Nature Communications
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2022
·Vol. 13
·期 1
·1-9
·
IF 17.694
Zhang He-Shan,Dong Xue-Mei,Zhang Zi-Cheng,Zhang Ze-Pu,Ban Chao-Yi,Zhou Zhe,Song Cheng,Yan Shi-Qi,Xin Qian,Liu Ju-Qing,Li Yin-Xiang,Huang Wei
Neuromorphic electronics, which use artificial photosensitive synapses, can emulate biological nervous systems with in-memory sensing and computing abilities. Benefiting from multiple intra/interactions and strong light-matter coupling, two-dimensional heterostructures are promising synaptic materials for photonic synapses. Two primary strategies, including chemical vapor deposition and physical stacking, have been developed for layered heterostructures, but large-scale growth control over wet-chemical synthesis with comprehensive efficiency remains elusive. Here we demonstrate an interfacial coassembly heterobilayer films from perylene and graphene oxide (GO) precursors, which are spontaneously formed at the interface, with uniform bilayer structure of single-crystal perylene and well-stacked GO over centimeters in size. The planar heterostructure device exhibits an ultrahigh specific detectivity of 3.1 × 10 13 Jones and ultralow energy consumption of 10 −9 W as well as broadband photoperception from 365 to 1550 nm. Moreover, the device shows outstanding photonic synaptic behaviors with a paired-pulse facilitation (PPF) index of 214% in neuroplasticity, the heterosynapse array has the capability of information reinforcement learning and recognition.
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JOURNAL OF FLUORESCENCE
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2025
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IF 3.1
Tang Qianyun,Huang Linling,Chen Tingting,Xie Feifei,Tan Hongyan,Chen Donghua
In this paper, a molecular imprinted metal-organic framework was prepared by a simple one-pot method using lanthanide terbium ions as the metal source, 2-aminoterephthalic acid as the organic ligand, and 4-nitrophenol as the template molecule at 120 °C. The materials of imprinted and non-imprinted metal-organic framework were characterized and analyzed by Scanning Electron Microscope, X-ray photoelectron spectroscopy, X-ray Diffraction, Brunauer-Emmett-Teller Specific Surface Area Analysis and fluorescence methods, etc., respectively. The fluorescence of the imprinted metal-organic framework was quenched by 4-nitrophenol in water, and there was a linear correlation between the fluorescence quenching efficiency of molecular imprinted metal-organic framework and the logarithm of 4-nitrophenol concentration in the range of 10–500 µmol L − 1 . The limit of detection was 3.3 µmol L − 1 (3σ) and the limit of quantitation was 11.0 µmol L − 1 (10σ). The molecular imprinted metal-organic framework was used for the determination of 4-nitrophenol concentration in water samples with the recoveries of 93.5-102.9% and the relative standard deviations less than 3.63%. The molecular imprinted metal-organic framework has the advantages of easy preparation, high stability, good sensitivity and selectivity, which has potential application for the detection of 4-nitrophenol in the environment samples. Graphical abstract
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Acta Geochimica
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2025
·
IF 1.3
Wang Zhenglong,Shang Linbo,Chou I-Ming,Chen Chen,Zhou Yunhe,Li Jianguo,Jiang Ziqi,Gao Xinwei,Wan Ye
The formation of copper deposits is closely related to hydrothermal processes. Understanding the migration of copper in hydrothermal fluids aids in reconstructing mineralization processes and deciphering deposit genesis. Copper primarily exists as Cu + and Cu 2+ in hydrothermal solutions, with redox conditions governing their interconversion. In chloride-rich geological fluids, Cu–Cl complexes are considered critical for copper transport. However, the specific types and valence transitions of Cu–Cl complexes under varying hydrothermal conditions remain poorly understood. This study employed in situ Raman spectroscopy to systematically analyze Cu + HCl and CuCl 2 + K 2 S 2 O 3 /H 2 systems under saturated vapor pressure at 25–300 °C, elucidating the effects of temperature, Cl − concentration, and redox conditions on copper speciation. In the Cu + HCl system, copper dissolved as monovalent Cu–Cl complexes. At high temperatures (> 200 °C), [CuCl 2 ] − is the dominated species, whereas [CuCl 3 ] 2− becomes prevalent at lower temperatures and higher HCl concentrations. For the Cu 2+ –Cl system, the dominant species transitioned from [Cu(H 2 O) n ] 2+ (< 50 °C) to [CuCl 4 ] 2− (100 °C) and further to [CuCl] + and [CuCl 2 ] 0 at 300 °C. The introduction of reducing agents (K 2 S 2 O 3 /H 2 ) facilitated Cu 2+ → Cu + reduction, thereby stabilizing Cu + –Cl complexes and inducing partial copper precipitation. The behavior of copper in chloride-rich hydrothermal fluids observed in this study indicates that high-temperature oxidizing fluids facilitate Cu mobilization, while cooling and redox changes promote deposition and ore minerals formation.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-12
