International Journal of Nanomedicine
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2026
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IF 6.5
Dezhao Chen,Xiaohan Zheng,Qiao Gao,Bing Chen,Yang Sun
Purpose: Natural ferritin Fn) is a cage-like protein with a central cavity, making it a promising vehicle for drug delivery. However, its non-specific accumulation in iron-metabolizing organs impairs targeting precision and therapeutic efficacy. To overcome this challenge, we aimed to develop a novel biomimetic nanoplatform based on manganese-mineralized ferritin loaded with dihydroartemisinin (DHA@MFn) for precise ovarian cancer treatment, enabling controlled drug release and amplified therapeutic effects within the tumor microenvironment.Methods: We constructed a manganese-mineralized ferritin nanocage encapsulating DHA, resulting in DHA@MFn with favorable physicochemical properties, including a particle size of 12.2 nm and a zeta potential of − 13.54 mV. The stability, stimuli-responsiveness, and in vitro release behavior of DHA@MFn were evaluated under weakly acidic conditions. We assessed its ability to catalyze Fenton-like reactions releasing Mn2+, induce ferroptosis via lipid peroxidation and GSH depletion, and enable controlled drug release. In vivo biodistribution, tumor accumulation, and therapeutic efficacy were investigated using SKOV3 tumor-bearing mice, alone and in combination with irradiation.Results: DHA@MFn remained stable and demonstrated excellent responsiveness to the tumor microenvironment, releasing Mn2+ ions that catalyzed Fenton-like reactions for hydroxyl radical production. The nanoplatform facilitated targeted tumor accumulation and retention, significantly reducing off-target organ distribution, particularly in the liver. The release of DHA induced ferroptosis through lipid peroxidation and GSH depletion, enhancing oxidative stress. Combined with irradiation, DHA@MFn achieved superior tumor ablation through synergistic ferroptosis, photothermal effects, and minimal systemic toxicity compared to free DHA, MFn alone, or their combinations with irradiation.Conclusion: This multifunctional biomimetic nanoplatform presents a promising strategy for precise, multimodal ovarian cancer therapy. By integrating controlled drug delivery, catalytic Fenton-like reactions, and synergistic radiotherapy, DHA@MFn demonstrates significant potential for clinical translation in targeted cancer treatment.
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ACS Omega
·
2026
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IF 4.3
Hegui Yang,Wei Li,Di Xu,Changhai Xu,Jinmei Du,Dagang Miao,Guowei Xiao,Xiaodong Jiang,Yang Jiang
This study developed a green multifunctional modification strategy for cotton fabrics through covalent coimmobilization of phytosynthesized silver nanoparticles (AgNPs) and N-(2-hydroxy)-propyl-3-trimethylammonium chitosan (HTCC) using dimethyloldihydroxyethyleneurea (DMDHEU). AgNPs were synthesized using Aloe vera extract with an average size of 81.96 nm (PDI 0.191) and integrated with HTCC via a pad-cure process. The cotton fabric modified with DMDHEU, HTCC, and AgNPs (Cotton-DHA, where “DHA” denotes the three modifying agents: DMDHEU, HTCC, and AgNPs) demonstrated synergistic antibacterial activity against Escherichia coli (E. coli) (99.81%) and Staphylococcus aureus (S. aureus) (99.29%), with over 90.00% inhibition retained after 20 washing cycles, indicating robust durability. The Cotton-DHA also exhibited significantly enhanced antioxidant capacity, with an ABTS free radical scavenging rate of 72.51%, in stark contrast to the 4.20% rate of pristine cotton. Natural dye affinity was substantially improved, as evidenced by the increase in K/S value from 0.30 to 2.58. The covalent bonding mediated by DMDHEU ensured durable immobilization, where HTCC provided primary antibacterial action (>94.00%) and AgNPs enhanced the efficacy to >99.00%. This synergistic system provides a sustainable approach to developing high-performance textiles with integrated antibacterial, antioxidant, and dyeing properties.
