SEPARATION AND PURIFICATION TECHNOLOGY
·
2020
·
IF 5.774
Yingying Yin,Lei Zhu,Tianchao Guo,Xurong Qiao,Shaopeng Gan,Xiao Chang,Xiaofang Li,Fujun Xia,Qingzhong Xue
The development of efficient oil/water separation membranes is highly significant for reducing severe environmental pollution nowadays. Constructing hierarchical structures with double-scale roughness and inverted trapezoidal geometry is an alternative rational design to fabricate low oil-adhesive membranes. Based on this design concept, a Cu mesh vertically wrapped with novel microphone-like Cu-CAT-1 hierarchical microstructures with double-scale roughness was tactfully prepared by a local concentration effect, which was referred to as CCMOF. The CCMOF possessed superior anti-oil-fouling performance and an outstanding water-absorbing capacity (180.3% larger than that of the pristine Cu mesh) due to its ingenious microphone-like structures and its high affinity for water. Therefore, it could separate various types of oil/water mixtures with a considerably high flux of over 25,000 L m −2 h −1 and an extremely low oil content in filtrate of below 10 ppm. The design concept of this work offered a simple idea to design low oil-adhesive membranes for efficient oil/water separation.
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DOI
高影响因子
Drug Design Development and Therapy
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2024
·
IF 4.7
Xiaona Lang,Liyan Xu,Lu Li,Xin Feng
Objective Catalpol, as a natural medicine small-molecule drug, has been proven to have anti-inflammatory and antioxidant pharmacological effects.Methods The effect of catalpol on oxidative damage of mouse epidermal fibroblast L929 model and its mechanism were investigated by using hydrogen peroxide model, CCK8 method, flow cytometry, and Western blot.Results The effect of catalpol on Nrf2/HO-1 signaling pathway was further studied to improve oxidative stress in cell models. The results showed that catalpol had no cytotoxicity to L929 cells, and inhibited the apoptosis of L929 cells after oxidative damage in a concentration-dependent manner, thus playing a role in cell protection. The oxidative damage of cells was inhibited by up-regulating the expression of the signature protein of Nrf2/HO-1 signaling pathway and inhibiting the interstitial formation of cells.Conclusion This study is a preliminary study on the protective function of catalpol against oxidation and apoptosis in dermal fibroblasts, which can provide a theoretical basis and drug guidance for promoting skin wound healing in the later stage.
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DOI
PubMed
高影响因子
Journal of Neuroinflammation
·
2024
·Vol. 21
·期 1
·1-24
·
IF 9.3
Wang Zhimeng,Liu Jing,Han Jing,Zhang Tianyi,Li Shangjin,Hou Yanfei,Su Huili,Han Fangping,Zhang Conggang
Accumulating evidence implicates that herpes simplex virus type 1 (HSV-1) has been linked to the development and progression of Alzheimer’s disease (AD). HSV-1 infection induces β-amyloid (Aβ) deposition in vitro and in vivo, but the effect and precise mechanism remain elusive. Here, we show that HSV-1 infection of the brains of transgenic 5xFAD mice resulted in accelerated Aβ deposition, gliosis, and cognitive dysfunction. We demonstrate that HSV-1 infection induced the recruitment of microglia to the viral core to trigger microglial phagocytosis of HSV-GFP-positive neuronal cells. In addition, we reveal that the NLRP3 inflammasome pathway induced by HSV-1 infection played a crucial role in Aβ deposition and the progression of AD caused by HSV-1 infection. Blockade of the NLRP3 inflammasome signaling reduces Aβ deposition and alleviates cognitive decline in 5xFAD mice after HSV-1 infection. Our findings support the notion that HSV-1 infection is a key factor in the etiology of AD, demonstrating that NLRP3 inflammasome activation functions in the interface of HSV-1 infection and Aβ deposition in AD.
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PubMed
高影响因子
CRYSTENGCOMM
·
2019
·Vol. 22
·期 5
·945-954
·
IF 3.382
Lanjian Xu,Yangyang Yuan,Jie Zhang,Yanfei Zhang,Xiaomin Zhang,Lei Chen,Lei Xu
A green, cost-effective and facile steam-assisted crystallization (SAC) strategy was developed to synthesize core–shell-structured zeolite composites with different frameworks between the core and shell. Chemical incompatibility from different structures has been circumvented by dip-coating Silicalite-1 seeds and an in situ transformation process. Beta@Silicalite-1 zeolites with a nanoscale polycrystal Silicalite-1 shell wrapped around the monocrystal Beta core was synthesized. The crystallization process and synthetic parameters, such as the composition of the core, crystallization temperature and gel composition of the seed solution, were investigated. The results revealed the importance of stability of the core and the crystallization rate of the Silicalite-1 shell. Interestingly, a trace amount of aluminum in the core zeolite could help resist corrosion during crystallization. Further investigation on alkylation and etherification reactions over Beta@Silicalite-1 demonstrated the advantage in selectivity control toward self-etherification versus alkylation.
