MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 6
·1-16
·
IF 5.3
Li Guiyin,Guo Fei,Liang Jianlu,Wan Bingbing,Liang Jintao,Zhou Zhide
A new sandwich-type electrochemical biosensing platform was developed by gold @polyphthalenediamine nanohybrids (AuNP@PoPD) as the sensing platform and phosphorus doped reduced graphene oxide-hemin-palladium nanoparticles (PrGO-Hemin-PdNP) as the signal amplifier for phosphatidylinositol proteoglycan 3 (GPC3). AuNP@PoPD, co-electrodeposited into the screen printed electrode with high conductivity and stability, is dedicated to assembling the primary GPC3 aptamer (GPC3 Apt ). The second GPC3 Apt immobilized on the high conductivity and large surface area of PrGO-Hemin-PdNP was utilized as an electrochemical signal reporter by hemin oxidation (PrGO-Hemin-PdNP-GPC3 Apt ). In the range 0.001–10.0 ng/mL, the hemin oxidation current signal of the electrochemical aptasensor increased log-linearly with the concentration of GPC3, the lowest detection limit was 0.13 pg/mL, and the sensitivity was 2.073 μA/μM/cm 2 . The aptasensor exhibited good sensing performance in a human serum sample with the relative error of 4.31–8.07%. The sandwich sensor showed good selectivity and stability for detection GPC3 in human serum samples, providing a new efficient and sensitive method for detecting HCC markers. Graphical Abstract
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-11
·
IF 14.7
Li Wulong,Yu Zhen,Zhang Yaoxin,Lv Cun,He Xiaoxiang,Wang Shuai,Wang Zhixun,He Bing,Yuan Shixing,Xin Jiwu,Liu Yanting,Zhou Tianzhu,Li Zhanxiong,Tan Swee Ching,Wei Lei
Cellulose fiber-based textiles are ubiquitous in daily life for their processability, biodegradability, and outstanding flexibility. Integrating cellulose textiles with functional coating materials can unlock their potential functionalities to engage diverse applications. Metal-organic frameworks (MOFs) are ideal candidate materials for such integration, thanks to their unique merits, such as large specific surface area, tunable pore size, and species diversity. However, achieving scalable fabrication of MOFs-textiles with high mechanical durability remains challenging. Here, we report a facile and scalable strategy for direct MOF growth on cotton fibers grafted via the diazonium chemistry. The as-prepared ZIF-67-Cotton textile (ZIF-67-CT) exhibits excellent ultraviolet (UV) resistance and organic contamination degradation via the peroxymonosulfate activation. The ZIF-67-CT is also used to encapsulate essential oils such as carvacrol to enable antibacterial activity against E. coli and S. aureus . Additionally, by directly tethering a hydrophobic molecular layer onto the MOF-coated surface, superhydrophobic ZIF-67-CT is achieved with excellent self-cleaning, antifouling, and oil-water separation performances. More importantly, the reported strategy is generic and applicable to other MOFs and cellulose fiber-based materials, and various large-scale multi-functional MOFs-textiles can be successfully manufactured, resulting in vast applications in wastewater purification, fragrance industry, and outdoor gears.
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Human Cell
·
2025
·Vol. 38
·期 3
·1-14
·
IF 3.1
Zhu Xiao-Yu,Li Pi-Song,Qu Hui,Ai Xing,Zhao Zi-Ting,He Jia-Bei
Radiotherapy resistance, is usually caused by enhanced tumor stemness and poses a significant challenge in treating breast cancer (BRCA). In this study, we investigated the molecular regulatory mechanism of radiotherapy sensitivity in BRCA associated with replication factor C4 (RFC4) and insulin-like growth factor 2 mRNA binding protein 2 mRNA Binding Protein 2 (IGF2BP2). RFC4 expression was increased in BRCA cell lines and tissues, and high RFC4 expression in BRCA patients predicted the occurrence of lymphatic metastasis. RFC4-specific short hairpin RNA sequences or RFC4 coding sequences were subsequently cloned and inserted into plasmid vectors to downregulate or upregulate RFC4 expression. Knockdown of RFC4 attenuated stemness, as evidenced by a reduction in sphere formation and the downregulation of CD44 and SOX2. RFC4 silencing inhibited migration and invasion, promoted apoptosis, and improved sensitivity to radiotherapy (4-Gy X-ray). The results were detected by a wound healing assay, a transwell assay, and flow cytometry. The overexpression of RFC4 had the opposite effect on BRCA cells. Like RFC4 expression, IGF2BP2 expression was also increased in the cancer tissues of breast cancer patients. The results of the dual luciferase assay and RIP assay confirmed the binding of IGF2BP2 to the RFC4 mRNA coding sequence. Knockdown of RFC4 eliminated the effects of IGF2BP2 overexpression on increasing cell viability, invasion, the expression of stemness markers and radioresistance, suggesting that the effect of RFC4 on the stemness of BRCA cells was regulated by IGF2BP2. In conclusion, we reported that RFC4, a key regulator of BRCA progression, promoted radioresistance in BRCA and was positively regulated by IGF2BP2.
