INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
·
IF 8.5
Xinyu Shao,Yanhui Xie,Anyang Chen,Longfa Lan,Qingbin Zhao,Lin Ma,Ziyan Chen,Jiehua Long,Wang Chen,Dongying Hu
UV-induced photo-oxidation critically compromises food quality, necessitating advanced materials that simultaneously mitigate light degradation and enable real-time freshness monitoring. Here, the excellent UV-blocking films with sensitive humidity and pH response are developed by synergistically incorporating sodium ligninsulfonate-derived carbon quantum dots (L-CDs) via a simple microwave-assisted generation and light absorption of lignin from lignocellulosic nanofibers. The resulting films with hybrid structure can block 99.74 % (UV-C), 99.86 % (UV-B), and 87.90 % (UV-A) of radiation while maintaining 85.60 % visible light transmittance (600 nm), and has excellent mechanical strength (61.51 MPa). Under the protection of composite film, pork, strawberries and grapes all maintained longer freshness than unprotected controls. Profited from the protonation and deprotonation of L-CDs and the disconnection/reconstruction of hydrogen bonds, it shows sensitive humidity and pH response with changes in blue fluorescence. Furthermore, the conductivity of the composite film increases exponentially as the increase of humidity, showing excellent humidity response monitoring. As expected, the prepared composite film can detect changes in conductivity and resistance for monitoring the freshness of food. So, this work provides the development prospects for multi-functional composite films with UV-blocking and intelligent humidity & pH sensing for food preservation and intelligent monitoring.
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International Journal of Nanomedicine
·
2023
·
IF 8
Nan Zhang,Yang Tan,Liwei Yan,Chunyang Zhang,Ming Xu,Huanling Guo,Bowen Zhuang,Luyao Zhou,Xiaoyan Xie
Background and Purpose Sonodynamic therapy (SDT) has been widely used for the noninvasive treatment of solid tumors, but the hypoxic tumor microenvironment limits its therapeutic effect. The current methods of reoxygenation to enhance SDT have limitations, prompting reconsideration of the design of therapeutic approaches. Here, we developed a tumor microenvironment-responsive nanoplatform by reducing oxygen consumption to overcome hypoxia-induced resistance to cancer therapy.Methods A pH-responsive drug-loaded liposome (MI-PEOz-lip) was prepared and used to reduce oxygen consumption, attenuating hypoxia-induced resistance to SDT and thereby improving therapeutic efficiency. Photoacoustic imaging (PAI) and fluorescence imaging (FI) of MI-PEOz-lip were evaluated in vitro and in breast xenograft tumor models. The pH-sensitive functionality of MI-PEOz-lip was applied for pH-triggered cargo release, and its capacity was evaluated. The MI-PEOz-lip-mediated SDT effect was compared with other treatments in vivo.Results MI-PEOz-lip was demonstrated to specifically accumulate in tumors. Metformin molecules in liposomes selectively accumulate in tumors by pH-responsive drug release to inhibit the mitochondrial respiratory chain while releasing IR780 to the tumor area. These pH-responsive liposomes demonstrated PAI and FI imaging capabilities in vitro and in vivo, providing potential for treatment guidance and monitoring. In particular, the prepared MI-PEOz-lip combined with ultrasound irradiation effectively inhibited breast tumors by producing toxic reactive singlet oxygen species (ROS), while the introduction of metformin inhibited mitochondrial respiration and reduced tumor oxygen consumption, resulting in excellent sonodynamic therapy performance compared with other treatments.Conclusion In this study, we present a novel strategy to achieve high therapeutic efficacy of SDT by the rational design of multifunctional nanoplatforms. This work provides a new strategy that can solve the current problems of inefficient oxygen delivery strategies and weaken resistance to various oxygen-dependent therapies.
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Surfaces and Interfaces
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2025
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IF 6.3
Rui Xu,Jingqi Bao,Ningru Xuan,Bingxin Zhou,Lingshan Liao,Qiusheng Zhou,Di Wu,Linfang Lu
The template sacrifice method is a pivotal strategy for synthesizing noble metal-based nanocrystals with enhanced catalytic properties. A critical limitation of this method lies in the challenges associated with regulating the morphology of the resultant nanocrystals. This study demonstrates that the morphology of PtCu nanocrystals can be effectively modulated by adjusting the pH in the Cu 2 O template sacrifice method. Various PtCu nanocrystals, including PtCu hollow nanoboxes and PtCu nanodendrites of differing sizes, have been successfully synthesized. Mechanistic investigations reveal that reduced pH corresponds to a lower electrode potential of Cu 2 O, which enhances its reducing capacity, thereby intensifying the galvanic replacement reaction with the Pt precursor. The driving force of Kirkendall effect during this process can be systematically manipulated via pH adjustments, leading to the generation of PtCu nanocrystals with diverse morphologies. The synthesized PtCu nanocrystals demonstrate significantly improved methanol oxidation reaction activity compared to commercial Pt/C. Specifically, the PtCu hollow nanoboxes exhibit a methanol oxidation reaction (MOR) activity of 1.93 A mg⁻¹, which is 5.4 times greater than that of the commercial Pt/C. Physical characterizations suggest that the superior catalytic performance of PtCu hollow nanoboxes catalyst is attributed to its increased surface electronic density of Pt resulting from the special hollow and porous morphology. The pH control strategy outlined in this research holds promise for the synthesis of other Cu-based nanoalloys with varying morphologies, and may be applicable to other catalytic systems.
