RSC Advances
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2016
·Vol. 6
·期 114
·113209-113218
·
IF 3.289
Jun Yu,Feng Xiao,James Asenso,Peng Zhou,Xiao-Dan Yang,Chun Wang,Wei Wei
Paeoniflorin (Pae), a water-soluble monoterpene glucoside, is the main effective component of total glucoside of paeony (TGP). Pae has a very low bioavailability (3.6%). The aim of this study was to investigate the effects of sex, food and disease status on the pharmacokinetics of paeoniflorin-6′-O-benzene sulfonate (acylated derivative of Pae, CP-25) and its primary metabolite (Pae, M1) after oral administration in the plasma of rats. A specific and sensitive ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) assay for rapid determination of CP-25 and Pae in rat plasma was developed and validated for the first time. The assay was validated in terms of selectivity, linearity, accuracy, precision, recovery, matrix effects and stability. We found that CP-25 had a more extensive distribution in females than that in males, but no differences in M1 levels were found. Food intake could also increase the extent of absorption and decrease the rate of clearance for CP-25 and M1 after oral administration in rats. The disease status would decrease the absorption of CP-25 in rats. Comparing single-doing and multiple-dosing in an adjuvant arthritis (AA) model, the absorption of CP-25 and M1 improved with increasing dosage. Furthermore, during the period of multiple-dosing, CP-25 exhibited a better anti-inflammatory effect in AA rats and no obvious side effects occurred during the dosing period. Our findings provide the basis, and some guidelines, for further studies into the clinical application of CP-25.
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Inorganic Chemistry Frontiers
·
2024
·
IF 6.1
Cheng Chen,Danyang Dou,Yunjie Bai,Bingbing Zhang,Ying Wang
The investigation of birefringent materials is predominantly focused on π-conjugated systems; however, a large band gap or deep ultraviolet (DUV) transmittance cannot be guaranteed. In this work, we propose an extended π-conjugated strategy to increase the birefringence while keeping the large band gap. In the scheme, two new fluoroaluminoborates, BaAlB3O6F2 and BaAl2(B3O6)2F2, are synthesized by combining the [BO3] group with the [AlO4F2] group and the [B3O6] group with the [AlO3F] group through a rational structural design. The experimental results indicate that both BaAlB3O6F2 and BaAl2(B3O6)2F2 exhibit shorter UV cutoff wavelengths (<200 nm) and larger birefringence (Δn > 0.07@546 nm). Notably, this is a new finding in the Ba–Al–B–O–F system since the discovery of the well-known nonlinear optical crystal BaAlBO3F2. In comparison with BaAlBO3F2, BaAlB3O6F2 and BaAl2(B3O6)2F2 exhibit a markedly elevated birefringence (0.0418 vs. 0.087/0.105 at 546 nm). Furthermore, BaAl2(B3O6)2F2 exhibits the largest band gap (7.87 eV) of all known F-containing aluminoborates. This work not only identifies two potential DUV birefringent materials, but also proposes a novel design approach for reconciling the conflicting properties between birefringence and bandgap.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2024
·
IF 5.7
Yanxia Yu,Chunying Zuo,Mingrui Li,Yuanyuan Tang,Lingxi Li,Fang Wang,Shuting Zhang,Baoshan Sun
In this study, an effective method for preparation of bioactive galloylated procyanidin B2-3′-O-gallate (B2-3′-G) was first developed by incomplete depolymerization of grape seed polymeric procyanidins (PPCs) using l-cysteine (Cys) in the presence of citric acid. The structure–activity relationship of B2-3′-G was further evaluated in vitro through establishing lipopolysaccharide (LPS)-induced inflammation in RAW264.7 cells. The results suggested that the better protective effects of B2-3′-G against inflammation were attributed to its polymerization degree and the introduction of the galloyl group, compared to its four corresponding structural units. In vivo experiments demonstrated that the B2-3′-G prototype was distributed in plasma, small intestine, liver, lung, and brain. Remarkably, B2-3′-G was able to penetrate the blood–brain barrier and appeared to play an important role in improving brain health. Furthermore, a total of 18 metabolites were identified in tissues. Potential metabolic pathways, including reduction, methylation, hydration, desaturation, glucuronide conjugation, and sulfation, were suggested.