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Nature Energy
·
2024
·
IF 49.7
Xie Congxin,Wang Chao,Xu Yue,Li Tianyu,Fu Qiang,Li Xianfeng
The ever-increasing need for energy-dense batteries with high safety is fuelling global research and innovations in new redox chemistry and device design. Here we show an aqueous battery employing highly concentrated hetero-halogen electrolytes that contain I − and Br - , resulting in a multielectron transfer process of I − /IO 3 − . The intermediate bromide species IBr and Br 2 , generated during the electrochemical process, enhances the reaction kinetics and alleviates the potential gap between oxidation and reduction. When using a 6 M I − electrolyte to achieve over 30 M electron transfers, the I − /IO 3 − cathode displayed a high specific capacity of over 840 Ah l catholyte −1 . A battery with Cd/Cd 2+ as the anode demonstrated a high energy density of over 1,200 Wh l catholyte −1 . Even at an exceptionally high current density of 120 mA cm −2 , an energy efficiency of 72% was obtained. Our work demonstrates that safe aqueous batteries with high energy density are possible, offering a development option for grid-scale energy storage and even electric vehicles.
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JOURNAL OF POROUS MATERIALS
·
2024
·
IF 2.5
Liu Quan,Kong Yong,Shen Xiaodong
This study aims to develop a hydrophobic silica aerogel with high specific surface area and pore volume for thermal insulation under humid and high temperature conditions. Silica aerogels are synthesized through the co-condensation of methyltriethoxysilane (MTES) and tetraethoxysilane (TEOS). The effect of MTES/TEOS ratio on chemical structure, hydrophobicity, and pore structure is investigated. The silica aerogel with a MTES/TEOS molar ratio of 1.4 (MT1.4) exhibits the highest water contact angle of 134°, in addition to a surface area of 1052 m 2 /g and a pore volume of 3.17 cm 3 /g. Excessive MTES results in a slight decrease in water contact angle as well as a significant reduction in specific surface area and pore volume. MT1.4 retains a water contact angle of 101° at 300 °C and a specific surface area of 695 m 2 /g at 500 °C. The thermal conductivity of MT1.4 is as low as 0.0182 W/(m·K) at 25 °C. In the long term up to 42 d, the liquid water and moisture sorption capacities of MT1.4 are as low as 1.9 wt% and 4.7 wt%, respectively. The thermal conductivity hardly changes after water soaking and hygrothermal aging for 42 d. Compared to its state-of-the-art counterparts, MT1.4 offers significant advantages in term of pore structure, thermal stability, thermal insulation, and water resistance, and thus shows great promise for thermal insulation under humid and high temperature conditions.
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-10
·
IF 14.7
Wang Tianjiao,Xin Yu,Chen Bingfeng,Zhang Bin,Luan Sen,Dong Minghua,Wu Yuxuan,Cheng Xiaomeng,Liu Ye,Liu Huizhen,Han Buxing
Achieving selective hydrodeoxygenation of α, β-unsaturated carbonyl groups to alkenes poses a substantial challenge due to the presence of multiple functional groups. In this study, we develop a ZnNC-X catalyst (X represents the calcination temperature) that incorporates both Lewis acidic-basic sites and Zn-N x sites to address this challenge. Among the catalyst variants, ZnNC-900 catalyst exhibits impressive selectivity for alkenes in the hydrodeoxygenation of α, β-unsaturated carbonyl compounds, achieving up to 94.8% selectivity. Through comprehensive mechanism investigations and catalyst characterization, we identify the Lewis acidic-basic sites as responsible for the selective hydrogenation of C=O bonds, while the Zn-N x sites facilitate the subsequent selective hydrodeoxygenation step. Furthermore, ZnNC-900 catalyst displays broad applicability across a diverse range of unsaturated carbonyl compounds. These findings not only offer valuable insights into the design of effective catalysts for controlling alkene selectivity but also extend the scope of sustainable transformations in synthetic chemistry.