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JOURNAL OF PHYSICAL CHEMISTRY B
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2010
·
IF 3.471
Shaoling Song,Naifei Hu
Poly(4-vinylpyridine) (P4VP) films were electropolymerized on a pyrolytic graphite (PG) electrode surface. The cyclic voltammetric (CV) response of ferrocenedicarboxylic acid (Fc(COOH)2) at P4VP film electrodes was very sensitive to the pH and perchlorate (ClO4−) concentration in testing solutions. Fc(COOH)2 was at the “on” state with a relatively large CV oxidation peak current for the films at pH 4.0 but showed the “off” state with significantly suppressed CV response at pH 7.0. The reversible ClO4− concentration-sensitive on−off property of P4VP films toward Fc(COOH)2 at pH 4.0 was also observed. In particular, the influence of pH and ClO4− concentration on the on−off behavior of the system is not independent or separate but synergetic or cooperative, and the electrostatic interaction between the films and the probe plays a predominant role in deciding the pH- and/or ClO4− concentration-dependent behavior for the system. The dual-responsive property of the P4VP films toward Fc(COOH)2 could also be used to control the bioelectrocatalysis of glucose by glucose oxidase. This synergetic-triggered bioelectrocatalysis on the basis of the intelligent interface system may establish a foundation for fabricating novel multiple factor-controllable biosensors based on enzymatic electrocatalysis.
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ANALYTICA CHIMICA ACTA
·
2025
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IF 6
Meihui Gao,Xianjing Zhang,Shiqi Li,He Gao,Xinyu Li,Dongyuan Xu,Longbin Xu
Background Wearable pH sensors have emerged as promising tools for real-time health monitoring, particularly for sports and clinical applications, due to their ability to monitor key physiological indicators such as sweat pH. Sweat analysis provides valuable insights into metabolic processes and physical exertion. However, the development of flexible, stable, and highly sensitive sensors for accurate sweat pH detection remains a challenge. Conductive polymer such as polyaniline (PANI), have gained attention due to their unique properties, but further improvements in mechanical flexibility and sensor performance are needed to fully realize their potential for wearable biosensing applications. Results We present a boric acid-functionalized PANI-ABA/PA hydrogel, synthesized via electrochemical deposition, where boric acid plays a crucial role in crosslinking the rigid PANI material into a flexible, porous grid structure. This crosslinking improves the mechanical properties of the hydrogel while enhancing its ion-exchange capacity, leading to greater sensitivity and selectivity for H + ions. PANI-ABA/PA hydrogel exhibits super-Nernstian behavior (77.80 mV pH −1 ) across the physiological pH range (3.00–10.00), with rapid response times, minimal temperature drift, and excellent repeatability. Moreover, the hydrogel exhibits outstanding antifouling properties, ensuring consistent performance even in dynamic environments. Real-time human subject testing confirms the sensor's ability to accurately monitor sweat pH during physical activity, providing reliable and real-time data. These results highlight the promising potential of the PANI-based hydrogel for wearable biosensors in health monitoring. Significance and novelty This study highlights the role of boric acid in facilitating the formation of a crosslinked PANI-based grid structure, which improves the sensor's performance in wearable applications. Enhanced sensitivity, stability, and mechanical flexibility make this smart wearable sensor a promising candidate for continuous, non-invasive health monitoring. It opens new opportunities for real-time athletic performance tracking, personalized healthcare, and disease diagnostics, positioning it as a leading technology for future wearable health-monitoring systems.
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POLYMER
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2020
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IF 4.231
Kun Yu,Xiyao Yang,Lihua He,Rong Zheng,Jie Min,Hongying Su,Shaoyun Shan,Qingming Jia
Dual and multi-stimuli responsive polymeric nanoparticles that can respond to two or more signals have been demonstrated as prospective drug carriers with enhanced tumor accumulation and on-demand drug release profiles. In this study, dextran-based (Dex-SS) nanogels were developed via a facile method based on the disulfide containing Schiff base formation between polyaldehyde dextran and cystamine in water-in-oil inverse microemulsion . Acidic and reductive (GSH) environment sensitive degradation behaviors of the resulted nanogels were investigated by morphology analysis of the treated nanogels using SEM imaging. Doxorubicin (DOX) was covalently conjugated into the dextran nanogels via Schiff base linkages, and pH/GSH dual sensitive drug release profiles were demonstrated. Effective cell uptake of the DOX-loaded nanogels was finally identified by human cancer cell line of H1299. Take advantage of the acidic and reductive tumor microenvironment, the dual-stimuli responsive Dex-SS nanogels can serve as microenvironment-sensitive drug delivery systems for tumor therapy.
