Small
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2026
·
IF 11.8
Yi Huang,Sihang Liu,Shuai Yin,Lian Xiao,Yugang Zhao,Zhi Tao,Haiwang Li
Understanding droplet-liquid pool interactions in immiscible systems is critical for advancing fluidic encapsulation strategies. Here, we uncover a previously unreported ‘endocytosis’ phenomenon in which an aqueous droplet impacts a deep immiscible pool and spontaneously engulfs the pool liquid, forming a stable double-layered liquid structure. This process origins from the focusing of capillary waves at the droplet-pool interface and followed by a pinch-off of a central oil column via Rayleigh-Plateau instability. We propose a dimensionless criterion for central column formation, determined by whether viscous dissipation of the droplet's kinetic energy. By introducing a UV-crosslinkable precursor, gelatin methacryloyl (GelMA) into the droplet, we succeed in encapsulating pool liquid into hydrogel capsules with tunable core-shell ratios by simply adjusting the impact velocity. This enables precise control of release mechanism: thick-shell capsules exhibit non-Fickian sustained release, while thin-shell capsules display delayed burst Case II release upon swelling. The proposed ‘endocytosis’ phenomena offer a surfactant-free, single-parameter controlled strategy compared to conventional liquid encapsulation methods, which offers a new opportunity for on-demand release in drug delivery and responsive materials.
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高影响因子
REACTIVE & FUNCTIONAL POLYMERS
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2026
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IF 5.4
Ruiqi Song,Zhengtao Wu,Youchao Zhang,Zikang Zheng,Tianhao Chen,Haitao Wu,Xinxin Sang,Yan Yuan
Developed stepwise modification strategy for UV-curable gelatin-based conductive hydrogels. • Optimized water/glycerol solvent system to achieve outstanding long-term moisture retention. • Constructed hybrid ionic-electronic networks via carboxylated CNT reinforcement. • Demonstrated stable wide-range strain sensing for wearable human motion monitoring. Conductive hydrogels serve as core matrix materials for flexible strain sensors, but conventional hydrogels suffer from rapid water loss under ambient conditions and an inherent trade-off between mechanical and conductive properties. This work develops a gelatin/poly(acrylic acid) composite conductive hydrogel synergistically functionalized with glycerol for moisture retention, aluminum salts for ionic crosslinking, and carboxylated multi-walled carbon nanotubes (c-MWCNTs) for reinforcement. Moisture retention is optimized by tuning the water-to-glycerol ratio, and three aluminum salts are compared to identify the optimal crosslinker. Multi-dimensional characterizations reveal interfacial interactions and microstructural evolution, and the regulatory effect of c-MWCNTs loading on electromechanical and sensing properties is systematically investigated. At a water-to-glycerol ratio of 50:50, the hydrogel retains over 82% water after 7 days of ambient storage. The aluminum chloride system exhibits the optimal ionic conductivity and balanced mechanical performance. With 0.025 wt% c-MWCNTs uniformly embedded via hydrogen bonding and coordination interactions, both conductivity and tensile toughness are significantly enhanced. The resulting flexible strain sensor features stable sensitivity over a wide strain range and excellent fatigue resistance, enabling accurate monitoring of human joint motions and showing great potential for wearable health monitoring. Download: Download high-res image (220KB) Download: Download full-size image
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Advanced Photonics Nexus
·
2026
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IF 6.3
Jiale Chen,Yuxiao Xiong,Ye Lu,Weisheng Zhang,Kunjue Shang,Zhenzhen Li,Mingsi Lai,Haolin Chen,Zhouyi Guo,Bo Xu,Zhiming Liu
Tumor-associated macrophages, the largest population of immune cells in the tumor microenvironment (TME), dominate the complexity of TME due to their highly phenotypic plasticity, leading to personalized tumor progression, differentiated drug response, and tolerance. However, current methods for the interpretation of cellular heterogeneity involve destructive, cumbersome, and high-cost sample pretreatment procedures. Herein, we present surface-enhanced Raman scattering cytomics (SERS-Cytomics) as a non-destructive and low-cost approach for macrophage phenotyping and metabolic profiling. SERS-Cytomics is capable of providing the whole molecular fingerprints of living cells at a single-cell level. A deep-learning model enables accurate classification of three phenotypes of macrophages exceeding 95%. Further, the Shapley additive explanations analysis is adopted to screen the differential metabolic signals, where two metabolic biomarkers at 1071 (glucose) and 1440 (cholesterol) cm−1 display the maximum weight in the classification of M1 and M2 macrophages, respectively. Correlation explanation of SERS-Cytomics and transcriptomics reveals the involvement of the glycolytic pathway and lipid metabolism in M1 and M2 macrophages, respectively. Therefore, SERS-Cytomics enables an efficient and non-destructive analytical tool for cellular heterogeneity explanation at a single living cell level.
