JOURNAL OF ELECTRONIC MATERIALS
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2025
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IF 2.5
Xiao Zhen,Yang Wutao,Zhu Jing,Sun Peng,Chen Jianfeng,Li Yinyan
Solar-light-responsive strontium titanate (SrTiO 3 ) samples with excellent specific surface area are synthesized via a facile hydrothermal process. The as-prepared samples are inspected by X-ray powder diffraction (XRD) and scanning electron microscopy (SEM) to illustrate the crystalline phase and particle morphology. The SrTiO 3 particles are characterized by the three-dimensional (3D) assembly of numerous highly oriented nanocubes according to oriented attachment and Ostwald ripening, thereby displaying a porous cube-like structure. By adjusting the reaction time, the morphology can be continuously tuned from a cube structure to irregular shape, then to a porous cube-like structure. Owing to the large specific surface area with highly active reaction sites, as well as the high utilization of light arising from reflections in the porous structure, the porous cube-like SrTiO 3 particles exhibit significantly enhanced photocatalytic activity compared to their cubic counterparts for the photocatalytic degradation of organic pollutants. Impressively, the rhodamine B (RhB) degradation rate for the porous cube-like SrTiO 3 particles can reach 96% after reaction for 6 h.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2024
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IF 3.8
Li Yue,Liu Hongmei,Wang Sikai,Zhang Sisi,Li Wen,Zhang Guoqi,Zhao Yan
In this study, xanthine oxidase was immobilized for the first time using a novel magnetic metal–organic framework material (Fe 3 O 4 -SiO 2 -NH 2 @MnO 2 @ZIF-8-NH 2 ). A ligand fishing method was established to rapidly screen XOD inhibitors from Ligusticum wallichii based on the immobilized XOD. Characterization and properties of the immobilized enzyme revealed its excellent stability and reusability. A ligand was screened from Ligusticum wallichii and identified as ligustilide by ultra-high performance liquid chromatography tandem mass spectrometry. The IC 50 value of ligustilide was determined to be 27.70 ± 0.13 μM through in vitro inhibition testing. Furthermore, molecular docking verified that ligustilide could bind to amino acid residues at the active site of XOD. This study provides a rapid and effective method for the preliminary screening of XOD inhibitors from complex natural products and has great potential for further discovery of anti-hyperuricemic compounds.
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APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
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2024
·Vol. 108
·期 1
·1-14
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IF 3.9
Xin Cheng,Zhou Jingming,Chen Yumei,Chen Zhuting,Xue Hua,Liu Yankai,Liu Hongliang,Liang Chao,Zhu Xifang,Zhang Ying,Qi Yanhua,Zhang Gaiping,Wang Aiping
Tetracycline (Tc) antibiotics, a class of synthetically produced broad-spectrum antimicrobial drugs, have been widely used in animal husbandry, leading to their widespread presence in animal-derived foods. However, misuse, overuse, and non-compliance with withdrawal periods in animal farming have resulted in excessive Tc residues in these foods, which can cause various adverse reactions in humans, induce bacterial resistance, and pose a significant threat to public health. Consequently, the detection of Tc antibiotic residues in animal-derived food has become a critical issue. This study aims to establish a novel method for quantifying Tc residues in animal-derived food using quantum dots (QDs) fluorescence immunoassay (FLISA). The developed method was optimized to achieve a detection limit of 0.69 ng/mL and a quantitative detection range of 1.30 ~ 59.22 ng/mL. The applicability of the method was demonstrated by successfully determining Tc residues in pork, chicken, fish, milk, eggs, and honey samples spiked with Tc standard solutions, yielding recoveries ranging from 94.01% to 110.19% and relative standard deviations between 1.10% and 11.39%. The significance of this study lies in its potential to provide a rapid and reliable approach for monitoring Tc residues in animal-derived food products, thereby contributing to the enhancement of food safety monitoring practices. Key points • Screen out tetracycline-specific blocking monoclonal antibodies • The quantitative detection has high specificity and sensitivity • This method can be a useful tool for laboratories or testing facilities
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Nature Sustainability
·
2024
·
IF 25.7
Liu Tao,Dong Tiantian,Wang Mengying,Du Xiaofan,Sun Youlong,Xu Gaojie,Zhang Huanrui,Dong Shanmu,Cui Guanglei
Silicon (Si) anode is widely viewed as a game changer for lithium-ion batteries (LIBs) due to its much higher capacity than the prevalent graphite and availability in sufficient quantity and quality. Most Si anode designs are nanostructured to overcome the large volume variation during cycling, but this comes at the expense of manufacturability, cost advantage and other merits. Here we demonstrate that micro-sized Si (μm-Si) recycled from photovoltaic waste can serve as anode material, exhibiting an average Coulombic efficiency of 99.94% and retaining 83.13% of its initial capacity after 200 cycles through the rational electrolyte design. With a formulated ether electrolyte of 3 M LiPF 6 in 1,3-dioxane (DX)/1,2-diethoxyethane (DEE), NCM811||μm-Si pouch cells survive 80 cycles and deliver an energy density of 340.7 Wh kg −1 even under harsh conditions. Responsible for the impressive electrochemical performance is a unique SEI chemistry where the flexible polymer-dominated outer layer well holds fractured Si particles together and the rigid Li 2 O/LiF-rich inner layer serves to facilitate ionic conduction and suppress side reactions. Our work not only suggests a more sustainable supply source for Si particles but also addresses the major problems facing μm-Si anode materials.
