FOOD SCIENCE AND BIOTECHNOLOGY
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2025
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IF 3.1
Nho Soo Bin,Do Sang-Hun,Oh Seongjin,Park Yong-Cheol,Kim Sun-Ki
This study aimed to develop a non-genetically modified organism (non-GMO) Saccharomyces cerevisiae strain with enhanced glutathione production using UV-induced random mutagenesis. Among 30 wild-type strains, S. cerevisiae KACC 48331 was selected for its high glutathione production. A #14 mutant with significantly higher glutathione content was isolated via acrolein resistance screening. Optimal batch fermentation was established at 20 °C and pH 4.5 using a cost-effective medium of molasses and corn steep liquor (CSL). In fed-batch fermentation, the #14 mutant achieved 1.98 g/L of glutathione using molasses and CSL as carbon and nitrogen sources, comparable to yields from expensive complex media containing peptone and yeast extract. Notably, over 99% of the glutathione produced was in the reduced, biologically active form. These results demonstrate the feasibility of using non-GMO yeast and industrial by-products for sustainable and economical glutathione production.
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JOURNAL OF FLUORESCENCE
·
2025
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IF 3.1
Gao Lu,Zhao Haimei,Zhou Xiaodan,Zhao Yuxian,Wang Yidi,Geng Huaixiao,Xu Jia,Zhang Zhichao,Han Shuang
Copper and nitrogen co-doped fluorescent carbon quantum dots (Cu-NCDs) were synthesized via a one-pot hydrothermal synthesis method using L-tyrosine and copper chloride as precursors. The as-prepared Cu-NCDs exhibited bright blue fluorescence (emission peak at 427 nm) with high photostability (10.5% intensity loss after 1 h irradiation at 365 nm). Upon introduction of tetracyclines antibiotics (TCs), include oxytetracycline (OTC), chlortetracycline (CTC) and tetracycline (TC), the fluorescence intensity of Cu-NCDs was selectively quenched through fluorescence resonance energy transfer (FRET), as confirmed by time-resolved fluorescence decay analysis. This phenomenon established a linear relationship between fluorescence quenching efficiency and TCs concentration. The calculated limits of detection (S/ N = 3) for three target analytes were determined to be 0.24 µM (OTC), 0.56 µM (CTC), and 0.19 µM (TC), respectively. Accurate quantification of TCs residues in tap water and dairy products demonstrated recovery rates of 97.94 − 112.20% (OTC), 94.93 − 110.00% (CTC), and 97.58 − 107.67% (TC), with relative standard deviations (RSDs) below 4.16% ( n = 3). Based on the paper sensor platform, on-site detection of TCs has been achieved, and visual semi quantitative analysis can be completed within 1 min.
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Nature Photonics
·
2025
·
IF 32.9
Zhang Jiakang,Yan Wenjian,Li Zhipeng,Jiang Haokun,Peng Cheng,Lan Mengjiao,Sun He,Yang Jinxian,Wang Yanbo,Li Chongwen,Pang Shuping,Zhou Zhongmin
The commercialization of perovskite photovoltaics faces significant hurdles due to device degradation under environmental stressors, such as illumination, humidity and heat, which represents a core challenge for industrial applications. Here we present a conformational engineering strategy targeting the buried interface of perovskite solar cells and based on the structural evolution of additives—from 1,1-diphenylethylene to 1-octyl-2-(1-phenylvinyl)benzene and diethylamino hydroxybenzoyl hexyl benzoate. We decouple the contributions of the additives, including ultraviolet shielding, strain regulation and chemical passivation. In conjunction with in situ characterization, we reveal that dynamic interfacial strain regulation plays a major role in improving device stability during light–dark cycling. Our devices achieve power conversion efficiencies of 26.47% and 22.67%, for active areas of 0.09 cm 2 and 20.5 cm 2 , respectively. Under maximum power point tracking, small-area devices maintain 96.2% of their initial power conversion efficiency after 1,132 h of testing in ISOS-L-1I (continuous illumination) and 88.8% after 348 h in ISOS-LC-1 (12-h day–night cycling). This research establishes an innovative design paradigm for stable and efficient perovskite solar cells through a multifunctional strategy driven by conformational engineering.