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Advanced Fiber Materials
·
2024
·
IF 17.2
Zhi Yifan,Zhang Honghua,Zhang Lugang,Li Qianqian,Kuang Xiangtian,Wu Wen,Zhou Qingqing,Li Ping,Li Wei,Zhang Huanxia
Piezoresistive pressure sensors have received considerable attention because of their simple structure, high sensitivity and low cost. Graphene, which is known for its outstanding mechanical and electrical properties, has shown great application potential as a sensor material. However, its durability and performance consistency in practical applications still require enhancement. In this study, magnetic graphene fibers (MGFs) are prepared via wet spinning, using graphene oxide (GO), doped with Fe 3 O 4 nanoparticles. The resulting MGFs exhibit a high tensile strength of 58.6 MPa, a strain of 5.3% and an electrical conductivity of 1.7 × 10 4 S/m. These MGFs are utilised to construct a multilayer fabric for fabrication of flexible pressure sensors. The confinement within the spinning channel facilitates an ordered arrangement of GO sheets, resulting in MGFs with superior electrical and mechanical properties. The issuing MGFs pressure sensors demonstrate a wide detection range (0–120 kPa), high sensitivity (0.233 kPa −1 , 0–40 kPa) and rapid response/recovery times (121 ms/158 ms). In addition, it exhibits a remarkable durability, maintaining performance over 1300 cycles, during continuous operation, with negligible degradation. This sensor shows excellent capability in monitoring human physiological activities, indicating its substantial application potential in wearable devices. Graphical
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CELL BIOCHEMISTRY AND BIOPHYSICS
·
2024
·
IF 1.8
Liu Yunfeng,Sun Zongyi,Zhou Xiaoling,Wang Haibin,Yu Miaomiao,Li Dejun
The activation, injury, and dysfunction of endothelial cells are considered to be the initial key events in the development of atherosclerosis. Di (2-ethylhexyl) phthalate (DEHP), a prevalent organic pollutant, can cause damage to multiple organs. Polysaccharide of Atractylodes macrocephala Koidz (PAMK) is a bioactive compound extracted from A. macrocephala Koidz with various biological activities. This study investigates the protective effects of PAMK on porcine aortic valve endothelial cells (PAVEC) damaged by DEHP. PAVECs treated with DEHP alone or with PAMK showed reduced cell apoptosis and death in PAMK-pretreated cells. PAMK up-regulated Bcl-2 expression and down-regulated Bax protein, suppressing apoptosis. Flow cytometry analysis demonstrated that PAMK protected PAVECs from DEHP-induced damage. These findings suggest that PAMK inhibits cell apoptosis and protects against DEHP damage in endothelial cells.
