together with 10 known compounds (9–18), from a marine-derived fungusPenicilliumsp. TW58-16. The planar structures of these compounds were elucidated by extensive 1D and 2D NMR, which was supported by HR-ESI-MS data. The absolute configurations of these compounds were determined by experimental and calculated electronic circular dichroism (ECD), and their optical rotations compared with those reported. Evaluation of the anti-inflammatory activity of compounds1–18revealed that compound5significantly inhibited the release of nitric oxide (NO) induced by lipopolysaccharide (LPS) in RAW264.7 cells, correlating with the inhibition of expression of inducible nitric oxide synthase (iNOS). In addition, we revealed that compounds1,3–6,14,16,and18showed strongα-glucosidase inhibitory effects with inhibition rates of 35.4%, 73.2%, 55.6%, 74.4%, 32.0%, 36.9%, 88.0%, and 91.1%, respectively, which were comparable with or even better than that of the positive control, acarbose. Together, our results illustrate the potential of discovering new marine-based therapeutic agents against inflammation and diabetes mellitus.Keywords:marine-derived fungus;drimane sesquiterpene;polyketide;anti-inflammatory effect;α-glucosidase inhibitory effect
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Juanjuan Feng,Yu Tian,Kunlin Li,Fei Wang,Kai Li,Ping Ning
Toxic H 2 S limits the high-value utilization of high-concentration CO in yellow phosphorus tail gas. High-performance adsorbents play a significant role in the purification of yellow phosphorus tail gas and the recovery of CO. In this study, manganese-based adsorbents doped with other metals (Cu, Co, Ni, Ce, and Fe) were synthesized and tested for H 2 S removal. The results demonstrate that doping α-MnO 2 with metals significantly enhances its desulfurization performance. Notably, the 20 % Ni/Mn adsorbent achieves the best performance, exhibiting an adsorption duration of approximately 50 h under test conditions and H 2 S capacity up to 854.35 mg/g. Mechanism studies show that the performance improvement is mainly attributed to the doping of Ni, which disrupts the growth of the α-MnO 2 rod-like structure, promoting the formation of fine particles and exposing more crystal interfaces. This is conducive to the migration and release of active lattice oxygen species on the adsorbent, thereby enhancing the adsorption-oxidation performance of the adsorbent for H 2 S. Moreover, Ni significantly promotes the formation of high-valent Mn, enhancing the adsorbent’s oxidation capability and facilitating the decomposition of H 2 S. This study proposes an innovative synthetic strategy for constructing adsorbents with high H 2 S adsorption performance under anaerobic and dry conditions.
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ORGANIC & BIOMOLECULAR CHEMISTRY
·
2014
·Vol. 12
·期 29
·5509-5516
·
IF 3.487
Wei-Guo Jia,Dan-Dan Li,Yuan-Chen Dai,Hui Zhang,Li-Qin Yan,En-Hong Sheng,Yun Wei,Xiao-Long Mu,Kuo-Wei Huang
Binuclear complexes [{(DMOX)CuCl}2(μ-Cl)2] (1), mononuclear complexes [(DMOX)CuBr2] (2) (DMOX = 4,5-dihydro-2-(4,5-dihydro-4,4-dimethyloxazol-2-yl)-4,4-dimethyloxazole) and the pybox Cu(II) complex [(Dm-Pybox)CuBr2] (3) (Dm-Pybox = 2,6-bis[4′,4′-dimethyloxazolin-2′-yl]pyridine) were obtained by reactions of CuX2 (X = Cl, Br) with DMOX and Dm-Pybox ligands, respectively. The molecular structures of 1, 2 and 3 have been determined by single-crystal X-ray diffraction analyses. The complexes 2 and 3 are efficient in catalyzing α-amination of ketones and esters through α-bromo carbonyl intermediate. The procedures are environmentally benign methods using molecular oxygen as an oxidant with water as the only byproduct.
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Food Biophysics
·
2026
·Vol. 21
·期 4
·141
·
IF 3.9
Chi Guoxiang,Tang Laiyun,Liu Huipeng
Pectin-derived polygalacturonic acid exhibits valuable bioactivities yet suffers from poor solubility that limits its application in the food and pharmaceutical industries; the controllable preparation of uniform oligogalacturonides (OGAs) remains a key technical bottleneck. This work aimed to establish an eco-friendly depolymerization route for polygalacturonic acid and clarify the structural features and combined hypoglycemic-antioxidant bioactivities of the resulting OGAs. Hydrogen peroxide was used as a green degradation reagent to break polygalacturonic acid chains, and target OGAs were recovered via ethanol precipitation. Multiple characterization techniques including FT-IR, NMR, HPAEC and UPLC-MS/MS were adopted to analyze the chemical structures of OGAs, while in vitro radical scavenging and α-glucosidase inhibition assays combined with molecular simulation were conducted to assess biofunctions and binding mechanisms. Structural identification confirmed that OGAs contained esterified and non-esterified galacturonic acid backbones with minor neutral sugar branches, with degrees of polymerization distributed from 3 to 11. OGAs exerted obvious concentration-dependent antioxidant capacity, achieving 78.68% DPPH and 73.98% ABTS radical clearance at 18 mg/mL, and reached 57.14% α-glucosidase inhibition at 1.5 mg/mL. Molecular simulation proved that longer OGAs form stronger hydrogen bond interactions with enzyme active pockets, with binding energy decreasing from -9.8 kcal/mol (GalA 3 ) to -16.0 kcal/mol (GalA 8 ). This green H 2 O 2 degradation method enables efficient preparation of structurally defined OGAs, and the dual antioxidant and hypoglycemic properties of OGAs support their promising potential for exploitation in functional foods and antidiabetic agents.
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