查找使用阿拉丁产品的科研文献

A combination strategy of HPLC and boric acid modified β-CD polymer for super-efficiently separating chiral substances with O/N atoms in chiral and/or adjacent carbons

Xiaoqian Yuan,Yuchen Cui,Yaqin Nan,Ruijun Tang,Xinru Wang,Yanmei Xu,Xinghua Jin,Yiwen Wang,Ding Cheng,Youxin Li

Background Cyclodextrins (CDs) and their derivatives have been widely used as chiral selectors in HPLC. However, many derivatized CDs lack specificity for certain drugs and often exhibit limited resolution. Furthermore, their synthesis typically involves complex multi-step procedures, hindering scalability and cost-efficiency. To overcome these limitations, this study aims to develop a simple and scalable boric acid-modified β-cyclodextrin polymer (BA-β-CDP), targeting chiral substances with O/N atoms in chiral and/or adjacent carbons. Results BA-β-CDP was synthesized on a large scale using inexpensive reagents and a random substitution strategy, avoiding tedious protection-purification steps. Structural and chromatographic compatibility was confirmed by nine characterization techniques. In HPLC using the chiral mobile-phase additive (CMPA) method, BA-β-CDP enabled the efficient separation of 25 racemates. Among them, 24 achieved complete or baseline separation, and 10 exhibited resolution (Rs) values > 10. Typical cases included bisoprolol (Rs = 48.19), propranolol (Rs = 45.50), chlorpheniramine (Rs = 38.36), and metoprolol (Rs = 20.26). Additionally, the material demonstrated excellent batch-to-batch reproducibility, recyclability, and reusability. Significance and novelty This work presents a practical and cost-effective chiral selector. The synergistic mechanism offers strong and specific recognition toward chiral substances with O/N atoms in chiral and/or adjacent carbons. This approach represents a novel strategy for efficient and economical HPLC-based enantioseparation using widely accessible materials and methods.

Synthesis of Liquid Polysilazoxanes for Si?O?C?N Ceramics With Adjustable Composition and High-Temperature Properties

Chiyuan Wang,Xin Long,Changwei Shao,Jiawei Huang,Jiaqi Ren

Preparing polysilazoxanes with a controlled molecular structure is the ideal route for fabricating Si  O  C  N ceramics with adjustable composition and properties. In this paper, liquid polysilazoxanes were synthesized via a controlled substitution reaction between trichlorosilane and alcohols (R  OH), followed by the condensation with ammonia. By adjusting the alkyl groups (R tert -butyl, dioxane and triazolylmethyl) of alcohols, three kinds of polysilazoxanes with Si  N  Si backbones, but different side chains were synthesized. During high-temperature pyrolysis, tert -butoxy groups in polysilazoxanes are easily removed, producing low-carbon (< 4 wt%) ceramics, while dioxane and triazolylmethyl groups decompose to form oxygen-rich and nitrogen-rich ceramics, respectively. Due to the composition distinction, the resulting Si  O  C  N ceramics showed quite different high-temperature behavior. This report provides a direct and effective method for obtaining polysilazoxanes with a controlled molecular structure, which is useful for fabricating Si  O  C  N ceramics with improved high-temperature performance.

The 2-EHA-AA-MMA terpolymer binder realizes a long-chain sulfur SPAN cathode via S-O covalent anchoring to construct high-capacity and shuttle-free Li-S batteries

Xinyou Zhang,Yutong Yang,Jianxin Wang,Jianjiao Xin,Wendi Wang,Yao Chen,Guangming Yin,Hong Pan

