GREEN CHEMISTRY
·
2023
·
IF 9.8
Shihao Su,Guojun Lv,Xuyang Zou,Jiangzhang Wang,Chaoyi Zhou,Yan Chen,Jialing Shen,Yangbin Shen,Zhongmin Liu
In the cyclic alkene epoxidation reactions using molecular oxygen as oxidant, aldehyde is generally added as co-oxidant to assist transition metal catalyst to activate the oxygen molecule, oxidizing cyclic alkene and producing the corresponding epoxide; however, the added aldehyde would be converted into byproduct carboxylic acid. Herein, we report the room-temperature tandem conversion of cyclic alkenes into 1,2-diols through the application of byproduct carboxylic acid as a catalyst for epoxide hydration reaction, realizing effective utilization of the byproduct and saving energy consumption. Four kinds of nanosized MnO2 specimens, including α-, β-, δ-, and γ-MnO2, were hydrothermally synthesized and applied as heterogeneous catalysts for the room-temperature tandem conversion of cyclohexene into 1,2-cyclohexanediol using molecular oxygen as oxidant and isobutyraldehyde as co-oxidant. The characterization results demonstrated that the obtained β-MnO2 sample had the maximum Mn4+/Mn3+ ratio of 1.42 and the minimum Oads/OLatt ratio of 0.34, consistent with its least oxygen vacancies evidenced by EPR measurement. Accordingly, the β-MnO2 sample revealed the quickest alkene epoxidation reaction rate and could achieve a 99.2% cyclohexene conversion within 1 h, and meanwhile, a 73.6% 1,2-cycloheanediol yield could be attained within 24 h. A plausible mechanism for the tandem conversion of cyclohexene into 1,2-cyclohexanediol over the β-MnO2 heterogeneous catalyst was proposed and further verified by quenching experiments and DFT calculations. Furthermore, the synthesized β-MnO2 catalyst sample could be reused more than ten times, and meanwhile, the tandem conversion way could be expanded to most of the cyclic alkene substrates, which demonstrated that the β-MnO2 catalyst was an active and stable heterogeneous catalyst for tandem conversion of cyclic alkenes into 1,2-diols.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2023
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IF 5.2
Yingying Zhang,Carice Chong,Wangshu Tong,Haitao Li,Hiang Kwee Lee,Jie Han
Polyvinylidene fluoride (PVDF) is promising for piezo-catalytic applications owing to its excellent biocompatibility, flexibility, and durability. However, it is limited by weak electroactivity originating from its intrinsically low β piezoelectric phase content (<20%) and insulating properties. Here, we achieve efficient piezo-catalysis by introducing a self-polarized PVDF-based composite containing carbon nanotube (CNT) as conductive fillers. Notably, our self-polarized CNT/PVDF (SCP) ensemble exhibits a high β phase content of ∼95%, which is up to 6-fold higher than the original PVDF powder, and superior electrical activity by exploiting the polarity induction effect of water molecules. As a proof-of-concept demonstration, the SCP realizes efficient degradation of organic-polluted water by at least 95% within 2 h of ultrasonication (240 W), even at high pollutant concentration (40 mgL −1 ). Systematic investigations unveil its excellent recyclability and adaptability to various tropical or subtropical natural waters. More importantly, the SCP also achieves efficient H 2 O 2 production of up to ∼13.5 mmol g CNT −1 h −1 , which is > 6-fold and > 19-fold better than standalone self-polarized PVDF (i.e., without CNT content) and emerging piezo-catalytic designs, respectively. This study offers a unique approach for designing PVDF-based piezo-catalyst to expedite mechanically-driven catalysis towards practical applications.
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KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
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2023
·
IF 3.3
Peng-Cheng Zhong,Zhi-Wen Liu,Qi-Chang Xing,Jia Chen,Rui-Pei Yang
Non-small cell lung cancer (NSCLC) accounts for ~85% of all lung cancer cases. Neferine is used as a traditional Chinese medicine with many pharmacological effects, including antitumor properties; however, it has not been reported whether neferine plays an anticancer role by causing pyroptosis in NSCLC cells. We used two typical lung cancer cell lines, A549 and H1299, and 42 lung cancer tissue samples to investigate the regulatory effects of neferine on TGF-β and MST1. We also treated lung cancer cells with different concentrations of neferine to study its effects on lung cancer cell survival, migration, invasion, and epithelial–mesenchymal transition (EMT) as well as on pyroptosis. Lentivirus-mediated gain-of-function studies of TGF-β and MST1 were applied to validate the roles of TGF-β and MST1 in lung cancer. Next, we used murine transplanted tumor models to evaluate the effect of neferine treatment on the metastatic capacity of lung cancer tissues. With increasing neferine concentration, the viability, migration, invasion, and EMT capacity of A549 and H1299 cells decreased, whereas pyroptosis increased. Neferine repressed TGF-β expression to modulate the induction of reactive oxygen species (ROS) by MST1. Overexpression of TGF-β in either in vitro or mouse-transplanted A549 cells restored the inhibitory effect of neferine on tumor development. Overexpression of MST1 clearly enhanced pyroptosis. Neferine contributed to pyroptosis by regulating MST1 expression through downregulation of TGF-β to induce ROS formation. Therefore, our study shows that neferine can serve as an adjuvant therapy for NSCLC patients.