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Nature Photonics
·
2025
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IF 32.9
Gao Yuping,Liu Hang,Song Zonglong,Chen Yu,Yang Liu,Hu Ziyang,Zou Yu,Chen Yongsheng,Liu Yongsheng
Achieving uniform crystallization across both top and buried interfaces in perovskite films is crucial for unlocking their full photovoltaic potential, yet remains an unresolved challenge. The buried interface, in particular, suffers from poor crystallization relative to the top surface, resulting in suboptimal crystal quality and increased defect densities. Here we propose a one-step strategy to induce the spontaneous formation of near-phase-pure two-dimensional perovskites at the buried interface via the introduction of organic cation halide salts in the perovskite precursor solution. Single-crystal structure analysis highlights the pivotal role of molecular engineering in facilitating the spontaneous formation of buried two-dimensional perovskite phases. The low dipole moments and planar rigidity structures of organic spacers promote their aggregation at perovskite grain boundaries, followed by their migration to the film’s bottom interface. The two-dimensional perovskite layer simultaneously promotes uniform crystallization and efficient defect passivation at the buried interface, leading to a power conversion efficiency of 26.31% (certified 26.02%). Unencapsulated devices retain 95% of their initial power conversion efficiency after 1,000 hours of continuous illumination.
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Nano-Micro Letters
·
2024
·Vol. 17
·期 1
·1-18
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IF 31.6
Yu Ming-Yuan,Wu Jing,Yin Guang,Jiao Fan-Zhen,Yu Zhong-Zhen,Qu Jin
A flow-bed water purification system with an asymmetric solar-thermal and catalytic membrane is designed for synergistic solar-thermal desalination of seawater/brine and catalytic degradation of organic pollutants.
The hydrogen bonding networks can be regulated by the abundant surface –OH groups and the in situ generated ions and radicals during the degradation process for promoting solar-driven steam generation.
The de-solvation of solvated Na + and subsequent nucleation/growth of NaCl are effectively inhibited by SO 4 2− /HSO 5 − ions.
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Cellular & Molecular Immunology
·
2025
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IF 19.8
Bai Ying,Ren Hui,Leng Shuo,Yuan Mengqin,Jiang YiXin,Zhang Shenyang,Wang Yu,Ju Minzi,Wang Zhi,Xi Wen,Xu Lian,Zheng Bingjing,Li Daxing,Huo Xinchen,Zhu Tianhao,Zhang Beicheng,Shen Ling,Zhang Yuan,Jiang Wei,Zhang John H.,Han Bing,Yao Honghong
Splenic sympathetic activity critically modulates peripheral immunity after ischemic stroke, thus intervention in spleen sympathetic activity represents a promising therapeutic strategy for stroke. However, the mechanisms underlying spleen-brain-immune axis communication remain poorly understood. Here, we utilized a surgical denervation protocol to perform splenic sympathetic denervation (SDN), which significantly attenuated brain injury following stroke. Through single-cell RNA sequencing, we identified a novel GZMK + CD8 + CD27 + CCR7 + T-cell subset in patients with acute ischemic stroke (AIS), which we designated stroke-associated T (Tsa) cells. The expansion of Tsa cells was positively correlated with the severity of clinical symptoms and was driven by the splenic sympathetic nervous system. Stroke-induced sympathetic activation triggers the release of splenic norepinephrine (NE), which preferentially signals through ADRB2 on Tsa cells to promote their mobilization. Additionally, ischemic injury induces endothelial cell-specific expression of CCL19, which chemoattracts Tsa cells into the brain parenchyma via their cognate CCR7 receptor, exacerbating neuroinflammatory injury and neurological deficits in a transient middle cerebral artery occlusion (tMCAO) mouse model. We developed a CCR7-targeting peptide to disrupt this chemotactic axis and reduce T-cell infiltration, thereby mitigating brain injury. Our findings highlight SDN as a promising therapeutic strategy to attenuate ischemia‒reperfusion injury and suggest its potential as an adjunctive therapy for reperfusion treatment in AIS patients.
