JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2026
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IF 6.7
Tingting Yan,Minglin Wang,Danping Wang,Binglei Song,Ming Liu,Lulu Zhou
The development of supramolecular systems from renewable forestry resources holds considerable significance. In this study, a glycosylated surfactant (R-8-Glu) was synthesized from rosin. Its rigid dehydroabietic skeleton and the polyhydroxylated glucosyl headgroup drove the formation of elongated wormlike micelles, conferring remarkable viscoelasticity. Rheological measurements revealed that the zero-shear viscosity exhibited two distinct concentration-scaling regimes with exponents of 8.2 and 28.8, significantly surpassing predictions from classical polymer models. Cryo-TEM illustrated a concentration-dependent transformation from spherical to wormlike micelles with cross-sectional diameters of 5–6 nm, while circular dichroism spectroscopy demonstrated the emergence of right-handed supramolecular chirality during the one-dimensional micellar growth. 1H–1H 2D NOESY NMR indicated that hydrophobic packing of the rosin skeleton and amide interactions cooperatively drove the self-assembly. This work highlights rosin-based surfactants as sustainable building blocks for viscoelastic and chiral soft materials in food, cosmetic, and biomedical applications.
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MOLECULAR PHARMACEUTICS
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2026
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IF 4.9
Li Li,Weijia Huang,Zhenyang Zhao,Yuan Gao,Rui Zhang,Zhonghao Liao,Yuxin Hu,Qing Ma,Yang Yang,Yongjun Wang,Hongzhuo Liu
Antidrug antibodies (ADAs) compromise the pharmacokinetics and efficacy of biologics and can trigger adverse reactions. We engineer a tolerogenic liposomal platform in which rapamycin is covalently conjugated to cholesterol (RAPA-chol) and formulated as nanoliposomes (RA-c@L) to induce antigen-specific immune tolerance to coadministered proteins. Covalent anchoring enables high drug encapsulation (>95%) and improves colloidal stability. In a three-dose weekly tolerization regimen with uricase, followed by a high-dose challenge, RA-c@L markedly suppresses ADA formation: by day 42, antiuricase IgG titers are reduced by 2.15-fold compared to uricase alone and 2.17-fold compared to free rapamycin. Responses to an irrelevant antigen (KLH) remain unchanged, indicating antigen specificity. Importantly, coadministration of RA-c@L with rAAV8-SEAP enables vector readministration, yielding approximately 2-fold higher sustained serum SEAP expression after the second dose compared to rAAV alone. Mechanistically, intravenously delivered RA-c@L preferentially accumulates in the liver and reshapes systemic immunity, with reduced splenic T follicular helper cells and germinal-center B cells and an expansion of CD4+Foxp3+ regulatory T cells. Together, these data show that RA-c@L establishes durable, antigen-specific tolerance to therapeutic proteins and facilitates AAV redosing, offering a practical strategy to mitigate ADA-mediated loss of efficacy in repeated biotherapeutic treatments.
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ACS Applied Nano Materials
·
2026
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IF 5.8
Guanheng Wang,Lin Li,Biao Xue,Yu Li,Yaling Zhang,Jiapeng Wang,Yulei Cui,Chunlei Li,Xiuwen Zheng
In this study, a pH-responsive Cu-doped zeolitic imidazolate framework-8 nanoplatform was coloaded with paclitaxel and doxorubicin for synergistic tumor therapy. Hyaluronic acid modification on the outer surface of the nanomaterials enhances tumor targeting via CD44 receptor-mediated endocytosis. ZIF-8, derived from metal–organic frameworks, is an excellent nanocapsulator capable of specifically responding to the acidic tumor microenvironment. Upon reaching the tumor site, it rapidly degrades, releasing copper ions and chemotherapeutic drugs to exert antitumor effects. Copper ions consume endogenous hydrogen peroxide and glutathione through Fenton-like reactions, thereby generating cytotoxic reactive oxygen species, enhancing chemodynamic therapy efficiency, and inducing cuproptosis. The released PTX and DOX not only exert chemotherapeutic effects but also induce pyroptosis by activating the classical pathway mediated by caspase-3 and Gasdermin E. Due to excessive activation of the Wnt/β-catenin signaling pathway, PTX faces drug resistance in the treatment of triple-negative breast cancer, whereas DOX can inhibit this pathway by promoting β-catenin degradation. These therapies act synergistically to trigger immunogenic cell death, release damage-associated molecular patterns, promote dendritic cell maturation, activate T cells, and effectively reshape the immunosuppressive tumor microenvironment. This multimodal nanoplatform demonstrates remarkable potential as an antitumor treatment.