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CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Qinghua Liu,Leihuan Mu,Hui Liu,Jiehui Li,Ruizhe Zhang,Jinmei He,Lei Zhu,Mengnan Qu
A fibrous electronic textile couples passive thermal management with multimodal physiological sensing. • Radiative cooling suppresses solar heat accumulation under outdoor conditions. • Decoupled pressure and temperature sensing enables reliable dual-parameter perception. • Hydrophobic fibrous surfaces provide self-cleaning capability against dust contamination. • The MPS enables simultaneous monitoring of pulse, respiration, skin temperature, and distress signals. In response to the impact of heat accumulation on the sensing reliability and wearing comfort of wearable sensors in hot outdoor environments, this study was inspired by the surface microstructure and multisensory perception characteristics of the tropical white beetle Cyphochilus . By integrating electrospinning and screen printing techniques, we developed a fiber-based multifunctional piezoresistive sensor (MPS) combining passive daytime radiative cooling, hydrophobic protection (WCA = 135.0 ± 0.4°), and pressure/temperature monitoring. The separated pressure and temperature sensing units enable signal decoupling, achieving sensitivities of 7.51 kPa −1 and − 1.3% °C −1 , respectively, for stable and simultaneous monitoring of carotid pulse, respiratory activity, and skin temperature. Meanwhile, the polylactic acid/calcined kaolin top layer provides passive thermal regulation, exhibiting a solar reflectance of 85.4% and a broadband infrared emissivity of 91.8%, achieving an approximately 4.0 °C reduction in surface temperature compared with ordinary white cotton fabric under outdoor sunlight exposure. This work provides a feasible strategy for integrating thermal management and multiparameter sensing in wearable electronics for complex environments. Download: Download high-res image (286KB) Download: Download full-size image
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APPLIED THERMAL ENGINEERING
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2026
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IF 7.5
Yuhang Wang,Xiaoke Wei,Canying Zhang,Daxiong Wu,Haitao Zhu
Fluorinated PI film integrates with BaHPO 4 /SiO 2 particles to form a Janus structure. • The film achieves 96.94% solar reflectivity and 94.70% MIR emissivity (6-16 μm). • Outdoor test shows 13 and 22 °C lower than commercial coatings and standard paints. • The film is flexible, durable, self-cleaning, and flame-retardant. Radiative cooling offers a promising passive strategy for thermal management of electronic devices; however, achieving the combination of high solar reflectivity, broadband mid-infrared (MIR) emissivity, and robust mechanical performance remains challenging. In this work, a fluorinated polyimide (PI)-based composite film with enhanced radiative cooling capability is developed via electrospinning followed by vacuum-assisted filtration. By incorporating BaHPO₄ and SiO₂ particles into a fibrous PI matrix, a gradient-structured composite is formed, enabling synergistic spectral regulation. The best-performing film exhibits a high average solar reflectivity of 96.94% (0.25-2.5 μm) and a strong broadband MIR emissivity of 94.70% (6-16 μm), matching the thermal radiation characteristics of typical electronic devices. The fabrication strategy also improves interfacial bonding, resulting in a tensile strength of 17.15 MPa. Experimental evaluations using a simulated electronic device demonstrate significant cooling performance, with temperature reductions of 13 °C and 22 °C compared to commercial high-reflectivity coatings and conventional paints, respectively. Additional tests confirm excellent flexibility, wear resistance, flame retardancy, hydrophobicity, and weather stability. This study provides a scalable approach to engineering high-performance radiative cooling films for energy-efficient thermal management of electronic systems operating under both indoor and outdoor conditions.
