MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Yao Liu,Runzi Zhang,Xiaoyu Yang,Yi He,Xiao Yang
Herein, a dual-enhanced SERS biosensor has been developed for the detection of bisphenol S (BPS) based on silver nanoflowers coated zeolitic imidazolate-based metal-organic framework (AgNFs@ZIF-8) cooperate with host-guest recognition amplification technology. The biosensor utilizes the molecularly imprinted polymer (MIP) and BPS aptamer chain (APT) as dual recognition element to achieve a significant increase in selectivity. In the presence of the target, the APT on AgNFs@ZIF-8@β-cyclodextrin(β-CD) specifically binds with BPS, which further recognized by MIP to form a sandwich structure. At this time, due to the large surface area, and stable Raman enhancement ability, AgNFs@ZIF-8@β-CD could not only provide multiple active “hot spots” as the surface-enhanced Raman scattering (SERS) enhanced substrate, but also specific capture large number of methylene blue (MB, SERS tag) through the host-guest recognition. Moreover, multiple host-guest recognition can be achieved by further addition of AgNFs@ZIF-8@β-CD and MB, which greatly improve the detection sensitivity. This SERS sensor, characterized by an extensive linear detection range from 1.00 × 10 −13 to 1.00 × 10 −6 M and an exceptionally low limit of detection (LOD) of 1.36 × 10 −14 M, has been effectively utilized for the detection of BPS in plastic pacifiers, receipts, and river water samples. As an extremely sensitive and highly specific analytical method for detecting BPS, this SERS-based method has promising applications in the fields of environmental monitoring and food safety.
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高影响因子
BIOORGANIC CHEMISTRY
·
2022
·
IF 5.307
Junjie Wu,Mengmeng Zhang,Lulu Song,Yahong Tan,Yosuke Taniguchi,Christopher John Hipolito,Youming Zhang,Yizhen Yin
Oxidative lesions, such as 8-oxo-dG and 8-oxo-dA, are continuously generated from exposure to reactive oxygen species. While 8-oxo-dG has been extensively studied, 8-oxo-dA has not received as much attention until recently. Herein, we report the synthesis of duplex DNAs incorporating dA, 8-oxo-dA, 7-deaza-dA, 8-Br-dA, and 8-Br-7-deaza-dA, which have different substitutions at 7- and 8-position, for the investigation into the implications of N7-hydrogen and C8-keto on the base pairing preference, mutagenic potential and repair of 8-oxo-dA. Base pairing study suggested that the polar N7-hydrogen and C8-keto of 8-oxo-dA, rather than the syn -preference, might be essential for 8-oxo-dA to form a stable base pair with dG. Insertion and extension studies using KF-exo − and human DNA polymerase β indicated that the efficient dGTP insertion opposite 8-oxo-dA and extension past 8-oxo-dA:dG are contingent upon not only the stable base pair with dG, but also the flexibility of the active site in polymerase. The N7-hydrogen in 8-oxo-dA or C7-hydrogen in 7-deaza-dA and 8-Br-7-deaza-dA was suggested to be important for the recognition by hOGG1, although the excision efficiencies of 7-deaza-dA and 8-Br-7-deaza-dA were much lower than 8-oxo-dA. This study provides an insight into the structure-function relationship of 8-oxo-dA by nucleotide analogues.
