FOOD CHEMISTRY
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2018
·
IF 4.946
Xiaofeng Ren,Ting Hou,Qiufang Liang,Xi Zhang,Di Hu,Baoguo Xu,Xinxiang Chen,Meram Chalamaiah,Haile Ma
In this study, resveratrol was successfully encapsulated using zein-chitosan complex coacervation. The encapsulation efficiency was markedly improved (51.4%) after chitosan coating at 1:2.5 zein/chitosan ratio, compared with 38.6% using native zein . Analysis of multi-model frequency ultrasound treatment effects on resveratrol encapsulation using zein-chitosan complex coacervation showed that 28/40 kHz dual-frequency ultrasound led to the highest encapsulation efficiency (65.2%; 31.9% increase) and loading capacity (5.9%; 31.1% increase) of resveratrol, followed by multi-frequency ultrasound at 20/28/40 kHz (17.8% encapsulation efficiency increase; 17.8% loading capacity increase). Dual-frequency ultrasound treatment significantly reduced the zein-chitosan complex coacervation particle size and reduced their distribution, however, did not change the zeta potential. Fourier transform infrared spectroscopy and fluorescence spectroscopy analysis demonstrated that ultrasound treatment had no effect on secondary structure of zein-chitosan complex but markedly decreased the fluorescence emission intensity. Differential scanning calorimetry and X-ray diffraction results indicated that Dual-frequency ultrasound treatment improved the thermal stability of zein-chitosan complex coacervation but had no effect on the crystal structure. Atomic force microscopy and scanning electron microscopy images revealed uniform distribution of zein-chitosan complex coacervation followed by ultrasonic treatment.
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MATERIALS & DESIGN
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2018
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IF 4.525
Shi-Neng Li,Baoqiang Li,Li-Xiu Gong,Zhi-Ran Yu,Yujie Feng,Dechang Jia,Yu Zhou,Long-Cheng Tang
Hyperbranched polysiloxane (HSi) molecules with tunable molecular structure were synthesized and served as a novel crosslinker for fabricating polyacrylamide/chitosan (PCH) hydrogels. Various characterizations demonstrated that HSi molecules with tunable bi-functional vinyl and epoxy groups were successful prepared and utilized to optimize the network architecture and interactions of polymer chains. Benefiting from the structure of bi-functional crosslinker, PCH hydrogels demonstrated remarkably improved mechanical properties, superior to that of conventional crosslinker or HSi with single vinyl or epoxy group. A tensile strength of 302 kPa, elongation at break of 2263%, and toughness of 3.85 MJ·m –3 can be achieved by optimizing the molecular structure and content of HSi with bi-functional group (e.g. ratio of vinyl/epoxy = 0.68). Additionally, such hydrogels showed outstanding antifatigue ability to withstand cyclic compressive tests. Based on the structure observation and analysis, the improved mechanical properties are likely derived from the combination of homogeneous and strong polymer network and improved interactions of polymer chains (e.g. covalent and hydrogen bonds). Approaches in this study may inspire the design and development of novel crosslinker for fabricating mechanically robust hydrogels.
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NEW JOURNAL OF CHEMISTRY
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2018
·Vol. 42
·期 19
·16013-16020
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IF 3.201
Xuemin Liu,Shuo Chang,Xinzhi Chen,Xin Ge,Chao Qian
Three different types of functionalized-CS were prepared and anchored with copper salts for use as the catalyst for the Ullmann C–X coupling reaction. The Schiff-basic chitosan supported copper complex (PCCS@CuI) exhibits the highest catalytic activity. The structure of the catalyst was characterized by FTIR spectroscopy, TG, XRD, SEM, EDS and XPS. This catalyst exhibited high applicability for the C–N and C–S coupling reactions, in which good to excellent yields were obtained. Its easy separation, good reusability and stability were notable.