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JOURNAL OF FOOD BIOCHEMISTRY
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2026
·Vol. 2026
·期 1
·1491407
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IF 2.3
Hui Sun,Sam Al-Dalali,Fei Pan,Long Huang,Min Wei,Jinghan Wang,Rui Dai,Lingyun Wen,Miying Du,Zhigui He
This study investigated the effect of a polyphenolic ethanolic extract from Camellia nitidissima Chi (CNFC) flowers on the reduction of DSS-induced ulcerative colitis in a C57BL/6 mouse model by regulating antioxidant and anti-inflammatory mechanisms. The interaction of the fisetin molecule with essential anti-inflammatory proteins (NF-κB and NLRP3) and the antioxidant protein Keap1 was examined through molecular docking analysis. The phenolic content in CNFC was measured at 2.09 mg/g, while the flavonoid content was 2.80 mg/g. The ethanolic extract of CNFC showed IC 50 values of 0.605, 0.862, and 0.299 mg/mL against DPPH, ABTS, and OH·, respectively, indicating robust antioxidant activity. Three phenolic compounds have been identified for the first time in CNFC flowers: 6-hydroxyflavone, fisetin, and (2S,3S,4S,5R,6S)-6-[2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxochromen-7-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid. The model group mice experienced greater weight loss and had a colon length of 45 mm, much shorter than the intervention group’s 65 mm. The spleen inflammation index was 62.1 mg/10 g, markedly higher than the 44.2 mg/10 g in the intervention group. Additionally, the histopathology score of 7 exceeded that of the intervention group, as did the disease activity index score of 7, compared with the intervention group’s score of 1. The binding interactions of fisetin with NF-κB, Keap1, and NLRP3 proteins indicate a potential affinity for these proteins. CNFC exhibits notable antioxidant and anti-inflammatory properties, and this study offers a technical reference and theoretical foundation for advancing CNFC as a functional and therapeutic food. The present study was designed to elucidate the antioxidant and anti-inflammatory mechanisms of CNFC in DSS-induced colitis, which may serve as a reference for future studies of the multiomics profiles of CNFC’s therapeutic activity, such as gut microbiome profiling, Western blotting, and qPCR-based assessment of related gene expression, for a more detailed understanding.
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ACS Applied Materials & Interfaces
·
2026
·Vol. 18
·期 33
·44984-45002
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IF 7.8
Wang Shuaihang,Ji Zhonghao,Shen Ding,Liu Siyu,Hao Jingbin,Cheng Qi,Jia Bao,Guo Liang,Shang Jie,Chen Kai,Han Meng
Currently, the repair of bone defects faces multiple challenges, including insufficient angiogenesis and limited osteogenic differentiation capacity, which pose significant obstacles to treatment. In this study, a ternary composite scaffold composed of PCL-nHA-nMgO (PHM) was fabricated using 3D printing technology. After surface modification with a photothermal polydopamine (PDA) coating, a PHM@PDA composite scaffold was obtained. Metformin (Met) and PDA were loaded into GelMA hydrogels to produce GPM hydrogels. The GPM hydrogels were then packed into the PHM@PDA composite scaffolds, resulting in near-infrared region-I (NIR-I)-responsive PHM@PDA/GPM composite scaffolds. The outer GPM layer serves as a three-dimensional in vivo-like microenvironment, providing physical transport channels for cellular nutrient exchange. Upon stimulation by NIR-I, the scaffold enables the dynamic release of Mg 2+ and Met, upregulates the expression of the VEGF and KDR, accelerates vascular network reconstruction, and creates a mild microenvironment conducive to cell proliferation. Furthermore, by activating the PI3K/AKT signaling pathway, it promotes the expression of osteogenesis-related factors (such as transcription factor Sp7, alkaline phosphatase, and osteocalcin), thereby accelerating the osteogenic differentiation process. In vivo animal experiments, micro-CT and tissue staining confirmed that, under near-infrared light (NIR-I) stimulation, this scaffold significantly increased bone mineral density, trabecular bone thickness, and trabecular bone count and demonstrated excellent angiogenic effects. In summary, this NIR-I-responsive composite scaffold can meet the dual requirements of reconstructing the vascular network and promoting osteogenic differentiation, enabling personalized precision therapy and offering a promising new treatment strategy for complex bone defects where vascular regeneration and osteogenic differentiation are challenging.
