SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2025
·
IF 4.6
Yifan Chen,Fan Yang,Xiaomin Hou
As representative compounds spanning three generations of diamide insecticides, flubendiamide, chlorantraniliprole, and tetraniliprole have been extensively employed in agricultural practices. However, their widespread application induces oxidative stress in plants and underlying toxic mechanisms remain poorly understood. Given the important roles in oxidative stress, glutathione reductase 2 from Arabidopsis thaliana ( At GR2) was applied as a biomarker to evaluate the toxicological effects of diamide insecticides. Firstly, the root elongation in Arabidopsis seedlings was significantly inhibited and the At GR2 gene expression level was up-regulated under exposure of the diamide insecticides. Then the glutathione reductase activity of At GR2 was decreased with the increase concentration of these three insecticides, especially for flubendiamide with similar detrimental effects at much lower concentrations. Moreover, the binding affinity between flubendiamide and At GR2 was also stronger than that of chlorantraniliprole and tetraniliprole, which was conformed with molecular docking results. Additionally, much more evident effects on the structure of At GR2 under exposure of flubendiamide was detected through multispectral techniques compared to the other two insecticides. Hence this study systematically explored the binding mechanism of these three-generations of diamide insecticides with At GR2 at the molecular level, and further provided critical assessments of their phytotoxic effects on plant development and agricultural systems.
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产品关联
DOI
PubMed
高影响因子
NANO
·
2018
·
IF 1.1
Xu Yan,Ziyang Wu,Yong Zhao,Biao Liu,Yubin Tang
Silver nanoparticles (NPs) and related semiconductors are a family of very important and widely applied photocatalysts. However, the preparation of high stability and activity of this photocatalyst is still a challenge. In this work, we report a stable Ag/AgCl/AgBi(MoO 4 ) 2 heterojunction photocatalyst fabricated via a simple in situ anion-exchange reaction followed by the photoreduction treatment. In the treatment of tetracycline (TC) wastewater under visible light, the AC-0.4 sample (prepared with 0.4 mmol KCl) exhibits the significantly improved activity (degradation ratio, DR of 71.3%) compared with the pristine AgBi(MoO 4 ) 2 (30% DR) and Ag/AgCl sample (synthesized by the photoreduction of AgCl) (37% DR) under identical experimental conditions. This activity promotion is from the fast interfacial electron transfer between the heterojunction phases of AgCl/AgBi(MoO 4 ) 2 and the SPR effect of Ag NPs. After five successive recycles, the AC-0.4 sample still maintains good stability and activity for TC degradation, which shows a great potential to be used in practical application. Through the ESR and controlled scavenged experiments, we found the • OH and • O 2 − are the major reactive intermediate species in the TC photodegradation reaction. Our work provides a new insight into the synthesis of stable and high efficient Ag-based heterojunction photocatalysts for the application of wastewater treatment.
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DOI
高影响因子
iScience
·
2023
·
IF 5.8
Chang-Yu Yan,Yue Ye,Han-Lu Mu,Tong Wu,Wen-Shan Huang,Yan-Ping Wu,Wan-Yang Sun,Lei Liang,Wen-Jun Duan,Shu-Hua Ouyang,Rui-Ting Huang,Rong Wang,Xin-Xin Sun,Hiroshi Kurihara,Yi-Fang Li,Rong-Rong He
Prenatal stress has been extensively documented as a contributing factor to adverse cardiac development and function in fetuses and infants. The release of glucocorticoids (GCs), identified as a significant stressor, may be a potential factor inducing cardiac hypertrophy. However, the underlying mechanism remains largely unknown. Herein, we discovered that corticosterone (CORT) overload induced cardiac hypertrophy in embryonic chicks and fetal mice in vivo , as well as enlarged cardiomyocytes in vitro . The impaired mitochondria dynamics were observed in CORT-exposed cardiomyocytes, accompanied by dysfunction in oxidative phosphorylation and ATP production. This phenomenon was found to be linked to decreased mitochondrial fusion protein mitofusin 2 (MFN2). Subsequently, we found that CORT facilitated the ubiquitin-proteasome-system-dependent degradation of MFN2 with an enhanced binding of appoptosin to MFN2, serving as the underlying cause. Collectively, our findings provide a comprehensive understanding of the mechanisms by which exposure to stress hormones induces cardiac hypertrophy in fetuses.
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DOI
PubMed
高影响因子
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
·
2013
·Vol. 2013
·期 32
·7411-7420
·
IF 3.344
Zhengkai Chen,Weijun Yang,Lijun Xu,Lili Zhang,Maozhong Miao,Hongjun Ren
Graphical Highly substituted 2-hydroxyflavanones can be obtained through a tandem O -arylation/hydroxylation process from triazenylaryl-substituted diketones in the presence of a Lewis acid. A transition-metal-free tandem O -arylation/hydroxylation approach has been developed for the efficient synthesis of highly substituted 2-hydroxyflavanones from triazenylaryl-substituted diketones. The intermediate benzopyrylium cation may be involved in these reactions.