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JOURNAL OF MICROENCAPSULATION
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2018
·
IF 1.793
Zhen Jiao,Xiudong Wang,Yuting Yin,Jingxin Xia,Yanan Mei
Vitamin C (VC) and folic acid (FA) are the important nutrient and antioxidant in human body. In order to improve their stability, their co-loaded liposomes (VCFA-Lip) and chitosan-coated liposomes (CS-VCFA-Lip) are prepared and characterised. The mean particle size of VCFA-Lip and CS-VCFA-Lip is 138 nm and 249 nm, respectively. The encapsulation efficiencies of both drugs for CS-VCFA-Lip are much higher than those for VCFA-Lip. Furthermore, the experimental results show that the antioxidant activity of CS-VCFA-Lip is higher than that of VCFA-Lip. Moreover, the storage stability study reveals that the chitosan coating can efficiently improve the physical stability of VCFA-Lip. These results indicate that stability of VC and FA can be greatly improved after being wrapped by liposomes. In addition, the performance of CS-VCFA-Lip is better than VCFA-Lip, indicating CS-VCFA-Lip can be applied as a promising delivery system for the antioxidant defence system to the food industry and cosmetic industry.
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Scientific Reports
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2018
·Vol. 8
·期 1
·1-10
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IF 4.122
Liu Weixiang,Qin Yukun,Liu Song,Xing Ronge,Yu Huahua,Chen Xiaolin,Li Kecheng,Li Pengcheng
Based on a condensation reaction, a chitosan-derivative-bearing amino pyridine group was prepared and subsequently followed by coordination with cupric ions, zinc ions and nickel ions to synthesize chitosan metal complexes. The calculations using the density functional theory (DFT) show that the copper ions and nickel ions underwent dsp 2 hybridization, the zinc ions underwent sp 3 hybridization, and they all formed a coordination bond with the carbon atom in the p-π conjugate group. The antifungal properties of O-CSPX-M against Phytophthora capsici (P. capsici) , Verticillium alboatrum (V. alboatrum) , Botrytis cinerea (B. cinerea) and Rhizoctonia solani (R. solani) were also assayed. Apparently, chitosan metal complexes showed enhanced antifungal activity against four fungi at the tested concentrations compared to that of chitosan. It was shown that Cu complexes can inhibit the growth of P. capsici 100%, and Ni complexes can inhibit the growth of B. cinerea 77.1% at a concentration of 0.4 mg/mL and 0.2 mg/mL, respectively. The pot experiment also verified the result. In addition, the phytotoxicity experiment showed that O-CSPX-M had no obvious toxicity on wheat leaves. This kind of complexes may represent as an attractive direction for chemical modifications of metal fungicides.
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RSC Advances
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2018
·Vol. 8
·期 20
·10806-10817
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IF 2.936
Ying Bu,Hai-Xing Xu,Xin Li,Wen-Jin Xu,Yi-xia Yin,Hong-lian Dai,Xiao-bin Wang,Zhi-Jun Huang,Pei-Hu Xu
Polymer materials with electrically conductive properties have good applications in their respective fields because of their special properties. However, they usually exhibited poor mechanical properties and biocompatibility. In this work, we present a simple approach to prepare conductive sodium alginate (SA) and carboxymethyl chitosan (CMCS) polymer hydrogels (SA/CMCS/PPy) that can provide sufficient help for peripheral nerve regeneration. SA/CMCS hydrogel was cross-linked by calcium ions provided by the sustained release system consisting of D-glucono-δ-lactone (GDL) and superfine calcium carbonate (CaCO3), and the conductivity of the hydrogel was provided by doped with polypyrrole (PPy). Gelation time, swelling ratio, porosity and Young's modulus of the conductive SA/CMCS/PPy hydrogel were adjusted by polypyrrole content, and the conductivity of it was within 2.41 × 10−5 to 8.03 × 10−3 S cm−1. The advantages of conductive hydrogels in cell growth were verified by controlling electrical stimulation of cell experiments, and the hydrogels were also used as a filling material for the nerve conduit in animal experiments. The SA/CMCS/PPy conductive hydrogel showed good biocompatibility and repair features as a bioactive biomaterial, we expect this conductive hydrogel will have a good potential in the neural tissue engineering.