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AAPS PHARMSCITECH
·
2023
·Vol. 24
·期 7
·1-12
·
IF 3.3
Lv Jianhua,Wu Pan,Fang Yaru,Zhang Wenchang,Liu Dongwen,Wu Mi,Shang Lei,Li Huaiguo,Zhao Yan
By selecting L-arginine as the hydrogen bond acceptor (HBA) and 2-hydroxypropyl-β-cyclodextrin (2HPβCD) as the hydrogen bond donor (HBD), deep eutectic solvents (DESs) with various water content were prepared at the 4:1 mass ratio of L-arginine to 2HPβCD with 40 to 60% of water, and were studied for its application in transdermal drug delivery system (TDDS). The hydrogen bond networks and internal chemistry structures of the DESs were measured by attenuated total reflection Fourier transform infrared (ATR-FTIR) and 1 H-nuclear magnetic resonance spectroscopy ( 1 H-NMR), which demonstrated the successful synthesis of DESs. The viscosity of DES was decreased from 10,324.9 to 3219.6 mPa s, while glass transition temperature (Tg) of the DESs was increased from − 60.8 to − 51.4 °C, as the added water was increased from 45 to 60%. The solubility of ibuprofen, norfloxacin, and nateglinide in DES with 45% of water were increased by 79.3, 44.1, and 3.2 times higher than that in water, respectively. The vitro study of transdermal absorption of lidocaine in DESs showed that the cumulative amounts of lidocaine reached 252.4 µg/cm 2 , 226.1 µg/cm 2 , and 286.1 µg/cm 2 at 8 h for DESs with 45%, 50%, and 60% of water, respectively. The permeation mechanism of DES with lower content of water (45%) was mainly by changing the fluidization of lipids, while changing the secondary structure of keratin in stratum corneum (SC) at higher water content (50% and 60%). These nonirritant and viscous fluid like DESs with good drug solubility and permeation enhancing effects have broad application prospect in the field of drug solubilization and transdermal drug delivery system. Graphical Abstract
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JOURNAL OF CONTROLLED RELEASE
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2023
·
IF 10.8
Li Li,Yinglu Wang,Zhengjun Huang,Zuxian Xu,Ruipin Cao,Jiaxin Li,Biyi Wu,Jian Ren Lu,Hu Zhu
Bacterial infections and excessive inflammation can impede the healing of wounds. Hydrogels have emerged as a promising approach for dressing bacterial-infected injuries. However, some antibacterial hydrogels are complex, costly, and even require assistance with other instruments such as light, making them unsuitable for routine outdoor injuries. Here, we developed an in-situ generating hydrogel via hybridizing oxidized β -D-glucan with antimicrobial peptide C 8 G 2 through the Schiff base reaction. This hydrogel is easily accessible and actively contributes to the whole healing process of bacterial-infected wounds, demonstrating remarkable antibacterial activity and biological compatibility. The pH-sensitive reversible imine bond enables the hydrogel to self-heal and sustainably release the antibacterial peptide, thereby improving its bioavailability and reducing toxicity. Meanwhile, the immunoregulating β -D-glucan inhibits the release of inflammatory factors while promoting the release of anti-inflammatory factors. In methicillin-resistant Staphylococcus aureus (MRSA)-infected full-thickness skin wound models, the hybrid hydrogel showed superior antibacterial and anti-inflammatory activity, enhanced the M2 macrophage polarization, expedited wound closure, and regenerated epidermis tissue. These features make this hydrogel an appealing wound dressing for treating multi-drug-resistant bacteria-infected wounds.