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DOI
高影响因子
RESEARCH ON CHEMICAL INTERMEDIATES
·
2014
·Vol. 41
·期 10
·7695-7702
·
IF 1.54
Jin Qingdong,Li Fubo,Li Ying,Jin Fei,Jiang Lin
A series of α-alkoxyimino-[1-(4-methylpiperazino-1-yl)carbonylmethyl-1 H -benzimidazol-2-yl] acetonitriles were synthesized from o -phenylenediamine, ethyl cyanoacetate, chloroacetyl piperazine, and haloalkane/benzyl chloride by multi-step reactions. The structures of the target compounds were elucidated by IR, 1 H NMR, MS, and elemental analysis. All the target compounds were tested for in vitro antifungal activities against Sclerotinia sclerotiorum and Botrytis cinerea by the mycelium growth rate method, and the results indicated that some compounds displayed higher antifungal activity as compared to carbendazim.
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DOI
高影响因子
ENVIRONMENTAL POLLUTION
·
2020
·
IF 6.793
Xulei Zhao,Teng Zhang,Junhe Lu,Lei Zhou,Jean-Marc Chovelon,Yuefei Ji
Sulfate radical (SO 4 − )-based advanced oxidation processes (SR-AOPs) are promising in-situ chemical oxidation technologies widely applied for soil/groundwater remediation. The presence of non-target water constituents may interfere the abatement of contaminants by SR-AOPs as well as result in the formation of unintended byproducts. Herein, we reported the formation of toxic chloronitrophenols during thermally activated persulfate oxidation of 2-chlorophenol (2CP) in the presence of nitrite (NO 2 − ). 2-Chloro-4-nitrophenol (2C4NP) and 2-chloro-6-nitrophenol (2C6NP) were identified as nitrated byproducts of 2CP with total yield up to 90%. The formation of nitrated byproducts is a result of coupling reaction between 2CP phenoxyl radical (ClPhO ) and nitrogen dioxide radical (NO 2 ). As a critical step, the formation of ClPhO was supported by density functional theory (DFT) computation. Both 2C4NP and 2C6NP could convert to 2-chloro-4,6-dinitrophenol (2C46DNP) upon further treatment via a denitration-renitration process. The formation rate of 2C4NP and 2C6NP was closely dependent on the concentration of NO 2 − , solution pH, and natural water constituents. ECOSAR calculation suggests that chloronitrophenols are generally more hydrophobic and ecotoxic than 2CP. Our result therefore reveals the potential risks in the abatement of chlorophenols by SR-AOP, particularly when high level of NO 2 − is present in water matrix.
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高影响因子
Nature Communications
·
2021
·Vol. 12
·期 1
·1-7
·
IF 14.919
Liu Yanting,Wang Ran,Qi Haifeng,Liu Xiao Yan,Li Guangyi,Wang Aiqin,Wang Xiaodong,Cong Yu,Zhang Tao,Li Ning
The exploration of highly efficient processes to convert renewable biomass to fuels and value-added chemicals is stimulated by the energy and environment problems. Herein, we describe an innovative route for the production of methylcyclopentadiene (MCPD) with cellulose, involving the transformation of cellulose into 3-methylcyclopent-2-enone (MCP) and subsequent selective hydrodeoxygenation to MCPD over a zinc-molybdenum oxide catalyst. The excellent performance of the zinc-molybdenum oxide catalyst is attributed to the formation of ZnMoO 3 species during the reduction of ZnMoO 4 . Experiments reveal that preferential interaction of ZnMoO 3 sites with the C=O bond instead of C=C bond in vapor-phase hydrodeoxygenation of MCP leads to highly selective formations of MCPD (with a carbon yield of 70%).
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DOI
高影响因子
Frontiers of Chemical Science and Engineering
·
2021
·Vol. 15
·期 6
·1514-1523
·
IF 4.204
Qu Huaxin,Deng Jie,Wang Bei,Ouyang Lezi,Tang Yong,Yu Kai,Lou Lan-Lan,Liu Shuangxi
A base-free catalytic system for the aerobic oxidation of 5-hydroxymethyl-2-furfural was exploited by using Pt nanoparticles immobilized onto a thermoresponsive poly(acrylamide- co -acrylonitrile)- b -poly( N -vinylimidazole) block copolymer, with an upper critical solution temperature of about 45 °C. The Pt nanocatalysts were well-dispersed and highly active for the base-free oxidation of 5-hydroxymethyl-2-furfural by molecular oxygen in water, affording high yields of 2,5-furandicarboxylic acid (up to >99.9%). The imidazole groups in the block copolymer were conducive to the improvement of catalytic performance. Moreover, the catalysts could be easily separated and recovered based on their thermosensitivity by cooling the reaction system below the upper critical solution temperature. Good stability and reusability were observed over these copolymer-immobilized catalysts with no obvious decrease in catalytic activity in the five consecutive cycles.
