SENSORS AND ACTUATORS B-CHEMICAL
·
2026
·
IF 8.3
Luoyuan Shi,Xinying Jiang,Shuang Sun,Chunping Jia,Xiaojun Bian,Jianlong Zhao
Rapid and reliable detection of foodborne pathogens is essential for ensuring food safety, yet achieving high selectivity and sensitivity in complex matrices remains challenging. Herein, we report a sensitive and selective electrochemical sensing platform integrating a bacteria-imprinted polymer (BIP) capture interface with concanavalin A-functionalized Fe 3 O 4 (Fe 3 O 4 -ConA) for the detection of Escherichia coli O157:H7 ( E. coli O157:H7). The BIP film was electropolymerized in situ on glassy carbon electrode to generate recognition sites for efficient capture of E. coli O157:H7. Subsequently, Fe 3 O 4 -ConA bound to surface glycans on the captured bacteria through lectin-glycan interactions, forming a sandwich-like sensing interface. The anchored Fe 3 O 4 nanozyme catalyzed the H 2 O 2 -mediated oxidation of o -phenylenediamine, producing amplified electrochemical signals for bacterial quantification. Benefiting from the combination of imprinting-based recognition and catalytic amplification, the sensor achieved an ultrasensitive detection limit of 2.8 CFU mL −1 and a linear range from 10 1 to 10 5 CFU mL −1 . Recoveries of 93.29–113.62% were obtained in spiked milk, fish, and juice samples, with reliable detection down to 10 CFU mL −1 in complex food matrices. This work provides an effective strategy for constructing nanozyme-amplified electrochemical sensors for sensitive and selective monitoring of foodborne pathogens.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2026
·
IF 6.7
Yizhe Wang,Siyue Li,Ye Yuan,Qixin Zhuang,Xiaoyun Liu,Peiyuan Zuo
The rational design of yolk–shell structured materials with integrated dielectric–magnetic synergy has emerged as a critical strategy for developing lightweight and high-performance electromagnetic wave (EMW) absorbers. Comparing to the conventional yolk–shell structures that typically rely on single cavity configuration, the air-induced dual-cavity yolk–shell structures offer both lightweight absorber design and substantial enhancements in interfacial polarization over wide frequency range. To this end, this study proposes a novel “coating-protected etching-high temperature carbonization” strategy to successfully construct an air-induced dual-cavity yolk–shell hollow Fe₃O₄@air@Co/C composite absorber. The unique nanostructure possesses two independent cavities: one within the inner hollow Fe₃O₄ core, and another between the inner Fe₃O₄ core and the Co/C shell. The dual cavities not only significantly reduce the material density but also optimize the impedance matching. Importantly, the synergistic effects of the air-induced dual-cavity interfaces (Fe₃O₄-air and Co/C-air) amplify multi-interfacial polarization and improve the absorption ability via combined magnetic and dielectric loss mechanisms. Experimental results demonstrate that the optimized absorber achieves a remarkable reflection loss of –67.21 dB and a maximum effective absorption bandwidth (EAB) of 5.12 GHz (12.08–17.20 GHz) at an ultra-thin thickness of 2.0 mm and a low filler loading of 20 wt%. Collectively, our findings provide a new design approach for constructing high-efficiency, lightweight EMW absorption materials.
