MICROCHIMICA ACTA
·
2020
·Vol. 187
·期 5
·1-10
·
IF 6.232
Yang Yan,Li Guoliang,Wu Di,Wen Aying,Wu Yongning,Zhou Xuxia
β-Cyclodextrin-functionalized magnetic covalent organic framework (Fe 3 O 4 @COF@Au-β-CD) was developed as sorbent for magnetic solid phase extraction of trace sulfonamides in meat samples prior to HPLC-MS/MS analysis. The sorbent was synthesized by loading gold nanoparticles onto a Fe 3 O 4 @COF surface and then functionalized by thiolated-β-cyclodextrin immobilization via Au-S bonding formation. The prepared composite material was employed for sulfonamides extraction. The main parameters were optimized to obtain the best extraction efficiency. The experiments of adsorption kinetics were carried out to investigate the adsorption mechanism. Results showed the pseudo-second-order kinetic was better fitted with the adsorption kinetics of sulfonamides. Under optimized conditions, the magnetic solid phase extraction-HPLC method showed good linearity ( R 2 ≥ 0.9936), and the limits of detection were in the range of 0.8–1.6 μg kg −1 . The proposed method was successfully used for quantitation of sulfonamides in real samples. The recoveries ranged from 78.9 to 112.0% with relative standard deviations (RSDs) < 10% ( n = 5). The proposed method exhibited great potential for enrichment and determination of sulfonamides in many other food or environment samples.
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JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
·
2019
·Vol. 108
·期 3
·645-653
·
IF 3.221
Teliang Lu,Shenglei Feng,Fupo He,Jiandong Ye
Pore structure plays an important role in the in vivo osteogenesis for bone repair materials. In this study, honeycomb β-tricalcium phosphate (β-TCP) scaffolds were prepared by extrusion method, and gelatin microspheres were used as porogens to modify the pore structure of the scaffolds. The honeycomb β-TCP scaffolds were characterized by channel-like square macropores and unidirectional interconnection. To improve the pore interconnectivity of the scaffold, the spherical pores were formed in the channel walls by burning off the gelatin microspheres. Compared with unidirectional honeycomb β-TCP scaffold, the honeycomb β-TCP scaffold with interconnected pore structure had significantly higher porosity and faster degradation rate, at the expense of the mechanical strength. The in vivo assessment results demonstrated excellent osteogenesis of the honeycomb scaffolds. Moreover, the honeycomb β-TCP scaffold with interconnected pore structure markedly promoted new bone formation in comparison with the unidirectional honeycomb β-TCP scaffold. This work provides a new approach to prepare scaffolds with interconnected pore structure, and the honeycomb β-TCP scaffold with interconnected pore structure is expected to serve as an efficient bone repair material.
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MATERIALS CHEMISTRY AND PHYSICS
·
2019
·
IF 2.781
Wenfeng Han,Haili Wang,Bing Liu,Xiliang Li,Haodong Tang,Ying Li,Huazhang Liu
With Al(NO 3 ) 3 ·9H 2 O as the Al precursor and PVDF as the fluorine source, freestanding AlF 3 sub-microspheres were fabricated following calcination , without the involvement of corrosive HF solution. With the varying of Al(NO 3 ) 3 ·9H 2 O to PVDF weight ratio, θ -AlF 3 and β -AlF 3 , α -AlF 3 were obtained respectively. The formation mechanism, morphology, surface properties and catalytic activities for the dehydrofluorination of 1,1,1,2-tetrafluoroethane to trifluoroethylene were investigated. During the fabrication process, Al(NO 3 ) 3 interacts with O=C bond in DMF. Meanwhile, DMF further interacts with CH 2 species in PVDF. Following calcination , PVDF decomposes to CO 2 and HF fluorinating Al species to AlF 3 . The growth of AlF 3 crystal and particle are confined by PVDF. Consequently, θ -AlF 3 , β -AlF 3 and α -AlF 3 are achieved. At 450 °C, HFC-134a conversion of 23% and reaction rate of 1.9 mmol g −1 h −1 are approached over θ -AlF 3 catalyst. The reaction rate is almost 3 times higher than that of β -AlF 3 and is 40% higher than that of high surface area α -AlF 3 prepared by sol-gel method. No significant deactivation is observed in time on stream of 40 h. The stability is attributed to the interaction of AlF 3 with carbon frame work. The present study provides a scalable and facile synthesis route for AlF 3 spheres with controllable phase structures.
