INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2019
·
IF 3.375
Yue Chen,Tong Wu,Guoliang Xing,Yichuan Kou,Boxun Li,Xinying Wang,Ming Gao,Lei Chen,Yaxin Wang,Jinghai Yang,Yang Liu,Yongjun Zhang,Dandan Wang
In this study, the three-dimensional (3D) flowerlike porous Fe3O4 microcrystals were prepared by a self-assembly approach with the assistance of ethylene glycol (EG). The generation mechanism of the 3D flowerlike Fe3O4 microcrystals was revealed through controlling the parameters of the hydrothermal reaction time, the molar mass of the urea, and the calcination temperature. The proposed 3D flowerlike Fe3O4 microcrystals exhibited superparamagnetic behaviors with high saturation magnetization (i.e., up to 73.1 emu·g–1) at room temperature. The Fe3O4–Au magnetic composites (MCs) were further prepared by a seed deposition process, and surface features were revealed by TEM, XRD, XPS, UV–vis, and SQUID techniques. Compared with the Fe3O4 microcrystals themselves, the Au (∼20 nm) covered Fe3O4 microcrystals provided efficient and recyclable catalytic performance (e.g., unprecedented high turnover frequency of 2.874 min–1) for 4-nitrophenol (4-NP). More importantly, the proposed Fe3O4–Au MCs could be used to reduce 4-NP for more than six cycles, elaborating that Fe3O4–Au MCs are promising catalysts in the field of environmental purification.
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高影响因子
PHARMAZIE
·
2018
·Vol. 73
·期 9
·503-507
·
IF 1.016
Liu Yixian,Wang Yafeng,Peng Youmei,Liu Bingjie,Ma Fang,Jiang Jinhua,Wang Qingduan,Chang Junbiao
The purpose of the present study was to dig into recent studies designed to characterize the impacts of 2'-deoxy-2'-β-fluoro-4'-azidocytidine (FNC) on P-glycoprotein (P-gp), multidrug resistance-associated protein 2 (MRP2) and breast cancer resistance protein (BCRP). Specifically,
the modulation effects of FNC on P-gp, MRP2 and BCRP protein expressions were assessed by western blot methods. 5 (and 6)-Carboxy-2',7'-dichloroflourescein (CDF) and BODIPY-prazosin were used to provide indications of alterations of MRP2 and BCRP activities. The effects of P-gp, MRP2 and BCRP
on FNC were evaluated in the in situ single-pass intestinal perfusion model. The results showed that FNC at higher concentrations and with longer incubation times can upregulate the protein expression of P-gp, MRP2 and BCRP in Caco-2 cells. The upregulated proteins were also functionally
active, as revealed by a lower degree of CDF and BODIPY-prazosin uptake by the cell monolayers. The intestinal absorptive coefficient (Peff) was observed to significantly increase with the inhibitors of P-gp, MRP2 and BCRP. These results suggested that FNC could modulate the expressions and
functions of P-gp, MRP2 and BCRP, while P-gp, MRP2 and BCRP were involved in the efflux transport of FNC. The inductive effects of FNC on P-gp, MRP2 and BCRP suggested the possibility of FNC to contribute to the inter- and intra-individual variability of itself, as well as to alter the absorption
of other drugs that may be administered concomitantly.
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PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2018
·
IF 6.735
Na Tian,Xike Tian,Yulun Nie,Chao Yang,Zhaoxin Zhou,Yong Li
Peroxymonosulfate (PMS) activation has drawn increasing attention in eliminating the recalcitrant organic pollutants in water. Manipulation of generated reactive oxygen species (ROS) over Ce doped Mn 2 O 3 during the PMS activation was firstly reported for the complete degradation of 2,4-dichlorophenol (2,4-DCP) in this study. Ce in-situ introduction can greatly enhance the PMS activation performance of Mn 2 O 3 . For example, 100% of 2,4-DCP degradation can be obtained at 90 min over 4 wt% Ce doped Mn 2 O 3 at pH 7 (82.1% for Mn 2 O 3 at 90 min). The reaction rate constant ( k ) was also about 3.6 times higher than that of Mn 2 O 3 (0.0668 min −1 for Ce doped Mn 2 O 3 vs. 0.0186 min −1 for Mn 2 O 3 ). Besides 1 O 2 , OH and SO 4 − were identified and involved in 2,4-DCP degradation process over Ce doped Mn 2 O 3 , while only 1 O 2 was detected over 3D Mn 2 O 3 . Moreover, the contribution of OH and SO 4 − to 2,4-DCP degradation can be regulated by adjusting the Ce doping amount. The key role of Ce substitution in the regulation of reactive oxygen species was further investigated by XPS and electrochemical experiments. The Ce dopant can lead to a higher current density and greater reductive capability due to the improved charge transfer capability, which is important to the generation of more aggressive OH and SO 4 − and complete 2,4-DCP degradation.
