TALANTA
·
2017
·
IF 4.162
Yong Hu,Hai-Long Wu,Xiao-Li Yin,Hui-Wen Gu,Rong Xiao,Li-Xia Xie,Zhi Liu,Huan Fang,Li Wang,Ru-Qin Yu
The aim of the present work was to develop a rapid and interference-free method based on liquid chromatography-mass spectrometry (LC-MS) for the simultaneous determination of nine B-group vitamins in various energy drinks. A smart and green strategy that modeled the three-way data array of LC-MS with second-order calibration methods based on alternating trilinear decomposition (ATLD) and alternating penalty trilinear decomposition (APTLD) algorithms was developed. By virtue of "mathematical separation" and "second-order advantage", the proposed strategy successfully solved the co-eluted peaks and unknown interferents in LC-MS analysis with the elution time less than 4.5 min and simple sample preparation. Satisfactory quantitative results were obtained by the ATLD-LC-MS and APTLD-LC-MS methods for the spiked recovery assays, with the average spiked recoveries ranging from 87.2–113.9% to 92.0–111.7%, respectively. These results acquired from the proposed methods were confirmed by the LC-MS/MS method, which shows a quite good consistency with each other. All these results demonstrated that the developed chemometrics-assisted LC-MS strategy had advantages of being rapid, green, accurate and low-cost, and it could be an attractive alternative for the determination of multiple vitamins in complex food matrices, which required no laborious sample preparation, tedious condition optimization or more sophisticated instrumentations.
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APPLIED SURFACE SCIENCE
·
2024
·
IF 6.3
Dingdiao Mo,Guoxiang Chen,Jiaxing Zhang,Zhiwei Xiang,Chao Huang,Weitong Cai,Jie Cui,Wei Su
Designing low-cost, efficient, and durable bifunctional electrocatalysts can significantly reduce the cost of industrial electrolysis of water. In this article, a novel self-supported nickel–iron foam completely covered with Ni 2 B particles was prepared through a solid-phase boronization method as the substrate (referred to as NFF-B). Then, an independent columnar Co-doped NiSe electrocatalyst composed of petal-shaped nanosheets was synthesized on NFF-B via a stirring-electrodeposition method. For comparison, a series of reference samples were also synthesized using the same process. The synthesized Ni 0.5 Co 0.5 Se/NFF-B exhibited excellent bifunctional catalytic activity and stability, with an HER overpotential of 90 mV and an OER overpotential of only 182 mV in 1 M KOH at 10 mA‧cm −2 . More importantly, the assembled Ni 0.5 Co 0.5 Se/NFF-B||Ni 0.5 Co 0.5 Se/NFF-B overall water splitting system required only 1.49 V to drive the electrolysis of water at 10 mA‧cm −2 , maintaining exceptional stability for 115 h under these conditions, surpassing most previously reported bifunctional electrocatalysts. Our work offers a new strategy for preparing efficient and durable bifunctional electrocatalysts.
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Molecular Medicine Reports
·
2017
·Vol. 16
·期 4
·5121-5128
·
IF 1.692
Hongzhang Cui,Shu Li,Caiming Xu,Jingwen Zhang,Zhongwei Sun,Hailong Chen
The present study aimed to evaluate the protective effects of emodin on severe acute pancreatitis (SAP)‑associated acute lung injury (ALI), and investigated the possible mechanism involved. SAP was induced in Sprague‑Dawley rats by retrograde infusion of 5% sodium taurocholate (1 ml/kg), after which, rats were divided into various groups and were administered emodin, FK866 [a competitive inhibitor of pre‑B‑cell colony‑enhancing factor (PBEF)] or dexamethasone (DEX). DEX was used as a positive control. Subsequently, PBEF expression was detected in polymorphonuclear neutrophils (PMNs) isolated from rat peripheral blood by reverse transcription‑quantitative polymerase chain reaction and western blotting. In addition, histological alterations, apoptosis in lung/pancreatic tissues, apoptosis of peripheral blood PMNs and alterations in the expression of apoptosis‑associated proteins were examined by hematoxylin and eosin staining, terminal deoxynucleotidyl‑transferase‑mediated dUTP nick end labeling assay, Annexin V/propidium iodide (PI) assay and western blotting, respectively. Serum amylase activity and wet/dry (W/D) weight ratios were also measured. An in vitro study was also conducted, in which PMNs were obtained from normal Sprague‑Dawley rats and were incubated with emodin, FK866 or DEX in the presence of lipopolysaccharide (LPS). Apoptosis of PMNs and the expression levels of apoptosis‑associated proteins were examined in cultured PMNs in vitro by Annexin V/PI assay and western blotting, respectively. The results demonstrated that emodin, FK866 and DEX significantly downregulated PBEF expression in peripheral blood PMNs. In addition, emodin, FK866 and DEX reduced serum amylase activity, decreased lung and pancreas W/D weight ratios, alleviated lung and pancreatic injuries, and promoted PMN apoptosis by regulating the expression of apoptosis‑associated proteins: Fas, Fas ligand, B‑cell lymphoma (Bcl)‑2‑associated X protein, cleaved caspase‑3 and Bcl‑extra‑large. In addition, the in vitro study demonstrated that emodin, FK866 and DEX significantly reversed the LPS‑induced decrease of apoptosis in PMNs by regulating the expression of apoptosis‑associated proteins. In conclusion, the present study demonstrated that emodin may protect against SAP‑associated ALI by decreasing PBEF expression, and promoting PMN apoptosis via the mitochondrial and death receptor apoptotic pathways.