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高影响因子
Energetic Materials Frontiers
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2022
·
IF 0
Zhi-qiang Wang,Zhen-qi Zhang,Shan-hu Sun,Mi Yan,Shi-liang Huang,Shuang-qi Hu,Jin-jiang Xu,Li-shuang Hu
Polymorphs of energetic materials generally exhibit distinct features, such as density, thermal stability, sensitivity, and detonation performance. These features are important in determining the appropriate applications of a given polymorph. To understand the thermal stability of new high explosive 4,4′,5,5′-tetranitro-1H,1′H- [2,2′-biimidazole]-1,1′-diamine (DATNBI), we systematically investigated its polymorphic transition (PT) under thermal stimulation and discovered a novel stable γ form of DATNBI. The results showed that the solid-solid PT path was β → α → γ . In this study, the three polymorphs of DATNBI were prepared through solvent recrystallization, and their PT processes in solution were explored. Crystal structure analysis of γ -DATNBI suggested that its special cross-cross grid crystal packing may be the main reason for its stable existence at room temperature and its lack of PT process before chemical decomposition, which starts at 240 °C. To further explore the PT process of DATNBI, the solid phase transition mechanism of DATNBI was analyzed using non-isothermal kinetics. The results demonstrated that the two high-temperature PT processes— β → α and α → γ —were not single-step reactions but complex multi-step reactions. The PT activation energy of the β → α process was slightly higher than that of the α → γ process. In addition, the influences of different polymorphs on the performance of DATNBI were explored. The results revealed that safety and detonation performance should decrease as a result of the incorporation of γ -DATNBI. This study contributes to understanding the PT behavior and the crystal structure evolutionary mechanism of DATNBI. This study provides practical support for formula design, process condition selection, and thermal stability evaluation of DATNBI explosives.
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CHEMICAL ENGINEERING JOURNAL
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2011
·
IF 3.074
Ting Wu,Xiang Cai,Shaozao Tan,Hongye Li,Jiesheng Liu,Weidong Yang
In order to explore the potential of graphene (G) in removal of hazardous chemicals in waste water, chemically reduced graphene oxide was employed as the adsorbent and the adsorption characteristics of graphene toward acrylonitrile (AN), p-toluenesulfonic acid (p-TA), 1-naphthalenesulfonic acid (1-NA) and methyl blue (MB) were evaluated under laboratory conditions. The results showed that the organic chemicals with larger molecule size and more benzene rings possessed a higher adsorption speed and a higher maximum adsorption capacity on G. The maximum adsorption capacities of p-TA, 1-NA and MB on G are ∼1.43 g/g G, ∼1.46 g/g G and ∼1.52 g/g G at 30 °C, respectively, which are the highest values of p-TA, 1-NA or MB adsorption on different kinds of today's nanomaterials. Under the maximum adsorption capacity, the absorption quantity of MB on G was dependent on the initial concentration of MB, and higher temperature could facilitate the adsorption process. The G efficiency remains almost constant during the first five cycles of the adsorption–desorption process. In addition, the fluorescence spectra implied that the adsorption of MB on G was a π–π stacking adsorption process. In conclusion, the G could serve as a promising adsorbent for the removal of chemicals containing benzene rings in waste water.
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高影响因子
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
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2019
·
IF 3.218
Wei Chen,Jiayue Dong,Sihan Zhou,Chunyong Zhang,Degang Fu
1-naphthol (1-NAP) and 2-naphthol (2-NAP) are both hazardous pollutants which pose great threat to our living environment. In the current work, a comparative investigation on the electrochemical mineralization of 1-NAP and 2-NAP using boron-doped diamond (BDD) anode was presented. Experiments were carried out using synthetic 1-NAP or 2-NAP solutions containing Na 2 SO 4 as supporting electrolyte . A two-level factorial design methodology was adopted to optimize the mineralization process, six mathematical models were thus constructed and used to explore the structure-property relation involved. The results obtained suggested that 1-NAP was easier and faster to break down than 2-NPA under the same oxidation conditions, which were in line with the outcome obtained from cyclic voltammetry , HPLC and TOC measurements. To understand the destruction mechanism, the electron structures of 1-NAP and 2-NAP were further examined by the quantum chemistry calculations with density functional theory. It was also found that the results from frontier orbital analysis could well explain the differing mineralization performances recorded in BDD anode cell. Finally, with the aid of LC/MS analysis, the oxidation pathways of 1-NAP or 2-NAP on BDD anodes were proposed.