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Nature Communications
·
2022
·Vol. 13
·期 1
·1-12
·
IF 17.694
Wang Sihong,Jiang Qu,Ju Shenghong,Hsu Chia-Shuo,Chen Hao Ming,Zhang Di,Song Fang
Unraveling the precise location and nature of active sites is of paramount significance for the understanding of the catalytic mechanism and the rational design of efficient electrocatalysts. Here, we use well-defined crystalline cobalt oxyhydroxides CoOOH nanorods and nanosheets as model catalysts to investigate the geometric catalytic active sites. The morphology-dependent analysis reveals a ~50 times higher specific activity of CoOOH nanorods than that of CoOOH nanosheets. Furthermore, we disclose a linear correlation of catalytic activities with their lateral surface areas, suggesting that the active sites are exclusively located at lateral facets rather than basal facets. Theoretical calculations show that the coordinatively unsaturated cobalt sites of lateral facets upshift the O 2p -band center closer to the Fermi level, thereby enhancing the covalency of Co-O bonds to yield the reactivity. This work elucidates the geometrical catalytic active sites and enlightens the design strategy of surface engineering for efficient OER catalysts.
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Nature Communications
·
2022
·Vol. 13
·期 1
·1-13
·
IF 17.694
Zhang Ying-Jie,Huang Gui-Xiang,Winter Lea R.,Chen Jie-Jie,Tian Lili,Mei Shu-Chuan,Zhang Ze,Chen Fei,Guo Zhi-Yan,Ji Rong,You Ye-Zi,Li Wen-Wei,Liu Xian-Wei,Yu Han-Qing,Elimelech Menachem
Removal of organic micropollutants from water through advanced oxidation processes (AOPs) is hampered by the excessive input of energy and/or chemicals as well as the large amounts of residuals resulting from incomplete mineralization. Herein, we report a new water purification paradigm, the direct oxidative transfer process (DOTP), which enables complete, highly efficient decontamination at very low dosage of oxidants. DOTP differs fundamentally from AOPs and adsorption in its pollutant removal behavior and mechanisms. In DOTP, the nanocatalyst can interact with persulfate to activate the pollutants by lowering their reductive potential energy, which triggers a non-decomposing oxidative transfer of pollutants from the bulk solution to the nanocatalyst surface. By leveraging the activation, stabilization, and accumulation functions of the heterogeneous catalyst, the DOTP can occur spontaneously on the nanocatalyst surface to enable complete removal of pollutants. The process is found to occur for diverse pollutants, oxidants, and nanocatalysts, including various low-cost catalysts. Significantly, DOTP requires no external energy input, has low oxidant consumption, produces no residual byproducts, and performs robustly in real environmental matrices. These favorable features render DOTP an extremely promising nanotechnology platform for water purification.
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Nature Communications
·
2022
·Vol. 13
·期 1
·1-7
·
IF 17.694
Xu Haojie,Guo Wuqian,Ma Yu,Liu Yi,Hu Xinxin,Hua Lina,Han Shiguo,Liu Xitao,Luo Junhua,Sun Zhihua
Metal-free antiferroelectric materials are holding a promise for energy storage application, owing to their unique merits of wearability, environmental friendliness, and structure tunability. Despite receiving great interests, metal-free antiferroelectrics are quite limited and it is a challenge to acquire new soft antiferroelectric candidates. Here, we have successfully exploited binary CMBr x I 1- x and CMBr x Cl 1- x solid solution as single crystals (0 ≤ x ≤ 1, where CM is cyclohexylmethylammonium). A molecule-level modification can effectively enhance Curie temperature. Emphatically, the binary CM-chloride salt shows the highest antiferroelectric-to-paraelectric Curie temperature of ~453 K among the known molecular antiferroelectrics. Its characteristic double electrical hysteresis loops provide a large electric polarization up to ~11.4 μC/cm 2 , which endows notable energy storage behaviors. To our best knowledge, this work provides an effective solid-solution methodology to the targeted design of new metal-free antiferroelectric candidates toward biocompatible energy storage devices.