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JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
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2023
·
IF 4.1
Jing Cheng,Guangwen Zhang,Liu Liu,Jianming Luo,Xichun Peng
BACKGROUND Beta-glucan is widely sourced and has various physiological activities including anti-inflammation. However, the strength of the anti-inflammatory activity of β-glucans from different sources remained elusive due to the lack of rapid and effective biomarkers. Therefore, this study aimed to screen out the β-glucan with strong anti-inflammatory activity from 5 different sources and to further screen out possible biomarkers in metabolites after fermented the β-glucans by gut microorganisms. RESULTS The results showed that all five β-glucans inhibited the production of LPS-induced pro-inflammatory mediators and suppressed the mRNA expression level of TLR4/MyD88. Their anti-inflammatory mechanisms involved the inhibition of intracellular ROS production and suppression of mRNA expression of the NF-κB pathway and JNK pathway. Among them, barley β-glucan exhibited the strongest anti-inflammatory effect, followed by Ganoderma lucidum β-glucan. Enhanced anti-inflammatory activity of β-glucan after fermentation was found and may be related to the increased abundance of metabolites such as the vanillin, dihydroxyphenylacetic acid, caffeic acid, acetic acid, butyric acid, and lactic acid. They are strongly positively correlated to the abundance of beneficial bacteria such as Blautia , suggesting that the production of those metabolites may be responsible for the flourishing of the beneficial bacteria. CONCLUSION In conclusion, barley was a preferred raw material for the preparation of β-glucans with high anti-inflammatory activity. Vanillin, dihydroxyphenylacetic acid, caffeic acid, acetic acid, butyric acid, and lactic acid were the possible biomarkers that could be utilized to evaluate the anti-inflammatory effect of β-glucans. This article is protected by copyright. All rights reserved.
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CRYSTENGCOMM
·
2018
·Vol. 21
·期 3
·513-523
·
IF 3.304
Xiao Liu,Naru Zhao,Xiaoheng Guo,Haibo Duan,Jingjing Diao,Yifan Dong,Yingjun Wang
Cellular behavior is a result of homologous responses to biomaterials, especially material surfaces. An effective way to elicit a desired biological response is to employ micro/nanostructured constructions for biomaterial surface design; however, the brittleness of inorganic materials usually hinders structure regulation. In this study, a micro/nanostructured surface was fabricated using a hydrothermal treatment that did not require crystal regulation reagents. The precursor, β-tricalcium phosphate, was mixed with CaSiO3. The resulting micro/nanostructured surface had a hybrid structure containing nanowires, microrods, and rod clusters. In vitro cellular proliferation, cytotoxicity and osteodifferentiation experiments indicated that the micro/nanostructured surfaces alleviated material cytotoxicity, improved cell proliferation, and effectively promoted osteogenic differentiation of mouse bone mesenchymal stem cells. These results suggest that this simplified surface treatment is an efficient way to improve cell biological response to inorganic biomaterials.
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MATERIALS RESEARCH INNOVATIONS
·
2023
·
IF 0
Yunhang Liu,Jiale Han,Yurii Mishchenko,Andrii Butenko,Vladyslav Kovalenko,Hongyuan Zhao
Herein, a novel electrochemical sensor was designed for the sensitive determination of methyl parathion (MP) using the Super P Li carbon black@β-cyclodextrin (SPLCB@β-CD) decorated glassy carbon electrode (GCE). SPLCB with high electroactive area exhibited exceptional conductivity and good dispersive property, which is beneficial for forming the interlinked conductive network structure. β-CD could not only promote the uniform dispersion of SPLCB but also effectively realise the enrichment of MP molecules. Moreover, the existence of SPLCB could make up for the defect of poor conductivity of β-CD. Under the optimal experimental condition (pH = 7.0, enrichment time: 60 s). The collaborative cooperation of SPLCB and β-CD achieved the excellent MP detection property (LOD: 8.6 nM; concentration range: 0.01–10 μM). The SPLCB@β-CD/GCE sensor exhibited acceptable repeatability and reproducibility. In addition, the proposed sensor was successfully employed to detect MP in apple juice (Recoveries: 98.0–98.6%, RSD values: 3.68–4.63%).