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BIOMACROMOLECULES
·
2024
·
IF 5.5
Danyu Lv,Wanjun He,Wei Liu,Yuqiang Cheng,Yan Cui,Xiujuan Zhou,Yanwen Xue,Siming Yu,Ningjin Zhang,Hecheng Meng,Yongguang Guan,Jian-He Sun,Xian-Ming Shi
The γ-cyclodextrin (γ-CD) metal–organic frameworks (CD-MOF-1) consist of γ-CD and potassium (K+) ions through coordinating an eight-coordinated K+ ion with two C5-linked oxygen and C6-linked hydroxyl (C5–O/C6–OH) groups in the primary faces of adjacent γ-CD units and two C2- and C3-linked hydroxyl (C2–OH/C3–OH) groups in the secondary faces. Herein, we found polysaccharide gels with only C2–OH/C3–OH or C5–O/C6–OH groups in pyranoid rings can form four-coordinated K+ ions and then coordinate γ-CD in a KOH solution for CD-MOF-1 growth. Exposure of C2–OH/C3–OH or C5–O/C6–OH groups in polysaccharide gels is important to form active four-coordinated K+ ions. Mechanism supporting this work is that four-coordinated K+ ion sites are first formed after coordinating C2–OH/C3–OH groups in pectin and then coordinating C5–O/C6–OH groups in the primary faces of γ-CD units. Alternatively, four-coordinated K+ ions with C5–O/C6–OH groups in chitosan can coordinate the C2–OH/C3–OH groups in the secondary faces of γ-CD units. Mechanism of CD-MOF-1 growing on pectin and chitosan gels through the proposed four-coordinated K+ ions is also universally applicable to other polysaccharide gels with similar C2–OH/C3–OH or C5–O/C6–OH groups such as alginate gel. Based on this mechanism, we developed pectin and chitosan gel-based CD-MOF-1 composites and exemplified applications of them in antibacterial and organic dye removal. To help future research and applications of this mechanism, we share our theoretical assumption for further investigations that any matrices with an ortho-hydroxyl carbon chain or ortho-hydroxyl ether structures may form four-coordinated K+ ions for CD-MOF-1 growth. The proposed mechanism will broaden the development of novel CD-MOF-1 composites in various fields.
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高影响因子
ENERGY
·
2025
·
IF 9.4
Yulei Zhang,Zonglu Yao,Junyi Ma,Jiadong Yu,Ping Ai,Ruixia Shen,Yi Liang,Lixin Zhao
Low interspecies electron transfer efficiency among microorganisms is a critical factor limiting anaerobic digestion performance. In this study, conductive and stable biochar (BC) was combined with redox-active anthraquinone-2-sulfonate (AQS) to enhance electron transfer efficiency through their synergistic effects, thereby improving the efficiency of anaerobic digestion. Results showed that cumulative methane production (CMP) reached 176.34 mL/g VS under optimal conditions, including an AQS impregnation concentration of 1 mmol/L, a BC/AQS addition of 5 %, and a total solid (TS) content of 10 %. The addition of BC/AQS enriched Proteiniphilum and Methanobacterium , which shifted the methanogenic pathway from acetoclastic to hydrogenotrophic, significantly improving volatile fatty acid conversion and total organic carbon degradation. Redundancy analysis (RDA) and changes in key enzyme-encoding genes indicated that BC/AQS enhances the synergistic interaction between Proteiniphilum and Methanobacterium through the redox activity of quinone/C=O functional groups, which may play a key role in the formation of direct interspecies electron transfer (DIET). This study provides a promising strategy to enhance microbial electron transfer mechanisms in anaerobic digestion by leveraging the complementary properties of meso-materials, offering new insights into the utilization of agricultural waste for energy production.
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JOURNAL OF SOLID STATE CHEMISTRY
·
2024
·
IF 3.2
Hao Sun,Jingyi Yu,Cong Zheng,Sumei Wu,Tingting Yao,Zhiqiang Li,Nan Wang,Cunlei Zou,Weiwei Jiang,Hualin Wang,Shimin Liu,Chaoqian Liu,Wanyu Ding,Jiliang Zhang,Chuang Dong
Mg–Co–Ni–Cu–Zn–O is the firstly reported high entropy oxide (HEO) which has great promise in optoelectrical applications. However, the multicomponent and decreased configurational entropy by extracting one element from (Mg, Co, Ni, Cu, Zn) makes it difficult to synthesize single-phase medium entropy oxides (MEOs) especially when the cations are non-equimolar. In this paper, we synthesized different compositional-type of non-equimolar Co–Ni–Cu–Zn–O MEOs possessing single-phase rocksalt structure guided by the cluster-plus-glue-atom model. Interestingly, Co 21 Ni 43 Cu 16 Zn 16 O 96 and Co 17 Ni 47 Cu 16 Zn 16 O 96 have the lowest single-phase formation temperature (850 °C) when the total cation content is kept unchanged. Further increase or decrease of Co/Ni content (none, little, more) will increase the difficulty of single-phase formation ability and temperature (900–1200 °C). It is suggested the single-phase formation ability of Co–Ni–Cu–Zn–O MEOs is closely related to the Gibbs free energy ( ΔG ) and average cation-size difference ( δ ). The linear decrease of Co content and increase of Ni content can monotonously enlarge the energy band gap ( E g ) from 1.52 eV to 1.93 eV and increase the electrical impedance with five orders of magnitude (∼10 3 Ω–∼10 8 Ω), which may be valuable in the fields of optoelectrical devices.
