JOURNAL OF COORDINATION CHEMISTRY
·
2025
·
IF 2.1
Ruojing Song,Yuxi Sun
A hydrazone compound 4-hydroxy-N’-(2-hydroxy-5-methylbenzylidene)benzohydrazide (HL) was prepared from the condensation reaction of 5-methylsalicylaldehyde with 4-hydroxybenzohydrazide. The compound was characterized by IR, UV-Vis, 1H NMR, and 13C NMR spectra. Reaction of HL with copper nitrate and copper chloride, respectively, afforded two new copper(II) complexes, [Cu2L2(CH3OH)2]·2NO3 (1) and [CuL(DMF)]·Cl (2). The complexes were characterized by IR and UV-Vis spectra. Structures of HL and the complexes were confirmed by single-crystal X-ray determination. The powder X-ray diffraction was performed to verify the purity of the bulk samples of the complexes. The hydrazone compound coordinates to the Cu atoms through phenolate oxygen, imino nitrogen, and carbonyl oxygen. The Cu atoms in complex 1 are in square pyramidal coordination, while that in complex 2 is in square planar coordination. The antibacterial study using the free hydrazone compound and the two copper complexes against both Gram-positive and Gram-negative bacteria are performed, the two complexes showed antibacterial activity against both Gram-positive and Gram-negative bacteria, whereas the free ligand shows no activity.
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Scientific Reports
·
2024
·Vol. 14
·期 1
·1-12
·
IF 3.8
Jiang Tianying,Wang Yanhui,Yu Zhiyu,Du Liangwei
Herbicides are widely used to control weeds in agriculture filed, however, the excessive use of the conventional formulation causes harmful side effects on the environment. To relieve this problem, natural polymer nanoparticles as herbicide carrier were rapidly developed and applied in recent years. In the present study, chitosan/tripolyphosphate (CS/TPP) nanoparticles were synthesized as nanocarrier to load herbicide 4-chloro-2-methylphenoxyacetate sodium salt (MCPA-Na). The encapsulation efficiency (EE) of 51.32% was obtained through measuring indirectly by high performance liquid chromatography (HPLC). The free and MCPA-Na-loaded CS/TPP nanoparticles were characterized by using dynamic light scattering (DLS), zeta potential, Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). The encapsulation of MCPA-Na in CS/TPP nanoparticles resulted in the change of MCPA-Na release profile in different pH media and displayed effective sustained-release under neutral condition. The evaluation of herbicidal activity against Bidens pilosa L. showed that the efficacy enhancement of MCPA-Na was realized after encapsulation in CS/TPP nanoparticles. The proposed herbicide nanoformulation presented a good potential as a sustainable alternative for weed control in agriculture.
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高影响因子
POULTRY SCIENCE
·
2025
·
IF 4.2
Yuxin Shao,Yipu Li,Shuxian Xie,Bo Zhang,Jing Li,Yalei Wang,Yusheng Gao,Jianyuan Ma,Tenghe Ma,Zheng Wang
This study aimed to evaluate the effects of 4-hydroxyphenylacetic acid ( 4-HPAA ), a phenolic acid compound from Yucca schidigera extract, in Caco-2 cells and artificial rearing of pigeons. In vitro experiments showed that 4-HPAA at different levels exhibited higher cell viability than shikimic acid and 3,4-dihydroxybenzoic acid, and with the highest viability observed at 600 μM. Additionally, 600 μM 4-HPAA alleviated LPS-induced upregulation of IL-1β and CASPASE1 expressions ( P < 0.05) . In vivo results demonstrated that supplemental 4-HPAA at 500, 1000, and 2000 mg/kg levels did not affect the body weight of 25-day-old pigeons ( P > 0.05), but all levels increased immunoglobulin G ( IgG ) and IgM levels ( P < 0.05). Compared with control, 2000 mg/kg 4-HPAA significantly reduced serum L-lactic acid, D-lactic acid and lactate dehydrogenase ( LDH ) activity ( P < 0.05); increased spleen and bursa of Fabricius indices and intestinal total antioxidant capacity activity of 25-day-old pigeons ( P < 0.05); and elevated ileal barrier-related genes ( OCCLUDIN, CLAUDIN1 and MUC2) in 7-day-old pigeons, as well as jejunal MUC2 and ileal OCCLUDIN in 25-day-old meat pigeons ( P < 0.05). It also inhibited glycolytic gene hexokinase 2 expression, while upregulating the signaling pathway genes CAMK2G and MKNK1 ( P < 0.05). Supplemental 500 and 1000 mg/kg 4-HPAA significantly increased serum total cholesterol levels ( P < 0.05). Notably, 500 mg/kg 4-HPAA had an adverse effect on intestinal integrity, as indicated by the highest serum diamine oxidase content, and increased glycolytic gene LDH-B expression; However, it enhanced microbial richness and diversity in the intestines of 7-day-old pigeon ( P < 0.05). Besides, 1000 mg/kg 4-HPAA impaired intestinal morphology, as evidenced by a lower ileal villus height-to-crypt depth ratio ( P < 0.05), but resulted in the highest abundance of Lactococcus in 25-day-old pigeons. In conclusion, 600 μM 4-HPAA exhibits anti-inflammatory activity in Caco-2 cells, and 2000 mg/kg 4-HPAA promotes immune function and intestinal barrier integrity while inhibiting glycolytic gene expression and the production of related serum metabolites in meat pigeons.