✓ 已验证
产品关联
DOI
高影响因子
International Journal of Nanomedicine
·
2026
·
IF 8.7
Hao Ding,Dan li Li,Zi yi Zhou,Xiang Dong Lai,Nan Yang,Liu chang Tan,Yuan gang Lu
Background Malignant melanoma is a highly aggressive skin cancer. Dacarbazine (DTIC) chemotherapy, while historically used, is limited by poor solubility, short half-life, and systemic toxicity. Fe3O4 nanoparticles have been explored as drug delivery vectors with potential for photothermal conversion and Fenton-like catalytic activity. Cell membrane-camouflaged platforms may offer improved tumor targeting.Methods A biomimetic nanoplatform (Fe3O4PD@CCM) was engineered by encapsulating an Fe3O4 core within a DTIC-loaded PLGA-PEG2000 matrix, followed by functionalization with B16F10 cancer cell membranes. Physicochemical properties were characterized by dynamic light scattering (DLS), scanning electron microscopy (SEM), and liquid chromatography–mass spectrometry (LC-MS). Antitumor effects were assessed in B16F10 melanoma cells and in a subcutaneous syngeneic mouse model (n=4 per group).Results Fe3O4PD@CCM Nanoparticles (NPs) exhibited a hydrodynamic diameter of ~25–30 nm, sustained DTIC release, and retention of membrane proteins. In vitro, the Fe3O4PD@CCM + NIR (Near-infrared irradiation) group showed reduced cell viability, increased apoptosis, G2/M phase arrest, and elevated intracellular reactive oxygen species (ROS) levels compared to controls. In vivo, Cy5-labeled Fe3O4PD@CCM NPs showed preferential fluorescence accumulation in tumors relative to non-coated NPs, with whole-body fluorescence diminishing within 24 h. In a 12-day efficacy study, Fe3O4PD@CCM + NIR treatment was associated with reduced tumor growth compared to control groups. Acute biosafety assessment at 24 h post-injection of a single high dose (200 mg/kg) revealed no overt abnormalities in the evaluated hematological, biochemical, or histopathological parameters.Conclusion Fe3O4PD@CCM NPs combined with NIR suppressed B16F10 cell activity in vitro and subcutaneous tumor growth in a preliminary mouse model. These findings represent a proof-of-concept demonstration. Further studies—including detailed mechanistic validation, long-term toxicity assessment, and evaluation in more clinically relevant models—are required to assess the translational potential of this platform.
✓ 已验证
DOI
高影响因子
JOURNAL OF ENVIRONMENTAL MANAGEMENT
·
2026
·
IF 9.2
Chuan Cao,Siyang Chang,Zhirong Sun,Jun Cui,Xiang Hu
Alloy catalysts have been recognized as one of the promising methodologies to modulate the electronic structure to generate ·OH. Although various alloy catalysts play an essential role in H 2 O 2 activation, systematic investigations conducted within a unified framework remain scarce. Here, three adjacent transition metals (Mn, Co, and Ni) were employed as dopants to construct a series of Fe 3 O 4 -FeM/C (M = Mn, Co and Ni) alloy catalysts, and their H 2 O 2 activation performance and underlying catalytic mechanisms were systematically investigated. Density functional theory analysis indicated that the alloy structure can form a built-in electric field within the catalyst, which can facilitate the migration of electrons from the catalyst interior to the exterior. Meanwhile, according to the bader charge analysis, the amount of charge transferred to the carbon shell follows the order: Mn (0.36 e − ) > Co (0.19 e − ) > Ni (0.01 e − ). This trend indicated that when Mn formed an alloy with Fe, it most effectively facilitated electron migration from the internal metal sites to the external carbon shell, thereby markedly enhancing the catalytic activation of H 2 O 2 . Therefore, the Fe 3 O 4 -FeM/C exhibited superior performance compared with the other electrodes, achieving a 92.0% degradation of tetracycline within 12 min. Furthermore, electron spin resonance tests combined with probe quantification verified that transition metals incorporation enhanced the production of ·OH species, among which the Mn-doped catalyst exhibited the most significant enhancement. This study elucidates the catalytic mechanism of alloy catalysts toward H 2 O 2 from an electronic transfer perspective, providing theoretical guidance for the reasonable design of highly active alloy catalysts.