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Chemical and Biological Technologies in Agriculture
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2026
·Vol. 13
·期 1
·1
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IF 5.2
Meng Lifen,Ding Pengpeng,Ou Meiya,Zhang Yu
Background CQDs are an ideal platform material that integrates excellent optical properties, superior biosafety, flexible, and adjustable chemical properties. They serve as a bridge connecting nanotechnology with fields such as life sciences, environmental energy, and more. Methods In this study, Hc -DES-CQDs based on natural deep eutectic solvents and Houttuynia cordata were successfully prepared. Results The prepared Hc -DES-CQDs exhibits strong blue fluorescence and excellent photostability. The detection of trace Cr 6+ under acidic and alkaline conditions can be realized by Hc -DES-CQDs, and also successfully applied to practical environmental water samples. Spectral analysis reveals that Hc -DES-CQDs exhibits emission behavior related to excitation, with a quantum yield of approximately 17.3%. The Hc -DES-CQDs demonstrated excellent antibacterial and free radical scavenging effects (such as DPPH, ·OH). Conclusions Therefore, the Hc -DES-CQDs has potential applications in the analysis and combating of cellular oxidative stress. Graphical abstract
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MICROCHEMICAL JOURNAL
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2026
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IF 5.1
Fan Wu,Junyao Li,Ning Gu,Wenxin Huang,Datong Wu,Wenrong Cai,Zheng-Zhi Yin,Yong Kong
Since d -glucose (D-Glu) plays significant roles in energy generation and metabolite production while l -glucose (L-Glu) cannot be metabolized, discrimination and detection of Glu enantiomers is of great importance for people's daily life. Herein, chiral Au/Co 3 O 4 nanoclusters are synthesized by using L-cysteine (L-Cys) as the chiral inducer and Au 3+ as the self-assembly inducer. The introduction of Au can also enhance the conductivity of the chiral Au/Co 3 O 4 . The resulting L-Au/Co 3 O 4 nanoclusters show higher affinity toward L-Glu due to the consistent chirality of L-Au/Co 3 O 4 nanoclusters and L-Glu, which can be used for the electrochemical discrimination and detection of Glu enantiomers. Accordingly, the D-Au/Co 3 O 4 nanoclusters synthesized by using D-Cys as the chiral inducer show higher affinity toward D-Glu, and thus they can also be used for the electrochemical discrimination and detection of Glu enantiomers. The chiral Au/Co 3 O 4 exhibits high selectivity, reproducibility and stability when used for the discrimination of Glu enantiomers. Although the linear range is relatively narrow (0.05–1.5 mM), both chiral discrimination and electrochemical detection can be achieved by the proposed dual-functional sensor, which is quite different from the common Glu sensors.
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Frontiers in Cellular and Infection Microbiology
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2026
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IF 4.8
Chunjiao Zheng,Wei Li,Yuanyuan Wang,Lulu Li,Linan Ni,Xiaoping Liu,Jingwen Tan,Lianjuan Yang,Qian Yu
Introduction: Chromoblastomycosis (CBM) is a chronic cutaneous infection caused by dematiaceous fungi, characterized by therapeutic challenges such as difficulty in pathogen clearance and high recurrence rates. Fonsecaea pedrosoi (F. pedrosoi), the most common etiological agent of CBM, relies on its virulence factor DHN-melanin to evade host immune responses—especially by suppressing neutrophil function—further contributing to disease persistence and treatment resistance. Thus, we intended to explore therapeutic approaches that target both fungal virulence mechanisms and host immune regulation to overcome the clinical hurdles of CBM.Objectives: This study aimed to investigate the effects of tricyclazole (TCZ) on F. pedrosoi and neutrophil antifungal responses, with a particular focus on its potential actions in inhibiting DHN-melanin synthesis and enhancing host oxidative immune mechanisms.Methods: We conducted in vitro assays to assess the effects of TCZ on F. pedrosoi melanin and fungal antioxidant enzymes, as well as reactive oxygen species (ROS) production and neutrophil extracellular traps (NETs) formation in human neutrophils. The in vivo mouse model was used to evaluate inflammatory responses, neutrophil-related markers, and fungal clearance.Results: In vitro tests showed TCZ dose-dependently inhibited fungal DHN-melanin synthesis and disrupted the antioxidant enzyme system (including superoxide dismutase and catalase); this effect not only weakens the fungus’s ability to resist host oxidative stress but also reduces its capacity to evade immune recognition, creating conditions for subsequent immune clearance. In vitro co-culture models revealed that TCZ significantly enhanced neutrophil ROS production and NET formation; this strengthens the oxidative killing function of neutrophils, directly counteracting the immunosuppressive effect of DHN-melanin on neutrophils and improving the host’s ability to eliminate pathogens. In a mouse infection model, TCZ treatment significantly alleviated pedal inflammation, reduced neutrophil activation markers, and completely eliminated fungal colonization; these results validate TCZ’s in vivo therapeutic efficacy, demonstrating its potential to mitigate inflammatory tissue damage while achieving effective fungal eradication.Conclusions: This study reveals a novel mechanism by which TCZ counteracts F. pedrosoi-mediated suppression of neutrophil antifungal effector functions, particularly oxidative burst and NET formation, thereby facilitating fungal clearance in CBM. These findings provide a novel strategy for CBM treatment by integrating immunomodulation with antifungal therapy.