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BMC Oral Health
·
2025
·Vol. 25
·期 1
·1-16
·
IF 3.1
Li Congcong,Zhao Li,Chen Xiaotao,Aierken Aikepaer,Yu Min,Kong Chuifan,Baheti Wufanbieke
Background Pure titanium and titanium alloy implants have been widely utilized in dental implantology due to their excellent biocompatibility and favorable elastic modulus. However, the inherent bioinertness of titanium-based implant surfaces often results in suboptimal osseointegration with surrounding bone tissue. Consequently, surface modification is essential to enhance the osseointegrative capacity of titanium implants. Methods We fabricated hydroxyapatite-graphene oxide (HA-GO) coatings via electrochemical deposition and systematically compared four distinct protein loading methods. Ultimately, we developed a hydroxyapatite-graphene oxide/interleukin-4 (Ti@HA-GO@IL-4) coating on pure titanium substrates to investigate its physicochemical properties and biocompatibility. Results The composite coating was successfully fabricated on pure titanium substrates, inducing significant surface modifications including the incorporation of bioactive functional groups, enhanced hydrophilicity, and altered surface morphology. Comparative characterization revealed that the composite coating exhibited superior hydrophilic properties, improved mechanical compatibility with bone tissue, stable Interleukin-4 (IL-4) adsorption and sustained-release behavior, as well as excellent biosafety confirmed by proliferation and adhesion assays using mouse embryo osteoblast precursor (MC3T3-E1) cells, when compared to unmodified titanium controls. Conclusions Ti@HA-GO@IL-4 represents a composite coating material with exceptional physicochemical properties and biological performance. This material demonstrates efficient IL-4 loading capacity and sustained release characteristics, thereby effectively promoting osteogenesis. These findings provide valuable insights for developing bioactive functional materials to enhance implant osseointegration.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Gaoling Liang,Lei Liao,Xudong Zhou,Wanjiang You,Jie Wen,Minjie Chen,Weifeng Zhang,Junjie Tan,Hao Lei,Ning Pan,Xiaoqiang Wang,Hao Zou
Silver-based adsorbents have demonstrated exceptional performance in capturing gaseous radioactive iodine from nuclear fuel reprocessing plants. However, their widespread industrial applications have been hindered by high costs. In this paper, K 2 Hg(NO 3 ) 4 @SiO 2 was first studied to trap gaseous iodine, which was synthesized by hydrothermal reaction, impregnation treatment and drying processing. K 2 Hg(NO 3 ) 4 was used as the adsorption active sites and was uniformly dispersed in the silica gel. The static adsorption capacities of K 2 Hg(NO 3 ) 4 @SiO 2 for I 2 and CH 3 I were 253.5 ± 2.3 mg/g and 257.7 ± 5.4 mg/g, respectively. The dynamic adsorption capacities of K 2 Hg(NO 3 ) 4 @SiO 2 were 200.2 mg/g and 131.3 mg/g at the inlet concentrations of 20.0 ± 0.5 mg/L and 5.2 ± 0.2 mg/L of I 2 , respectively. Furthermore, the dynamic adsorption capacities of K 2 Hg(NO 3 ) 4 @SiO 2 were 198.2 mg/g and 127.7 mg/g at the inlet concentrations of 7.6 ± 0.3 mg/L and 2.8 ± 0.2 mg/L of CH 3 I, respectively. The adsorption mechanistic analyses revealed that the I 2 was primarily captured through the formation of HgI 2 and Hg(IO 3 ) 2 , while the CH 3 I was predominantly captured in the form of HgI 2 . Regarding stability, K 2 Hg(NO 3 ) 4 @SiO 2 exhibited excellent stability in environments with strong oxidizing, strong radiation and high temperatures. More importantly, the cost of K 2 Hg(NO 3 ) 4 @SiO 2 was less than one-third that of silver-based adsorbents. Generally, the K 2 Hg(NO 3 ) 4 @SiO 2 gained advantages in adsorption performance and application cost, which was a promising alternative to silver-based adsorbents.