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高影响因子
CRYSTENGCOMM
·
2021
·Vol. 24
·期 1
·95-106
·
IF 3.545
Yunping Zhoujin,Yang Tao,Panpan Zhou,Sean Parkin,Tonglei Li,Ju Guo,Faquan Yu,Sihui Long
Addition of methyl group(s) to either or both aromatic rings of fenamic acid (FA) afforded three FA derivatives (1–3), designed to investigate the effect on the polymorphic behavior of these compounds exerted by substitution. A relatively comprehensive polymorph screen led to the discovery of four polymorphs for compound 3, for which substitution took place on both aromatic rings, in contrast to the production of either two or one form(s) for compounds 1 and 2, both of which are mono-substituted. The observation indicated that both substitution position and pattern are important in the polymorphism of these compounds. The thermal properties of each system were investigated by differential scanning calorimetry (DSC). Conformational scans and Hirshfeld surface analyses were performed to study the mechanism of polymorphism and the intermolecular interactions contributing to the stability of each crystal form.
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高影响因子
CHINESE JOURNAL OF POLYMER SCIENCE
·
2020
·Vol. 39
·期 3
·327-336
·
IF 3.154
Shi Zhen,Wang Qi,Li Gui-Fei,Shou Yu-Feng,Zong Hong-Jie,Yan Shi-Feng,Zhang Kun-Xi,Yin Jing-Bo
Self-healing hydrogels with the shear-thinning property are novel injectable materials and are superior to traditional injectable hydrogels. The self-healing hydrogels based on 2-ureido-4[1 H ]-pyrimidinone (UPy) have recently received extensive attention due to their dynamic reversibility of UPy dimerization. However, generally, UPy-based self-healing hydrogels exhibit poor stability, cannot degrade in vivo and can hardly be excreted from the body, which considerably limit their bio-application. Here, using poly (l -glutamic acid) (PLGA) as biodegradable matrix, branching α-hydroxy- ω -amino poly(ethylene oxide) (HAPEO) as bridging molecule to introduce UPy, and ethyl acrylate polyethylene glycol (MAPEG) to introduce double bond, the hydrogel precursors (PMHU) are prepared. A library of the self-healing hydrogels has been achieved with well self-healable and shear-thinning properties. With the increase of MAPEG grafting ratio, the storage modulus of the self-healing hydrogels decreases. The self-healing hydrogels are stable in solution only for 6 h, hard to meet the requirements of tissue regeneration. Consequently, ultraviolet (UV) photo-crosslinking is involved to obtain the dual crosslinking hydrogels with enhanced mechanical properties and stability. When MAPEG grafting ratio is 35.5%, the dual crosslinking hydrogels can maintain the shape in phosphate-buffered saline solution (PBS) for at least 8 days. Loading with adipose-derived stem cell spheroids, the self-healing hydrogels are injected and self-heal to a whole, and then they are crosslinked in situ via UV-irradiation, obtaining the dual crosslinking hydrogels/cell spheroids complex with cell viability of 86.7%±6.0%, which demonstrates excellent injectability, subcutaneous gelatinization, and biocompatibility of hydrogels as cell carriers. The novel PMHU hydrogels crosslinked by quadruple hydrogen bonding and then dual photo-crosslinking of double bond are expected to be applied for minimal invasive surgery or therapies in tissue engineering.
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DOI
高影响因子
Journal of CO2 Utilization
·
2016
·
IF 4.764
Xian-Dong Lang,Yi-Chen Yu,Zheng-Ming Li,Liang-Nian He
Despite recent renaissance of CO 2 chemistry, transformation of CO 2 at ambient conditions remains still of great challenge. In this work, an easily prepared protic ionic liquid e.g. 1,1,3,3-tetramethylguanidinium imidazolide [HTMG][Im] was developed as highly efficient, recyclable and bifunctional catalyst for the carboxylative cyclization of 2-aminobenzonitriles with CO 2 at atmospheric pressure and room temperature. The catalytic protocol was found to be applicable to various 2-aminobenzonitriles bearing electron-withdrawing or electron-donating substituents, affording the corresponding quinazoline-2,4(1H,3H)-diones in moderate to excellent yields. In addition, the catalyst could be conveniently recovered and reused for five cycles with almost consistent activity. Consequently, this process represents an alternative approach for the efficient and greener chemical fixation of CO 2 to afford valuable heterocycles.
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DOI
高影响因子
POLYMER
·
2016
·
IF 3.586
Gang Li,Guoping Zhang,Rong Sun,Ching-Ping Wong
Via the radical polymerization of 2-(dimthylamino) ethyl methacrylate in the polyacrylic acid solution, we obtain the dually pH-reponsive polyelectrolytes complex hydrogel, which could be triggered to be swollen either in acid and basic environments. The results show that the responsive behavior of these PEC hydrogels is insensitive to monomer concentration in the prepolymerization, but can be tuned by changing the charge ratio or introducing chemical crosslinker. Moreover, other amazing propertise of the prepared PEC hydrogel are presented, which are including the ionic strength-responsiveness, the modest mechanical property (a tensile stress of 0.2 MPa and a tensile strain of 1500%) and the self-healing ability (a self-healing efficiency of ca. 70%). In brief, we report a multi-functional hydrogel which might serve as a new platform for responsive materials.
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DOI
高影响因子
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