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高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2024
·
IF 5.8
Jingjing Wang,Zhiwei Liu,Liying Wang,Lu Li,Qian Liu,Zhiwei Liu,Zhenzhu Cao,Yongfeng Zhang,Lin Cheng,Jucai Yang
Type II heterojunction photocatalysts possessed excellent redox properties and had great potential for environmental remediation applications. In this paper, a novel Bi source of Bi-MOF was created by using NaBiO 3 . Additionally, KCl was incorporated to contest Bi-MOF for the Bi source, with the objective of generating floral BiOCl. Subsequently, heterostructures based on metal-organic skeletons (MOFs) were constructed with Bi-MOF and BiOCl, with the aim of exposing the (002) crystal faces of BiBDC. The modification of the (002) crystal surface was employed to create holes or generate more photogenerated electrons, resulting in efficient degradation of rhodamine B (RhB) and simultaneous reduction of hexavalent chromium. The heterogeneous structure demonstrated a degradation rate of 97 % for rhodamine B (RhB) after reaching adsorption equilibrium in 30 min of dark reaction and 10 min of visible light irradiation. Furthermore, the reduction rate of hexavalent chromium (Cr (VI)) was 95.5 % after reaching adsorption equilibrium in 30 min of dark reaction and 70 min of visible light irradiation . The results of the cycling experiments demonstrated that both 1:1 BBOC and 1:3 BBOC retained their structural integrity following four cycles. The active species trapping results indicated that the hole radicals (h + ) and electrons were responsible for the degradation of RhB and the reduction of hexavalent chromium, respectively. This study also revealed the degradation pathways and mechanisms of heterojunctions, providing new ideas for the preparation of photocatalysts for environmental remediation.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2024
·
IF 8.1
Lu Li,Shiyu Ma,Huimin Liu,Zixuan Zeng,Qijie Li,Chunlin Song,Jingang Yang
Ammonia borane (NH 3 BH 3 ) as a solid chemical hydrogen storage material with a high hydrogen content can be hydrolyzed under mild conditions to release hydrogen. In this work, Fe–Ni–B/Cu(OH) 2 –Cu foam was synthesized by combining in situ growth and electroless plating. Compared with the binary Fe–B/Cu(OH) 2 –Cu foam and Ni–B/Cu(OH) 2 –Cu foam prepared by the same method, the ternary Fe–Ni–B/Cu(OH) 2 –Cu foam has superior catalytic performance. The Fe–Ni–B/Cu(OH) 2 –Cu foam catalyst was able to achieve a maximum hydrogen production rate of 5.6 ml min −1 cm −2 at 298 K with an activation energy as low as 46.3 kJ mol −1 . And more importantly, its catalytic efficiency has hardly decayed after ten cycles. These excellent properties are due to its low activation energy and the large specific surface, multi–site Cu(OH) 2 –Cu–foam carrier.