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Nature Nanotechnology
·
2025
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IF 34.9
Wang Shuibo,Lin Yichao,Li Yanle,Tian Ziqi,Wang Yu,Lu Zhiyi,Ni Baoxin,Jiang Kun,Yu Hongbo,Wang Shiwei,Yin Hongfeng,Chen Liang
Selective production of valuable glycerol chemicals, such as glycerate (which serves as an important chemical intermediate), poses a significant challenge due to the facile cleavage of C–C bonds and the presence of multiple reaction pathways. This challenge is more severe in the electro-oxidation of glycerol, which requires the development of desirable electrocatalysts. To facilitate the glycerol electro-oxidation reaction to glycerate, here we present an approach utilizing a high-entropy PtCuCoNiMn nanosurface. It exhibits exceptional activity (~200 mA cm −2 at 0.75 V versus a reversible hydrogen electrode) and selectivity (75.2%). In situ vibrational measurements and theoretical calculations reveal that the exceptional glycerol electro-oxidation selectivity and activity can be attributed to the unique characteristics of the high-entropy surface, which effectively modifies the electronic structure of the exposed Pt sites. The catalyst is successfully applied in an electrolyser for long-term glycerol electro-oxidation reaction, demonstrating excellent performance (~200 mA cm −2 at 1.2 V cell ) over 210 h. The present study highlights that tailoring the catalytic sites at the catalyst–electrolyte interface by constructing a high-entropy surface is an effective strategy for electrochemical catalysis.
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CHINESE JOURNAL OF POLYMER SCIENCE
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2024
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IF 4.1
Xiao Le-Ping,Qiu Lv-Ming,Wu Zhen,Wang Guo-Jie
To realize single-stimulus-induced simultaneous multi-behaviors in hydrogels is still quite challenging nowadays. Herein, an intelligent pH-responsive hydrogel (BP4VA/PAS) with rapid and high contrast changes in color, fluorescence, and shape simultaneously is reported. The BP4VA/PAS hydrogel is fabricated by incorporating styryl anthracene derivative (BP4VA) into copolymer networks (PAS) of acrylamide and sodium 4-styrene sulfonate. Under acid conditions, the protonation of BP4VA generates a rapid change with high color contrast from yellow to red and a fluorescence switch between bright green and weak red emission. At the same time, the electrostatic interactions between 2H-BP4VA 2+ and sulfonate anions suspended on PAS trigger BP4VA/PAS hydrogels to shrink. Upon alkaline treatment, the 2H-BP4VA 2+ /PAS hydrogel deprotonates and recovers to its original color, fluorescence, and shape. Furthermore, utilizing rapid and remarkable pH-responsive properties of BP4VA/PAS hydrogels, we successfully demonstrated its applications in biomimicry, camouflage, and multistage information encryption. Collectively, this work provided an elegant strategy to develop intelligent hydrogels in applications of biomimetic smart materials and information encryption.