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JOURNAL OF MOLECULAR STRUCTURE
·
2025
·
IF 4.7
Wei Ding,Xiaofeng Yuan,Ming Lu,Yuangang Xu
3-Nitro-1-(trinitromethyl)-1 H -pyrazole-4-carboxylic acid ( 4 ) and its corresponding ammonium ( 5 ) and hydroxylammonium ( 6 ) salts were successfully synthesized from 3-amino-1 H -pyrazole-4-carbonitrile. Their structures were characterized by infrared, nuclear magnetic resonance, elemental analysis, and confirmed by single-crystal X-ray diffraction to be triclinic P 1 ¯ ( 4 ), monoclinic C 2 /c ( 5 ) and Cc ( 6 ) Space group with 2, 8, and 4 molecules per unit cell. ADCH charge analysis revealed an uneven electron density distribution across the ring system of 4 , with notably high charge density around two oxygen atoms of the carboxyl group, which facilitates hydrogen bond formation. NICS aromaticity evaluation further confirmed the strong aromatic nature of the product, with an NICS(1)zz value below -20.0 ppm. Remarkably, the hydroxylammonium salt 6 not only retains outstanding detonation properties (detonation velocity D = 8878 m s - ¹, detonation pressure P = 35.60 GPa) but also demonstrates superior mechanical sensitivity (impact sensitivity IS = 12 J, friction sensitivity FS = 200 N). This achieves an optimal balance between high energy and low sensitivity, meeting the design objectives for high-energy insensitive materials. The findings offer valuable insights and experimental support for the molecular design of novel energetic compounds that integrate high energy performance with robust stability.
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BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
·
2024
·
IF 3.9
Wei Chen,Yuan Chen,Baoye Song,Lei Zhai,Geru Tao,Bingxiang Wang,Boyan Liu,Hao Wang,Cindy X. Zhang,Hong-mei Gu,Deling Yin,Shucun Qin,Da-wei Zhang
Surfeit locus protein 4 (SURF4) acts as a cargo receptor to mediate endoplasmic reticulum export of various cargos. We have shown that SURF4 is essential for secretion of hepatic very low-density lipoprotein and intestinal chylomicron. Knockdown of hepatic Surf4 also significantly reduces the development of atherosclerosis and liver fibrosis without causing overt liver damage. However, constitutive global Surf4 knockout results in embryonic lethality. To further understand the physiological role of Surf4 , we generated tamoxifen-inducible global Surf4 knockout mice. We found that conditional knockout of Surf4 in adult mice ( Surf4 ig-ko ) significantly reduced mouse body weight. Male and female Surf4 ig-ko mice died approximately 30 and 50 days after tamoxifen administration, respectively. Triglyceride secretion and serum levels of total cholesterol, triglycerides, free fatty acids, apolipoprotein B-100, and apolipoprotein-48 were significantly reduced in Surf4 ig-ko mice compared with Surf4 flox mice. Proteomics analysis of mouse serum samples revealed 308 proteins with significantly altered expression in Surf4 ig-ko mice that have unique functions and are involved in various biological processes. In addition, Surf4 ig-ko mice exhibited lipid accumulation in the intestine but not in the liver. However, in Surf4 ig-ko mice, liver weight was significantly reduced, and serum transaminase activity was significantly increased, indicating liver damage. Therefore, SURF4 is essential for survival in adult mice, suggesting that the therapeutic use of SURF4 requires precise tissue/cell type-specific targeting.