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MACROMOLECULES
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2026
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IF 5.7
Jianjun Li,Deyu Niu,Weijun Yang,Pengwu Xu,Piming Ma
Traditional bisphenol A-based polycarbonate (BPA-PC) has been restricted in food contact materials, particularly those for infants and babies, which has the potential chronic toxicity and estrogenic activity due to the presence of bisphenol A. In this study, a series of high-performance isosorbide (ISB)-based polyester-polycarbonates (PIs-PCLCs) were prepared using ISB, poly(caprolactone) diol, and diphenyl carbonate via melt transesterification polycondensation as a potential alternative to BPA-PC. The properties of the PIs-PCLC samples, such as strength, elongation, and glass transition temperature, gradually varied as increasing the polycaprolactone (PCL)-diol content from 0 to 10 mol %, and a good balance in performance was obtained at around 6.25% of the PCL-diol content. Notably, the PIs-PCLC-6.25 (6.25 represents the molar percentage of PCL diol) sample exhibited a tensile strength of 74.6 MPa, an elongation at break of 83%, a high glass transition temperature (Tg) of 122 °C, and an optical transmittance of 89.2% at 550 nm. This overall combination of properties was comparable to that of certain commercial engineering plastics. The small-angle X-ray scattering results obtained during tensile stretching reveal a transition in the deformation mechanism. While the poly(isosorbide carbonate) homopolymer exhibits craze-dominated fracture characteristics, the PIs-PCLC-6.25 sample demonstrates a shear band-mediated deformation process. This is attributed to the incorporation of flexible PCL diol chain segments, which leads to ductile fracture behavior. In summary, this study presents an efficient and viable strategy for fabricating high-performance PIs-PCLCs, thereby broadening the practical application prospects of high-performance biobased polymeric materials in areas such as food-contact packaging and medical devices.
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ACS Food Science & Technology
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2026
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IF 3
Jiayi Chen,Dandan Zhang,Lu Liu,Xiaoli Wu,Meihan Guo,Hong Yan Zou,Xi Yang
Herein, a cost-effective, naked-eye-readable platform for on-site biogenic amines (BAs) detection and shrimp freshness monitoring was developed based on a ratiometric fluorescent CDs–RhB hybrid nanosystem that was constructed by integrating carbon dots (CDs) with rhodamine B (RhB). Biogenic amines induced a significant enhancement in the green fluorescence emission of CDs, while the red fluorescence emission of RhB remained unchanged, enabling an instant self-calibration during detection. Loaded on filter paper to form disposable test strips, the nanosystem enabled a visible color transition from orange to green with increasing BAs concentration. Readable via a smartphone RGB app, the paper-based assay showed a linear response of 5.0–250 μM with a limit of detection (LOD) of 3.56 μM using histamine as the model analyte. Validated through on-site shrimp quality evaluation, the paper-based sensor established a reliable “nanoprobe–paper–phone” strategy, facilitating on-site and quantitative freshness assessment in real-world demand scenarios.
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Foods
·
2026
·Vol. 15
·期 4
·704
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IF 6
Fang Long,Zuomin Hu,Huanzhao Luo,Zhongxing Chu,Shuqin Li,Yaping Zhou,Anping Li,Feijun Luo
Bamboo shoot polysaccharides possess promising bioactivities, but their high molecular weight and complex branched structures limit their functional efficacy. In this study, bamboo (Phyllostachys edulis) shoots were fermented withMonascus purpureusATCC16426 to obtain a novel neutral polysaccharide (FBSP-1). Monosaccharide composition analysis indicated that FBSP-1 comprised glucose (Glc), xylose (Xyl), arabinose (Ara), galactose (Gal), and mannose (Man). Glycosidic linkage and nuclear magnetic resonance (NMR) spectroscopy data revealed that the backbone of FBSP-1 mainly consisted of →2)-α-Manp-(1→, →4)-α-Glcp-(1→, →3)-β-Xylp-(1→, →3)-α-Araf-(1→ and →2)-α-Araf-(1→. Compared with unfermented polysaccharide BSP-1, fermentation markedly altered the monosaccharide profile, increasing Glc, Xyl and Man, decreasing Ara and Gal, and reducing the molecular weight. In H2O2-treated Caco-2 cells, FBSP-1 significantly alleviated oxidative damage by reducing intracellular reactive oxygen species (ROS) and malondialdehyde (MDA) levels, while enhancing the activities of superoxide dismutase (SOD) and glutathione reductase (GR), demonstrating pronounced antioxidant protective effects. Overall, this study demonstrates thatMonascusfermentation is an effective strategy for the structural remodeling of bamboo shoot polysaccharides, enabling the enhancement of their antioxidant functionality and supporting their potential application as functional ingredients in plant-based antioxidant foods.