Among various cathode materials, sulfurized polyacrylonitrile (SPAN) is considered a highly promising cathode for Lithium-sulfur (Li-S) batteries due to its unique covalent sulfur fixation mechanism, which fundamentally suppresses polysulfide dissolution and the shuttle effect. However, conventional SPAN materials typically limit sulfur chains to short S 2 -S 4 structures to maintain a solid-solid reaction, restricting their theoretical capacity. Moreover, the material's insulating nature and significant volume changes during cycling greatly limit its electrochemical performance and practicality. To address these issues, this study designed and synthesized a high-elasticity water-based binder based on a 2-ethylhexyl acrylate/acrylic acid/methyl methacrylate (2-EHA-AA-MMA) terpolymer. Abundant carboxyl groups (-COOH) in its molecular chain form stable S-O covalent bonds with sulfur chains in SPAN. Combined with PAN's terminal fixation of sulfur chains, this achieves a synergistic “long-chain capacity enhancement and strong anchoring shuttle suppression” effect. It stabilizes long S 6 chains, improving cycling stability and reversible capacity, while also directing S 6 conversion directly to Li 2 S 3 , bypassing soluble Li 2 S 4 intermediates to suppress shuttle effects at the source. Experimental results show that the SPAN cathode with this binder delivers a high specific capacity of 850.3 mAh g −1 at 0.1 C, with 68.4% capacity retention after 100 cycles and effective polysulfide shuttle suppression.

From commercial melamine foam to C-O-M coupled La-doped MgAl-borate LDH/nitrogen-doped carbon composite: a multipollutant adsorbent for wastewater remediation over a broad pH range

Chen Tan,Jing Miao,Kanghui Liu,Aichun Zhao,Xinlong Guo,Linjie Qin

Developing cost-effective adsorbents capable of treating multipollutant wastewater under fluctuating pH conditions remains a major challenge for layered double hydroxide (LDH)-based materials. Herein, we report a La-doped MgAl-borate LDH/Nitrogen-doped carbon hybrid (LaMgAl-BLDH/NC) constructed through a C-O-M interfacial coupling, in which hydroxyl-rich N-doped carbon reacts with the metal‑oxygen layers of LaMgAl-BLDH to form robust covalent C-O-M linkages. This bonding-directed assembly produces a chemically durable and strongly integrated 3D porous network with enhanced charge heterogeneity and improved resistance to acidic or alkaline corrosion. Benefiting from this strengthened interfacial coupling and the synergistic effects of La incorporation, the LaMgAl-BLDH/NC composite exhibits high removal capacities toward structurally diverse pollutants, achieving maximum capacities of 995.20 mg/g for Congo red, 3020.19 mg/g for malachite green, and 151.34 mg/g for phosphate. Notably, compare with conventional LDHs that undergo structural degradation in acidic or alkaline environments, the C-O-M reinforced hybrid maintains excellent performance over a broad pH range of 4–10. The maximum adsorption capacities of the adsorbent for Congo red, malachite green and phosphate at pH 2, 4 and 12 correspond to 79.65%, 87.32% and 58.83% of those obtained at their respective optimal pH values. Mechanistic analysis reveals that electrostatic interaction, ion exchange, π-π stacking, pore filling jointly govern the removal process. Optimization via Box-Behnken response surface methodology further enhances removal efficiency by identifying favorable synthesis and operational conditions. This work establishes a generalizable, low-cost C-O-M bonding strategy for pH-tolerant LDH/carbon hybrids, enabling efficient remediation of multipollutant industrial wastewater.

Variation of Ni and Mg dopants in spinel ZnIn2(O,S)4 microflower to generate NiIn− and MgIn− substitutional defects for a high-rate visible-light-induced hydrogen generation

Hairus Abdullah,Sethupathi Shanmugasundaram,Mohamed Tarek Ahmed,Hardy Shuwanto,S.K. Krishna,Dong-Hau Kuo

Carbon-free based fuels are a promising solution to overcome the world energy crisis and environmental pollution . Therefore, hydrogen fuel is a critical and sustainable energy source to replace the limited carbon-based fossil fuels, which can be generated using a simple photocatalysis method. Herein, we demonstrated that Ni- and Mg-doped ZnIn 2 (O,S) 4 (NMZI) photocatalysts prepared with a hydrothermal process performed an unprecedented HER rate without a noble-metal cocatalyst under visible-light illumination. The amounts of Ni and Mg dopants in NMZI were varied and the as-prepared NMZI were characterized with SEM, TEM, XRD, Raman, FTIR, XPS, EPR, DRS, PL , EIS, TPC , CV, and tested for photocatalytic HER . It was found that the Ni and Mg co-dopants induced substitutional surface defects of Zn In − , Ni In − , and Mg In − . As a result, the formation of oxygen vacancy ( V O 2 + ) compensated the induced defect charges, which are crucial in the HER mechanism. EDS, ICP, and XPS analyses suggest a non-stoichiometric Zn(Zn,Ni,Mg,In) 2 (O,S) 3.5 with Zn, Ni, and Mg occupying In sites in the structure. The NMZI catalyst could achieve a maximum HER rate of 9.4 mmol/g․h under visible-light illumination. It is believed that the HER performance improvement is due to the defect formation on NMZI catalyst that subsequently enhances the optical, electrochemical, and photocatalytic properties. The photocatalytic HER mechanism has been elucidated and discussed thoroughly in this work.