·
IF 15.7
Fan Xiulian,Yi Jiali,Deng Bin,Zhou Cong,Zhang Zejuan,Yu Jia,Li Weihan,Li Cheng,Wu Guangcheng,Zhou Xilong,Sun Tulai,Zhu Yihan,Zhou Jian,Xia Juan,Wang Zenghui,Lai Keji,Peng Zheng,Li Dong,Pan Anlian,Zhou Yu
The experimental realization of single-crystalline high-κ dielectrics beyond two-dimensional (2D) layered materials is highly desirable for nanoscale field-effect transistors (FETs). However, the scalable synthesis of 2D nonlayered high-κ insulators is currently limited by uncontrolled isotropic three-dimensional growth, hampering the achievement of simultaneous high dielectric constants and low trap densities for small film thicknesses. Herein, we show a 2D edge-seeded heteroepitaxial strategy to synthesize ultrathin nonlayered 2D CaNb 2 O 6 nanosheets by chemical vapor deposition, exhibiting high-crystalline quality, thickness-independent dielectric constant (~ 16) and breakdown field strength up to ~ 12 MV cm −1 . The MoS 2 /CaNb 2 O 6 FETs exhibit an on/off ratio of over ~ 10 7 , a subthreshold swing down to 61 mV/dec and a negligible hysteresis. This work suggests a universal 2D edge-seeded heteroepitaxy and slow kinetic strategy for the scalable growth of 2D nonlayered dielectric and demonstrates 2D CaNb 2 O 6 nanosheets as promising dielectrics for facilitating 2D electronic applications.
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CELLULOSE
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2025
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IF 4.8
Xu Qingbo,Zhang Jinlong,Zhang Supeng,Wu Zheng,Tao Xuchen
Adaptive moisture and thermal management cotton fabrics can maintain human physiological comfort without requiring space heating or cooling, aligning with the goals of sustainable development, carbon neutrality, and carbon peak. However, the moisture and thermal management performance and wearing comfort of cotton fabrics require further study. In this study, mist polymerization technology and the “grafting through” polymerization method were used to graft poly[2-(2-methoxyethoxy) ethoxyethyl methacrylate] (PMEO2MA) onto the inner surface of cotton fabric and poly[ N,N -dimethyl(methacryloylethyl)ammonium propane sulfonate] (PDMAPS) onto the outer surface. The reversible wetting properties of both surfaces impart the fabric with excellent moisture and thermal management capabilities. The treated fabric reduces skin temperature by approximately 5.0 °C within 8 min when worn at 31.0 °C and increases skin temperature by around 3.0 °C–4.0 °C within 8 min when worn at 9.5 °C. This fabric, capable of rapidly managing moisture and thermal conditions in a short duration, exhibits considerable potential for application in harsh and demanding environments.
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RARE METALS
·
2025
·
IF 11
Yang Fan,Zhang Jun-Ning,Zhang Chao,Xu Xin-Da,Li Bing,Yang Woochul,Xie Wan-Feng
Real-time detection of acetic acid vapor is of concern for ensuring environmental and personal safety. However, acetic acid gas sensors, particularly those based on Bi 2 O 3 , often fail to meet practical performance requirements owing to their slow response characteristics and high operating temperature. To enhance sensing performance, highly permeable Bi 2 O 3 microspheres decorated by Pt-nanoparticles are rationally synthesized by a facile template method. Among the fabricated sensors, the one based on 3 wt% Pt-decorated Bi 2 O 3 demonstrated excellent sensing performance. Specifically, the sensor displayed high selectivity for acetic acid, rapid response and recovery times (22.5 and 9 s, respectively), strong resistance to interference, and good long-term stability at a low operating temperature (150 °C). Notably, the sensor exhibited an exceptionally high response of 126 to 100 ppm acetic acid—the highest reported value for Bi 2 O 3 -based sensors tested at a relatively low operating temperature in recent years. These results demonstrate that Pt-decorated Bi 2 O 3 holds strong potential for use in high-performance acetic acid sensors. Graphical abstract