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RSC Advances
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2012
·Vol. 2
·期 31
·11953-11962
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IF 0
Dali Wang,Xiuying Huan,Lijuan Zhu,Jinyao Liu,Feng Qiu,Deyue Yan,Xinyuan Zhu
A new type of salt/pH dual-responsive micelles based on supramolecular amphiphilic brush copolymers, poly(2-hydroxyethyl metharylate)-g-(poly(ε-caprolactone)-adenine:uracil-poly(ethylene glycol)) (PHEMA-g-(PCL-A:U-PEG)) was developed for the anticancer drug delivery owing to the fact that the tumor tissues show low pH and high salt concentration. The supramolecular structure of brush copolymer was confirmed by variable-temperature 1H NMR and Fourier transform infrared spectroscopy (FTIR). Doxorubicin (DOX) as a model anticancer drug was efficiently loaded into the supramolecular micelles (up to 70%) due to the compact structure of brush polymer. The cumulative release profile of the DOX-loaded micelles showed a low level of drug release (about 20 wt% in 25 h) at pH 7.4 with a low salt concentration, and was significantly accelerated at a lower pH (5.0) and a high salt concentration (over 70 wt% in 6 h), exhibiting an salt/pH dual-responsive controlled drug release capability. Methyl tetrazolium (MTT) assay showed that DOX-loaded micelles had high anticancer efficacy against Hela cancer cells and blank micelles had a very low cytotoxicity. These supramolecular brush copolymer micelles possess many favorable traits, such as low cytotoxicity and excellent biodegradability, adequate drug loading capacity, and rapid drug release in response to the intracellular level of pH and salt concentration, which endow them as a promise candidate for delivering anticancer drugs.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2018
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IF 2.829
Hongchao Ma,Shuo Li,Hao Zhang,Yanhui Wei,Lei Jiang
The combined therapeutic strategy have aroused significant interest in cancer therapy due to its enhanced treatment efficacy and reduced side effects. This paper describes the combined chemo- and photothermal therapy of cancer based on PDA@(PDDA-ADA) 3 -Dox nanocomposites. Polydopamine (PDA) serves not only as photothermal agent with strong near infrared absorbance and high energy conversion efficiency, but also as a core material to carry multilayer films formed by alternatively deposition of positively charged poly(diallyldimethylammonium chloride) (PDDA) and negatively charged alginate dialdehyde (ADA) through layer-by-layer (LBL) method. Doxorubicin hydrochloride (Dox) was loaded to the PDA@(PDDA-ADA) 3 nanoplatform via Schiff base bond and electrostatic interaction. The fabricated PDA@(PDDA-ADA) 3 -Dox nanocomposites exhibit outstanding pH-sensitive drug release, good biocompatibility and high photothermal conversion efficiency. These features make them achieve excellent anticancer therapeutic efficacy by combined chemo- and photothermal therapy. This work points that the PDA-based nanoplatform can be a universal scaffold for cancer treatment.
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ACS Nano
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2019
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IF 13.903
Wenchao Huang,Ronghe Chen,Ya Peng,Fei Duan,Yanfang Huang,Weisheng Guo,Xiaoyuan Chen,Liming Nie
Gastrointestinal diseases affect many people in the world and significantly impair life quality and burden the healthcare system. The functional parameters of the gastrointestinal tract such as motility and pH can effectively reflect the changes of gastrointestinal activity in physiological and pathological conditions. Thus, a noninvasive method for real-time and quantitative measurement of gastrointestinal functional parameters in vivo is highly desired. At present, there are many strategies widely used for the diagnosis of gastrointestinal diseases in clinic, including X-ray barium meal examination, ultrasound imaging, radionuclide examination, endoscopy, etc. However, these methods are limited in determining the gastrointestinal status and cannot provide comprehensive quantitative information. Photoacoustic imaging (PAI) is a rapid noninvasive real-time imaging technique in which multiple types of functional and quantitative information can be simultaneously obtained. Unfortunately, very few ratiometric PAI contrast agents have been reported for quantification of gastrointestinal functional parameters in vivo. In this work, a broad, pH-responsive ratiometric sensor based on polyaniline and Au triangular nanoplates was developed. Utilizing the sensor as a contrast agent, PAI served as an all-in-one technique, accurately measuring the gastrointestinal functional parameters in a single test. Notably, this sensor was examined to be ultrasensitive with pH responses as fast as 0.6 s and durability as long as 24 h, and was repeatable and reversible for longitudinal monitoring. The quantitative results demonstrated a significant disorder in motility and decrease in pH for gastric and duodenal ulcers. Collectively, the combination of PAI and this broad pH-responsive sensor might be a promising candidate for quantitative diagnosis of gastrointestinal diseases.