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JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2019
·Vol. 322
·期 3
·2033-2042
·
IF 1.186
Li Wei,Liu Huijun,Li Liuxing,Liu Kai,Liu Juan,Tang Ting,Jiang Wenkang
In this paper, a green synthesized citric acid-crosslinked β-cyclodextrin polymer (CA-β-CD) was applied in removing uranium from aqueous solutions. Citric acid acts not only as cross-linker but also as functional groups for providing adsorption sites. The adsorption properties by varying experimental conditions were carried out by batch tests. The maximum adsorption capacity could reach 150 mg g −1 . Adsorption process was fitted better with the pseudo-second-order and Freundlich model. Thermodynamic studies proved that adsorption process was spontaneous and endothermic. More significantly, the polymer showed high selectivity for uranium and excellent reusability, demonstrating that CA-β-CD can be utilized as a promising adsorbent for uranium.
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JOURNAL OF MOLECULAR LIQUIDS
·
2019
·
IF 4.561
Xu Hu,Xi Zhao,Yangchuan Ke
Synthesis of a novel β-cyclodextrin-functionalized hydrophobically associating polyacrylamide named ASM was carried out using acrylamide (AM), cetyl dimethyl allyl ammonium bromide (SD-16) and modified β-cyclodextrin (M-β-CD) via free-radical copolymerization . Effective characterization methods, including FT-IR, 1 H NMR and TGA , were adopted to evaluate ASM. Influences of SiO 2 nanoparticle (nano-SiO 2 ) on ASM solution properties were evaluated. The results showed that the addition of nano-SiO 2 significantly increased the temperature resistance, salt tolerance and shear resistance of the ASM solution. It was found that ASM/SiO 2 composite had 1.5 times higher viscosity than ASM in the range of 25–90 °C. The FT-IR data confirmed that the formation of hydrogen bond between silanol groups at surface of nano-SiO 2 and amide group, hydroxyl group of M-β-CD in ASM molecule contributed to the improved performance. What ’ s more, viscoelastic test indicated that nano-SiO 2 remarkably facilitated the cross-links among polymer molecules and enhanced the elasticity of ASM/SiO 2 composite. Based on the enhanced oil recovery tests, the oil recovery could remarkably enhance 10.08% for composite versus only 6.56% for ASM.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2022
·
IF 8.025
Xinyi Xing,Xian Shi,Rui Hu,Ying Guan,Hui Gao,Siquan Xu
In this work, a series of (x)Hf-β zeolite catalysts were prepared by a simple wet impregnation method and used as bifunctional catalysts with Lewis and Brønsted acid sites for synthesizing 5-hydroxymethylfurfural (5-HMF) from cellulose in H 2 O (NaCl) -THF biphasic system. Characterization analysis of (x)Hf-β zeolite catalysts with ICP-OES, N 2 adsorption-desorption isotherm, XRD, FTIR , SEM, NH 3 -TPD and Py-FTIR indicated that the catalysts possessed favorable pore structure, appropriate acid strength and acidity. A superior 86.3 % cellulose conversion and 53.4 % 5-HMF yield could be obtained at 200 °C for 4 h by using (5 %)Hf-β zeolite as the catalyst. In addition, the catalytic system provided a favorable 5-HMF yield from other carbohydrates, including glucose (85.1 %), sucrose (80.6 %), starch (65.1 %), maltose (65.0 %), dextran (59.9 %), and Moso bamboo (21.9 %). Nevertheless, the recyclability of (5 %)Hf-β zeolite catalyst was unsatisfactory and the 5-HMF yield showed a downtrend from 53.4 % to 24.4 % after 5 cycles. The catalyst has promising potential for converting biomass materials into high-value platform compounds.