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高影响因子
JOURNAL OF CHEMICAL SCIENCES
·
2024
·Vol. 136
·期 3
·1-11
·
IF 1.7
Zhao Zhicai
A series of 1-carbonyl-1 H -indoles were prepared by 2-iodoanilines and calcium carbide in a one-pot reaction catalyzed by recyclable10% Pb/C, resulting in the corresponding substituted indoles in good yields. This protocol offers several advantages, including the utilization of sustainable, low-cost calcium carbide, an easy-to-handle acetylene source, and recyclable Pb/C catalysts. Graphic abstract The synthesis of a series of 1-carbonyl-1 H -indoles were prepared by 2-iodoanilines and calcium carbide in a one-pot reaction catalyzed by 10% Pb/C, resulting in the corresponding substituted indoles in good yields. This protocol offers several advantages, including the utilization of sustainable, low-cost feedstock, an easy-to-handle acetylene source, and recyclable Pb/C catalysts.
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高影响因子
APPLIED ORGANOMETALLIC CHEMISTRY
·
2021
·Vol. 35
·期 4
·e6147
·
IF 4.105
Sujuan Ge,Yuming Zhou,Xiaoli Sheng,Chunfeng Mao,Lina Zhao,Jianxing Xu,Lei Qiu
Piperidinium-based ionic liquids (ILs) were synthesized under mild conditions by coordinating N -alkyl- N -methylpiperidinium bromide ([Pip 1,x ]Br) with anhydrous AlCl 3 . The weak basicity of N -methylpiperidine had little impact on downstream problems from proton impurities and catalyst poisoning. The results of Fourier transform infrared (FT-IR), electrospray ionization mass spectrometry (ESI-MS), and nuclear magnetic resonance ( 27 Al NMR) confirmed that the active components in [Pip 1,x ]Br-2AlCl 3 ( χ = 0.67) were [Al 3 Cl 9 Br] − and [Al 2 Cl 6 Br] − . Besides, the reaction performance of [Pip 1,8 ]Br-2AlCl 3 under different conditions was carried out by single-factor experiment and further confirmed by orthogonal experimental method. Among these reaction conditions, the optimal combination was the reaction temperature of 40°C, ILs/O molar ratio of 0.2:1, px/O molar ratio of 12:1, and the reaction time of 30 min. Furthermore, [Pip 1,8 ]Br-2AlCl 3 had excellent stability and can be recycled 14 times. It was the high-efficiency catalytic activity and prominent recyclability that made continuous industrial production possible.
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高影响因子
Autophagy
·
2024
·
IF 14.6
Juan Yi,He-Ling Wang,Guang Lu,Hailong Zhang,Lina Wang,Zhen-Yu Li,Liming Wang,Yihua Wu,Dajing Xia,Evandro F. Fang,Han-Ming Shen
Spautin-1 is a well-known macroautophagy/autophagy inhibitor via suppressing the deubiquitinases USP10 and USP13 and promoting the degradation of the PIK3C3/VPS34-BECN1 complex, while its effect on selective autophagy remains poorly understood. Mitophagy is a selective form of autophagy for removal of damaged and superfluous mitochondria via the autophagy-lysosome pathway. Here, we report a surprising discovery that, while spautin-1 remains as an effective autophagy inhibitor, it promotes PINK1-PRKN-dependent mitophagy induced by mitochondrial damage agents. Mechanistically, spautin-1 facilitates the stabilization and activation of the full-length PINK1 at the outer mitochondrial membrane (OMM) via binding to components of the TOMM complex (TOMM70 and TOMM20), leading to the disruption of the mitochondrial import of PINK1 and prevention of PARL-mediated PINK1 cleavage. Moreover, spautin-1 induces neuronal mitophagy in Caenorhabditis elegans (C. elegans) in a PINK-1-PDR-1-dependent manner. Functionally, spautin-1 is capable of improving associative learning capability in an Alzheimer disease (AD) C. elegans model. In summary, we report a novel function of spautin-1 in promoting mitophagy via the PINK1-PRKN pathway. As deficiency of mitophagy is closely implicated in the pathogenesis of neurodegenerative disorders, the pro-mitophagy function of spautin-1 might suggest its therapeutic potential in neurodegenerative disorders such as AD.Abbreviations: AD, Alzheimer disease; ATG, autophagy