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高影响因子
APPLIED SURFACE SCIENCE
·
2018
·
IF 4.439
Xin Ning,Fangxue Wei,Heyun Fu,Xiaolei Qu,Zhaoyi Xu,Shourong Zheng
Supported gold nanoparticles (AuNPs) have recently attracted significant interest in catalysis, with much emphasis on optimizing the catalytic activity of AuNPs. We herein reported the promotion effect of weak ultraviolet (UV) light on the activity of titania nanotube (TNT) supported AuNPs (Au/TNT) for catalytic reduction of 4-nitrophenol by sodium borohydride. The presence of low-intensity UV irradiation increased the turnover frequency of Au/TNT for the reaction by a factor of 2.56–4.97 (increase factor depending on the Au loading amount). The photonic efficiency of the reaction for Au/TNT was found to be far more higher than the literature values for titanium oxide-based catalysts, suggesting that the reaction was not primarily implemented via a photocatalytic pathway. We attributed the pronounced promotion effects to the negative surface charge on AuNPs that formed from the charge separation between AuNPs and TNT. The negative surface charge assisted the formation of active Au-H intermediates and the activation of 4-nitrophenol molecules, giving rise to markedly enhanced catalytic activity for 4-nitrophenol reduction under low-intensity UV irradiation. The findings imply that weak UV irradiation is a very efficient and cost-effective approach to tune the surface charge and hence catalytic activity of semiconductor supported AuNPs.
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高影响因子
ELECTROCHIMICA ACTA
·
2013
·
IF 3.777
Rui Li,Changxian Liu,Ming Ma,Zhengguo Wang,Guoqing Zhan,Buhai Li,Xian Wang,Huaifang Fang,Huijuan Zhang,Chunya Li
1,3-Di(4-amino-1-pyridinium)propane tetrafluoroborate (DAPPT) ionic liquid was successfully synthesized, and was used as a modifier to functionalize graphene nanosheets through covalent binding of amino groups and epoxy groups in an alkaline solution. The as-prepared graphene-DAPPT nanosheets (Gr-DAPPT) were confirmed with transmission electron microscopy (TEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), UV/vis and FTIR spectroscopy. A biocompatible platform based on Gr-DAPPT was constructed for the immobilization of hemoglobin (Hb) through a cross-linking step with chitosan and glutaraldehyde. The direct electron transfer and bioelectrocatalytic reaction of Hb immobilized on Gr-DAPPT surface were achieved. A pair of reversible redox peaks of hemoglobin was observed, and bioelectrocatalytic activity toward the reduction of H 2 O 2 was also demonstrated, displaying a potential application for the fabrication of novel biosensors to sense H 2 O 2 . Such results indicated that Gr-DAPPT based interface would be a promising platform for biomacromolecular immobilization and biosensor preparation.
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RSC Advances
·
2014
·Vol. 4
·期 21
·11003-11011
·
IF 3.708
Wenjun Liu,Dengrong Sun,Jinlong Fu,Rusheng Yuan,Zhaohui Li
Thiol-functionalized reduced graphene oxide (SRG) was prepared by coupling the carboxyl groups on the pre-carboxyl-functionalized graphene oxide (GO) with cysteamines through amide bonds. The as-prepared SRG can function both as a support and reducing agent for the formation of Au/SRG nanohybrids with evenly distributed Au nanoparticles on RGO. The thiol linkage on the RGO can act as anchor for Au nanoparticles and due to the existence of the strong interaction between them, the agglomeration of Au nanoparticles can be significantly impeded. The step-by-step assembly process of the Au/SRG nanohybrid was monitored and the products obtained were characterized by Fourier transform infrared spectroscopy (FT-IR), Raman spectroscopy, X-ray photoelectron spectroscopy (XPS), X-ray absorption near-edge spectroscopy (XANES), atomic force microscopy (AFM), powder X-ray diffraction (XRD), transmission electron microscopy (TEM) and high-resolution transmission electron microscopy (HRTEM). The as-prepared Au/SRG nanohybrid showed superior catalytic performance for the hydrogenation of 4-nitrophenol (4-NP) to 4-aminophenol (4-AP). It is expected that the method for the preparation of the Au/SRG nanohybrids can also be applied to the preparations of other RGO-based nanohybrid materials which may find a variety of interesting applications.