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ACS Biomaterials Science & Engineering
·
2021
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IF 4.749
Jiarui Wu,Zhanjie Zhang,Chenxu Qiao,Changfeng Yi,Zushun Xu,Tianyou Chen,Xiaofang Dai
In recent years, the combination treatment of chemotherapy and photothermal therapy (PTT) has emerged as an efficient approach to improve anticancer activity. Here, we combine zeolitic imidazolate framework-67 (ZIF-67) and CuSe to build a multifunctional therapeutic platform (ZIF-67@CuSe@PVP) with an efficient chemo-photothermal therapy for cancer treatment. ZIF-67@CuSe@PVP nanoparticles were characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), dynamic light scattering (DLS), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), UV–vis, Fourier transform infrared (FT-IR), and nitrogen adsorption–desorption isotherms. These nanoparticles exhibited excellent pH-responsive doxorubicin hydrochloride (DOX) releases due to the decomposition of ZIF-67 and excellent photothermal conversion efficiency (36%) without apparent deterioration during three cycles. In vivo biodistribution evaluation revealed the passive tumor-targeting ability of ZIF-67@CuSe@PVP@DOX via the enhanced permeability and retention (EPR) effect. Both in vitro and in vivo data demonstrated excellent anticancer efficacy of ZIF-67@CuSe@PVP in tumor-bearing mice. This multifunctional therapeutic platform could have certain clinical application potential.
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Food Biophysics
·
2022
·Vol. 17
·期 3
·386-396
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IF 3.34
Wang Yuhang,Fu Yuying,McClements David Julian,Ba Chujie,Li Teng
Propolis is a natural bioactive compound that is being explored as a nutraceutical because of its potential health benefits. In this study, propolis-loaded biopolymer nanoparticles were fabricated from folic acid-modified carboxymethyl chitosan (FA-CMCS) using the pH-driven method. The mean diameter of the propolis-loaded FA-CMCS nanoparticles was about 180 nm, and transmission electron microscopy showed they had a spherical shape. Fourier transform infrared spectroscopy analysis demonstrated that hydrogen bonding, electrostatic, and hydrophobic interactions were the major driving forces responsible for nanoparticle formation. The nanoparticles had good colloidal stability at pH 2.0, 3.0, 7.0, and 8.0 but exhibited some aggregation at intermediate pH values. The nanoparticles were also stable to salt addition up to 400 mM NaCl. Propolis-loaded FA-CMCS nanoparticles exhibited improved antioxidant properties compared to pure propolis and propolis-free nanoparticles. A simulated digestion model (fed state conditions) indicated that different amounts of propolis were released in different gastrointestinal regions: around 25%, 15%, and 25% in the stomach, small intestine, and colon, respectively. Our results suggest that the nanoparticles fabricated in this study have potential as colloidal delivery systems for sustained release of propolis in the human gut.
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ANALYST
·
2016
·Vol. 141
·期 15
·4766-4771
·
IF 4.033
Jingni Fu,Changqin Ding,Anwei Zhu,Yang Tian
Intracellular pH plays a vital role in cell biology, including signal transduction, ion transport and homeostasis. Herein, a ratiometric fluorescent silica probe was developed to detect intracellular pH values. The pH sensitive dye fluorescein isothiocyanate isomer I (FITC), emitting green fluorescence, was hybridized with reference dye rhodamine B (RB), emitting red fluorescence, as a dual-emission fluorophore, in which RB was embedded in a silica core of ∼40 nm diameter. Moreover, to prevent fluorescence resonance energy transfer between FITC and RB, FITC was grafted onto the surface of core–shell silica colloidal particles with a shell thickness of 10–12 nm. The nanoprobe exhibited dual emission bands centered at 517 and 570 nm, under single wavelength excitation of 488 nm. RB encapsulated in silica was inert to pH change and only served as reference signals for providing built-in correction to avoid environmental effects. Moreover, FITC (λem = 517 nm) showed high selectivity toward H+ against metal ions and amino acids, leading to fluorescence variation upon pH change. Consequently, variations of the two fluorescence intensities (Fgreen/Fred) resulted in a ratiometric pH fluorescent sensor. The specific nanoprobe showed good linearity with pH variation in the range of 6.0–7.8. It can be noted that the fluorescent silica probe demonstrated good water dispersibility, high stability and low cytotoxicity. Accordingly, imaging and biosensing of pH variation was successfully achieved in HeLa cells.
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