Design and synthesis of novel 7-ethyl-10-fluoro-20-O-(cinnamic acid ester)-camptothecin derivatives as potential high selectivity and low toxicity topoisomerase I inhibitors for hepatocellular carcinoma

Yin-Peng Bai,Cheng-Jie Yang,Nan Deng,Mi Zhang,Zhi-Jun Zhang,Lei Li,Yong Zhou,Xiong-Fei Luo,Chuan-Rui Xu,Bao-Qi Zhang,Yue Ma,Ying-Qian Liu

A series of new 7-ethyl-10-fluoro-20-O-(cinnamic acid ester)-camptothecin derivatives were synthesized and evaluated for cytotoxicity against four human tumor cell lines including HepG2 (hepatocellular carcinoma), SW480 (colorectal cancer), A2780 (ovarian cancer), and Hucct1 (intrahepatic cholangiocarcinoma). The results of cytotoxic activities in vitro showed that most of the camptothecin derivatives harbor promising cytotoxic activity against tested tumor cell lines. Among them, compound XJS-11 exhibited broad-spectrum inhibitory activities against HepG2, SW480, A2780, and Hucct1 cell lines with IC 50 values of 0.03, 0.09, 0.22, and 0.32 μM, respectively. Further investigation demonstrated that compound XJS-11 exhibited more effective growth inhibition against a variety of human hepatoma cells (Sk-hep-1, Hep3B and Huh7) and lower cytotoxicity against immortalized normal human liver cell line L02 than the positive control topotecan . Especially, XJS-11 showed higher selective toxicity in two kinds of human hepatoma cells and immortalized normal human liver cell line (IC 50(L-02) /IC 50(HepG2)  = 113.20; IC 50(L-02) /IC 50(Hep3B)  = 85.60) than topotecan (IC 50(L-02) /IC 50(HepG2)  = 9.45; IC 50(L-02) /IC 50(Hep3B)  = 8.52). Mechanistically, XJS-11 induced cell cycle arrest and cell apoptosis in HepG2 and Hep3B cells by inhibiting Top I activity in a manner similar to that of topotecan. Meanwhile, XJS-11 could attenuate the tumor growth in both xenograft and primary HCC mouse models. In addition, the acute toxicity assay showed that XJS-11 did not cause lethality or significant body weight loss with a single intraperitoneal dose at 100 mg/kg or with an intraperitoneal dose at 25 mg/kg for 7 days. Moreover, unlike topotecan, XJS-11 had no apparent toxicity to the mouse liver, kidney, and hemopoietic system of the C57BL/6 mice. Taken together, XJS-11 merits further development as a new generation of the camptothecin-derived drug candidate.

Cobalt and titanium co-doped zinc ferrite film photoanode with boosted interfacial photoelectrocatalytic activity for efficient degradation of tetracycline via the covalency competition in the Zn-O-Fe backbone