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高影响因子
JOURNAL OF COORDINATION CHEMISTRY
·
2015
·
IF 2.012
Yan Xie,Junjie He,Tingting Wang,Heping Zeng
Reactions of Zn(II) salts, 5-(4-(1H-imidazol-1-yl)phenyl)-1H-tetrazolate (HIPT) and 2-mercaptobenzoic acid or 2-propyl-1H-imidazole-4,5-dicarboxylic acid (H3PrIDC), result in two mixed-ligand coordination polymers (CPs), [Zn2(IPT)(DSDB)(OH)]n (H2DSDB = 2,2′-disulfanediyldibenzoic acid, 1) and [Zn2(IPT)(PrIDC)(H2O)]n (H3PrIDC = 2-propyl-1H-imidazole-4,5-dicarboxylic acid, 2). Compound 1 possesses a 2-D structure built by 1-D [Zn(IPT)]n chains and DSDB2− connectors, in which the DSDB2− is generated via in situ reaction from 2-mercaptobenzoic acid. It displays a new intricate 4-nodal {3·4·6·7·8·9}{3·6·7·8·9·10}{3·8·9}{4·6·8} topology. Compound 2 displays a 3-D framework with new 3-connected topology with Schläfli symbol of (4·8·10) (8·122), in which the 1-D Zn-carboxylate chains were bridged by 3-connected IPT− ligands. The thermal stabilities and luminescence properties of 1 and 2 have also been studied. The compounds exhibit intense solid-state fluorescent emissions at room temperature.
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高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2015
·
IF 7.435
Guangping He,Chunlan Xing,Xin Xiao,Ruiping Hu,Xiaoxi Zuo,Junmin Nan
Novel three-dimensional flower-like Bi 12 O 17 Cl 2 /β-Bi 2 O 3 composites are prepared using a facile solvothermal-calcining process and their photocatalytic performances for the degradation of 4- tert -butylphenol (PTBP, a representative alkylphenol) are evaluated under visible light irradiation. The formation of such composites is assumed to involve the reduction of Bi(III) to nano-metallic bismuth via a solvothermal process, followed by the reaction of bismuth with oxygen and bismuth oxide chloride hydroxide during the calcination in air. The XRD, XPS, EDS mapping, HRTEM, UV–vis DRS, and photocurrent measurement results indicate that heterojunctions are formed between Bi 12 O 17 Cl 2 and β-Bi 2 O 3 with broad contact interfaces. The as-synthesized Bi 12 O 17 Cl 2 /β-Bi 2 O 3 hybrid materials possess favorable band structures, heterojunction structures, relatively high specific surface areas, and hierarchical micro/nano-structures, resulting in superior photocatalytic and mineralization efficiencies for the decomposition of PTBP under visible light irradiation. The optimum photocatalytic activity of a Bi 12 O 17 Cl 2 /β-Bi 2 O 3 sample is approximately 3, 12, 51, and 107 times higher than the activities of single β-Bi 2 O 3 , Bi 12 O 17 Cl 2 , nitrogen-doped TiO 2 , and BiOCl, respectively. In addition, the photogenerated reactive species are identified based on free radicals trapping experiments and EPR analysis, which reveals that the photodegradation of PTPB over Bi 12 O 17 Cl 2 /β-Bi 2 O 3 under visible light is dominated by direct hole and superoxide radical oxidation rather than oxidized by hydroxyl radical.
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高影响因子
INORGANICA CHIMICA ACTA
·
2014
·
IF 2.041
Yong-Peng Xu,Jie Qin,Shi-Min Sun,Tong-Tong Liu,Xiao-Lin Zhang,Shao-Song Qian,Hai-Liang Zhu
Three novel complexes, [Ni II (dpp) 2 (L) 2 ] ( 1 ), [Ni II (eda) 2 (L) 2 ] ( 2 ) and [Ni II (deda) 2 (L) 2 ] ( 3 ) (L = 3-pyridinyl-4-amino-5-mercapto-1,2,4-triazole, dpp = 1,3-diaminopropane, eda = ethanediamine, deda = N,N-dimethyl ethylenediamine), were synthesized by reacting 3-pyridinyl-4-amino-5-mercapto-1,2,4-triazole with diamines and nickel(II) salt. The complexes were structurally determined by single-crystal X-ray diffraction. The inhibitory activity was tested in vitro against jack bean urease. Molecular docking was investigated to insert complexes into the crystal structure of jack bean urease at the active site to determine the probable binding mode. The experimental values and docking simulation exhibited that complexes 1 , 2 , 3 had better inhibitory activity than the positive reference acetohydroxamic acid, showing IC 50 values of 48.16, 32.35 and 15.22 μM, respectively. These complexes exhibited inhibitory activities as potent urease inhibitor.