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DOI
PubMed
高影响因子
Evidence-based Complementary and Alternative Medicine
·
2020
·
IF 1.813
Yuan-Yuan Li,Nan-Qu Huang,Fei Feng,Ying Li,Xiu-Mei Luo,Lin Tu,Jing-Qiu Qu,Yi-Man Xie,Yong Luo
Icaritin (ICT) is the main component in the traditional Chinese herb Epimedium, and it has been shown to have anti-Alzheimer’s disease (AD) effects, but its neuroprotective effects and the pharmacological mechanisms are unclear. In the present study, senescence-accelerated mouse prone 8 (SAMP8) mice were randomly divided into a model group and an ICT-treated group. Learning and memory abilities were detected by the Morris water maze assay, and the expression of amyloid beta protein (Aβ) and β-site APP cleavage enzyme 1 (BACE1) was determined by Western blotting and polymerase chain reaction (PCR). Histological changes in CA1 and CA3 were detected by hematoxylin-eosin staining (H&E staining), and the immunohistochemical analysis was used to detect the expression and localization of Bax and Bcl-2. The results showed that compared with the SAMP8 mice, the ICT-treated SAMP8 mice showed improvements in spatial learning and memory retention. In addition, the number of necrotic cells and the morphological changes in CA1 and CA3 areas were significantly alleviated in the group of ICT-treated SAMP8 mice, and the expression of BACE1, Aβ1-42 levels, and the Bax/Bcl-2 ratio in the hippocampus was obviously decreased in the ICT-treated group compared with the control group. The results demonstrated that ICT reduced BACE-1 levels, the contents of Aβ1-42, and the Bax/Bcl-2 ratio, suggesting that ICT might have potential therapeutic benefits by delaying or modifying the progression of AD.
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DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Qian Wang,Xinyuan Zheng,Meiling Ge,Rong Chen,Fangpei Ma,Jianming Pan,Fu Yang
Maintaining the long-term stability of flexible polymer-immobilized lipase remains a significant challenge in enzyme catalysis. The deformation of the polymer during the process often damages the lipase, severely limiting its practical application. In this work, we in situ constructed rigid Zeolitic Imidazolate Framework-8 (ZIF-8) in porous hydrophobic polymer PVIm as “rigid and flexible” composite PVIm/ZIF-8 through a self-assemble strategy. The implanted rigid ZIF-8 improves the network stability of the hydrophobic polymer PVIm. Additionally, it acts as a co-factor, leveraging defective Zn sites to immobilize lipase through bonding with its amino acid moieties. This approach represents a typical two-birds-with-one-stone strategy. The optimal biocatalyst CalA@PVIm/ZIF-8(0.3) affords the highest yield of biodiesel of 82 % with a TON of 136.6 g (biodiesel) /g (CalA) from waste cooking oil under 30 °C and 24 h. Compared to CalA@PVIm/ZIF-8(0.3), the TON of free CalA is only 25 % of that value. Compared to the ZIF-8-free CalA@PVIm, CalA@PVIm/ZIF-8(0.3) exhibits near 1.2 folds enhancement of performance, further unveiling the co-factor role of ZIF-8 in the reaction. More importantly, this incorporation of ZIF-8 makes the resulted CalA@PVIm/ZIF-8(0.3) afford at least 44 days operation period and retains 83 % original activity after 16 running recycles, superior to almost all the reported immobilized lipase researches, far outperforming that (24.1 % activity after 16 cycles) of CalA@PVIm. The wide flexibility in various biodiesel synthesis can be further demonstrated, affording the practical application value of developed catalyst.
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高影响因子
JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
·
2018
·
IF 0.827
Liwei Cao,Tian Wei,Yihui Shi,Xiaofang Tan,Jianxin Meng
Two rapid and sensitive analytical methods are developed for the determination of D-penicillamine (D-PEN) and tiopronin (TP) through high-performance liquid chromatography with fluorescence detection (HPLC-FLD) and capillary electrophoresis with laser-induced fluorescence detection (CE-LIF). A boron-dipyrrolemethene (BODIPY) fluorescence labeling reagent, 1,3,5,7-tetramethyl-8-bromomethyl-difluoroboradiaza-s-indacene (TMMB-Br) was successfully applied to derivatize these two thiol drugs. Fluorescein was used as the internal standard (IS) for the quantification of D-PEN and TP in CE-LIF. The derivatization and separation conditions were optimized carefully. Under the optimum conditions, the HPLC and CE separation of D-PEN and TP could be achieved within 12 min. The limits of detection were as low as 2.0 nmol/L for HPLC-FLD and 0.47 nmol/L for CE-LIF. The drugs in human urine and serum samples were determined successfully, and the recoveries were 95.0–06.7% and 95.2–104.3%, respectively.