Wei Deng,Kun Xiong,Nina Ge,Miao Yu,Lin Chen,Jun Wang

For efficient removal of the residual tetracycline (TC) in the aquatic environment, a novel cobalt (Co) and titanium (Ti) co-doped zinc ferrite (CoTiZFO) film was prepared via the Langmuir-Blodgett (LB) method in this study. With the co-doping of Co and Ti, the interfacial photoelectrocatalytic (PEC) activities for degradation of TC by the LB-assembled CoTiZFO (LB-CoTiZFO) films were significantly improved. As the applied voltage was 0.6 V in a two-electrode system, the five-layered LB-CoTiZFO (LB-CoTiZFO-5) films exhibited the optimal TC degradation rate and mineralization rate, which were accordingly 92.85% ± 1.45% and 81.92% ± 0.26%. In the same case, the kinetic rate constant ( k ) for PEC degradation of TC by the LB-CoTiZFO-5 films is equivalent to 3.3-fold of that by the films without the co-doping of Co and Ti. Under the PEC circumstances, the Co 3+ and Ti 4+ in the LB-CoTiZFO-5 film would be reduced to Co 2+ and Ti 3+ , while the Fe 2+ was oxidized to Fe 3+ , which results in the surface rearrangement of the LB-CoTiZFO-5 film. In addition, the Density Functional Theory (DFT) calculation results manifest the covalency competition in the Zn-O-Fe backbone can lead to the Fe-O bond breakage, the bare Fe metals with unpaired valence electrons will diffuse to the Helmholtz layer and serve as active sites, which endows the LB-CoTiZFO-5 films with boosted interfacial PEC activities. Therefore, the LB-CoTiZFO-5 film photoanode shows great prospective in efficient PEC degradation of TC.

Ag/APTES/CuxO (x = 1, 2)-MGS-Coated No-Core Fiber Surface Plasmon Resonance Gas Sensor and Its Application in Hydrogen Sulfide Detection

Cheng Li,Liu Xiao,Xiaozhan Yang,Wenlin Feng

Liquid-liquid extraction and purification of oil red O derived nitrogen-doped highly photoluminescent carbon dots and their application as multi-functional sensing platform for Cu2+ and tetracycline antibiotics

Lijuan Yang,Jing Zeng,Tian Quan,Shaochi Liu,Linlin Deng,Xun Kang,Zhining Xia,Die Gao

Oil red O was applied as precursor to synthesize nitrogen-doped carbon dots (NCDs) by a facile solvothermal method for the first time. Surprisingly, liquid–liquid extraction and purification resulted in the quantum yield (QY) of NCDs up to 68%. The purification mechanism is based on the difference in polarity and solubility between precursor, over-carbonized substances and NCDs. Further, optical properties and structure characterizations of NCDs were characterized by ultraviolet (UV) spectroscopy, fluorescence (FL) spectroscopy, transmission electron microscopy (TEM), Fourier-transform infrared (FT-IR) spectroscopy, X-ray photoelectron spectroscopy (XPS) and X-ray diffraction (XRD). Importantly, NCDs can be acted as an outstanding multi-functional sensing platform for Cu 2+ and tetracycline antibiotics (TCs). Compared with other coexisting metal ions and antibiotics, this platform showed special responses to Cu 2+ and TCs. NCDs showed high selectivity and sensitivity of fluorescence response to Cu 2+ over a broad range of 10 nM −50 μM and a satisfactory detection limit (LOD)of 4 nM. Besides, NCDs also showed high sensitivity for the detection of TCs with a LOD range of 50 pM-100 nM. In addition, the fluorescent quenching mechanism of Cu 2+ and TCs to NCDs were identified as IFE and static quenching. Finally, the platform was successful applied to detect Cu 2+ and TCs in actual samples (e.g., water, milk, urine) with satisfactory results. All results indicated that NCDs appeared to have tremendous potential for Cu 2+ and TCs detection in various fields.

The roles of breast cancer resistance protein (BCRP/ABCG2) and multidrug resistance-associated proteins (MRPs/ABCCs) in the excretion of cycloicaritin-3-O-glucoronide in UGT1A1-overexpressing HeLa cells

Shishi Li,Jinjin Xu,Zhihong Yao,Liufang Hu,Zifei Qin,Hao Gao,Kristopher W. Krausz,Frank J. Gonzalez,Xinsheng Yao