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RSC Advances
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2015
·Vol. 5
·期 86
·70109-70116
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IF 3.84
Gongyan Liu,Quanqing Luo,Haibo Wang,Weihua Zhuang,Yunbing Wang
To realize desirable functions in the rather complex biological systems, a suitable surface coating is desirable for gold nanoparticles, which plays an important role in their colloidal stability and biocompatibility. In this work, a novel multidentate PEGylated chitosan derivative was synthesized by conjugating PEG and dithiolane lipoic acid (LA) to the chitosan backbone. Under reduction conditions, gold nanoparticles (AuNPs) could be in situ formed by the electrostatic interaction between amino groups of the chitosan derivative and gold chloride ions (AuCl4−), with their surface covalently coated by the multidentate PEGylated chitosan via the disulfide bond from LA. After the surface modification, such AuNPs exhibited remarkable colloidal stabilities under extreme conditions, including high salt conditions and complex biological media containing serum. Moreover, the multidentate PEGylated chitosan also provided AuNPs with good biocompatibility and low cytotoxicity, resistance of protein adsorption and anti-phagocytosis by RAW 264.7 cells. This kind of AuNP was expected to be a promising platform for applications in nanomedicine.
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NANOTECHNOLOGY
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2013
·Vol. 24
·期 14
·145101
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IF 3.842
Dao-Lu Tang,Fei Song,Cheng Chen,Xiu-Li Wang,Yu-Zhong Wang
Increasing attention has recently been paid to the fabrication of drug delivery systems with excellent cell internalization and intracellular drug release properties. In this study, an amphiphilic block copolymer of chitosan was synthesized for the first time, which can self-assemble into micelles in a neutral aqueous solution but partially disassemble in an acidic endosomal/lysosomal environment. The antitumor drug, camptothecin (CPT), was encapsulated in the cores of the micelles for tumor cell therapy. In vitro drug release studies demonstrated that the micelles presented a much faster release of CPT at pH 5.0 than at pH 7.4. Blank micelles were found to be nontoxic in preliminary in vitro cytotoxicity assays. Cell experiments showed that the CPT-loaded micelles could be effectively internalized by Hela cells and accomplished a potent antitumor cell efficacy, indicating that the chitosan-based micelles might be an attractive new platform for efficient intracellular drug delivery.
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MOLECULAR PHARMACEUTICS
·
2013
·
IF 4.57
Juan Chen,Liuqing Huang,Huixian Lai,Chenghao Lu,Ming Fang,Qiqing Zhang,Xuetao Luo
Cancer nanotherapeutics are rapidly progressing and being implemented to solve several limitations of conventional drug delivery systems. In this paper, we report a novel strategy of preparing methotrexate (MTX) nanoparticles based on chitosan (CS) and methoxypoly(ethylene glycol) (mPEG) used as nanocarriers to enhance their targeting and prolong blood circulation. MTX and mPEG-conjugated CS nanoparticles (NPs) were prepared and evaluated for their targeting efficiency and toxicity in vitro and in vivo. The MTX–mPEG–CS NP size determined by dynamic light scattering was 213 ± 2.0 nm with a narrow particle size distribution, and its loading content (LC %) and encapsulation efficiency (EE) were 44.19 ± 0.64% and 87.65 ± 0.79%, respectively. In vitro release behavior of MTX was investigated. In vivo optical imaging in mice proved that MTX was released from particles subsequently and targeted to tumor tissue, showing significantly prolonged retention and specific selectivity. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay obviously indicated that the higher inhibition efficiency of MTX–mPEG–CS NPs meant that much more MTX was transferred into the tumor cells. A significant right-shift in the flow cytometry (FCM) assay demonstrated that MTX-loaded nanoparticles were far superior to a pure drug in the inhibition of growth and proliferation of Hela cells. These results suggest that MTX–mPEG–CS NPs could be a promising targeting anticancer chemotherapeutic agent, especially for cervical carcinoma.