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ENVIRONMENTAL TOXICOLOGY
·
2024
·
IF 4.4
Junjie Chen,Weibin Fan,Jing Fan,Jiao Xie,Yan Wang,Yinhui Wang,Nengming Lin,Bin Lin
The clinical application of polymyxin B (PMB) is limited by its nephrotoxic effects, making the reduction of PMB-induced nephrotoxicity has become a pressing concern for clinicians. Tetrahydrocurcumin (THC), known for its beneficial characteristics in biological functions, presents an attractive option for intervention therapy to mitigate PMB-induced nephrotoxicity. However, the underlying mechanism of how THC mitigates PMB-induced nephrotoxicity is still poorly understood. Here, we first evaluated the potential of THC intervention therapy to mitigate PMB-induced nephrotoxicity in an in vitro model of PMB-induced cell injury. Moreover, we demonstrated that THC effectively protected HK-2 cells from PMB-induced apoptosis by using cell counting kit-8 and flow cytometry assay. THC could also suppress PMB-induced endoplasmic reticulum (ER) stress via PERK/eIF2α/ATF4/CHOP pathway. In addition, using PERK inhibitor GSK2606414 to inhibit ER stress also alleviated PMB-induced apoptosis. Taken together, these findings provide novel insights that THC possesses the ability to alleviate PMB-induced nephrotoxicity by inhibiting the ER stress-mediated PERK/eIF2α/ATF4/CHOP axis, which sheds light on the benefits of THC as an intervention strategy to reduce PMB-induced nephrotoxicity, thus providing a potential avenue for improved clinical outcomes in patients receiving PMB treatment.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Sheng Wang,Xin Liang,Tengfei Lu,Ying Ma,Ziteng Wang,Xiangyu Zheng,Kaiyu Ruan,Tong Wang
Finding sustainable and efficient ways to extract natural products is becoming increasingly important for both the pharmaceutical and food industries. In this study, we propose a target-oriented approach for the rational design of composite bio-derived solvents, specifically tailored for the simultaneous extraction of salvianolic acid B, tanshinone I, cryptotanshinone and tanshinone IIA from Salvia miltiorrhiza root. We systematically evaluated the extraction efficiency of various bio-derived solvents, including glycerol carbonate, ethylene glycol, levulinic acid, glycerolformal, ethyl lactate and γ-valerolactone, both individually and in combination. Using a mixture design integrated with statistical modeling and optimization algorithms, we identified that the composite solvent system of GF/LA (57.8/42.2, v/v) greatly improved the extraction of both hydrophilic and lipophilic compounds. The extraction yields were significantly higher compared to those obtained using individual bio-derived or traditional solvents, while the overall solvent consumption was lower. Additionally, we explored the use of macroporous adsorption resins to recover the extracted compounds from GF/LA (57.8/42.2, v/v) extracts solution, achieving impressive recovery yields of over 80%. Our findings provide valuable insights into the sustainable extraction of bioactive compounds and suggest practical applications for both analytical and industrial-scale processes, aligning with green chemistry principles.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2025
·Vol. 36
·期 22
·1-15
·
IF 2.8
Zhou Hengqing,Li Xiao,Gao Guoqi,Sun Huajun,Liu Xiaofang
BiOBr/PVDF composite films with different precursor doping amounts were successfully prepared by in situ deposition phase conversion technology. The physicochemical properties of the composite films were analyzed in detail, and their piezoelectric-photocatalytic performance was systematically investigated. The experimental results showed that BP-0.8 (with a doping amount of 0.8 mmol for the BiOBr precursor) exhibited the best catalytic performance. Under the synergistic effect of visible light irradiation and ultrasonic vibration, the degradation rate of BP-0.8 for 50 mL of 40 mg/L Rhodamine B (Rh B) solution within 60 min could reach 96.73%, and the apparent reaction rate constant (k) of this sample was 0.06198 min⁻ 1 . It was 3.81 times and 27.06 times that of photocatalysis alone and piezoelectric catalysis alone, respectively. The radical capture experiment proved that the main active groups involved in the reaction were h⁺ and ·OH, and the mechanism of piezoelectric photocatalysis of BiOBr/PVDF composite thin films was proposed. In addition, compared with powder catalysts, flexible BiOBr/PVDF membranes were easier to recycle, did not require complex treatment, and still maintained good catalytic activity after ten cycles of testing. This work demonstrated the contribution of the piezoelectric effect to photocatalytic water purification and provided a promising strategy to utilize solar and mechanical energy.
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CONSTRUCTION AND BUILDING MATERIALS
·
2025
·
IF 8
Zhipeng Zhang,Yao Yin,Kai Liang,Ranzhao Shen,Xu Fan,Bihe Yuan
The high flammability and severe dripping behavior of ethylene-vinyl acetate (EVA) limit its widespread application. It remains a persistent challenge to enhance the flame retardancy and smoke suppression performance of EVA composites while maintaining their tensile properties. In this study, a microencapsulated P/N/B-based flame retardant, referred to as MBPAPP, was synthesized via a one-pot method. The flame retardant consists of a melamine-boric acid composite (MA-BA, shell) and piperazine pyrophosphate (PAPP, core). At a loading of 20 wt% MBPAPP, EVA/MBPAPP composite achieves a UL-94 V-0 rating without dripping. In the cone calorimetry test, compared with EVA/PAPP, EVA/MBPAPP exhibits reductions in the peak heat release rate (50.5 %), total heat release (16.9 %), total smoke production (17.1 %), and the peak of CO content (52.5 %). This is attributed to the fact that EVA/MBPAPP forms a boron-containing char layer composed of B-O and B-N structures, contributing to the enhancement of compactness and thermal stability. Moreover, compared with PAPP, microencapsulation enhances the compatibility between modified MBPAPP and EVA, mitigating the deterioration of tensile properties in the composite.