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NEW JOURNAL OF CHEMISTRY
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2026
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IF 2.5
Dong-Gui Guo,Lin-Lu Liu,Sijie Zhang,Hong-Xing Cen,Xiong-Li Liu,Hui-Juan Wang,Li-Jun Peng
Herein, we developed the biomimetic synthesis of densely functionalized dispiro sesquiterpene lactone type of alkaloids via azomethine ylide cycloaddition, subsequent N-oxidation and 1,2-migration followed by a ring expansion. This successful biomimetic synthesis demonstrated that biosynthesis of sesquiterpene lactone type of alkaloids I, reported by Song and Huang, might proceed in a similar pathway. It is noteworthy that such a biomimetic synthesis strategy provides a rapid access to densely functionalized products previously inaccessible from conventional methods. Then, these newly synthesized 29 compounds were evaluated for their anticancer activity, and some compounds showed more cytotoxicity than parent compound alantolactone. The most potent compound 3j may inhibit A549 cell proliferation and induces apoptosis by triggering mitochondrial depolarization, Caspase activation, and activation of the dead receptor pathway.
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DALTON TRANSACTIONS
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2026
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IF 3.3
Xiaopan Xue,Dongzhi Zhu,Wenjuan Zhang,Tongxin Zheng,Rui Wang,Yanping Ma,Wen Hua Sun
The series of 2-(dipehnylethyl)amino-6-iminopyridines, 2-((Ph2PCH2CH2)N=CMe)-6-(ArN=CMe)C5H3N (Ar=2,6-iPr2C6H3 (L1), 2,6-Et2C6H3 (L2), 2,6-Me2C6H3 (L3), 2,4,6-Me3C6H2 (L4), 2,6-(CHPh2)2−4-MeC6H2 (L5)), and its analogue 2-(n-butyl)amino-6-iminopyridine L6 were synthesized and used to form their dichlorozinc complexes, LZnCl2 (Zn1-Zn6). All organic compounds and zinc complexes were well characterized by 1H/13C/31P NMR spectroscopy and elemental analysis along with the single crystal X-ray diffraction of Zn1 and Zn4 indicating bistrigonal geometry around zinc. By treated with two equivalents of LiN(SiMe3)2, all Zn1-Zn6 performed high activities toward ring-opening polymerization (ROP) of L-lactide (L-LA), indicating the positive influences of substituents as well as auxiliary phosphine. Notably, the excellent activity was achieved even at high temperature; such as, Zn1/2LiN(SiMe3)2 catalyzed 2000 equiv. L-LA with 86% conversion in 10 minutes at 100 ℃, observing its TOF as 10320 h−1. The activities were observed in the order of substituents as: isopropyl > ethyl > methyl, so were higher activities for more alkyl substituents. The auxiliary phosphine enhanced the activities of zinc complexes; all Zn1-Zn5 showed higher activities than Zn6 (with butyl), which formed the PLA with relatively lower molecular weight. The coordination–insertion and ring expansion mechanism has been proposed for the ROP of L-lactide.