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LANGMUIR
·
2025
·
IF 3.9
Qianqian Li,Qinghong Shi,Xiaoyan Dong,Linling Yu,Yan Sun
The highly toxic organophosphate pesticide methyl parathion (MP) is widely used in agriculture and thus poses significant risks to the environment. Organophosphorus hydrolase (OPH) can effectively catalyze the hydrolysis of MP, but generate a toxic product of 4-nitrophenol (4-NP), so the following reduction of 4-NP to 4-aminophenol (4-AP) with low toxicity but high economic value has been designed for sustainable development. Therefore, the cascade conversion of highly hazardous MP to economically valuable 4-AP is an attractive strategy for both environmental remediation and industrial applications. In this study, we synthesized a reduction-catalytic cupric metal–organic framework (CuBDC) in solvent-free aqueous phase and under mild conditions and in situ encapsulated OPH within CuBDC via a cation polyelectrolyte poly(allylamine hydrochloride) (PAH)-assisted biomineralization, creating a chemoenzymatic cascade catalyst (OPH-PAH@CuBDC) for MP conversion to 4-NP. The optimized OPH-PAH@CuBDC exhibited 154% hydrolysis activity of free OPH, 130% reduction activities of pure CuBDC, and an average cascade conversion rate of 6.2 μmol·min–1·gcatalyst–1, affording a complete conversion of 50 μM MP to 4-AP in only 6 min at low reductant concentration (20 mM NaBH4), due to the Cu2+-activation effect on the encapsulated OPH and the PAH-induced exposure of more reduction-catalytic sites, respectively. Furthermore, OPH-PAH@CuBDC retained 95% activity in 10 day storage and about 50% activity in 10 recycles. The results proved that OPH-PAH@CuBDC is a promising chemoenzymatic catalyst with great potential in practical applications for MP detoxification and resourcilization.
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MICROCHIMICA ACTA
·
2017
·Vol. 184
·期 7
·1933-1940
·
IF 4.58
Zhang Xiaolong,Zeng Yongyi,Zheng Aixian,Cai Zhixiong,Huang Aimin,Zeng Jinhua,Liu Xiaolong,Liu Jingfeng
The authors describe a fluorescence immunoassay for galectin-4, a candidate biomarker for various cancers. Glucose oxidase was encapsulated into a zeolitic imidazolate framework to give a composite (GOx/ZIF-8 composite) that acts as a signal-transduction tag via a biomimetic mineralization process. After modification of the composite with streptavidin, it binds biotinylated antibody against galectin-4. In the immunoassay, the response to galectin-4 results from the enzymatic oxidation of glucose. This reaction produces hydrogen peroxide (H 2 O 2 ) that reacts with iron(II) ions to generate hydroxy radical (•OH), which leads to the quenching of the fluorescence of gold nanoclusters (AuNCs). Accordingly, the fluorescence quenching of AuNCs depends on the concentration of target galectin-4. The GOx/ZIF-8 composite has a high loading capacity for GOx at uncompromised enzymatic activity. The fluorescence of AuNCs is sensitively quenched by •OH radicals. Galectin-4 can be detected by this method in concentrations as low as 10 pg·mL −1 . It is expected that this kind of enzyme/MOF composite-based immunoassay has a wide scope in that it may be adapted to other low-abundance proteins and biomarkers.
Schematic of a fluorescence immunoassay for galectin-4, a candidate biomarker for various cancers. It is based on a composite consisting of glucose oxidase and a metal-organic framework (GOx/ZIF-8 composite) as well as gold nanoclusters (AuNC)-iron(II) system.
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MOLECULES
·
2025
·Vol. 31
·期 1
·133
·
IF 4.6
Yuancai Lv,Xuepeng Lin,Kai Yang,Yifan Liu,Xiaoxia Ye,Liang Song,Chunxiang Lin,Guifang Yang,Minghua Liu
Depolymerizing lignin to produce high-value chemicals has garnered increasing attention. Given the complex structure of real lignin, the cracking efficiency ofβ-O-4 linkages and the selectivity of depolymerization products are significantly lower than those of lignin model compounds. Meanwhile, the relationship between the structure of lignin and theβ-O-4 linkage cracking was ignored. In this work, to well address the issue, three real lignins (corncob lignin (CL), pinus massoniana lignin (PML), and eucalyptus lignin (EL)) were employed to discuss the impacts of special ether bonds in lignin on theβ-O-4 linkage cracking in the no-additional-hydrogen catalytic system mediated by a CoNi2@BTC catalyst. The lignin depolymerization results showed that the ether bonding structure in the lignin significantly impacted the cracking ofβ-O-4 linkages and selectivity of the final products, resulting in a great difference among their intermediates. Notably, the methoxy groups in the real lignin greatly inhibited the further hydrogenation of phenolic compounds, resulting in the accumulation of abundant methoxy-substituted phenolic compounds and a low yield of cycloalkanes (12.37% to 14.06%). To deeply discuss theβ-O-4 linkage cracking in the lignin depolymerization, degradation experiments with coexisting ether bond compounds were performed, and the activation energy was employed to quantitatively evaluate the impacts of other ether bonds on theβ-O-4 linkage cracking. The results revealed that multiple ether bonds (α-O-4, 4-O-5, and methoxy group) significantly increased the activation energy (from 236% to 373%) ofβ-O-4 linkages, resulting in the evident decline in theβ-O-4 model compound. In addition, the degradation of the methoxy-substitutedβ-O-4 model compound (GG) demonstrated that the methoxy-substituted aromatic ring products were resistant to further hydrogenation, resulting in the accumulation of methoxy-substituted aromatic ring products in the depolymerization of real lignin. All the findings will provide a novel perspective for the targeted high-value utilization of real lignin in chemical production.