Cycloicaritin is a bioactive natural phenolic compound from Epimedium species. However, the glucuronidation and excretion which would influence oral bioavailability and pharmacokinetics of cycloicaritin still remain unknown. Here we aimed to establish UGT1A1 stably transfected HeLa cells, and to determine the contributions of BCRP and MRPs transporters to excretion of cycloicaritin-3- O -glucuronide. First, β-estradiol was used to validate the expression of active UGT1A1 protein in engineered HeLa1A1 cells. Furthermore, Ko143 (5 and 20 μM) led to a significant decrease (42.4%–63.8%, p  < 0.01) in CICT-3-G excretion and obvious accumulation (19.7%–54.2%, p  < 0.05) of intracellular CICT-3-G, while MK571 (5 and 20 μM) caused a significant reduction (46.8%–64.8%, p  < 0.05) in the excretion and obvious elevation (50.7%–85.2%, p  < 0.01) of intracellular level of CICT-3-G. Furthermore, BCRP knocked-down brought marked reduction in excretion rates of CICT-3-G (26.0%–42.2%, p  < 0.01), whereas MRP1 and MRP4-mediated silencing led to significant decrease in the excretion of CICT-3-G (23.8%–35.4%, p  < 0.05 for MRP1 and 11.9%–16.0%, p  < 0.05 for MRP4). By contrast, neither CICT-3-G excretion nor CICT-3-G accumulation altered in MRP3 knocked-down cells as compared to scramble cells. Taken together, BCRP, MRP1 and MRP4 were identified as the most important contributors for CICT-3-G excretion. Meanwhile, the UGT1A1 modified HeLa cells were a simple and practical tool to study UGT1A1-mediated glucuronidation and to characterize BCRP and MRPs-mediated glucuronide transport at a cellular level.

Construction of W/O/W microcapsules based on the combination of polyglycerol polyricinoleate/protein for the co-encapsulation of crocin and quercetin: Physical properties, stability and in vitro digestion

Wei Fan,Yan Shi,Yueming Hu,Shu Wang,Jing Zhang,Wei Liu

Due to health reasons of polyglycerol polyricinoleate (PGPR), there has been a growing interest in reducing it. To address this, this study developed the PGPR/Protein (whey, pea, and chickpea protein isolates) emulsifier combinations. The effects of these combinations on the preparation, structure, physicochemical and in vitro digestive properties of W/O/W microcapsules were evaluated. The FTIR and XRD analyses revealed hydrogen bonding interactions between the protein and PGPR (or bioactive compounds), which may contribute to the enhanced encapsulation efficiency (EE) and stability of microcapsules. PGPR/pea protein isolate (PP) microcapsules exhibited more uniform size, better rehydration, and higher EE than other microcapsules. PP combinations prolonged shelf-life of microcapsules by 1.35 to 1.73-fold, as predicted by oxidation kinetic models. Furthermore, PP microcapsules improved the bioavailability of crocin (≥ 11.08 %) and quercetin (≥ 8.47 %). Overall, this study hoped to provide a promising strategy for preparing W/O/W microcapsules with low PGPR content.

Integrating gene knockout, GC-O-MS and multivariate statistical analysis: revealing the impact of fadA and bkdB genes on the aroma characteristics of Bacillus subtilis BJ3-2 fermented soybeans

Feng Wen,Yongjun Wu,Jing Jin,Lincheng Zhang,Shuoqiu Tong,Cen Li,Li Ran,Yuzhang Zhu

Fermented soybean products are an integral part of the Chinese diet, valued for their distinctive aroma. Bacillus subtilis ( B. subtilis ) BJ3-2 is a highly effective fermentation strain widely used in the industrial production of bacterial-type douchi. However, the specific aroma characteristics of soybeans fermented by this strain remain unclear. This study utilized gene knockout, GC-O-MS, and multivariate statistical analysis to comprehensively investigate the aroma components of soybeans fermented by B. subtilis BJ3-2. For the first time, 12 key aroma skeleton compounds were identified, including guaiacol, 2,5-dimethylpyrazine, and 2-methylbutyric acid, which primarily contribute to the smoky, roasted, and sweaty aroma attributes of fermented soybeans. Additionally, 17 compounds were considered to have important coordinating effects on soybean aroma, such as 3-hydroxy-2-butanone (buttery, creamy). Partial least squares regression (PLSR) analysis demonstrated a good correlation between key aroma compounds and sensory attributes. Gene knockout of fadA and bkdB resulted in a significant increase in 2,5-dimethylpyrazine and 1-octen-3-ol levels, along with a marked reduction in 2-methylbutyric acid levels. These changes enhanced the roasted and beany notes, reduced the sweaty aroma, and ultimately improved the overall aroma profile. These findings provide insights into the genetic regulation of aroma in fermented soybean products and form a foundation for reducing undesirable aromas and improving the overall aroma quality of industrially produced douchi. Bacillus subtilis fermented soy food is deeply loved by consumers, and its unique aroma characteristics are influenced by the fadA and bkdB genes.