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DOI
高影响因子
Small
·
2025
·
IF 12.1
Yunchuan Luo,Wen He,Haonan Zhang,Zixun Wang,Jie Zhou,Zilin Song,Zhuoyue Hao,Olim Ruzimuradov,Shavkat Mamatkulov,Butanov Khakimjan Turamuradovich,Kamoladdin Saidov,Dae Joon Kang,Zhongzhu Wang,Peihong Wang
Flexible triboelectric sensor (TES) provides an innovative solution for the energy challenges faced by wearable electronics. However, the generated charge easily escapes to the atmosphere or the inner electrode layer of TES, resulting in charge loss and decline of performance. In this study, based on the intermediate layer strategy, the fibrous TES (FTES) with a three-layer coaxial structure (inner electrode layer/Zeolitic imidazolate framework-8 (ZIF-8)-doped intermediate layer/outer friction layer) is constructed by the wet-spinning followed with casting technology. The optimized styrene-isoprene-styrene block copolymer (SIS)-Multi-Walled Carbon Nanotubes (MWCNTs)-acetylene black (AB)/SIS-ZIF-8/Ecoflex FTES (SZE-FTES) exhibits a high elongation at break of 552%, a sensitivity of 15.68 V N −1 within the low-pressure detection range of 0.05–0.25 N (1.7 times greater than that of FTES without an intermediate layer) and a rapid response time of 107 ms. The SZE-FTES can effectively monitor various human motions. By using the Long Short-Term Memory (LSTM) neural network to conduct deep learning, the FTES can accurately identify 9 different materials, with an accuracy rate as high as 99.4%. In addition, by encoding Morse code using SZE-FTES, a barrier-free communication system is successfully established. The as-prepared FTES provides an interdisciplinary research paradigm for wearable electronics, biomedical sensing, and barrier-free communication technology.
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DOI
PubMed
高影响因子
Journal of Environmental Chemical Engineering
·
2025
·Vol. 14
·期 1
·120685
·
IF 7.2
Weiping Li,Zhiqiang Cheng,Xuemei Liang,Ying Wang,Minglai Yang,Li Qin,Lijun Wang,Helong Yu,Yuxin Zhao
In this study, we employed an interfacial engineering strategy to construct a hierarchical heterojunction, ZIF-8/g-C₃N₄/CTAB (denoted as ZGC), in situ on a g-C₃N₄ substrate. The g-C 3 N 4 , synthesized via the urea pyrolysis method, served as a structural template, with its unique electronic structure and surface properties facilitating the separation and migration of photogenerated charge carriers. Upon dispersion in methanol, it functioned as a coordination reaction medium, directing the oriented nucleation of the ZIF-8 crystalline phase on its surface through hexahydrate zinc nitrate and 2-methylimidazole, facilitated by CTAB, culminating in a distinctive “core-shell” structure that enhances photocatalytic activity. This heterojunction demonstrated remarkable spectral adaptability: within a 30 ppm tetracycline hydrochloride degradation system (0.5 g/L catalyst), the degradation rates achieved under ultraviolet, blue laser, and visible light were 97.79 %, 95.38 %, and 94.48 %, respectively, within a 120-min period. The purpose of this comparison is to investigate the impact of different light sources on photocatalytic activity, thereby providing a theoretical basis for the selection of light sources in practical applications. We have made a novel discovery concerning wavelength-controlled reaction pathways, which offers a pioneering paradigm for interfacial engineering in the development of spectrally adaptive catalysts for environmental remediation.