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Nature Communications
·
2022
·Vol. 13
·期 1
·1-9
·
IF 17.694
Chen Xueyan,Ding Qianqian,Bi Chao,Ruan Jian,Yang Shikuan
Concentrating a trace amount of molecules from liquids, solid objects, or the gas phase and delivering them to a localized area are crucial for almost any trace analyte detection device. Analytes within a liquid droplet resting on micro/nanostructured surfaces with liquid-repellent coatings can be concentrated during solvent evaporation. However, these coatings suffer from complex manufacturing procedures, poor versatility, and limited analyte enrichment efficiency. Here, we report on the use of an acoustic levitation platform to losslessly concentrate the analyte molecules dissolved in any volatile liquid, attached to solid objects, or spread in air. Gold nanoparticles can be simultaneously concentrated with the analytes in different phases, realizing sensitive, surface-enhanced Raman scattering detection even at attomolar (10 −18 mol/L) concentration levels. The acoustic levitation platform-enabled, lossless analyte enrichment can significantly increase the analytical performance of many conventional microsensing techniques.
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Advanced Fiber Materials
·
2024
·Vol. 6
·期 2
·430-443
·
IF 17.2
Wu Simeng,Wang Chengjuan,Tang Yunxiang,Jiang Jiangyiming,Jiang Haotian,Xu Xiaodan,Cui Bowen,Jiang Yanyan,Wang Yanxiang
Refining the electromagnetic wave absorption characteristics of traditional metal–organic framework (MOF)-derived carbon composites remains a challenge because of their discontinuous conductive path. To overcome this limitation, in this work, MOF-derived hierarchical Cu 9 S 5 /C nanocomposite fibers are fabricated by electrospinning and subsequent carbonization-sulfurization process. Morphological analyses show that MOF-derived octahedral Cu 9 S 5 /C particles are evenly monodispersed inside carbonaceous fibers. This configuration creates a unique hierarchical structure, ranging from Cu 9 S 5 particle embedding, MOF-derived skeleton, to a three-dimensional network. The optimized composite fibers (Cu 9 S 5 /C-40) exhibit extraordinary electromagnetic wave absorption performance at a low mass fraction (20 wt%): the minimum reflection loss value reaches − 69.6 dB, and the maximum effective absorption bandwidth achieves 5.81 GHz with an extremely thin thickness of only 1.83 mm. Systematic investigations demonstrate that constructing the three-dimensional conductive network to connect MOF derivatives is crucial for activating performance enhancement. The unique nano-micro hierarchical structure synergized with elaborate-configured components endows the materials with optimal impedance matching and amplifies the loss capacity of each part. This work provides a reliable example and theoretical guidance for fabricating new-generation high-efficiency MOF-derived fibrous electromagnetic wave absorbers. Graphical Abstract
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IRANIAN POLYMER JOURNAL
·
2024
·
IF 2.4
Qin Jisong,Cheng Zhengzai,Djouonkep Lesly Dasilva Wandji,Gauthier Mario
To meet polymeric material sustainability requirements of the modern polymer industry, a novel diphenyl-based monomer, dimethyl 2,2’-((carbonylbis(4,1-phenylene))bis(oxy))diacetate (DPBD), was prepared from 4,4'-dixydroxybenzophenone, derived from potentially bio-sourced 4-hydroxybenzoic acid. The diester monomer DPBD was polymerized with either 1,4-butanediol, 1,6-hexanediol, 1,8-octanediol, or 1,4-cyclohexanedimethanol as aliphatic diols to afford aliphatic/aromatic copolyesters (P 1 –P 4 ). The copolyesters were characterized using gel permeation chromatography, differential scanning calorimetry, thermogravimetric analysis, dynamic mechanical analysis, and tensile testing, as well as biodegradation and earthworm acute toxicity assays. The effects of diol carbon chain length and cyclic diol monomers on polyester properties were investigated. From the results, the weight-average molecular weight (M w ) of the polyesters ranged from 37.5 to 45.5 kg/mol, glass transition temperature (T g ) ranged from 65 to 78 °C, initial thermal decomposition temperature (T d,5% ) varied from 324 to 353 °C, yield strength varied from 45 to 56 MPa, and elongation-at-break ranged from 215 to 290%. The properties can be adjusted by tuning the monomer structure, which induced a degradation rate of up to 4.6% after incubation in soil for 30 weeks, in contrast to poly(ethylene terephthalate) (PET) which showed no degradation under the same conditions. The ecotoxicity of the polyesters to earthworms remained low, even at high concentration polymer concentration tested (4000 mg/kg soil), the survival rate was above 82%. Therefore, polyesters offer a good combination of structure-to-property serving as potential alternatives to petroleum-based materials. Graphical abstract
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