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Nanomaterials
·
2026
·Vol. 16
·期 3
·166
·
IF 4.3
Yunfeng Zhang,Cheng Zhao,Zhongqun Li,Dexin Kong,Lingshuai Kong
Peroxymonosulfate (PMS)-based advanced oxidation is often hindered by pH instability and the lack of post-reaction separation. Herein, commercial magnesium hydroxide (Mg(OH)2) is introduced as a multifunctional catalyst to address these limitations. Mg(OH)2effectively catalyzed PMS decomposition via a nonradical pathway dominated by singlet oxygen (1O2) generation, achieving rapid and complete degradation of electron-rich pollutants like bisphenol A (BPA) within 40 min. The system exhibits exceptional pH self-regulation, stabilizing the solution at ~9.8 and maintaining high efficiency across an initial pH range of 3–11. Mechanistic studies confirm1O2as the primary reactive species with a steady-state concentration of 1.67 × 10−12M. The catalyst demonstrates strong resistance to common anions and humic acid, along with excellent stability over four cycles. Furthermore, Mg(OH)2enables in situ flocculation and removal of degradation products. This work highlights Mg(OH)2as an efficient, stable, and multifunctional activator, offering a integrated strategy for practical wastewater treatment.
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CHEMICAL ENGINEERING RESEARCH & DESIGN
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2026
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IF 4
Cong Liu,Xiaolong Miao,Dihang Zhou,Hongxing Wang
Isosorbide, a bio-based diol derived from sorbitol, is a promising alternative to bisphenol A (BPA) in polymer manufacturing, yet its large-scale production remains limited by diffusion constraints, secondary dehydration, and energy-intensive separation. In this work, we develop a continuous, high-selectivity process for isosorbide synthesis using a heterogeneous azeotropic catalytic distillation strategy. A direct-pump feeding system enables the continuous introduction of high-viscosity sorbitol without dilution, while an ion-exchange resin catalyst provides efficient dehydration under intensified reaction–separation conditions. Nearly complete sorbitol conversion (∼100 %) and 91.2 % isosorbide selectivity were achieved. Temperature-dependent LHHW kinetic modeling reveals that equilibrium shifting through continuous water removal, rather than mass-transfer limitations, governs selectivity enhancement. Process simulation further establishes a scalable three-column azeotropic catalytic distillation design capable of producing 10,000 tons per year, supported by favorable thermal and economic performance. This study demonstrates a practical and energy-efficient route for industrial isosorbide production and provides mechanistic and design guidance for future process scale-up.
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DYES AND PIGMENTS
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2026
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IF 3.9
Wenjing Zhang,Xinyan Yan,Xujuan Huang,Shanshan Wang,Zhaolan Zhai,Dan Wang,He Liu,Shibin Shang,Zhanqian Song
Stimuli-responsive aggregation-induced emission (AIE) materials that enable dynamic emission control and adaptive applications in dynamic information encryption and advanced anti-counterfeiting via external stimuli have attracted considerable attention. A bio-based AIE amphiphile ( CSMPANa ) was synthesized by integrating maleopimaric acid (MPA) with a α-cyanostilbene, which exhibited typical AIE characteristic and obvious solvatochromism. Importantly, the fluorescence emission of CSMPANa showed dual stimuli-responsiveness. Adding alkali caused the cyano group turned into an amide, red-shifting the fluorescence emission. Subsequent adding acid resulted in a blueshift. Furthermore, 365 nm UV light induced a [2+2] cycloaddition to form a dimer, leading to a redshift. The obvious solvatochromism and dual stimuli-responsiveness of CSMPANa were exploited for multi-level information encryption. AIE wormlike micelles were further prepared by mixing CSMPANa and cetyltrimethylammonium bromide (CTAB). The viscoelasticity and optical physical properties of CSMPANa /CTAB wormlike micelles could be modulated by varying its concentration, pH, or UV light irradiation. Additionally, the system exhibited selective recognition to 4-Nitrophenol in aqueous media with high anti-interference capability, enabling ultrasensitive visual detection (LOD = 17.29 μM). Density functional theory (DFT) calculations elucidated the sensing mechanism, revealing that the specific recognition originates from the synergistic effect of the strongest binding affinity and minimized steric hindrance of the 4-NP para-isomer. This work developed a system that is not solely dependent on organic solvents and possesses dual responsiveness.