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JOURNAL OF CELLULAR PHYSIOLOGY
·
2019
·Vol. 234
·期 10
·18480-18491
·
IF 4.522
Shi Xu,Beibei Yang,Tingting Tao,Ji Zhang,Yun Liu,Jun Hu,Yi Fan,Guangdong Zhang
Epidemiologic studies have shown a reduced risk of developing Parkinson's disease (PD) among cigarette smokers. Nicotine, as a key component in tobacco products, is thought as a possible candidate for action of smoking in neuroprotection. α7 nicotinic acetylcholine receptors (α7-nAChRs) is one of the most abundant nAChRs in the mammalian brain. Although nicotine is thought to exert this protective action by acting on nicotinic receptors, including the α7-nAChRs; the mechanisms underlying how α7-nAChRs protect against dopaminergic neuron loss are highly complex. Using nicotine and a selective α7-nAChR agonist PNU-282987, we first confirmed that their addition to SH-SY5Y cells challenged with 1-methyl-4-phenylpyridinium (MPP + ) could afford neuroprotection and result in a reduction in apoptotic cell death. Then, we found that the pretreatment with nicotine and PNU-282987 showed the neuroprotective antiapoptotic effects via activating the α7-nAChRs/MAPK/p53 axis. Furthermore, we used RNA interference to silence the expression of α7-nAChRs in SH-SY5Y cells and found that suppressing α7-nAChR expression diminished the antiapoptotic effects of nicotine and PNU-282987, not the toxic effects of MPP + . Moreover, α7-nAChR knockdown could only decrease the inhibitory effects of nicotine and PNU-282987 on the phosphorylated extracellular signal-regulated kinase (ERK), not c-Jun amino-terminal kinase and p38. Therefore, our findings indicate the important roles of ERK/MAPK signaling in the neuroprotective effects of α7-nAChRs and suggest that α7-nAChR agonists may be validated as novel treatments for PD.
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高影响因子
DRUG METABOLISM AND DISPOSITION
·
2015
·Vol. 43
·期 10
·1430-1440
·
IF 3.252
Hua Sun,Xiao Wang,Xiaotong Zhou,Danyi Lu,Zhiguo Ma,Baojian Wu
Sulfonation is an important metabolic pathway for hesperetin. However, the mechanisms for the cellular disposition of hesperetin and its sulfate metabolites are not fully established. In this study, disposition of hesperetin via the sulfonation pathway was investigated using human embryonic kidney (HEK) 293 cells overexpressing sulfotransferase 1A3. Two monosulfates, hesperetin-3′-O-sulfate (H-3′-S) and hesperetin-7-O-sulfate (H-7-S), were rapidly generated and excreted into the extracellular compartment upon incubation of the cells with hesperetin. Regiospecific sulfonation of hesperetin by the cell lysate followed the substrate inhibition kinetics (Vmax = 0.66 nmol/min per mg, Km = 12.9 μM, and Ksi= 58.1 μM for H-3′-S; Vmax = 0.29 nmol/min per mg, Km = 14.8 μM, and Ksi= 49.1 μM for H-7-S). The pan–multidrug resistance-associated protein (MRP) inhibitor MK-571 at 20 μM essentially abolished cellular excretion of both H-3′-S and H-7-S (the excretion activities were only 6% of the control), whereas the breast cancer resistance protein–selective inhibitor Ko143 had no effects on sulfate excretion. In addition, knockdown of MRP4 led to a substantial reduction (>47.1%; P < 0.01) in sulfate excretion. Further, H-3′-S and H-7-S were good substrates for transport by MRP4 according to the vesicular transport assay. Moreover, sulfonation of hesperetin and excretion of its metabolites were well characterized by a two-compartment pharmacokinetic model that integrated drug uptake and sulfonation with MRP4-mediated sulfate excretion. In conclusion, the exporter MRP4 controlled efflux transport of hesperetin sulfates in HEK293 cells. Due to significant expression in various organs/tissues (including the liver and kidney), MRP4 should be a determining factor for the elimination and body distribution of hesperetin sulfates.
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