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Food Analytical Methods
·
2022
·Vol. 16
·期 2
·318-329
·
IF 3.498
Yun Ning,Lu Chaoqun,Sun Tian,Xu Baocai,Song Yushen,Zong Zibing,Chen Kangwen,Huang Ganhui,Chen Xingguang,Gu Qianhui
Red pepper oil is a kind of condiment used in food factories, and its spicy degree can be reflected by the content of capsaicin. However, the classification method of red pepper oil is too subjective to be applied in food factories. In our work, a sensitivity electrochemical sensor for detecting capsaicin was constructed based on the glassy carbon electrode (GCE) modified with β-cyclodextrin (β-CD) assisted reduced graphene oxide (rGO). The results showed that the introduction of β-CD made rGO more dispersed, increasing the electrochemical active surface area of β-CD/rGO, thus improving the charge transfer rate. Furthermore, polycyclodextrin with selective recognition ability was dispersed on the surface of rGO, providing the possibility of capsaicin enrichment on the surface of the sensor. Based on these reasons, the sensor had a lower detection limit (0.05 μg/mL), and acceptable stability and anti-interference. Most importantly, β-CD/rGO/GCE displayed a satisfactory recovery rate (94.83 ~ 115.75%) in the detection of red pepper oil, and there was no statistical significance difference between this method and the LC–MS method.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2026
·
IF 4.8
Chennan Zheng,Jiahao Li,Yijin Chang,Dazhi Zhou,Changchun Hao
Ligand glycosylation is often assumed to enhance protein binding by increasing hydrogen-bonding capacity, but its actual role in coumarin–β-lactoglobulin (β-LG) recognition has not been clearly resolved. Here, fraxin (FXN) and its aglycone fraxetin (FXT) were used as a paired model to examine how a glucose moiety regulates β-LG binding through multispectroscopic analysis and molecular simulations. Both ligands associated with β-LG and quenched its intrinsic fluorescence, but FXT showed stronger quenching, higher apparent affinity, a shorter FRET-derived donor–acceptor distance, and a more pronounced reduction in fluorescence lifetime. Thermodynamic analysis indicated spontaneous, entropy-favored binding for both systems. Synchronous and three-dimensional fluorescence spectra further showed that FXT caused greater perturbation of the aromatic-residue microenvironment, whereas far-UV CD revealed only limited secondary-structure fluctuations without a consistent concentration-dependent trend. Docking, MD simulation, and MM/PBSA calculations indicated that the glucose group in FXN introduced additional polar contacts but also a larger polar-solvation penalty and possible steric constraints. In contrast, FXT achieved closer hydrophobic accommodation near the fluorescence-sensitive region of β-LG. These results suggest that glycosylation does not simply strengthen coumarin–β-LG binding, but reshapes molecular recognition through a trade-off among polar interactions, desolvation, and hydrophobic fitting.
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JOURNAL OF MEDICINAL CHEMISTRY
·
2019
·
IF 6.054
Lan-Lan Lou,Fu-Qiang Ni,Lin Chen,Sharpkate Shaker,Wei Li,Rong Wang,Gui-Hua Tang,Sheng Yin
A germacrane sesquiterpenoid library containing 30 compounds (2–31) was constructed by structural modification of a major component aristolactone (1) from the traditional Chinese medicine Aristolochia yunnanensis. Compound 11 was identified as a promising anticardiac fibrosis agent by systematic screening of this library. 11 could inhibit the expression of fibronectin (FN), α-smooth muscle actin (α-SMA), and collagens in transforming growth factor β 1 (TGFβ1)-stimulated cardiac fibroblasts at a micromolar level and ameliorate myocardial fibrosis and heart function in abdominal aortic constriction (AAC) rats at 5 mg/kg dose. Mechanistic study revealed that 11 inhibited the TGFβ/small mother against decapentaplegic (Smad) signaling pathway by targeting TGFβ type I receptor (IC50 = 14.9 ± 1.6 nM). The structure–activity relationships (SARs) study indicated that the unsaturated γ-lactone ring and oxidation of C-1 were important to the activity. These findings may provide a new type of structural motif for future anticardiac fibrosis drug development.
