JOURNAL OF COORDINATION CHEMISTRY
·
2025
·
IF 2.1
Ruojing Song,Yuxi Sun
A hydrazone compound 4-hydroxy-N’-(2-hydroxy-5-methylbenzylidene)benzohydrazide (HL) was prepared from the condensation reaction of 5-methylsalicylaldehyde with 4-hydroxybenzohydrazide. The compound was characterized by IR, UV-Vis, 1H NMR, and 13C NMR spectra. Reaction of HL with copper nitrate and copper chloride, respectively, afforded two new copper(II) complexes, [Cu2L2(CH3OH)2]·2NO3 (1) and [CuL(DMF)]·Cl (2). The complexes were characterized by IR and UV-Vis spectra. Structures of HL and the complexes were confirmed by single-crystal X-ray determination. The powder X-ray diffraction was performed to verify the purity of the bulk samples of the complexes. The hydrazone compound coordinates to the Cu atoms through phenolate oxygen, imino nitrogen, and carbonyl oxygen. The Cu atoms in complex 1 are in square pyramidal coordination, while that in complex 2 is in square planar coordination. The antibacterial study using the free hydrazone compound and the two copper complexes against both Gram-positive and Gram-negative bacteria are performed, the two complexes showed antibacterial activity against both Gram-positive and Gram-negative bacteria, whereas the free ligand shows no activity.
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高影响因子
POULTRY SCIENCE
·
2025
·
IF 4.2
Yuxin Shao,Yipu Li,Shuxian Xie,Bo Zhang,Jing Li,Yalei Wang,Yusheng Gao,Jianyuan Ma,Tenghe Ma,Zheng Wang
This study aimed to evaluate the effects of 4-hydroxyphenylacetic acid ( 4-HPAA ), a phenolic acid compound from Yucca schidigera extract, in Caco-2 cells and artificial rearing of pigeons. In vitro experiments showed that 4-HPAA at different levels exhibited higher cell viability than shikimic acid and 3,4-dihydroxybenzoic acid, and with the highest viability observed at 600 μM. Additionally, 600 μM 4-HPAA alleviated LPS-induced upregulation of IL-1β and CASPASE1 expressions ( P < 0.05) . In vivo results demonstrated that supplemental 4-HPAA at 500, 1000, and 2000 mg/kg levels did not affect the body weight of 25-day-old pigeons ( P > 0.05), but all levels increased immunoglobulin G ( IgG ) and IgM levels ( P < 0.05). Compared with control, 2000 mg/kg 4-HPAA significantly reduced serum L-lactic acid, D-lactic acid and lactate dehydrogenase ( LDH ) activity ( P < 0.05); increased spleen and bursa of Fabricius indices and intestinal total antioxidant capacity activity of 25-day-old pigeons ( P < 0.05); and elevated ileal barrier-related genes ( OCCLUDIN, CLAUDIN1 and MUC2) in 7-day-old pigeons, as well as jejunal MUC2 and ileal OCCLUDIN in 25-day-old meat pigeons ( P < 0.05). It also inhibited glycolytic gene hexokinase 2 expression, while upregulating the signaling pathway genes CAMK2G and MKNK1 ( P < 0.05). Supplemental 500 and 1000 mg/kg 4-HPAA significantly increased serum total cholesterol levels ( P < 0.05). Notably, 500 mg/kg 4-HPAA had an adverse effect on intestinal integrity, as indicated by the highest serum diamine oxidase content, and increased glycolytic gene LDH-B expression; However, it enhanced microbial richness and diversity in the intestines of 7-day-old pigeon ( P < 0.05). Besides, 1000 mg/kg 4-HPAA impaired intestinal morphology, as evidenced by a lower ileal villus height-to-crypt depth ratio ( P < 0.05), but resulted in the highest abundance of Lactococcus in 25-day-old pigeons. In conclusion, 600 μM 4-HPAA exhibits anti-inflammatory activity in Caco-2 cells, and 2000 mg/kg 4-HPAA promotes immune function and intestinal barrier integrity while inhibiting glycolytic gene expression and the production of related serum metabolites in meat pigeons.