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Scientific Reports
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2025
·Vol. 15
·期 1
·1-11
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IF 3.9
Hu Lili,Wu Na,Wang Jue,Cai Donghui
The anti-inflammatory effect of phellodendrine (PHE), derived from Phellodendri Chinensis Cortex, has been verified in previous studies. Major depressive disorder (MDD) is associated with immune dysregulation and inflammatory processes. This study aimed to explore the therapeutic effects of PHE on MDD through network pharmacology and experimental validation. Multiple databases were used to predict the targets of PHE and MDD. The intersection targets between PHE and MDD were obtained to identify as targets for PHE against MDD, followed by protein–protein interaction network, Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses. Molecular docking was applied to further confirm the anti-MDD effects of PHE. The mitochondrial DNA (mtDNA) copy number, inflammatory cytokines and pathway-related mRNA expressions in PC12 cell were determined via quantitative PCR (qPCR) and enzyme-linked immunosorbent assay to verify our finding. Thirty-eight intersection targets were obtained between PHE and MDD. PHE exerted an anti-MDD effect by regulating SLC6A4, SLC6A3, SLC6A2, MAOA and other targets through serotonergic synapse, salivary secretion, dopaminergic synapse, and cAMP signalling pathway. In vitro, PHE induced an increment in mtDNA copy number compared with the CORT group. PHE affected the levels of IL6 and IL1β with different concentrations. The mRNA levels of CHRM1, HTR1A and key targets of the PI3K/Akt signalling pathway were also influenced. Our research reveals novel mechanisms underlying the anti-MDD effects of PHE through network pharmacology and experiments, which provides a new direction for the development of antidepressants.
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Cell Communication and Signaling
·
2024
·Vol. 22
·期 1
·1-17
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IF 8.2
Zhang Yu,Wu Rong,Zhan Xi,Wang Xuan-Yi,Xiang Lin-Wei,Duan Ya-Qian,You Yan,Zhang Jian-Bo,Wu Rui,Zhang Yun-Yuan,Duan Liang
Background Absent in melanoma 2 (AIM2) inflammasome-dependent pyroptosis and neutrophil extracellular traps (NETs) have been implicated in chronic liver disease (CLD). However, the specific intrahepatic cell type that undergoes AIM2 inflammasome-dependent pyroptosis and how their interaction augments hepatic inflammation/fibrosis remains unclear.Methods The expression and correlation of AIM2 inflammasome-dependent pyroptosis-related indicators and NETs were analyzed in biopsy tissue and blood specimens from chronic hepatitis patients (CHs). Cell-based experiments were conducted to investigate their interaction. In vitro and in vivo experiments were used to analyze their effects on the progression of hepatic inflammation/fibrosis as well as their clinical importance.Results Elevated levels of AIM2 inflammasome-dependent pyroptosis indicators and NETs were detected in biopsy tissue and blood specimens. Circulating NETs were positively correlated with pyroptosis-related indicators, and both were related with disease severity. Confocal imaging revealed that AIM2 was mainly localized to hepatic macrophages, indicating that hepatic macrophages were the major cell type that underwent pyroptosis. NETs were directly engulfed by macrophages and then stimulated AIM2 inflammasome-dependent macrophage pyroptosis in vitro, which amplified the activation of hepatic stellate cells (HSCs) and increased collagen deposition. Administration of the NETs degradation agent DNase I or the AIM2 inflammasome activation inhibitor ODN A151 effectively alleviated chronic liver inflammation/fibrosis progression in vivo.Conclusion sNETs-induced AIM2 inflammasome-dependent pyroptosis in macrophages facilitates liver inflammation/fibrosis progression. The identified NET–AIM2 inflammasome cascade could serve as a novel therapeutic target for hepatic inflammation/fibrosis progression.
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-9
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IF 14.7
Guo Chenyue,Tang Huajie,Wang Pengfei,Xu Qihao,Pan Haodan,Zhao Xinyu,Fan Fan,Li Tingxian,Zhao Dongliang
Harvesting electricity from ubiquitous water vapor represents a promising route to alleviate the energy crisis. However, existing studies rarely comprehensively consider the impact of natural environmental fluctuations on electrical output. Here, we demonstrate a bilayer polymer enabling self-sustaining and highly efficient moisture-electric generation from the hydrological cycle by establishing a stable internal directed water/ion flow through thermal exchange with the ambient environment. Specifically, the radiative cooling effect of the hydrophobic top layer prevents the excessive daytime evaporation from solar absorption while accelerating nighttime moisture sorption. The introduction of LiCl into the bottom hygroscopic ionic hydrogel enhances moisture sorption capacity and facilitates ion transport, thus ensuring efficient energy conversion. A single device unit (1 cm 2 ) can continuously generate a voltage of ~0.88 V and a current of ~306 μA, delivering a maximum power density of ~51 μW cm −2 at 25 °C and 70% relative humidity (RH). The device has been demonstrated to operate steadily outdoors for continuous 6 days.