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CARBOHYDRATE POLYMERS
·
2015
·
IF 4.074
Sha Peng,Kunyan Hao,Feng Han,Zheng Tang,Beibei Niu,Xu Zhang,Zhen Wang,Song Hong
The removal of bisphenol-AF (BPAF) from aqueous solutions onto chitosan-modified zeolite (Ch-Z) in the absence and presence of sodium cholate (NaC) was investigated. It was found that NaC significantly increased the adsorption capacity of Ch-Z for BPAF. At an initial concentration of 100 μmol/L, the removal of BPAF by adsorption onto Ch-Z with NaC was more than ninefold higher than without NaC, and the maximum removal was achieved at a Ch-Z dosage of 1 g/L with a NaC concentration of 1.68 mmol/L. Besides, batch studies were performed to evaluate the effects of various experimental parameters on the removal of BPAF. Kinetic studies and adsorption isotherms indicated that the adsorption process of BPAF onto Ch-Z with NaC could be expressed by a pseudo second-order model and the Freundlich isotherm model, respectively. For the enhanced removal, an interaction mechanism was proposed involving the co-effect of BPAF and NaC adsorbed onto Ch-Z.
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JOURNAL OF MATERIALS SCIENCE
·
2015
·Vol. 50
·期 14
·4914-4925
·
IF 2.371
Cheng Cui,Xia Dandan,Zhang Xiuli,Chen Li,Zhang Qiqing
The therapeutic concentration of cisplatin (CDDP) is usually associated with dose-limiting side effects. To avoid these harmful effects, a biocompatible hydrogel carrier which consisted of poly( N -isopropylacrylamide) and carboxymethyl chitosan was designed to deliver CDDP to the local environment of a solid tumor. The poly( N -isopropylacrylamide)-g-carboxymethyl chitosan hydrogels were synthesized by chemical crosslinking. Scanning electronic microscopy images showed that the hydrogels exhibited a cross-linked structure with the average pore size from 100 to 200 µm. Water contact angles and swelling studies suggested that the hydrogels had good hydrophilicity and the lower critical solution temperature lay in the vicinity of 32 °C. The MTT assays implied that the hydrogels were non-cytotoxic on NIH3T3 cells. In vitro release experiment demonstrated that the release of CDDP was controllable and sustained over a long period. Moreover, the released CDDP retained its anticancer activity on A549 cells. The hydrogels are promising carriers for sustained release of cisplatin.
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MATERIALS RESEARCH BULLETIN
·
2015
·
IF 2.288
Dechao Shi,Fanyong Yan,Meng Wang,Yu Zou,Tancheng Zheng,Xuguang Zhou,Li Chen
In this paper, a novel fluorescent adsorbent (CS-RC) was developed for mercury(II) (Hg 2+ ) detection and removal by grafting a rhodamine derived probe onto the surface of chitosan. The UV–vis spectra and Fourier transform-infrared spectroscopy confirmed the successful loading of rhodamine derived probe. Compared with traditional chitosan adsorbents, this type of adsorbent not only showed extraordinary adsorption and removal ability for mercury ions, but served as an excellent colorimetric and fluorescence turn-on “naked-eye” sensor. The sensing performance suggested that the resulting adsorbent showed exclusively distinguish Hg 2+ from various metal ions and the linear response of fluorescence emission intensity to the concentration of Hg 2+ was obtained over a wide range of 0–6.0 μM with a detection limit of 3.42 × 10 −6 M. The adsorption and removal performance were also investigated and proved to be superior to pure chitosan. More importantly, this adsorbent still exhibited excellent adsorption performance after several regeneration cycles.
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