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PubMed
高影响因子
PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
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2026
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IF 7.9
Hengxin Liu,Ruohan Li,Yueming Han,Yuntao Guan,Lixun Zhang
Intensive rice cultivation faces the dual challenges of low nitrogen use efficiency and heavy metal pollution risk. In this study, a previously developed magnesium–iron layered double hydroxide-loaded biochar (Mg/Fe-LDH@BC) composite was evaluated in paddy soil to determine its effects on nitrogen retention, heavy metal activity, crop growth and bacterial community organization. With the addition of the 1% Mg/Fe-LDH@BC, NH 4 + −N retention increased by 41.7% while NO 3 - −N accumulation decreased by 9.8%. Meanwhile, NH 3 volatilization decreased by 24.2%, and N 2 O emissions were reduced by over 50%. These changes were accompanied by increased rice biomass and grain dry mass, together with decreased concentrations of multiple geochemically reactive metals. Microbial community analysis showed that this material reshaped the topology of the bacterial co-occurrence network. The 1% Mg/Fe-LDH@BC material formed the most complex network (1446 nodes and 11,063 edges) and shifted key species from slow-growing groups (such as Syntrophus ) to metabolically active groups associated with carbon, iron, and sulfur cycles (e.g., Streptomyces , Pelobacter , and Thiobacillus ). This network exhibited both high connectivity and a highly modular structure, indicating a more interconnected and compartmentalized pattern of microbial associations. Furthermore, the porous structure of BC may create micro-anaerobic niches that support the survival of anaerobic taxa (e.g., Anaerolinea ). Although the LDH can directly immobilize heavy metals through physicochemical mechanisms, sulfur cycle-related bacteria (e.g., Desulfatitalea ) were identified as key species in the network, suggesting that microorganisms may contribute to in situ heavy metal immobilization through sulfide production.
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高影响因子
Nature Communications
·
2026
·
IF 18.1
Liu Xu,Cao Miao,Jia Feiyue,Jia Hongbao,Li Zonglin,Guo Xueping,Zhang Junrong,Hua Weijie,Li Lina,Wu Qian,Zhao Hongying
Antibiotic-resistant bacteria (ARB) and their genes (ARGs) pose a significant risk to public health and the ecosystem. Conventional water disinfection efficiently eliminates pathogens, however, it requires intensive chemical consumption but inefficiently removes ARGs. Herein, we propose an on-demand electrochemical platform that simultaneously eliminate both ARB and ARGs with in-situ generated hydroxyl radicals (·OH) without additional chemical inputs. Single-atom copper catalysts with CuN 4 coordination structure (SA-CuN 4 /NC) are precisely tuned to directly convert oxygen into controllable ·OH via three-electron oxygen reduction reaction (3e⁻ ORR). Operando X-ray adsorption near-edge spectroscopy reveals a potential-driven self-reconstruction of single-atom Cu sites to optimize ·OH concentration. Specially, the preferentially adsorbed H + onto the adjacent N atoms promotes the breaking of Cu-N bonds to form stable Cu 2 -CuN 2 cluster as a genuine active site. As expected, the SA-CuN 4 /NC with moderate ·OH (~11.5 μM) exhibits ultra-fast degradation of E. coli HT115 , accomplishing an ~ 8 log removal within 1 min and a complete elimination of ARGs in 30 min. Excess ·OH (~47.9 μM) triggers bacterial aggregation which compromises bacterial inactivation. These findings demonstrate that 3e⁻ ORR is a sustainable and effective strategy to obtain fast and complete water disinfection, preventing environmental spread of ARGs.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2026
·
IF 9.6
He Li,Shuo Liu,Huiwu Huang,Zixin Dai,Lu-Bin Zhong,Zhaoling Li,Jianyong Yu,Shichao Zhang