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DRUG METABOLISM AND DISPOSITION
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2026
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IF 4
Yan Zhang,Zihao Cheng,Jie Dai,Chunlei Zhang,Xueqian Cheng,Ying Peng,Weiwei Li,Jiang Zheng
Corydalis Decumbentis Rhizoma (CDR) is a traditional Chinese herbal medicine, which has been clinically used for treating migraine, relieving the symptoms of rheumatoid arthritis, and reversing osteoporosis. Bicuculline (BIC) is one of the main bioactive ingredients present in CDR. The purpose of this study was to comprehensively investigate the interaction of BIC with cytochrome P450 enzymes and the alteration of the pharmacokinetic properties of the active thiol metabolite 4 of clopidogrel when co-administered. BIC showed time-, concentration-, and NADPH-dependent inhibitory effects on CYP2C19. BIC (2.0 μM) inhibited CYP2C19 activity by about 64% after 9 min of incubation at 30 °C, and K I and k inact were 0.09 μM and 0.051 min -1 , respectively. Ticlopidine showed a significant protective effect against BIC-induced CYP2C19 inactivation. Dialysis did not restore the inhibited enzyme activity induced by BIC. Moreover, the addition of catalase/superoxide dismutase or glutathione (GSH) did not show protective effects against BIC-induced enzyme inactivation. It is speculated that carbene intermediates were involved in BIC-induced inactivation of CYP2C19, since K 3 Fe (CN) 6 restored the enzymatic activity. In addition, BIC and CDR extract pretreatment resulted in a significant decrease in the C max and AUC of the plasma thiol metabolite in rats given clopidogrel.
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FOOD RESEARCH INTERNATIONAL
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2026
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IF 8
Ning Zhang,Xuan Lu,Jingru Chen,Xinyi Li,Suo Zheng,Fei Liu,Qingfeng Ban,Xiangchen Meng
To improve the stress resistance of Lactococcus lactis subsp. lactis (L. lactis) KLDS 4.0325 in harsh environments, we constructed a novel thiolated hyaluronic acid (HA SH )-whey protein isolate (WPI) encapsulation system. The formation of a non-covalent HA SH -WPI complex was confirmed via Fourier-transform infrared spectroscopy and sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Incrementing the amount of HA SH in the complex significantly increased the particle size and absolute Zeta potential to 1393.67 ± 44.15 nm and 53.28 ± 0.68 mV, respectively, while instilling excellent antioxidant activity: 28.41 ± 0.51% scavenging of 2,2-diphenyl-1-picrylhydrazyl and 41.80 ± 0.86% scavenging of 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid). In addition, increasing the HA SH content also caused a transition of the secondary structure of WPI from α-helix to β-sheet, with the latter content increasing from 20% to 24%. Morphological analysis shows that the 0.8% HA SH -WPI complex exhibited a uniformly dispersed and compact structure that provided the best protective effect for L. lactis KLDS 4.0325, with survival rates in 0.8% HA SH -WPI microcapsules of 96.04 ± 0.49% after freeze-drying, 76.58 ± 0.13% after gastrointestinal digestion, and 93.12 ± 0.24% after pasteurization. This study confirms that the dense network structure formed by the HA SH -WPI complex can serve as a physical barrier to provide enhanced protection for probiotics. Additionally, ex vivo intestinal imaging directly demonstrated that the complex significantly increased probiotic adhesion to the colon. This study provides a promising strategy for constructing efficient, stable, and colon-retentive probiotic delivery systems.
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Human Cell
·
2026
·Vol. 39
·期 2
·36
·
IF 3.1
Hu Xiwen,Sha Rui,Yang Feiran,Chai Jinwen,Liu Bin,Xu Xiaoqing
Lung adenocarcinoma (LUAD), the most prevalent and aggressive form of non-small cell lung cancer. Natural compounds have gained increasing attention as potential anti-cancer agents. The therapeutic potential of chebulagic acid (CA)—a hydrolysable tannin with documented anti-proliferative properties—has not been investigated in LUAD. In the present study, functional experiments revealed that CA treatment markedly suppressed proliferation and induced mitochondrial-dependent apoptosis of LUAD cells. In addition, CA augments natural killer (NK) cell migration by enhancing LUAD CCL5 production. Quantitative proteomics identified FBXO38 as the most significantly upregulated protein following CA treatment. FBXO38 silencing abrogated CA-induced CCL5 production and NK cell migration in LUAD cells. The in vivo experiments showed that CA significantly inhibited tumor growth and enhanced NK cell infiltration in mice, accompanied by decreased Ki67 + proliferating cells, increased cleaved caspase-3 + apoptotic cells, and upregulated FBXO38 expression. Collectively, our findings demonstrate that CA may be exert anti-LUAD effects through FBXO38/CCL5-mediated NK cell recruitment.