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PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Yusen Chen,Shuzhao Zhang,Xiongcheng Duan,Jia Liu,Hengye Li,Meijie Wei,Wei Wang
The rapid and efficient removal of radioiodine from water is a challenging and meaningful task to safeguard human health. Herein, two calix[4]pyrrole-based polymers were prepared through Mannich reaction between nitrogen-rich 2,4,6-tri(piperazin-1-yl)-1,3,5-triazine (TPT) and two configurational isomers of tetra- meso resorcinol-functionalized calix[4]pyrrole (2α2β-CP and 4α-CP), referred as 2α2β-CP-TPT and 4α-CP-TPT, respectively. The nitrogen contents of 2α,2β-CP-TPT and 4α-CP-TPT were as high as 15.11 % and 14.84 %, respectively. Accompanied by the bowl-shaped calix[4]pyrroles, the CP-TPTs showed high vapor iodine uptake, especially 4.82 g/g for 4α-CP-TPT. More importantly, the CP-TPTs exhibited rapid adsorption kinetics for capture iodine from aqueous phase, with the 2α,2β-CP-TPT at 1 mg/mL level showing a k 2 value as high as 7.374 × 10 −3 g/(mg min). In addition, high iodine adsorption capacity for 2α,2β-CP-TPT and 4α-CP-TPT were achieved to be 1989.6 and 2812.6 mg/g from water, respectively. Even more impressive was the removal efficiency above 98 % in flow-through applications even at flow rate as high as 10 mL/min and in simulated seawater conditions. The CP-TPTs could also exhibit high dynamic iodine adsorption capacity from water as well as excellent stability and outstanding reusability. Adsorption mechanism study discovered the foundational role of the charge transfer interaction on the excellent adsorption performance of the CP-TPTs. All these features demonstrated promising application prospects of the CP-TPTs for iodine removal from water.
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高影响因子
Carbohydrate Polymer Technologies and Applications
·
2025
·
IF 6.5
Yi Wang,Yabin Ding,Xiaomei Wei,Wenxiu Tian,Wenxiang Zheng,Yongliang Liu,Chuanqin Shi,Xinxin Xiang
Pancreatic ductal adenocarcinoma (PDAC) presents a significant clinical challenge due to its high mortality and resistance to chemotherapy. Over the past decade, fucoidan has been explored as a potential treatment for cancers of the lung, breast, bladder, colon, and pancreas. However, investigations into the efficacy of fucoidan within the tumor microenvironment (TME) of pancreatic cancer are scarce, and its governing mechanisms are not fully understood. Herein, fucoidan (Mfu) from Fucus vesiculosus significantly induced the mRNA expression of inflammatory cytokines (interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-ɑ) by real-time fluorescence quantitative PCR (qPCR) in macrophages. RNA spatial transcriptome sequencing and western blotting showed that Mfu specifically targeted the tumor necrosis factor receptor superfamily member 9 (4-1BB), thereby triggering the TNF signaling pathway in RAW 264.7 cells. Mfu-activated macrophages indirectly elicited the apoptosis and G1-phase arrest of PAN02 cells, as shown by apoptotic protein detection and flow cytometry, suggesting a regulatory effect on pancreatic cancer cell death. In a PDAC allograft model in mice, Mfu (100–400 mg/kg/day, oral gavage) exhibited robust anti-tumor efficacy. Besides, immunohistochemistry (IHC) revealed that Mfu targeted 4-1BB specifically to activate macrophages within the TME. By engaging with the 4-1BB receptor and activating macrophages, Mfu offers a promising strategy to advance the development of pancreatic cancer immunotherapy.