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Nature Plants
·
2025
·
IF 13.6
Chen Xiuxiu,Jin Songsong,Du Hong,Liu Zebin,Hou Congcong,Tang Ling,Wang Yuanyuan,Wang Yuxi,Yang Zhaolin,Zhao Tong,Ma Jinying,Zhang Lanjun,Li Meijing,Qi Dongdong,Li Wenlong,Wang Xiaohua,Sun Runze,Moore John P.,Liu Yongxiu,Lin Jinxing,Deng Xin
Autophagy and apoplastic ascorbic acid (AsA) play important roles in plant drought tolerance. However, the trans-plasma membrane transport of AsA and its association with autophagy during drought stress are unclear. Here we report an AsA-induced autophagy pathway in plants, wherein plasma-membrane-located cytochrome b561 and DOMON domain (CYBDOM) proteins play positive roles. CYBDOM proteins from the resurrection plant Boea hygrometrica (BhDB) and Arabidopsis (AtDB1) can transport electrons across the plasma membrane using intracellular AsA as an electron donor and apoplastic monodehydroascorbic acid or Fe 3+ as electron acceptors in Xenopus laevis oocytes. Increased apoplastic AsA, autophagy and drought tolerance are observed in BhDB - and AtDB1 -overexpressing Arabidopsis compared with the wild type. CYBDOM proteins interact with respiratory burst oxidase homologue D (RbohD), which serves as the adaptor to bind autophagy related gene 8 protein (ATG8) and cargo protein for autophagic degradation. AsA increases AtDB1 protein level and its interaction with RbohD. Together, the AsA-activated CYBDOM–RbohD synergy to induce autophagy suggests a novel mechanism in plant drought and desiccation tolerance.
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PHARMACEUTICAL CHEMISTRY JOURNAL
·
2025
·Vol. 59
·期 2
·270-274
·
IF 1
Bao Yongfen,Wang Xingfeng,Wang Minjuan,Shan Shigang,Wei Mingjie,Ou Yingbao
A fluorescent probe ( N -(4-methyl-2-oxo-2 H -chromen-7-yl)-2,4-dinitrobenzenesulfonamide) for selective detection of tiopronin was synthesized and characterized. The probe displays weak fluorescence attributed to electron transfer from the fluorophore to the electron-withdrawing 2,4-dinitrobenzenesulfonyl group. However, upon effective cleavage of the electron-withdrawing 2,4-dinitrobenzenesulfonyl moiety by tiopronin from the weakly fluorescent probe, the fluorescence intensity is significantly enhanced. Under optimal conditions, the fluorescence intensity exhibited a linear correlation with tiopronin concentration within the range of 30 nM to 50 μM. The proposed strategy is characterized by its simplicity, specificity, and sensitivity. The proposed probe was employed for the determination of tiopronin in urine samples and commercial tablets, demonstrating potential applications in disease diagnosis.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-20
·
IF 15.7
Ruan Bankang,Deng Weiliang,Che Jingjing,Yi Shujuan,Liu Jie,Xu Weiping,Jiang Yuyan,zhou Ya,Xie Pan,Zhang Huhai,Zhao Hongwen,Huang Jiaguo
Acute kidney injury (AKI) frequently arises as a complication of hepatic ischemia-reperfusion injury (HIRI), yet simultaneous optical imaging of both remains challenging due to the lack of unimolecular dual-responsive probes. Herein, we report a library of hemicyanine-based chemiluminophores (HCLs) with tunable emission to second near-infrared window (725 − 1025 nm) achieved by integrating bicyclic dioxetane onto hemicyanine skeletons to develop multiple-responsive chemiluminescent probes. HCL1 and HCL5 respectively emitting at 725 nm and 1025 nm are selected to construct a cascaded activatable reporter CAR for crosstalk-free duplex chemiluminescence imaging of interlinked biomarkers. Following systemic injection to male mice, CAR preferentially accumulates in the liver and reports HIRI-associated superoxide anion (O 2 •− ), which initiates self-fragmentation and liberates the secondary reporter KIR into kidneys to report AKI-associated N-acetyl-β-D-glucosaminidase (NAG). Such mechanism allows CAR to serve as a reservoir for gradual release of AKI reporters, providing a significantly prolonged imaging window compared to co-administering separate probes. CAR further permits remote detection of HIRI-induced AKI via urinalysis. This study not only offers a powerful tool for simultaneous detection of HIRI and HIRI-induced AKI, but also highlights a unimolecular probe design for ultrasensitive detection of deeply-seated intercorrelated diseases.