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BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
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2026
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IF 1.9
Wei Min,Yang Jian,Yu Zejia,Li Shan,Xie Hui,Yuan Shiyang,Huang Qiujie,Zhang Hui,Feng Jun
Acute lung injury (ALI) is a common complication of sepsis in connection with excessive inflammation and accumulation of oxidative stress. Sorting nexin 10 (SNX10) is a sorting nexin family member involved in inflammatory processes. This study aimed to explore the function of SNX10 in ALI. The cecal ligation and puncture (CLP) model was established to induce ALI in C57BL/6J mice. CLP mice exhibited elevated levels of SNX10 expression in the lung tissues. Mice were intratracheally injected with 50 μL adenovirus (108 PFU) containing short hairpin RNA plasmid targeting SNX10. SNX10 knockdown mice showed remission of CLP-induced pulmonary edema, hemorrhage, inflammatory infiltration, and thickened alveolar septum. SNX10 downregulation reduced reactive oxygen species (ROS) levels, increased superoxide dismutase activity and glutathione content, and decreased malondialdehyde content in the lung tissues. SNX10 knockdown decreased the phosphorylation of NF-κB p65 and its nuclear translocation, thus inhibiting the levels of tumor necrosis factor (TNF)-α and interleukin (IL)-6. Furthermore, SNX10 downregulation inhibited the NLRP3, p20 caspase 1, and ASC protein levels and the levels of IL-18 and IL-1β. A549 cells were treated with lipopolysaccharide (LPS) (10 μg/mL) for 24 h to simulate the inflammatory condition and SNX10 was knocked down using small interfering RNA. SNX10 knockdown cells showed increased viability and less ROS accumulation. Consistent with the in vivo results, the NF-κB/NLRP3 pathway and the secretion of inflammatory cytokines were inhibited after SNX10 knockdown in A549 cells. In summary, SNX10 downregulation mitigated sepsis-induced oxidative stress and pulmonary inflammation by inhibiting the NF-κB/NLRP3 pathway.
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Food Chemistry-X
·
2026
·
IF 9.2
Ying Liu,Linlin Yu,Shuxiang Yan,Xiaowei Fang,Tenggao Zhu,Huanwen Chen,Dong Wu
Metabolic changes during the ripening of wolfberry ( Lycium barbarum L.) fruits reflect their quality and pharmacological properties. To decipher the metabolic evolution underlying this physiological process, a systematic analysis of wolfberry fruits at different ripening stages (7–35 days after anthesis) was conducted by theta-nano-extractive electrospray ionization mass spectrometry. Multivariate analysis effectively discriminated the various stages and identified proline, γ-aminobutyric acid, arginine, and N 1 -caffeoyl- N 10 -dihydrocaffeoyl spermidine as potential differential metabolites. Polyamine and flavonoid metabolism were significantly activated during the early ripening stages, leading to the rapid accumulation of antioxidant components such as spermidine, rutin, and chlorogenic acid. In the late ripening stages, amino acid metabolism was markedly enhanced, resulting in a substantial increase in betaine, serine, and threonine. This study elucidates the key stages and metabolic foundation of quality formation in wolfberry fruits at the metabolomic level, providing a theoretical basis for determining the optimal harvest time and regulating nutritional quality.
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COLLOIDS AND SURFACES B-BIOINTERFACES
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2026
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IF 5.9
Cong He,Hairong Yu,Jiaqi Tian,Ziling Huang,Xue Yang,Jingru Zhang,Wenjing Chen,Yayue Zhang,Xuran Ding,Yabing Hua,Yuan He,Yan Liu,Ziming Zhao,Yihua Yang
The advancement of cell-based drug delivery systems (Cell-DDS) enables precise tumor targeting. Utilizing bone marrow mesenchymal stem cells (BMSC) as carriers, transferrin (Tf)-modified BMSC (BMSC Tf ) were engineered via sugar metabolism replacement and click chemistry. Liposomes co-encapsulating phthalocyanine (Pc) and oxygen-carrying perfluorohexane (PFH) were integrated with BMSC Tf through membrane fusion, constructing the Tf-functionalized delivery system Pc/O₂@BMSC Tf . This system achieved Pc loading efficiency of 1.7 μg per 10⁵ cells and an oxygen-carrying capacity of 11.2 μg per 10⁷ cells, demonstrating active tumor targeting, significant antitumor efficacy in vitro and in vivo , and high biocompatibility. At tumor sites, localized near-infrared irradiation triggered Pc-mediated ROS generation, while the nanoliposomes provided real-time oxygen replenishment, overcoming hypoxia to potentiate photodynamic therapy (PDT). This novel stem cell-based drug delivery system represents a promising strategy for targeted tumor therapy.
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