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Journal of Environmental Chemical Engineering
·
2024
·
IF 7.4
Peipei Song,Zhirui Fan,Shuai Sun,Chengye Sun,Jun Wang
In recent years, lead (Pb) contaminated soil has caused irreversible damage to human beings. It is urgent to develop a novel technology for accurate detection of Pb in the soil solution. Herein, a new electrochemical sensor was fabricated. Fe/ZIF-8 was used as the modification material, gold nanoparticles (AuNPs) were electrodeposited, and DNAzyme was applied on the surface as the probe. Under the optimum conditions (DNAzyme concentration of 1 μmol, fixation time of 4 min, incubation time of 17 h and reaction time of 30 min), the detection range was 5×10 −12 ∼ 5×10 −5 M, and the minimum detection limit was 10 −13 M (3δ). Furthermore, the electrochemical sensor demonstrated outstanding anti-interference ability to common cations, anions, organic compounds and other interference factors. After four consecutive tests, the relative standard deviation (RSD) was only 0.39%, and it still displayed excellent reproducibility with 0.69% of RSD. After 20 days, the sensor’s response to Pb 2+ remained at 93.58%. In addition, the sensor could accurately detect Pb 2+ in the actual soil solutions, and the recoveries of the samples ranged from 92% to 109.4%. In conclusion, this electrochemical sensor can specifically detect Pb 2+ in the soil solution with enhanced sensitivity, anti-interference capability and stability, which is of great significance for Pb 2+ detection in the field.
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高影响因子
Sustainable Materials and Technologies
·
2025
·
IF 9.2
Xueying Yan,Xinyu Lin,Yanhui Huang,Yingjie Hong,Zhi Liu,Zongling Zhang,Liyan Liu,Jun Tian,Feicui Qi,Luyi Huang,Changhua Fang
Bamboo scrimber (BS) as an engineering material has been widely used in outdoor areas, in order to improve the protective properties of bamboo scrimber, this study prepared a new composite coating. Wood wax oil (WO) and Zeolitic Imidazolate Framework-8 (ZIF-8) nanoparticles were prepared separately, and ZIF-8 nanoparticles were modified with low surface energy perfluorooctyltriethoxysilane (POTS). ZIF-8/POTS nanoparticles were constructed on the surface of bamboo scrimber to form ZIF-8/POTS/WO/BS composite coatings via the mediating effect of wood wax oil. The composite coatings were superhydrophobic, with a water contact angle of 161.4°. After aging tests, the contact angle of the composite coatings decreased by only 6.51 %, indicating that they remained superhydrophobic. Compared with uncoated substrates, after anti-mildew and preservative treatment tests, the bamboo scrimber coated with ZIF-8/POTS/WO/BS showed an improvement in its discoloration level from grade 4 to grade 1 and an infection level improvement from grade 3 to grade 0. The composite coatings had a nanoscale surface roughness with a surface energy of 2.94 mJ/m 2 . The coatings also exhibited self-cleaning performance, with a dust removal efficiency of 90.91 %. The air layer created on the surface of the composite coating made it difficult for water and microorganisms to directly contact the surface of the coatings. Furthermore, The Zn 2+ ions and 2-methylimidazole released by ZIF-8 disrupted the ionic balance in the surrounding environment, achieving a dual synergistic antifungal effect, which inhibited microbial growth and reproduction on the surface of the coatings, thus providing greater outdoor protection. This work pioneered the use of MOFs and wood wax oil to construct superhydrophobic, self-cleaning, and weather-resistant composite coatings on bamboo scrimber. This coating may enable bamboo scrimber to be used in outdoor building structures, highway guardrails, and bridge components, especially in harsh and wet outdoor environments.