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ELECTROCHIMICA ACTA
·
2025
·
IF 5.6
Tie Liu
The development of magnetic carbonous composites for enhancing the performance of lithium-oxygen batteries continues to pose a significant challenge. In this study, we propose a facile approach without any template agent and surfactant to prepare a porous carbon matrix with discrete active FeCo-BN/C sites, achieving a total metal loading of ca. 4.67 at.%. This lightsome and magnetic composite exhibits a hydrangea-like hierarchical morphology and possesses key features essential for cathodic catalysis, including high catalytic activity and a large porous surface structure capable of accommodating abundant discharge products. Consequently, this interesting structure shows enhanced electrocatalytic activity and cyclic stability, surpassing that of commercial Pd/C catalyst. DFT calculations also revealed that the synergistic effect of dual-metal FeCo-N/C sites with B-doping coordination induced asymmetric charge distribution, amplifying the adsorption/desorption of oxygen intermediates. This work establishes a significant paradigm for the structural construction of hierarchical bimetal-BN/C catalysts tailored for air cathodes.
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CERAMICS INTERNATIONAL
·
2025
·
IF 5.6
Huilin Lun,Yi Zeng,Xiang Xiong,Houbu Li,Ziming Ye,Xiaoxu Liu
This work introduces fabricating single-phase ternary-anion carbide solid solution via solid-state diffusion of B and N. Initially, non-stoichiometric (Zr,Hf,Ti)C x with carbon vacancies was synthesized by modified spark plasma sintering. Then, using B 2 O 3 and g -C 3 N 4 as sources, (Zr 0.3 Hf 0.5 Ti 0.2 )(C 0.87 B 0.03 N 0.07 ) with face-centered-cubic structure was produced via B diffusion at 1100 °C and N diffusion at 1600 °C. Trace B (0.23 wt%) and N (0.71 wt%) in (Zr 0.3 Hf 0.5 Ti 0.2 )(C 0.87 B 0.03 N 0.07 ) was found to significantly enhance the oxidation resistance (higher onset temperature 520 ± 3 °C (particle size 2.5 ± 1.3 μm) than 475 ± 3 °C of (Zr 0.3 Hf 0.5 Ti 0.2 )C 0.85 and improve structural stability with more negative binding energy.
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Environmental Chemistry and Ecotoxicology
·
2025
·
IF 8.2
Huizi Zheng,Zhipeng Zhang,Guanlan Wu,Haoming Sun,Xiaolin Zhu,Jiao Qu,How Yong Ng
Nanoplastics and bisphenols (including bisphenol A and its alternatives) are emerging co-contaminants in aquatic ecosystems, yet their combined toxicological effects remain poorly understood. To address this gap, we developed a novel electrochemical biosensor using HepG2 cells and a nanocomposite of hydroxylated multi-walled carbon nanotubes, poly(diallyldimethylammonium chloride), and boron-doped graphene quantum dots (MWCNT-OH/PDDA/B-GQDs). This unique composite design, verified by density functional theory (DFT) calculations, revealed strong adsorption energies for cellular electroactive substances (xanthine: −1.12 eV; guanine: −1.56 eV), confirming the sensor's superior detection capability. The biosensor was used to assess the cytotoxicity of polystyrene nanoplastics (PS 25 nm ) and five bisphenols individually; their mixture exhibited an additive combined effect. Beyond rapid toxicity screening, we further conducted comprehensive mechanistic investigations through oxidative stress analysis, apoptosis assessment, and transcriptome sequencing. Results indicated that exposure to PS 25 nm and bisphenols, either individually or in combination, induced oxidative stress, as evidenced by decreased glutathione (GSH) levels and reduced superoxide dismutase (SOD) activity. Transcriptome analysis revealed substantial enrichment of differentially expressed genes in the pathways related to protein synthesis, oxidative stress response, and liver disease. This study not only establishes a rapid and sensitive approach for evaluating the toxicity of nanoplastics and bisphenols in aquatic environments but also provides a comprehensive understanding of the underlying mechanisms through integrated multi-level analysis, thereby providing essential mechanistic data to support their comprehensive biosafety assessment and regulatory management.
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