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MATERIALS RESEARCH BULLETIN
·
2023
·
IF 5.4
Song Wu,Junli Wang,Xuanbing Wang,Di Jiang,Jinlong Wei,Xiaoning Tong,Zhenwei Liu,Qingxiang Kong,Naixuan Zong,Ruidong Xu,Linjing Yang
s Ti-based PbO 2 electrodes must currently address the high overpotential and low corrosiveness of the anodic oxygen evolution reaction (OER) during zinc electrowinning. In this study, a composite electrode composed of Ti/TiH 2 /β-PbO 2 − Mn 3 O 4 @C (0.6 g L –1 ) was fabricated using Ti/TiH 2 generated by electrochemical reduction of Ti/TiO 2 prepared by laser ablation as an intermediate layer, co-deposited β-PbO 2 , and Mn 3 O 4 @C micro-flakes prepared by high-temperature pyrolysis-oxidation as the active layer. In a zinc electrowinning test solution (50 g L –1 ZnSO 4 mixed with 150 g L –1 H 2 SO 4 ), the oxygen evolution and corrosion behavior of the obtained Ti/TiH 2 /β-PbO 2 − Mn 3 O 4 @C composite anodes were systematically investigated. Ti/TiH 2 /β-PbO 2 − Mn 3 O 4 @C (0.6 g L –1 ) exhibited a low overpotential of 493 mV, a low Tafel slope of 73.6 mV dec −1 , a low i corr of 2.320 × 10 −5 A cm −2 and voltage stability of 1.65 V vs. RHE for up to 72 h in stability tests, with an overall performance outperformed most of the reported Ti-based PbO 2 electrode materials. The outstanding catalytic activity is primarily attributable to the low resistance and porous interlayer of TiH 2 nanosheets, which speeds up the rate of electron transfer. The addition of Mn 3 O 4 @C micro-flakes to the active layer enhances the composite electrode's OER performance and corrosion resistance.
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CARBOHYDRATE POLYMERS
·
2023
·
IF 11.2
Wenwen Bie,Shuzhao Zhang,Lin Zhang,Hengye Li,Xiaoyu Sun,Tianpei Cai,Zhongxia Wang,Fenying Kong,Wei Wang
Herein, a thioether-functionalized porous β-cyclodextrin polymer (P(Bn-S-CD)) was prepared for efficient removal of heavy metal ions and organic micropollutants (OMPs) from water. P(Bn-S-CD) showed a surface area of 763 m 2 /g and a sulfur content 5.83 wt%. Based on screening studies, Hg 2+ and diclofenac sodium (DS) were selected as model pollutants. P(Bn-S-CD) could adsorb Hg 2+ and DS simultaneously, while the adsorbed Hg 2+ afforded positive charges to the primary rims of CDs, greatly enhancing the adsorption rate and adsorption capacity of DS. Although the adsorbed DS showed no obvious effect on Hg 2+ adsorption, it improved the affinity of Hg 2+ upon P(Bn-S-CD). Adsorption mechanism studies confirmed the essential role of electrostatic interactions for these results. P(Bn-S-CD) also showed good selectivity towards heavy metal ions, excellent adsorption performance in real water at environmental levels and good reusability, implying great promise for water treatment.
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INTERNATIONAL IMMUNOPHARMACOLOGY
·
2023
·
IF 5.6
Runxiao Lv,Lili Du,Lunhao Bai
Osteoarthritis (OA) is a chronic joint disease characterized by the progressive degradation of articular cartilage. In this study, as determined by histological staining, the cartilage surface of the OA rats was damaged, defective and broken, and chondrocytes and proteoglycan were reduced. While moderate physical exercise showed protective effects on the cartilage. Besides, RNA-seq was performed to select a target protein and RNF125 (an E3 ubiquitin ligase) was decreased in the cartilage tissues of OA rats and increased after physiological exercise. However, the precise role of RNF125 in OA is still unknown. This work aimed to investigate the involvement and underlying mechanism of RNF125 in OA pathogenesis. Our results defined that adenovirus-mediated overexpression of RNF125 inhibited the degradation of extracellular matrix of chondrocytes induced by IL-1β, as revealed by increased chondrocyte viability, upregulated COL2A1 and ACAN levels, and downregulated MMP1, MMP13 and ADAMTS5 levels, which was abrogated by NR4A2 knockdown. In vivo, RNF125 relieved OA, manifested as reduced cartilage injury and increased chondrocytes. Mechanically, NFATC2 bound to the RNF125 promoter and directly regulated RNF125 transcription, as illustrated by luciferase reporter, Ch-IP and DNA pull-down assays. Furthermore, RNF125 overexpression inhibited the nuclear translocation of β-catenin, thus suppressing activation of the Wnt/β-catenin signaling pathway. Also, RNF125 as E3 ubiquitin ligase led to the ubiquitination and degradation of TRIM14 protein, and TRIM14 overexpression efficiently reversed the effects of RNF125 overexpression on OA progression. Totally, this study provides new insights into OA pathogenesis regulated by RNF125. RNF125 may be a novel biomarker for OA therapy.
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