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高影响因子
RSC Advances
·
2015
·Vol. 5
·期 107
·88045-88051
·
IF 3.84
Xueqing Gao,Guangrui Xu,Yan Zhao,Shuni Li,Feng Shi,Yu Chen
Graphene nanosheet (GNS) supported gold nanoparticle (Au-NP) composites (Au-NP/GNS) have attracted a lot of attention due to their important applications in catalysis, sensing, optics, medicine, and fuel cells. In this study, based on the strong electrostatic and/or hydrogen bonding interactions between the amine-functionalized Au-NP (Au-NP@NH2) and phosphonate-functionalized GNS (GNS-PO3H2), a self-assembly strategy was used to synthesize Au-NP/GNS composites. The physical and chemical properties of Au-NP@NH2, GNS-PO3H2, and the Au-NP/GNS composites were fully investigated using various physical characterization, including X-ray powder diffraction, X-ray photoelectron spectroscopy, ultraviolet-visible spectroscopy, transmission electron microscopy, and zeta potential analysis. The experimental results demonstrate that the phosphonate-functionalization of GNS was critical for the generation of high-quality Au-NP/GNS composites. The as-prepared Au-NP/GNS composites show improved catalytic activity for the degradation of 4-nitrophenol compared to functionalized Au-NP, which was ascribed to the amine-functionalization of the Au-NP and the introduction of the GNS with high electrical conductivity and large surface area.
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高影响因子
Molecular Medicine Reports
·
2015
·Vol. 11
·期 6
·4671-4677
·
IF 1.554
Qigen Du,Guang Xin,Hai Niu,Wen Huang
The 4[(Tetrahydro‑2H‑pyran‑2‑yl) oxy] phenol (XG‑d) hydroquinone analog, is found in Vaccinium vitis‑idaea L. Although it is known for its antioxidant properties and high level of safety, its antitumor activity remains to be elucidated. In the present study, the anticancer effect of XG‑d was determined in vitro and in vivo. The cytotoxicity of XG‑d against C26 murine colon carcinoma cells was found to occur in a time‑ and concentration‑dependent manner, whereas little effect was observed in the two normal cell lines (HK‑2 and L02) investigated. Oral administration of XG‑d (100 mg/kg) had effects on the tumor growth of tumor‑bearing mice. Furthermore, marked apoptosis was observed using Hoechst 33258 staining and flow cytometric analysis with annexin V/propidium iodide double staining. XG‑d also downregulated the expression of B‑cell lymphoma 2 (Bcl‑2), increased the expression levels of Bcl‑2‑associated X protein and activated caspase‑9, caspase‑3 and poly(adenosine diphosphate‑ribose) polymerase. The present study demonstrated for the first time, to the best of our knowledge, that XG‑d inhibited cancer cell growth via the induction of apoptosis and was also able to inhibit tumor growth in vivo. These results demonstrated that XG‑d may be used as a potential natural agent for cancer therapy with low toxicity.
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高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2014
·
IF 4.331
Yanlin Ren,Guangyin Fan,Chenyu Wang
Reduced graphene oxide (RGO) supported rhodium nanoparticles (Rh-NPs/RGO) was synthesized through one-pot polyol co-reduction of graphene oxide (GO) and rhodium chloride. The catalytic property of Rh-NPs/RGO was investigated for the aqueous phase hydrodechlorination (HDC) of 4-chlorophenol (4-CP). A complete conversion of 4-CP into high valued products of cyclohexanone (selectivity: 23.2%) and cyclohexanol (selectivity: 76.8%) was successfully achieved at 303 K and balloon hydrogen pressure in a short reaction time of 50 min when 1.5 g/L of 4-CP was introduced. By comparing with Rh-NPs deposited on the other supports, Rh-NPs/RGO delivered the highest initial rate (111.4 mmol/g Rh min) for 4-CP HDC reaction under the identical conditions. The substantial catalytic activity of Rh-NPs/RGO can be ascribed to the small and uniform particle size of Rh (average particle size was 1.7 ± 0.14 nm) on the surface of the RGO sheets and an electron-deficient state of Rh in the catalyst as a result of the strong interaction between the active sites and the surface function groups of RGO.
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