✓ 已验证
DOI
PubMed
高影响因子
ANALYTICA CHIMICA ACTA
·
2026
·
IF 6.1
Leheng Wang,Jiyao Zhou,Zimeng Chen,Yi Lu,Guang Huang,Yechen Hu,Changgao Huang,Bangbang Wei,Yun Chen
Trypsin inhibitors (TIs) are common anti-nutritional factors in legumes and grains, necessitating reliable detection for food nutrition assessment and feed safety control. This study took advantage of immobilized enzymes and successfully constructed an efficient magnetic core-shell composite material, Fe 3 O 4 @SA/Trypsin@UiO-66. Within this structure, the sodium alginate (SA) hydrogel provides a mild microenvironment for trypsin immobilization, while the outer UiO-66 metal-organic framework (MOF) shell not only enhances the nanoreactor's stability but also improves substrate enrichment and catalytic efficiency through a nanoconfinement effect. The nanoreactor exhibits robust magnetic separability, well-retained catalytic activity, and long-term applicability. Systematic performance studies revealed that, compared to free enzyme, the nanoreactor exhibited enhanced stability under freeze-thaw cycles and across broad pH (2-11) and temperature (25-70 °C) ranges, maintaining over 70% of its initial activity after multiple uses. In practical sample detection, the established nanoreactor system, which uses the nanoreactor as the core material and benzoyl- l -arginine ethyl ester (BAEE) as the substrate, was successfully applied to analyze TI content in various grain flours and fish feeds. In addition, the results provide evidence supporting the role of thermal processing in reducing TI activity. This research provides a reliable approach for the efficient detection of anti-nutritional factors in complex matrices.
✓ 已验证
DOI
高影响因子
BIOCATALYSIS AND BIOTRANSFORMATION
·
2021
·
IF 2.181
Hongqian Dai,Yuan Lu,Hanbing Shi,Lan Tang,Xingyuan Sun,Zhimin Ou
Fe3O4 magnetic nanoparticles were prepared by chemical co-precipitation and modified with 3-aminopropyltriethoxysilane (APTES) and CS2 to form Fe3O4-APTES-CS2 magnetic carriers. Magnetically immobilized enzymes are attractive owing to their potential applications in many biological fields. When an alternating magnetic field is applied, the magnetic nanoparticles experience a force in the direction of the field, and the magnetic moments of the magnetic nanoparticles are apt to align in the direction of the field. Thus, magnetic nanoparticles behave like microscopic stirrers. The optimal reaction conditions of the acylation reaction using Fe3O4-APTES-CS2-lipase were 200 mmol/L 1-methyl-3-amphetamine, 100 mg immobilized lipase, 200 μL ethyl acetate, 12.6 × g rotating speed, 40 °C, and 5 days in the shaker. The conversion and enantiomeric excess of R-2a reached a maximum of 36.8% and 98.5%, respectively. 1-Methyl-3-phenylpropylamine was resolved using Fe3O4-APTES-CS2-lipase in an alternating magnetic field. The optimal magnetic field frequency and magnetic field intensity were determined to be 500 Hz and 12 Gs, respectively. The conversion and enantiomeric excess of R-2a reached a maximum of 40.3% and 98.5%, respectively. The results revealed that conversion under a magnetic field was significantly higher than that without a magnetic field. Highly optically active (R)-N-acetyl-1-methyl-3-amphetamine can be obtained via an efficient resolution of racemic 1-methyl-3-phenylpropylamine with immobilized lipase magnetic nanoparticles as a catalyst and ethyl acetate as an acyl donor in organic solvents in an alternating magnetic field.
✓ 已验证
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2026
·
IF 3.9
Ma Kuanjie,Li Nana,Lu Guochao,Zhang Lianwei,Hu Zhiwei,Liu Wenjing,Cai Yurong