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MICROCHEMICAL JOURNAL
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2026
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IF 5.1
Qiongyao Zeng,Jiawei Zhou,Jingshu Li,Yuee Zhong,Pengli Zhang,Weibo Wen,Meiling Liu
Alkaline phosphatase (ALP), as a crucial hydrolase in biological processes, plays a significant role in disease diagnosis and drug screening. However, conventional methods for ALP detection often suffer from limitations such as low sensitivity, complex procedures, and the requirement of sophisticated instruments, which hinder their applicability in point-of-care testing and large-scale screening. Therefore, the development of simple, highly sensitive, and reliable ALP detection platforms remains an urgent need to facilitate early diagnosis and therapeutic monitoring. In this study, a novel Ag₂S/CuO/SBOC/ITO heterojunction modified electrode was fabricated. The well-aligned energy levels among Ag₂S quantum dots (Ag₂S QDs), CuO, and sulfur-doped BiOCl (SBOC) effectively suppress the recombination of photogenerated carriers, leading to significantly enhanced photocurrent intensity and stability. Based on the synergistic effect between CuO nanoparticles (NPs) and SBOC, as well as the ascorbate oxidase-like activity of CuO NPs, an innovative dual-mode photoelectrochemical-fluorescence (PEC-FL) sensing platform was proposed for ALP activity and its inhibitors. The detection mechanism relies on ALP-catalyzed hydrolysis of L-ascorbic acid-2-phosphate trisodium salt (AAP) to generate ascorbic acid (AA) as an electron donor, which proportionally modulates the PEC response. Subsequently, the produced AA is oxidized to dehydroascorbic acid (DHAA) catalyzed by CuO NPs. DHAA then reacts with o -phenylenediamine (OPD) to yield a fluorescent product, enabling the quantification of ALP and its inhibitors via FL detection. Compared with conventional methods, this platform integrates both the photoelectric properties and nanozyme activity of CuO NPs, thereby simplifying the construction and detection procedures of the dual-mode sensors while substantially minimizing interference from electron donor oxidation and environmental factors. The cascade catalytic system comprising natural enzymes and nanozymes ensures both high sensitivity and specificity of the sensing platform. Furthermore, this strategy can be extended to monitor other enzymatic activities and inhibitors, demonstrating promising potential for clinical diagnostics and pharmaceutical development.
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2026
·Vol. 27
·期 2
·705
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IF 4.9
Di Chen,Aoyun Meng,Zhen Li,Jinfeng Zhang
Designing and constructing heterojunctions has emerged as a pivotal strategy for improving the photocatalytic efficiency of semiconductors. In this study, we report the controlled synthesis of an Au/Zn3In2S6Schottky junction through a combination of hydrothermal and in situ photodeposition methods. The structural, morphological, and photoelectrochemical properties of the catalyst were meticulously characterized using a suite of techniques including X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), diffuse reflectance spectroscopy (DRS), X-ray photoelectron spectroscopy (XPS), photoelectrochemical (PEC) measurements, and electron spin resonance (ESR) spectroscopy. The optimized 3% Au/Zn3In2S6composite exhibited a remarkable enhancement in both photocatalytic activity and stability, achieving a 90.4% removal of bisphenol A (BPA) under UV–visible light irradiation within 100 min. The corresponding first-order reaction rate constant was approximately 1.366 h−1, nearly 4.37 times greater than that of the pristine Zn3In2S6. This substantial improvement can be attributed to several key factors, including increased BPA adsorption, enhanced light absorption, and the efficient charge separation facilitated by the Au/Zn3In2S6heterojunction. Photogenerated holes, superoxide radicals, and hydroxyl radicals were identified as the primary reactive species responsible for the BPA degradation. This work highlights the potential of metal-modified semiconductors for advanced photocatalytic applications, offering insights into the design of highly efficient materials for environmental remediation.
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