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Advanced Sustainable Systems
·
2024
·Vol. 8
·期 10
·2400212
·
IF 6.5
Hanya Zhang,Pengkun Zhang,Zhengjie Su,Dong-Hau Kuo,Qinhan Wu,Ting Huang,Ping Li,Mengistu Tadesse Mosisa,Jinguo Lin,Xiaoyun Chen,Dongfang Lu
A novel La/O co-doped SnS oxysulfide catalyst (labeled SnLaOS) with heterovalent tin states and sulfur vacancy defects is successfully synthesized for effective catalytic reduction of toxic organics heavy metal ions with NaBH 4 in the dark. La/O co-doped and hydrogen peroxide-driven SnLaOS catalyst with suitable heterovalent Sn 2+ /Sn 4+ states and sulfur vacancy defects exhibited excellent catalytic reduction capability. The 100 mL 20 ppm of 4-nitrophenol (4-NP) and 50 ppm of rhodamine-B (RhB), methylene blue (MB), methyl orange (MO), and Cr(VI) solution are entirely reduced by 5 mg SnLaOS-3 within 10, 12, 12, 16, and 14 min, respectively, with durable stability. Synergistic transition metal La 3+ -cation and O 2− -anion co-doped SnS adjusted the energy bandgap and introduced sulfur vacancy defects, and the hydrogen peroxide-driven regulated the SnLaOS with suitable Sn 4+ /Sn 2+ states ratio. The sulfur vacancies in SnLaOS provide active sites for adsorbed proton for pollutants reduction, and heterovalent Sn 2+ /Sn 4+ states in SnLaOS facilitates electrons efficient transfer through electron hopping between Sn 2+ and Sn 4+ for pollutants reduction. This study provides a novel efficient catalyst for the water pollutants treatment.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Chunhua Li,Xiaoyu Hu,Zhenghao Chen,Zilun Ding
The excessive use of imidacloprid (IMD) poses a severe threat to human health and ecological stability. This study uniformly anchors MOF808 to the edges of Zn 3 In 2 S 6 nanosheets with sulfur vacancies by introducing EDTA ligands onto MOF808, successfully constructing a MOF808-EDTA/S-Zn 3 In 2 S 6 (MEZ) Z-scheme heterojunction for the efficient degradation of IMD. The presence of sulfur vacancies and interfacial In-O bonds in MEZ facilitates the enrichment of electrons on the S-Zn 3 In 2 S 6 side, thereby enhancing its ability to adsorb and activate oxygen and endowing MEZ with excellent photocatalytic activity. The optimized MEZ achieves a degradation rate of 98.4 % for IMD, with rate constants 5.0 and 76 times higher than those of S-Zn 3 In 2 S 6 and MOF808, respectively. After five photocatalytic cycles, MEZ still retains over 90 % photocatalytic activity, demonstrating the excellent stability of the surface catalyst, which can be successfully applied to the degradation of IMD in actual water. Singlet oxygen, superoxide radicals, and hydroxyl radicals preferentially attack the C7, C9, and N14 sites of IMD, leading to hydroxylation, denitration, ring-opening reactions, and dealkylation. These reactions decompose IMD into smaller products and significantly reduce IMD’s environmental risks. This study proposes an effective strategy to regulate the distribution of metal–organic frameworks on semiconductor surfaces and offers new insights for rationally developing Z-scheme photocatalysts to remove emerging pollutants in environmental remediation.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Qian Ren,Tingting Tian,Bin Wang,Jun Pan,Yong Huang,Li Zhong,Yehong Wang,Xia Wang,Xiao Huang
Photodynamic therapy (PDT) remains underutilized as a primary cancer treatment due to the limited lethality of reactive oxygen species (ROS) and poor targeting efficiency of traditional photosensitizers. This the aim of the study is to develop a Fe₃O₄@ZnO nanoparticle photosensitizer co-loaded with anti-EGFR antibody, brusatol, and Nrf2-siRNA to improve the therapeutic effect of PDT. This system can be guided to tumors by a magnetic field and further targets cancer cells through EGFR-specific binding. Under UVA light, brusatol and Nrf2-siRNA are released, enabling combined chemo-, gene, and photodynamic therapy. With the photosensitizer treatment, ROS levels in cutaneous squamous cell carcinoma cells were elevated by 191.09 ± 10.02 % through suppression of Nrf2 and its associated antioxidant defenses, significantly enhancing cell lethality and reducing cell viability by 80.43 ± 9.37 %. In vivo studies further demonstrated a tumor suppression rate of 76.30 ± 5.12 % in nude mice, highlighting the robust anti-tumor efficacy of the photosensitizer and its potential for clinical application in targeted cancer therapy. The biocompatibility and high therapeutic efficacy of this photosensitizer highlight its promise as a safer and more effective option for treating cutaneous squamous cell carcinoma.