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JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
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2024
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IF 1.5
Xia Xue,Li Weimin,Feng Haining,Shen Weiwei,Liu Chang,Nie Xiaoqin,Dong Faqin
During the production of UO 2 core fuel elements for high-temperature gas-cooled reactors, a complex organic low-level radioactive wastewater (OLLRW) containing large amounts of tetrahydrofurfuryl alcohol (THFA), polyvinyl alcohol (PVA), and other organics is generated. So it’s urgent to have a pretreatment method to efficiently degrade the large and small molecular organic matters. Therefore, the Fenton continuous oxidation method developed in this study cleverly utilizes the secondary enhanced oxidation of H 2 O 2 . Compared with the conventional advanced oxidation method, the degradation efficiency of organic matter in simulated wastewater by continuous Fenton oxidation can be doubled, reaching 99.5%. The chemical oxygen demand (COD) of real complex uranium-containing OLLRW was reduced from 18,480 to 979.0 mg L −1 . After further oxidative degradation of organic compounds in simulated OLLRW, the COD of wastewater can be reduced to 88.9 mg L −1 . This method can effectively mitigate the "toxic" effect of organic matter on adsorption process, thus providing a new idea for the pretreatment of complex OLLRW in high-temperature gas-cooled reactors. Graphical Abstract
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MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 11
·1-11
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IF 5.3
Yang Jingqi,Wang Xinru,Yu Ying,Cao Yujuan,Guo Manli,Hu Xiaogang,Wang Li,Lin Bixia
By combining boric acid-modified carbon dots ( p -CDs) and alizarin red (ARS), a double emission probe p -CDs@ARS with fluorescence at 410 nm and 600 nm is designed for the detection of glyphosate. When Cu 2+ is added, it binds with ARS to cause ARS release from p -CDs@ARS, which decreases the fluorescence at 600 nm. However, in the presence of glyphosate, glyphosate competes to the binding of Cu 2+ , releasing ARS to bind with p -CDs again. Therefore, the fluorescence of 600 nm recovers. Based on this, the fluorescence of 410 nm and 600 nm act as the reference and response signal, respectively, achieving the ratiometric fluorescence detection of glyphosate. The linear range of glyphosate detection is 0.5–50 µM with a limit of detection at 0.37 µM which is well below the maximum residue limit for glyphosate in food. When the probe is used to detect the glyphosate residue in Pearl River water and cucumber, the detection results are well consistent with those detected by HPLC. The established method based on p -CDs@ARS has the advantages that the assembly of ratiometric fluorescence probe is simple, and the detection speed is fast. Additionally, a typical INHIBIT logical system has been successfully constructed based on glyphosate, Cu 2+ , and the fluorescence signal of p -CDs@ARS. Graphical
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JOURNAL OF NANOBIOTECHNOLOGY
·
2025
·Vol. 23
·期 1
·1-29
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IF 12.6
Li Yang,Xue Xiaoxia,Yu Liuchunyang,Qian Jinxiu,Li Xiaoyu,Tian Meng,Yang Jue,Deng Rongjun,Lu Cheng,Xiao Cheng,Liu Yuanyan
Introduction Atherosclerosis serving as the main underlying factor of cardiovascular disease (CVD) remains the primary cause of mortality and morbidity globally, while the deposition of massive cholesterol in macrophage-derived foam cells exerts pivotal roles in the occurrence and progression of atherosclerosis. Celastrol (CEL) is a bioactive ingredient owning potent capability to modulate lipid metabolism, whereas the poor bioavailability and potential toxicity limit its clinical application. Objectives This study aims to design a CEL-loaded recombinant high-density lipoprotein (rHDL) delivery platform for active targeting, which may effectively promote lipid degradation in foam cells and reversely transport excessive cholesterol to the liver for metabolism in time. Methods The rHDL loaded with CEL (CEL-rHDL) was prepared by the thin film dispersion method. Then the anti-atherosclerotic efficacy and targeted delivery to foam cells of atherosclerotic lesions were verified both in vitro and in vivo. RNA-sequence was applied to reveal the potential mechanism against early atherosclerosis, which was further validated through several molecular biology experiments. Results The prepared CEL-rHDL increased the targeting efficiency to foam cells of atherosclerotic lesions, mitigated its off-target toxicity, and improved anti-atherosclerotic efficacy. Importantly, CEL-rHDL decreased lipid storage in foam cells by triggering lipophagy via the activation of Ca 2+ /CaMKKβ/AMPK/mTOR signaling pathway and reverse cholesterol transport (RCT). Conclusion A combination of hypolipidemic chemo-intervention with rHDL participated specific and reverse delivery may offer a promising strategy for biocompatible treatment of early atherosclerosis. Graphical abstract
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