To address the need for rapid desorption in protein adsorption applications, we developed and characterized magnetic core–shell nanoparticles composed of a zeolite imidazolate framework-8 (ZIF-8) coating on magnetite (Fe 3 O 4 ) cores (Fe 3 O 4 @ZIF-8). This nanostructure integrates the pH-sensitive properties of ZIF-8 with the magnetic responsiveness of Fe 3 O 4 , enabling rapid separation within one minute via an external magnetic field. In the synthesis of Fe 3 O 4 @ZIF-8, the particle size of the ZIF-8 shell was found to increase concurrently with the molar ratio of zinc nitrate hexahydrate to 2-methylimidazole. The resulting shells were uniformly distributed on the surface of the Fe 3 O 4 cores. Furthermore, a positive correlation was observed between the ZIF-8 particle size and the adsorption capacity for histidine-rich proteins. In adsorption experiments using bovine hemoglobin (BHB) as a model protein, Fe 3 O 4 @ZIF-8 achieved an adsorption capacity of 1013.5 mg/g within 3 min, representing 87% of its maximum adsorption potential. Saturation adsorption, with a capacity of 1164.3 mg/g, was reached within 8 min. Importantly, the pH-responsive nature of the ZIF-8 component facilitated highly efficient desorption. A high release efficiency of 90% was achieved in just 1 min using a phosphate buffer at pH 5.2. This dual pH- and magnetic-responsive system demonstrates significant potential for applications requiring fast and controllable protein adsorption and desorption, positioning it as an ideal tool for targeted protein recovery in various biochemical and industrial processes.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF POWER SOURCES
·
2023
·
IF 9.2
Xiaoyu Yang,Ying Qi,Peng Wei,Qixu Hu,Jian Cheng,Yahong Xie
Carbon-based CsPbI 2 Br perovskite solar cells (C–PSCs) have the advantages of low cost and stable performance, but the poor contact and energy mismatch between the perovskite layer and the carbon electrode lead to low power conversion efficiency (PCE). In this work, uniform spindle-shaped Fe 3 O 4 @NC composites have prepared by calcining Fe-based metal organic framework (Fe-MOF) NH 2 -MIL-88B(Fe), which has synthesized by solvothermal reaction using 2-aminoterephthalic acid as nitrogen and carbon sources. Using Fe 3 O 4 @NC composite and UV-Ozone treated Fe 3 O 4 @NC composite (Fe 3 O 4 @NC UVO) as the interfacial layer between the perovskite layer and the carbon electrode, the devices with a structure of FTO/SnO 2 /CsPbI 2 Br/interfacial layer/Carbon exhibit a maximum PCE of 12.25%, which is about 19.28% higher than that of the pristine device. The improved optoelectronic performance is mainly attributed to more matched energy level, denser interface contact, better carrier separation performance and better conductivity. After 19 days of storage at room temperature and ambient humidity, Fe 3 O 4 @NC UVO device has retained 87% of the initial PCE. This work provides a simple and effective strategy to improve the PCE and stability of carbon-based CsPbI 2 Br PSCs with Fe-MOFs-derived carbon materials .
✓ 已验证
产品关联
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2023
·
IF 4.8
Haixia Hu,Mingqin Wu,Liping Yao,Huiling Deng,Jiang Hu,Yukun Huang,Xiao Yang,Lijun Wang,Xianggui Chen
Recently, aptamer-enhanced nanozyme activity sensing platforms have gained considerable attention in the bioanalytical and diagnostic fields due to their simplified operations, rapid speed of analysis and visual observation convenience. However, the ability of an aptamer to enhance nanozyme activity has thus far been restricted by oligonucleotide type and length, in turn resulting in the typically high limit of detection (LOD) of aptamer-enhanced nanozyme activity sensing platforms. In this study, a novel cytosine-rich single-stranded DNA (C-rich ssDNA) was designed to overcome these drawbacks and, thereby, significantly enhance the peroxidase-like activity of Fe 3 O 4 @Au nanoparticles (NPs). The ability of this C-rich ssDNA to enhance the peroxidase-like activity of Fe 3 O 4 @Au NPs was shown to be 30% more effective than aptamers. To verify this outstanding performance, a C-rich ssDNA-enhanced Fe 3 O 4 @Au NPs activity sensing platform was developed for the detection of Salmonella Typhimurium ( S. Typhimurium). Under optimum conditions, the novel colorimetric method realized quantitative S. Typhimurium determination ranging from 2.8 × 10 1 to 2.8 × 10 6 CFU/mL, with an ultralow detection limit of 1.8 CFU/mL. Additionally, the feasibility of the proposed colorimetric method was validated in spiked lettuce and milk, with LODs of 2.7 and 3.2 CFU/mL, respectively. These results indicate the significant potential of this novel colorimetric method for effective S . Typhimurium detection in food samples.