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LWT-FOOD SCIENCE AND TECHNOLOGY
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2023
·
IF 6
Shenwan Wang,Lili Zheng,Yuxue Ji,Yang Yang,Xiaoyan Zheng,Dao Xiao,Mingfu Wang,Binling Ai,Zhanwu Sheng
Numerous studies have demonstrated the potential of banana blossom polyphenols as antioxidants and antifungal agents. However, their application in the food field is extremely limited due to their vulnerability to environmental conditions. This study aims to increase the stability of banana blossom polyphenols and explore their potential in food preservation, particularly against fungal infections. To achieve this, β-lactoglobulin@ferulic acid-quercetin-vanillic acid nanoparticles ( N -β-LG@FA-QT-VA) with a particle size of 74.5–80.7 nm were successfully obtained using β-lactoglobulin (β-LG) as the encapsulating material, combined with protein heating modification and emulsification-evaporation techniques. The encapsulation process resulted in a significant increase in antioxidant activity, with an improvement of 42.3% over the free polyphenols. Furthermore, N -β-LG@FA-QT-VA nanoparticles displayed significantly higher antifungal activity and fruit preservation abilities compared to β-LG and FA-QT-VA mixtures. They effectively inhibited the germination and expansion of Penicillium digitatum , a common fruit pathogen. Applying this knowledge, these nanoparticles were tested on orange fruits inoculated with P. digitatum . A successful delay in green mold infection and decay was observed, demonstrating the potential of N -β-LG@FA-QT-VA nanoparticles as a natural alternative to synthetic fungicides, all while maintaining fruit quality.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2023
·
IF 5.2
Xiang-Hua Ling,Yue-Feng Tang,Guo-Zhi Han
The composite of hydrogels and noble metal nanoparticles has wide applications in the field of functional materials . In this paper, we developed a novel and green strategy to synthesize a kind of composite hydrogel microspheres containing silver nanoparticles and β-cyclodextrin (β-CD) modified sodium alginate (β-CD@SA@Ag) without use of strong reducing reagent. First, β-CD was chemical linked to SA by epichlorohydrin (ECH) to form the β-CD modified polymer (β-CD@SA). then AgNO 3 was added to the as-prepared polymer solution , in which silver nanoparticles were formed by the reducing power of β-CD units. Subsequently, by reversed-phase emulsion method and ionic cross-linking, a kind of β-CD@SA@Ag hydrogel microspheres were obtained. The structure and morphology of the composite material were characterized in detail by Fourier infrared spectroscopy (FT-IR), thermogravimetric analysis (TG), scanning electron microscope (SEM), transmission electron microscope (TEM) and X-ray diffraction (XRD). Test data indicated that silver nanoparticles evenly dispersed in the composite material. On the basis, the adsorption and catalytic performances of the β-CD@SA@Ag hydrogel microspheres were studied towards to the reduction of aromatic nitro compounds. Research results showed that the β-CD@SA@Ag hydrogel microspheres had excellent catalytic activity along with high environmental adaptability. whether in pure water, tap water or river water, aromatic nitro compounds can be completely reduced within 2–13 min. Moreover, the morphology of microspheres of the composite material endows the composite material with high stability and reusability. We believe that our work would provide a new idea for the green synthesis of organic-inorganic composite functional materials .
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FOOD CONTROL
·
2023
·
IF 6
Dan Shen,Xia Chang,Liling Zhou,Dandan Hao,Zhongxiang Fang,Yang Shan,Lvhong Huang,Gaoyang Li
In this study, an inclusion complex (IC) of citral (CIT) within hydroxypropyl- β -cyclodextrin (HP β CD) was prepared by ultrasound technique. The structural characterization, thermal stability, phase solubility, antifungal properties and applications of CIT/HP β CD-IC in strawberry storage were investigated. The results showed that CIT/HP β CD-IC was successfully formed and had better thermal stability than CIT only. The apparent stability constant and Gibbs free energy change of the inclusion process was determined to be 142.08 M −1 and −12.87 kJ mol −1 , respectively, by the phase solubility method. The in vitro antifungal tests demonstrated that the IC had a certain antifungal effect against Geotrichum citri-aurantii , with a significant inhibitory effect against the growth of Botrytis cinerea and Alternaria alternata at concentrations above 5 mg mL −1 . Additionally, the treatment of CIT/HP β CD-IC on strawberry effectively reduced the decay rate and decrease of weight loss, soluble solids, firmness, and pH, thereby extending the shelf life. This research indicated that the ultrasonically synthesized CIT/HP β CD-IC effectively improved the water solubility and stability of CIT and could be utilized as an antifungal preservative for storage and preservation of strawberry, and potentially other fruits and vegetables.
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FOOD CHEMISTRY
·
2023
·
IF 8.8
Jiaxuan Li,Yu Li,Wentao Su,Xuedi Zhang,Duo Liang,Mingqian Tan
Fucoxanthin (Fx) has poor water solubility and bioavailability, which limits its application in the food industry. To improve the physicochemical properties of Fx, hydroxypropyl-β-cyclodextrin (HP-β-CD) encapsulated Fx nanofibers (Fx/HP-β-CD nanofibers) were fabricated via electrospinning without using polymer. Molecular docking analysis showed the Fx/HP-β-CD nanofibers contained Fx and HP-β-CD at 1:2. Morphological analysis revealed the nanofibers were homogeneous without beads, having a diameter around 499 nm. The thermostability of Fx was significantly improved after encapsulationg by HP-β-CD. Animal studies showed that there was a 14% decrease of body weight, 11% white adipose tissue reduction and 9% lower of liver triglyceride for the mice treated with Fx/HP-β-CD nanofibers as compared with that of Fx treated mice. The total cholesterol was reduced by 23% in mice serum after treatment with Fx/HP-β-CD as compared with that of Fx. Interestingly, the Fx/HP-β-CD in this study could attenuate the testicular histopathology in obese mice.
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