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高影响因子
MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Guangli Li,Yafeng Zhang,Rui Zhu,Zian Liu,Yuan Jin,Nanke Ma,Xuliang He
The indiscriminate use and excessive consumption of ciprofloxacin (CIP) may induce adverse effects in both humans and animals, while concurrently contributing to environmental contamination. Hence, there is an urgent demand to establish highly efficient detection methods for trace ciprofloxacin residues. Herein, a highly efficient electrochemical sensor based on ZIF-8 metal-organic framework (MOF)-derived N-containing porous carbon-supported Fe 3 O 4 nanoparticles (Fe 3 O 4 /NPC) was fabricated for the sensitive determination of CIP residues in milk and honey. Due to the synergistic interaction between Fe 3 O 4 NPs and NPC, the composite exhibited large specific surface area, high conductivity, and abundant internal catalytic sites, effectively improving the voltammetric response of CIP. As a result, the Fe 3 O 4 /NPC demonstrated significant electrocatalytic activity for CIP oxidation, with two wide linear response ranges (0.01–1.0 μM and 1.0–10 μM), high sensitivity (3.312 and 0.8574 μM μA −1 ), and a low limit of detection (0.002 μM). The Fe 3 O 4 /NPC/GCE showed strong anti-interfering capabilities even in excess potential interference substances, and could operate stably for at least one month (with a current retention rate of 81.9 %). Moreover, the Fe 3 O 4 /NPC/GCE was successfully applied to the determination of CIP in milk and honey, achieving satisfactory recovery (95.2 %–103.8 %). Considering its significant advantages such as cost-effectiveness, ease of operation, and excellent sensing properties, the Fe 3 O 4 /NPC has broad application prospects on sensitive detection CIP residues at trace level.
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高影响因子
ACS Sensors
·
2026
·
IF 9.1
Shaorui Qi,Lei Sun,Fansheng Meng,Guimei Shi,Yunlong Sun,Bo Jiang,Junbo Li,Yukihiro Ozaki,Wei Ji
Abnormal lactic acid (LA) enantiomeric excess (ee) in biofluids is closely associated with various intestinal diseases. Here, we report a chiral-label-free nonplasmonic surface-enhanced Raman scattering (SERS) platform using a ZIF-8/ZnS heterojunction that enables direct quantification of LA enantiomers and their ee values in raw human urine through a charge-transfer-driven chiral recognition mechanism. Our findings indicate that an enantioselective hydrogen bonding between 4-mercaptopyridine (4-MPy) probes and LA enantiomers induces differential charge-transfer effects within the ZIF-8/ZnS@4-MPy system, evidenced by the selective enhancement of specific vibrational modes in the SERS spectra of 4-MPy and enantiomer-specific changes in the fluorescence lifetime of ZnS. This innovative system integrates signal amplification and stereoselectivity without the use of noble metals or chiral modifiers, overcoming critical limitations associated with the complexity of preparing chiral plasmonic substrates. The platform achieves ultrasensitive detection limits (10 nM), linear response to ee values (R2 = 0.98), high measurement precision (RSD < 8.28%, n = 20), long-term stability (28-day), and clinical-grade accuracy against enzymatic assays (RMSEP = 1.97). This work presents an efficient, noninvasive method for the analysis of chiral metabolites in urine, while establishing a novel direction for plasmon-free SERS chiral sensing.
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DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Yongshi Li,Peng Shan,Fuyou Yu,Hui Li,Lincai Peng
An environmental-friendly composite films containing waste fish scale-derived gelatin (FSG), sodium alginate (SA) and carvacrol loaded ZIF-8 (CV@ZIF-8) nanoparticles were designed and fabricated to develop active food packaging materials capable of sustained antibacterial activity. The microstructure and physicochemical properties of the FSG/SA/CV@ZIF-8 composite films were investigated. The incorporation of CV@ZIF-8 into FSG/SA matrix significantly enhanced the UV-light blocking and the elongation at break, improved water resistance and reduced water vapor permeability, and improved the thermal stability of composite film. The FSG/SA/CV@ZIF-8 film not only exhibited strong antioxidant activity with DPPH radical scavenging rate of 92.35 %, but also showed the satisfactory and long-acting antibacterial ability against E. coli and S. aureus due to slow release of CV from composite film. Strawberry preservation experiment revealed that FSG/SA/CV@ZIF-8 film decelerated the texture deterioration and retarded the growth of spoilage microorganism, resulting in the prolonged shelf-life of 8 days under ambient condition, indicating its promising application prospect in food preservation packaging.
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PubMed
高影响因子
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