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高影响因子
DYES AND PIGMENTS
·
2025
·
IF 4.2
Ling Chen,Xu Guo,Wenjing Du,Jifang Shang,Duo Yang,Dongdong Li,Shaohui Liu,Zhiwei Ma
Solution-processed zinc oxide nanoparticles (NPs) films are recognized as efficient electron transport layers (ETLs) for quantum dot light-emitting diodes (QLEDs), offering both good stability and high efficiency. However, due to the inherently high work function of such films, exciton quenching occurs at the QDs/ZnO interface in these QLEDs, thereby compromising performance. In this study, we propose a simple surface modification method for solution-processed magnesium-doped ZnO (ZnMgO) ETLs treated with 4-methylthiophenol (MTP). The effects of MTP treatment on the chemical, morphological, and electrical properties of thin films based on colloidal ZnMgO NPs were meticulously analyzed. For the first time, the proposed MTP-modified ZnMgO films were applied in QLEDs to investigate the impact of surface modification of the ETLs on device performance. The optimization of charge balance and the prevention of QD emission quenching were successfully decoupled. Full-color QLEDs utilizing the MTP-modified ZnMgO ETLs demonstrated impressive peak external quantum efficiencies: 10.27 % for blue-QLEDs, 21.03 % for green-QLEDs, and 17.41 % for red-QLEDs. Moreover, by modifying the surface of ZnMgO with MTP, the sensitivity of ZnMgO to water molecules was significantly reduced, thereby enhancing the stability of ZnMgO NPs. Consequently, these QLEDs featuring more stable ZnMgO exhibit extended lifetimes with T 50 values of 105,422 h (red), 48,071 h (green), and 187 h (blue). This discovery offers a novel strategy for improving the efficiency and lifetime of QLEDs by employing MTP-treated ZnMgO NPs as the ETLs.
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高影响因子
Sustainable Energy & Fuels
·
2022
·Vol. 6
·期 11
·2745-2754
·
IF 6.813
Hua Tan,Xuecheng Li,Hao Ma,Xiaolin Yang,Tong Zhan,Wenyu Xie,Suhua Wang,Jiaping Zhu
Herein, N-doped carbon embedded Ni catalysts were prepared by a co-impregnation method followed by pyrolysis in a N2 atmosphere for transfer hydrogenolysis of lignin β-O-4 alcohol and ketone model compounds using isopropanol as the hydrogen source. It was found that pyrolysis at 800 °C resulted in the formation of graphitic N-doped carbon shell encapsulated Ni nanoparticles (Ni@NC-800). The obtained Ni@NC-800 exhibited higher activity and selectivity to aromatics in the conversion of 2-phenoxy-1-phenylthanol and 2-phenoxyacetophenone, compared with Ni@NC-600 and Ni/NC-800. Moreover, the selectivity to aromatics could be further improved over Ni@NC-800-H, which is Ni@NC-800 after strong acid leaching. However, the presence of Cα–OH in lignin β-O-4 model compounds was essential for their product distributions. The control and characterization experiments suggested that the catalytic reaction occurred on the surface of N-doped carbon shells, because the encapsulated Ni NPs could donate electrons to the outer shells, leading to surface electron enrichment, thus making inert shells the new active sites in Ni@NC-800-H. In addition, Ni@NC-800-H was efficient for the conversion of various lignin β-O-4 alcohol and ketone model compounds with methoxyl groups with high yields of the aromatic products and also possessed high stability during consecutive reaction runs, which is because Ni nanoparticles are physically isolated from the reactive environment.
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高影响因子
MICROCHIMICA ACTA
·
2017
·Vol. 184
·期 7
·1933-1940
·
IF 4.58
Zhang Xiaolong,Zeng Yongyi,Zheng Aixian,Cai Zhixiong,Huang Aimin,Zeng Jinhua,Liu Xiaolong,Liu Jingfeng
The authors describe a fluorescence immunoassay for galectin-4, a candidate biomarker for various cancers. Glucose oxidase was encapsulated into a zeolitic imidazolate framework to give a composite (GOx/ZIF-8 composite) that acts as a signal-transduction tag via a biomimetic mineralization process. After modification of the composite with streptavidin, it binds biotinylated antibody against galectin-4. In the immunoassay, the response to galectin-4 results from the enzymatic oxidation of glucose. This reaction produces hydrogen peroxide (H 2 O 2 ) that reacts with iron(II) ions to generate hydroxy radical (•OH), which leads to the quenching of the fluorescence of gold nanoclusters (AuNCs). Accordingly, the fluorescence quenching of AuNCs depends on the concentration of target galectin-4. The GOx/ZIF-8 composite has a high loading capacity for GOx at uncompromised enzymatic activity. The fluorescence of AuNCs is sensitively quenched by •OH radicals. Galectin-4 can be detected by this method in concentrations as low as 10 pg·mL −1 . It is expected that this kind of enzyme/MOF composite-based immunoassay has a wide scope in that it may be adapted to other low-abundance proteins and biomarkers.