A sponge assembled by curly and hollow carbon fibers was fabricated in one step. • The curly structure of the carbon fibers endowed the sponge with good elasticity. • The carbon sponge demonstrated radiative heating and Joule heating capabilities. • The sponge exhibited striking oil absorption performance and good recyclability. Oil spill accidents cause severe damage to the ecological environment and social resources, highlighting an urgent need for high-performance oil adsorption materials. However, existing materials typically suffer from limited adsorption capacity and unsatisfactory oil retention, hindering their effectiveness in oil remediation. Here, inspired by lotus stems, a curly carbon micro/nanofiber sponge with hollow channels is created based on phase-driven shrinkage electrospinning for high-efficiency oil remediation. By regulating the asymmetric shrinkage degree and compatibility of polymer precursors, curly fibers are induced to form and then entangle to assemble into a fluffy sponge during the rapid phase separation and solidification process of the jet; the carbon micro/nanofiber sponge with hollow channels is subsequently constructed through high-temperature template removal. Benefiting from the entangled network formed by curly fibers, the carbon sponge exhibits remarkable elasticity (almost no plastic deformation after 500 compression cycles) while maintaining high porosity. Furthermore, the sponge demonstrates outstanding oil adsorption performance (up to 37 g/g) and good recyclability, as well as the capability for all-weather oil cleanup enabled by the synergistic effect of its photothermal and electrothermal properties. This work offers a new perspective for developing advanced carbon sponges for applications in the energy and environmental fields. Download: Download high-res image (251KB) Download: Download full-size image
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STAR Protocols
·
2026
·Vol. 7
·期 3
·104786
·
IF 1.4
Yuchen Huang,Lexuan Hou,Lin Zhu,Xi Yang,Gang Li
Summary Here, we present a dynamic combinatorial library-versus-proteome activity-based protein profiling (DCL-ABPP) workflow for high-throughput covalent ligand discovery. We describe steps for integrating a dynamic combinatorial library with proteome-wide mass spectrometry to generate and screen hundreds of ligands in situ , eliminating the need for pre-synthesis. We detail procedures for two complementary modes: competitive screening, which identifies enzyme inhibitors (e.g., serine hydrolases) through family-wide probe competition; and direct screening, which maps covalent ligand binding sites on cysteines. For complete details on the use and execution of this protocol, please refer to Huang et al. 1
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JOURNAL OF CATALYSIS
·
2026
·
IF 6
Xiaoqiang Zhang,Quanlei Wang,Chuang Wang,Junli Ren,Xinze Du,Huixiang Li,Da-Ming Gao
Efficient hydrodeoxygenation (HDO) of biomass-derived phenolics relies on the effective coupling of hydrogen activation and C-O bond cleavage. Here, we report a Ni-NiO interfacial catalyst that enables interfacial synergy by integrating hydrogenation and deoxygenation functions within a confined nanoscale interface. By tailoring the reduction temperature of NiO/Al 2 O 3 , the Ni/NiO ratio is precisely controlled, with the catalyst reduced at 400 °C exhibiting highly dispersed Ni species intimately interfaced with NiO. Mechanistic studies suggest that hydrogen dissociated on metallic Ni can spill over to adjacent NiO, generating interfacial hydrogen species and enhanced acidity that facilitate C-O bond cleavage. Meanwhile, the close proximity of Ni and NiO enables efficient coupling of the hydrogenation and deoxygenation functions, thereby promoting rapid tandem conversion at the interface and lowering the apparent activation barrier for vanillin HDO.
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危险品化学品经营许可证（带存储）