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MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 8
·1-10
·
IF 5.3
Mo Guangquan,Huang Jiayin,Lin Yueting,Ouyang Yuehan,Hu Bingjie
Novel zeolitic imidazolate frameworks (ZIFs), classical subtypes of metal organic frameworks (MOFs), and nanostructures are electro-engineered onto carbon fiber (CF), leading to a unique freestanding electrochemical platform of budlike nano Zn-ZIFs decorated CF (BN-Zn-ZIFs/CF). The unique morphology, structure, and composition are characterized by electron microscopy and energy spectrum analysis. Notably, the BN-Zn-ZIFs/CF platform displays superb electrocatalysis towards the oxidation of isoeugenol with encouragingly low overpotential and high current response. The strong electrocatalytic oxidation capability of BN-Zn-ZIFs/CF makes it an excellent sensing platform for isoeugenol detection. BN-Zn-ZIFs/CF sensor exhibits high-performance isoeugenol sensing with an extremely low limit of detection (13 nM) and wide detection range (0.1–700 µM). Besides, the BN-Zn-ZIFs/CF sensor can greatly resist interference from common ions, major biomolecules, and some amino acids. Moreover, excellent reliability, stability, and practicality are obtained. Our work demonstrates that the as-prepared BN-Zn-ZIFs/CF can act as an high-performance electrochemical sensor for the isoeugenol detection, the well-developed ZIF nanocrystal-modified conductive substrates can be a unique platform for the efficient sensing of other molecules, and the electrochemical engineering strategy can be an effective method for the growing of fresh MOF nanocrystals at conductive substrates in various electrochemical applications. Graphical abstract
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JOURNAL OF POLYMER RESEARCH
·
2025
·Vol. 32
·期 1
·1-11
·
IF 2.8
Zhou Haitao,Liu Yan,Lu Tianhao,Xia Wulin,Qin Ying,Kuang Guankun,Xin Binjie
In this paper, a string of waterborne polyurethane (WPU) emulsions synergistically modified with PDMS and GMS were successfully prepared by incorporating Polydimethylsiloxane (PDMS) into the soft segments of waterborne polyurethanes, and using glycerol monostearate (GMS) as a chain extender. FTIR, TGA, SEM, particle size test, water contact angle and other tests were used to characterize the effects of variable GMS contents on the structure and function of WPUs. The experimental tests showed that the WPUs synthesised with 30% PDMS-8% GMS synergism had better overall performance. The water contact angle could reach 115.4°, and the water absorption was reduced to 10.52% at 72 h. Furthermore, this innovative WPU film had excellent thermal stabilization, and this study provided a new approach to improve waterproofing performance, hydrophobicity and thermal stability of waterborne polyurethanes, which is expected to be applied in coatings, adhesives and water-resistant agents.
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JOURNAL OF POLYMER RESEARCH
·
2024
·Vol. 31
·期 5
·1-12
·
IF 2.6
Liu Jianhui,Li Zhe,Yang Wenjian,Gong Bichuan,He Linwei,Xu Hui,Su Anxiang,Xie Minhao
Triazine pesticides can easily remain in the environment and food, causing serious harm to organisms. Developing a pretreatment technology with strong purification and enrichment capabilities is of great significance for the detection of triazine. In this paper, magnetic dual-template nanomolecular imprinted polymers (MMIPs) were synthesized using silica-modified Fe 3 O 4 magnetic shell nanoparticles as carriers, methacrylic acid (MAA) as a functional monomer, and cyromazine and melamine as template molecules. This material was characterized by transmission electron microscope (TEM), Fourier-transform infrared spectroscopy (FTIR), and X-ray diffraction (XRD). The adsorption experiments were carried out and the results showed that the MMIPs had the chemical properties of surface molecular imprinting. The binding constants of MMIPs were 26.95 mg/L and 657.89 mg/L, and their maximum apparent binding capacity was 2.02 mg/g and 8.59 mg/g, respectively. The prepared MMIPs were used as adsorbents for dispersive solid phase extraction, and high-performance liquid chromatography analysis was coupled to determine triazine pesticides from three samples. The recovery of this method was between 84.8% and 109.5% and the limits of detection were between 0.01–0.03 µg/L. This method greatly shortens the sample pretreatment time and achieves the purpose of rapid pretreatment.
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JOM
·
2025
·
IF 2.3
Duan Liang-hong,Yang Sheng-hai,Chen Yong-ming,Xu Zhi-peng,Xia Xin-bing,Wang Chang-hong
The ammonia system—compared to traditional acid system—presents considerable benefits when treating zinc (Zn) secondary resources that contain high concentrations of iron, fluorine, chlorine, and low Zn. However, the ammonia-based approach is still facing challenges in maintaining high-quality and efficient Zn electrodeposition. Herein, we propose an efficient ammonia system—enhanced with polyethylene glycol with a molecular weight of 20,000 (PEG20000) and bone glue (BG)—for smooth, compact, and fine-grain Zn electrodeposition. In the bench-scale operation, we achieve a notably low energy consumption of 2415.58 kW h/t Zn and a high current efficiency of 97.46%, with smooth and compact zinc deposit in fine-grained size of 25.4 nm. Electrochemical behavior analysis indicates that introducing the synergistic PEG20000 and BG promotes electrodeposition polarization and a three-dimensional instantaneous nucleation mode. Overall, the integration of PEG20000 and BG as additives in the ammonia system emerges as a technically and economically feasible strategy for zinc electrodeposition.
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