Schematic of a fluorescence immunoassay for galectin-4, a candidate biomarker for various cancers. It is based on a composite consisting of glucose oxidase and a metal-organic framework (GOx/ZIF-8 composite) as well as gold nanoclusters (AuNC)-iron(II) system.
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高影响因子
NEW JOURNAL OF CHEMISTRY
·
2022
·Vol. 46
·期 19
·9229-9237
·
IF 3.925
Jiabin Liu,Yuxiang Xin,Yiyang Bai,Wei She,Jing Wang,Gaungming Li
The selective oxidation of alkylbenzenes contributes greatly to the production of high-value chemicals. However, developing novel and efficient catalysts remains a great challenge. To explore new and efficient catalysts, a series of POMs of H(4+n)SiMo(12−n)VnO40 (SiMoVn, n = 1, 2 and 3) were reacted with rht-MOF-1 ([Cu6O(TZI)3(H2O)6]4·nH2O) by a one-pot self-assembly solvothermal method. As a result, three SiMoVn@rht-MOF-1 (1, n = 1; 2, n = 2 and 3, n = 3) were isolated. Single crystal analysis revealed that SiMoVn were successfully introduced in the cages of rht-MOF-1. When complex 3 was employed as a catalyst, it effectively catalyzed the selective oxidation of alkylbenzene with a conversion of 99% and selectivity of 99% under optimized reaction conditions. Recycling experiments proved that complex 3 is stable and recyclable after six cycles. In comparison with analogous catalysts, complex 3 exhibits outstanding catalytic performance. Furthermore, the kinetics and reaction mechanism were investigated and verified by EPR and XPS analysis. This approach paves a facile route to prepare POMs@MOFs for the selective oxidation of various alkylbenzenes.
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高影响因子
NEW JOURNAL OF CHEMISTRY
·
2021
·Vol. 45
·期 25
·11380-11389
·
IF 3.591
Rui Yang,Yifei Liu,Zhen Dong,Haiyan Li,Zhiwen Ye
As an environmentally friendly energetic group, the azide group can not only control the melting point but also increase the energy of the compound. Therefore, the design and synthesis of energetic compounds with azido groups have long been a focus of research in the field of energetic materials. 3-R-4-(5-methyleneazide-1,2,4-oxadiazol-3-yl)furazan energetic materials were synthesized and fully characterized. Using computational chemistry methods, the interactions of some compounds were studied, and the physical and chemical properties of all of compounds were examined. The results show that 3-amino-4-(5-methyleneazide-1,2,4-oxadiazol-3-yl)furazan (2) has a melting point similar to that of TNT and can be a potential carrier for molten-cast explosives. Hydroxylamine salt (4) has an excellent detonation velocity and detonation pressure of 9090 m s−1 and 35.76 GPa, respectively, and its energy is significantly higher than that of RDX, enabling replacement of RDX as a high-energy explosive. Although the detonation performance of compound 4 is slightly lower than that of HMX, its sensitivity is better than that of HMX, which shows that compound 4 still has a high application value. Non-covalent interactions (NCIs) and Hirshfeld surface models indicate that hydrogen bonding and π–π interactions are the key factors that reduce the sensitivity of compounds. Therefore, our results for 3-R-4-(5-methyleneazide-1,2,4-oxadiazol-3-yl)furazan energetic materials suggest that it may be competitive for application in both molten-cast explosives and high-energy explosives.