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Nature Communications
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2025
·Vol. 16
·期 1
·1-12
·
IF 15.7
Huang Jiayong,Shen Zhuanglin,Xiao Xiaoyun,Wang Lanteng,Zhang Jiwen,Zhou Jiahai,Gu Yang
The clinical efficacy of the antidiabetic drug acarbose is hampered by degradation by the acarbose-preferred glucosidase (Apg) from K. grimontii TD1. Understanding the catalytic mechanism of Apg can aid the design of next-generation hypoglycemic pharmaceuticals acarbose analogs. Here, we determine several crystal structures of Apg to identify the catalytic residues and the ligand-binding pocket of Apg. Structural analyses and computational modeling reveal D448 as the active nucleophile, contrasting with prior studies that assumed D336 to be the nucleophile. In addition to E373 proposed as the proton donor in previous reports, we find that R334 might be an alternative proton donor. Our experimental and computational analyses indicate the two-ring product acarviosine is the two-step hydrolyzed product, where the second hydrolysis is the rate-limiting step. Additionally, further investigation of the acarbose analogs acarstatins A and B that are resistant to Apg is conducted by computational analysis. Overall, our studies provide perspectives into the intricacies of Apg’s catalytic mechanism, contributing to the design of next-generation hypoglycemic pharmaceuticals.
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GENOME BIOLOGY
·
2025
·
IF 9.4
Junhui Lv,Zhinang Yin,Conghui Li,Honglin Wen,Jian Ni,Peiyuan Yang,Zemin Song,Ying Xiang,Honghong Wang,Rui Lu,Li Huang,Ying Zhou,Hai-Bing Zhou,Ruijing Xiao,Pingping Fang,Kaiwei Liang
Background KAT6A-CBP (K/C) and KAT6A-P300 (K/P) fusions are recurrent genetic alterations in acute myeloid leukemia (AML) associated with poor prognosis. Despite their strong oncogenic potential, the mechanisms underlying their genomic targeting and leukemogenic function remain unclear. A major challenge has been their large size, which has impeded preclinical model development and mechanistic studies. Results We employ a domain-focused truncation strategy to generate de novo murine models of K/C and K/P fusions, which faithfully recapitulate the morphological, immunophenotypic, and transcriptomic features of KAT6A-rearranged AML. Genomic profiling reveals that KAT6A fusions preferentially localize to H3K4me2/3-marked regions, while biochemical analyses uncover that KAT6A interacts with the Nucleosome Remodeling Factor (NURF), a key H3K4me2/3 reader. Disrupting NURF-chromatin interactions via depletion or small-molecule inhibition of its subunit, Bromodomain PHD Finger Transcription Factor (BPTF), impairs K/C recruitment and disrupts MLL/COMPASS-mediated H3K4me2 deposition, defining a functional epigenetic module involving KAT6A chimeras, NURF, and MLL/COMPASS. Notably, CBP/P300 inhibition reduces histone acetylation and chromatin accessibility, further impairing the recruitment of this epigenetic module. Targeting this module via NURF or CBP/P300 inhibition demonstrates efficacy in K/C leukemia models, with enhanced therapeutic effects observed when combined. Conclusions Our study identifies a self-reinforcing epigenetic module of histone modifiers and readers in KAT6A-rearranged AML, providing mechanistic insights into the genomic targeting of KAT6A chimeras and highlighting promising combinatorial therapeutic strategies. Supplementary Information The online version contains supplementary material available at 10.1186/s13059-025-03743-y.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-9
·
IF 15.7
Wei Yi,Zhang Yan,Li Yawen,Li Chen,Wang Yuxuan,Luo Zhishan,Liu Yulian,Kang Huimin,Chen Xihan,Quan Zewei
Chiral recognition through fluorescence changes enables the rapid and sensitive determination of enantiomers. However, the rational design and synthesis of fluorescent probes for efficient chiral recognition remain a challenge. Here we present a novel platform for chiral recognition based on zero-dimensional hybrid copper halides with unique symmetry-dependent properties. The use of mesomeric 1,2-diaminocyclohexane (DACH) ligands promotes the formation of centrosymmetric, non-luminescent Cu 2 I 6 4− units. The incorporation of enantiopure S - or R -DACH ligands into these mesomeric compounds breaks their symmetry, spontaneously transforming them into chiral compounds and generating Cu 4 I 6 2− units that exhibit intense circularly polarized luminescence. Additionally, introducing opposite chiral ligands into these chiral compounds leads to the formation of racemic, non-luminescent CuI 3 2− units, whereas the addition of same-chirality ligands preserves the structure and optical properties of the chiral Cu 4 I 6 2− units. This enantioselective response by utilizing symmetry-dependent optical properties offers a pathway toward advanced chiral sensing technologies.
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