related; BafA1, bafilomycin A1; CALCOCO2/NDP52, calcium binding and coiled-coil domain 2; CCCP, carbonyl cyanide m-chlorophenyl hydrazone; COX4/COX IV, cytochrome c oxidase subunit 4; EBSS, Earle’s balanced salt; ECAR, extracellular acidification rate; GFP, green fluorescent protein; IA, isoamyl alcohol; IMM, inner mitochondrial membrane; MAP1LC3/LC3, microtubule associated protein 1 light chain 3; MMP, mitochondrial membrane potential; mtDNA, mitochondrial DNA; nDNA, nuclear DNA; O/A, oligomycin-antimycin; OCR, oxygen consumption rate; OMM, outer mitochondrial membrane; OPTN, optineurin; PARL, presenilin associated rhomboid like; PINK1, PTEN induced kinase 1; PRKN, parkin RBR E3 ubiquitin protein ligase; p-Ser65-Ub, phosphorylation of Ub at Ser65; TIMM23, translocase of inner mitochondrial membrane 23; TOMM, translocase of outer mitochondrial membrane; USP10, ubiquitin specific peptidase 10; USP13, ubiquitin specific peptidase 13; VAL, valinomycin; YFP, yellow fluorescent protein.
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高影响因子
MICROBIOLOGICAL RESEARCH
·
2016
·
IF 2.723
Waseem Raza,Ning Ling,Dongyang Liu,Zhong Wei,Qiwei Huang,Qirong Shen
The volatile organic compounds (VOCs) produced by soil microbes have a significant role in the control of plant diseases and plant growth promotion. In this study, we examined the effect of VOCs produced by Pseudomonas fluorescens strain WR-1 on the growth and virulence traits of tomato wilt pathogen Ralstonia solanacearum . The VOCs produced by P. fluorescens WR-1 exhibited concentration dependent bacteriostatic effect on the growth of R. solanacearum on agar medium and in infested soil. The VOCs of P. fluorescens WR-1 also significantly inhibited the virulence traits of R. solanacearum . The proteomics analysis showed that the VOCs of P. fluorescens WR-1 downregulated cellular proteins of R. solanacearum related to the antioxidant activity, virulence, inclusion body proteins, carbohydrate and amino acid synthesis and metabolism, protein folding and translation, methylation and energy transfer, while the proteins involved in the ABC transporter system, detoxification of aldehydes and ketones, protein folding and translation were upregulated. This study revealed the significance of VOCs of P. fluorescens WR-1 to control the tomato wilt pathogen R. solanacearum . Investigation of the modes of action of biocontrol agents is important to better comprehend the interactions mediated by VOCs in nature to design better control strategies for plant pathogens.
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PubMed
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2019
·
IF 4.175
Lili Ke,Xiaoyan Gan,Wenhui Zhao,Liling Guo,Hanxing Liu
At present, perovskite solar cells using two-dimensional perovskite hybrids have been researching, for their good optical performance and humidity stability work. However, there is still a great obstacle obtaining two-dimensional perovskite films of high quality and high performances. In this work, we succeeded in fabricating dense and highly crystallized Q-2D (C 6 H 5 C 2 H 4 NH 3 ) 2 FA n-1 Pb n I 3n+1 by adopting a novel two-step solution deposition method, from which a stoichiometric precursor containing PEAI and PbI 2 was first spin-coated and FAI solution was then dropped and spin-coated on the substrate. It was found that the amount of FAI solution dropped onto the substrate during the second step had great influence on the microstructure and performance of the Q-2D (C 6 H 5 C 2 H 4 NH 3 ) 2 FA n-1 Pb n I 3n+1 . Our first–generation Q-2D (C 6 H 5 C 2 H 4 NH 3 ) 2 FA n-1 Pb n I 3n+1 perovskite solar cells were higher than its 3D perovskite counterpart FAPbI 3 in moisture stability. We finally obtained Q-2D (C 6 H 5 C 2 H 4 NH 3 ) 2 FA n-1 Pb n I 3n+1 perovskite solar cells, showing an open-circuit voltage of 0.826 V and a power conversion efficiency of 11.46%.
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高影响因子
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