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高影响因子
JOURNAL OF POLYMER RESEARCH
·
2018
·Vol. 25
·期 1
·1-9
·
IF 1.434
Li Hanyuan,Wang Wei,Chen Guofei,Liu Yinfeng,Fang Xingzhong
Novel highly soluble phenylethynyl-endcapped oligoimides derived from mixed thioetherdiphthalic anhydride isomers ( m -TDPA) and 5(6)-amino-1-(4-aminophenyl)-1,3,3-trimethylindane (DAPI), 4,4′-oxydianiline (4,4’-ODA) with 4-phenylethynylphthalic anhydride (PEPA) as a reactive endcapping agent were synthesized. The calculated molecular weights of all the oligoimides were 2500 g·mol −1 .The effect of the mole ratio of DAPI/4,4’-ODA on solubility and melt viscosity of oligoimides as well as the thermal and mechanical properties of cured polyimide films was investigated. Experimental results indicated that DAPI greatly improved the solubility (>30 wt.%) of the oligoimides in low boiling points solvents when the content of DAPI was more than 10 mol% per total diamine. All the oligoimides exhibited very good processability with minimum melt viscosity lower than 60 Pa·s at about 330 °C. Tough and brown films were obtained after thermally cured at 370 °C for 1 h and dynamic mechanical analysis (DMA) showed that glass transition temperatures of the cured films increased up to 340 °C with the increasing content of DAPI. However, the thermal stability and mechanical properties decreased with the increase of DAPI content. The temperature of 5% weight loss was higher than 470 °C in both air and N 2 atmosphere obtained by thermogravimetric analysis (TGA). And the tensile strengths of the cured films were about 60 MPa.
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高影响因子
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2020
·Vol. 325
·期 2
·673-682
·
IF 1.137
Liu Bing,Jia Yongzhong,Jing Yan,Zhang Quanyou,Shao Fei,Yao Ying
Abstract The lithium isotope separation (LIS) plays a vital role in development of nuclear industry. The liquid–liquid extraction technologies open up new possibilities for LIS. This work presents preliminary results of the study on the extractions and separation of 6 Li/ 7 Li by mixed system, comprising amino-derivatives of benzo-15-crown-5 (4AB), ionic liquid and anisole. 4AB was used as an extractant. The eparation factor ( α ) is 1.031 ± 0.001, and abundance of 6 Li in loaded organic phase is 7.76%. Meanwhile, the reason why 4AB has better separation efficiency than B15C5 was explored brief by Fourier transform infrared (FT-IR) spectrum and quantum chemical calculations. Graphic abstract
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高影响因子
MICROCHIMICA ACTA
·
2019
·Vol. 186
·期 9
·1-9
·
IF 5.479
Li Xinli,Niu Zhiying,Lin Zhenfeng,Qin Yuan,Xu Jingxi,Huang Huayu,Wang Liancheng,Zhang Jianjian,Xu Zhigang
Boron nitride (BN) was used as a support and covered with an ionic liquid (IL) and tungsten disulfide (WS 2 ) nanoparticles to obtain an electrode for the determination of 4-aminophenol (4-AP). BN was prepared using a “solvent cutting” method, and the BN-IL-WS 2 nanocomposite was obtained by an ultrasonic method. BN and its hybrids were characterized by scanning electron microscopy, transmission electron microscopy and X-ray diffraction. When the BN-IL-WS 2 composites were coated on the surface of the electrode, the response to 4-AP was strongly amplified due to the strong synergetic effect between the three materials. The voltammetric response of the modified sensor (with a maximum at 0.29 V vs. Ag/AgCl) in solutions with a pH of 6 is linear in the 0.01–50 μΜ 4-AP concentration range, and the limit of detection is 3 nM. A modified glassy carbon electrode was applied for the determination of 4-AP in seawater and dispersions containing paracetamol tablets. The results were consistent with those obtained by HPLC.
Schematic representation of the voltammetric determination process of 4-aminophenol (4-AP). The electrochemical sensor based on the glassy carbon electrode modified with boron nitride (BN), ionic liquid (IL) and tungsten disulfide (WS 2 ) nanomaterials. They, exhibit an excellent performance compared with other electrodes.
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高影响因子
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