✓ 已验证
产品关联
DOI
高影响因子
Frontiers in Bioengineering and Biotechnology
·
2023
·
IF 5.7
Xinglong Shi,Jifa Liu,Guannan Wang
Hepatocellular carcinoma (HCC) is one of the most commonly diagnosed and malignant cancers worldwide. Conventional therapy strategies may not completely eradicate the tumor and may cause side effects during treatment. Nano-catalytic therapy, as a novel strategy, has attracted a great deal of attention. This study aimed to synthesize a multifunctional magneto-gold nanozyme AuNC@Fe 3 O 4 and evaluate its anti-cancer potential in HepG2 cells in vitro . The characteristics of AuNC@Fe 3 O 4 were assessed using a transmission electron microscope, dynamic light scattering, and energy-dispersive X-ray. The photothermal performance and peroxidase (POD)-like activity of AuNC@Fe 3 O 4 were detected, using thermal camera and ultraviolet-visible spectrophotometer, respectively. The anti-cancer potential of AuNC@Fe 3 O 4 was examined using cell counting kit-8, live/dead cell staining, and apoptosis analysis. Further research on HepG2 cells included the detection of intracellular reactive oxygen species (ROS) and lysosomal impairment. We observed that the AuNC@Fe 3 O 4 had a small size, good photothermal conversion efficiency and high POD-like activity, and also inhibited cell proliferation and enhanced cell apoptotic ability in HepG2 cells. Furthermore, the AuNC@Fe 3 O 4 enhanced ROS production and lysosomal impairment via the synergistic effect of photothermal and nano-catalytic therapies, which induced cell death or apoptosis. Thus, the magneto-gold nanozyme AuNC@Fe 3 O 4 may offer a potential anti-cancer strategy for HCC.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2023
·
IF 8.6
Jinxin Li,Dan Zhong,Feiyu Li,Kefei Li,Wencheng Ma,Jun Ma,Jingna Zhang,Aoshuang Sun
A bifunctional electro-Fenton (EF) cathode with Fe 3 O 4 -LaFeO 3 /C embedded graphite felt (GF) was synthesized through a hydrothermal process, which was used for in situ electrochemical formation of active oxygen species (ROS) for coal pyrolysis wastewater (CPW) removal. Experimental results illustrated that the mineralization efficiency of dimethylphenol (DMP) was achieved at 90.7 % within 150 min reaction. On the basis of quenching test and free radical detection, the ∙OH and ∙O 2 − were the detectable ROS in the hetero-EF system for DMP removal. Meanwhile, the formed oxygen vacancies (OVs) and the redox of Fe 2+ /Fe 3+ promoted the oxygen adsorption and H 2 O 2 activation. Density functional theory (DFT) calculations further discussed that the Fe 3 O 4 -LaFeO 3 interface possessed more downward spin density of states in the conduction band, resulting in a higher total density of states (DOS) value near the Fermi level. Moreover, the Fe 3 O 4 -LaFeO 3 /C/GF cathode displayed good recyclability with low metal ion dissolution for 5 times (99.5 % DMP removal and 78.6 % TOC removal) and underlying actual CPW application potential (80.2 % of COD removal and 100 % of total phenol (Tph) removal). Overall, this work invented a novel and stable bifunctional cathode for the efficient removal of refractory CPW in the hetero-EF system.
✓ 已验证
产品关联
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2023
·Vol. 47
·期 19
·9143-9152
·
IF 3.3
Yaxiong Zhao,Ming Zhou,Ruifeng Ni,Yi Li,Jiangyu Huang,Zhenyu Li,Jingyu Chen
Pseudocapacitive electrodes with high rate retention and good cycling stability are highly desirable in constructing high-performance supercapacitors due to their rapid charge/discharge capacity and long service life, but they are still a challenge to realize. Herein, a ternary Fe3O4/reduced graphene oxide/phytic acid (PA)-doped polyaniline (F-RGO-p-PANI) hybrid has been prepared to address this challenge. Prompted by the multiple synergistic effects among RGO, Fe3O4, PA, and PANI, our F-RGO-p-PANI material exhibits a high specific capacitance (Cs) of 459.1 F g−1 with a current density of 0.5 A g−1. Interestingly, our supercapacitor displays both high capacitance retention (∼83.5%) under a broad current density range (from 0.25 to 20 A g−1) and high cycling stability (∼80.8%) over 10 000 cycles under a high current density (20 A g−1), better than previous results. Moreover, our supercapacitor also shows a high specific energy density of 58.1 W h kg−1 with a power density of 0.5 kW kg−1. These results imply that our ternary F-RGO-p-PANI holds tremendous potential in fabricating rapidly charged/discharged supercapacitors.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）