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高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2025
·
IF 3.9
Han-Bing Gao,Yue-Lun Wang,Dao-Ran Liu,Jin-Xuan Xie,Le-Le Qiu,Jian Xiao,Jing Liang,Fang-Jing Liu,Yun-Peng Zhao
Achieving high efficiency and selectivity in cleaving aryl C–O bonds is critical for lignin valorization and the production of aromatic chemicals. A green and sustainable approach has been developed using bimetallic Ni–W catalysts, which controlled the hydrogen supply and mediated hydrogen transfer via in situ hydrogen donors. An appropriate W/Ni ratio is essential for enhancing the supply of active hydrogen, the adsorption capacity for reactive molecules, and the efficiency of hydrogen transfer, thereby optimizing the overall catalytic performance. A comprehensive investigation was conducted on the factors influencing the catalytic transfer hydrogenolysis of lignin derivatives, focusing on the reaction temperature, solvent, hydrogen source, pressure, and duration. Under optimal conditions (180 °C, 1.0 MPa N2, and <2.5 h), various lignin-derived aryl ethers achieved complete conversion with 100% monomer selectivity. This study demonstrated the excellent reusability of the Ni–W catalyst for four cycles. More significantly, the mechanisms underlying active hydrogen transfer, transfer hydrogenolysis, and bimetallic interactions were elucidated. The integration of Ni and W species significantly enhanced the synergy among active metal sites, oxygen defects, and acid sites. This synergistic mechanism enabled H• and H+ to function as the primary active hydrogen species. Furthermore, the in situ generation and targeted migration of H• radicals and H+ ions facilitated the preferential cleavage of C–O bonds over the hydrogenation of aromatic units within lignin, leading to the formation of high-value aromatic monomers.
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BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT
·
2021
·
IF 1.632
Bo Wang,Feng Gao,Jing Xu,Jianjie Gao,Zhenjun Li,Lijuan Wang,Fujian Zhang,Yu Wang,Yongsheng Tian,Rihe Peng,Quanhong Yao
Biological treatment is a cost-effective and environmentally friendly technique for treating toluene. However, this process is limited by the type and quantity of toluene degraders that can be applied to different environments and methods. It is a feasible solution to constructing new genetic engineering organisms for toluene degradation through biotechnology. To facilitate genetic manipulation and improve gene expression, the toluene/o-xylene monooxygenase locus from Pseudomonas stutzeri was reconstructed and artificially synthesized. All six genes were optimized and driven with a monocistronic transcriptional pattern by T7 promoter and terminator to be expressed at a high level. The engineered bacteria can hydroxylate toluene to a mixture of o-, m- and p-cresol, which are then further oxidized to 3- and 4-methylcatechol. Benzene can also be oxidized to phenol, catechol and pyrogallol successively. The negative effects of toluene can be removed by the engineered bacteria via proteomics analysis. Overall, the artificial gene clusters established in this study can be used to construct different toluene and benzene degradation organisms for bioremediation.Supplemental data for this article is available online at https://doi.org/10.1080/13102818.2021.1996267 .
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APPLIED CATALYSIS B-ENVIRONMENTAL
·
2022
·
IF 24.319
Yong-Li He,Chuan-Shu He,Lei-Duo Lai,Peng Zhou,Heng Zhang,Ling-Li Li,Zhao-Kun Xiong,Yang Mu,Zhi-Cheng Pan,Gang Yao,Bo Lai
In this study, N and O co-doping carbon materials with porous structure (NOPC-x) were applied to activate peroxymonosulfate (PMS) for bisphenol (BPA) degradation and the underlying effects in affecting NOPC-x activity were revealed. Electrochemical characterization, electron paramagnetic resonance (EPR) tests, quenching and PMS adsorption experiments were applied to clarify the mechanism of BPA degradation. It’s found that BPA can be completely removed within 20 min ( k obs = 0.30 min −1 ) in the NOPC/PMS system depending on the electron transfer path with the necessity of moderate surfaced unpaired electrons for electrons delivery, which could be regulated by the modifier dosage. However, excessive surfaced unpaired electrons were unfavorable to PMS adsorption, resulting in deterioration of BPA degradation. This study indicates that controlling the amount of surfaced unpaired electrons in an appropriate range is essential to ensure the carbonaceous materials activity in PMS activation to obtain a satisfactory BPA degradation.
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